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Protein

FXYD domain-containing ion transport regulator 5

Gene

Fxyd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ion channel activity Source: InterPro
  2. sodium channel regulator activity Source: GO_Central

GO - Biological processi

  1. regulation of sodium ion transmembrane transporter activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 5
Gene namesi
Name:Fxyd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620827. Fxyd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 146125ExtracellularSequence AnalysisAdd
BLAST
Transmembranei147 – 16418HelicalSequence AnalysisAdd
BLAST
Topological domaini165 – 17814CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 178157FXYD domain-containing ion transport regulator 5PRO_0000010371Add
BLAST

Proteomic databases

PaxDbiP59647.

Expressioni

Tissue specificityi

Spleen, lung, skeletal muscle, and testis.

Gene expression databases

GenevestigatoriP59647.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028597.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi88 – 13447Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43413.
GeneTreeiENSGT00410000026316.
HOGENOMiHOG000112679.
HOVERGENiHBG051678.
InParanoidiP59647.
KOiK13362.
OMAiWPADETP.
OrthoDBiEOG7MKW85.
PhylomeDBiP59647.
TreeFamiTF338182.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPSQLCLL TIVALILPSE GQTPEKPRSS FTAHQSSVTT HVPVPDQTSP
60 70 80 90 100
GVQTTPPIWT SEAGEATGSQ TAAKTKTQQL TEMATANPVT DPGPLTSSEK
110 120 130 140 150
GTPALSRIKS PSPPKGYMPP SYIENPLDPN ENSPFYYDNT TLRKRGLLVA
160 170
AVLFITGIII LTSGKCRQFS QLCLNRHR
Length:178
Mass (Da):19,128
Last modified:September 5, 2006 - v2
Checksum:i99B30D88B928FF4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060571 mRNA. Translation: AAH60571.1.
RefSeqiNP_001257617.1. NM_001270688.1.
NP_001257618.1. NM_001270689.1.
NP_068709.2. NM_021909.2.
UniGeneiRn.234281.
Rn.24997.

Genome annotation databases

EnsembliENSRNOT00000028597; ENSRNOP00000028597; ENSRNOG00000021062.
GeneIDi60338.
KEGGirno:60338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060571 mRNA. Translation: AAH60571.1.
RefSeqiNP_001257617.1. NM_001270688.1.
NP_001257618.1. NM_001270689.1.
NP_068709.2. NM_021909.2.
UniGeneiRn.234281.
Rn.24997.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028597.

Proteomic databases

PaxDbiP59647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028597; ENSRNOP00000028597; ENSRNOG00000021062.
GeneIDi60338.
KEGGirno:60338.

Organism-specific databases

CTDi53827.
RGDi620827. Fxyd5.

Phylogenomic databases

eggNOGiNOG43413.
GeneTreeiENSGT00410000026316.
HOGENOMiHOG000112679.
HOVERGENiHBG051678.
InParanoidiP59647.
KOiK13362.
OMAiWPADETP.
OrthoDBiEOG7MKW85.
PhylomeDBiP59647.
TreeFamiTF338182.

Miscellaneous databases

PROiP59647.

Gene expression databases

GenevestigatoriP59647.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  2. "The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression."
    Sweadner K.J., Rael E.
    Genomics 68:41-56(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiFXYD5_RAT
AccessioniPrimary (citable) accession number: P59647
Secondary accession number(s): Q6P9W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 5, 2006
Last modified: April 29, 2015
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.