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P59647 (FXYD5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FXYD domain-containing ion transport regulator 5
Gene names
Name:Fxyd5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Spleen, lung, skeletal muscle, and testis.

Sequence similarities

Belongs to the FXYD family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionIon channel
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionion channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 178157FXYD domain-containing ion transport regulator 5
PRO_0000010371

Regions

Topological domain22 – 146125Extracellular Potential
Transmembrane147 – 16418Helical; Potential
Topological domain165 – 17814Cytoplasmic Potential
Compositional bias88 – 13447Pro-rich

Sequences

Sequence LengthMass (Da)Tools
P59647 [UniParc].

Last modified September 5, 2006. Version 2.
Checksum: 99B30D88B928FF4E

FASTA17819,128
        10         20         30         40         50         60 
MSPPSQLCLL TIVALILPSE GQTPEKPRSS FTAHQSSVTT HVPVPDQTSP GVQTTPPIWT 

        70         80         90        100        110        120 
SEAGEATGSQ TAAKTKTQQL TEMATANPVT DPGPLTSSEK GTPALSRIKS PSPPKGYMPP 

       130        140        150        160        170 
SYIENPLDPN ENSPFYYDNT TLRKRGLLVA AVLFITGIII LTSGKCRQFS QLCLNRHR 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[2]"The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression."
Sweadner K.J., Rael E.
Genomics 68:41-56(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC060571 mRNA. Translation: AAH60571.1.
RefSeqNP_001257617.1. NM_001270688.1.
NP_001257618.1. NM_001270689.1.
NP_068709.2. NM_021909.2.
UniGeneRn.234281.
Rn.24997.

3D structure databases

ProteinModelPortalP59647.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000028597.

Proteomic databases

PaxDbP59647.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028597; ENSRNOP00000028597; ENSRNOG00000021062.
GeneID60338.
KEGGrno:60338.

Organism-specific databases

CTD53827.
RGD620827. Fxyd5.

Phylogenomic databases

eggNOGNOG43413.
GeneTreeENSGT00410000026316.
HOGENOMHOG000112679.
HOVERGENHBG051678.
InParanoidP59647.
KOK13362.
OMAWPADETP.
OrthoDBEOG7MKW85.
PhylomeDBP59647.
TreeFamTF338182.

Gene expression databases

GenevestigatorP59647.

Family and domain databases

InterProIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP59647.

Entry information

Entry nameFXYD5_RAT
AccessionPrimary (citable) accession number: P59647
Secondary accession number(s): Q6P9W0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 5, 2006
Last modified: April 16, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families