ID   FXYD5_RAT               Reviewed;         178 AA.
AC   P59647; Q6P9W0;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   24-JAN-2024, entry version 115.
DE   RecName: Full=FXYD domain-containing ion transport regulator 5;
DE   Flags: Precursor;
GN   Name=Fxyd5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=10950925; DOI=10.1006/geno.2000.6274;
RA   Sweadner K.J., Rael E.;
RT   "The FXYD gene family of small ion transport regulators or channels: cDNA
RT   sequence, protein signature sequence, and expression.";
RL   Genomics 68:41-56(2000).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Spleen, lung, skeletal muscle, and testis.
CC   -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
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DR   EMBL; BC060571; AAH60571.1; -; mRNA.
DR   RefSeq; NP_001257617.1; NM_001270688.1.
DR   RefSeq; NP_001257618.1; NM_001270689.1.
DR   RefSeq; NP_068709.2; NM_021909.2.
DR   AlphaFoldDB; P59647; -.
DR   STRING; 10116.ENSRNOP00000028597; -.
DR   PhosphoSitePlus; P59647; -.
DR   PaxDb; 10116-ENSRNOP00000028597; -.
DR   GeneID; 60338; -.
DR   KEGG; rno:60338; -.
DR   AGR; RGD:620827; -.
DR   CTD; 53827; -.
DR   RGD; 620827; Fxyd5.
DR   VEuPathDB; HostDB:ENSRNOG00000021062; -.
DR   eggNOG; ENOG502TDJN; Eukaryota.
DR   HOGENOM; CLU_109413_0_0_1; -.
DR   InParanoid; P59647; -.
DR   OrthoDB; 4641958at2759; -.
DR   PhylomeDB; P59647; -.
DR   TreeFam; TF338182; -.
DR   PRO; PR:P59647; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000021062; Expressed in spleen and 20 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0003779; F:actin binding; ISO:RGD.
DR   GO; GO:0045296; F:cadherin binding; ISO:RGD.
DR   GO; GO:0017080; F:sodium channel regulator activity; IBA:GO_Central.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of monoatomic ion transport; IEA:InterPro.
DR   CDD; cd20323; FXYD_FXYD5; 1.
DR   Gene3D; 1.20.5.780; Single helix bin; 1.
DR   InterPro; IPR047297; FXYD_motif.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   PANTHER; PTHR14132:SF14; FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 5; 1.
DR   PANTHER; PTHR14132; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA; 1.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   PROSITE; PS01310; FXYD; 1.
DR   Genevisible; P59647; RN.
PE   2: Evidence at transcript level;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..178
FT                   /note="FXYD domain-containing ion transport regulator 5"
FT                   /id="PRO_0000010371"
FT   TOPO_DOM        22..146
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..178
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          21..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   178 AA;  19128 MW;  99B30D88B928FF4E CRC64;
     MSPPSQLCLL TIVALILPSE GQTPEKPRSS FTAHQSSVTT HVPVPDQTSP GVQTTPPIWT
     SEAGEATGSQ TAAKTKTQQL TEMATANPVT DPGPLTSSEK GTPALSRIKS PSPPKGYMPP
     SYIENPLDPN ENSPFYYDNT TLRKRGLLVA AVLFITGIII LTSGKCRQFS QLCLNRHR
//