P59647 (FXYD5_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FXYD domain-containing ion transport regulator 5

Gene names

Name:

Fxyd5

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Spleen, lung, skeletal muscle, and testis.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ion channel
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 178	157	FXYD domain-containing ion transport regulator 5		PRO_0000010371
Regions
	Topological domain	22 – 146	125	Extracellular Potential
	Transmembrane	147 – 164	18	Helical; Potential
	Topological domain	165 – 178	14	Cytoplasmic Potential
	Compositional bias	88 – 134	47	Pro-rich
Amino acid modifications
	Modified residue	112	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59647 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: 99B30D88B928FF4E	FASTA	178	19,128
	10 20 30 40 50 60 MSPPSQLCLL TIVALILPSE GQTPEKPRSS FTAHQSSVTT HVPVPDQTSP GVQTTPPIWT 70 80 90 100 110 120 SEAGEATGSQ TAAKTKTQQL TEMATANPVT DPGPLTSSEK GTPALSRIKS PSPPKGYMPP 130 140 150 160 170 SYIENPLDPN ENSPFYYDNT TLRKRGLLVA AVLFITGIII LTSGKCRQFS QLCLNRHR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[2]	"The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression." Sweadner K.J., Rael E. Genomics 68:41-56(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC060571 mRNA. Translation: AAH60571.1.
IPI	IPI00326309.
RefSeq	NP_001257617.1. NM_001270688.1. NP_001257618.1. NM_001270689.1. NP_068709.2. NM_021909.2.
UniGene	Rn.24997.
3D structure databases
ProteinModelPortal	P59647.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000028597.
Proteomic databases
PaxDb	P59647.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000028597; ENSRNOP00000028597; ENSRNOG00000021062.
GeneID	60338.
KEGG	rno:60338.
Organism-specific databases
CTD	53827.
RGD	620827. Fxyd5.
Phylogenomic databases
eggNOG	NOG43413.
GeneTree	ENSGT00410000026316.
HOGENOM	HOG000112679.
HOVERGEN	HBG051678.
InParanoid	P59647.
KO	K13362.
OMA	TWPADET.
OrthoDB	EOG4VDQ18.
Gene expression databases
Genevestigator	P59647.
GermOnline	ENSRNOG00000021062. Rattus norvegicus.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FXYD5_RAT

Accession

Primary (citable) accession number: P59647
Secondary accession number(s): Q6P9W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program