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P59647

- FXYD5_RAT

UniProt

P59647 - FXYD5_RAT

Protein

FXYD domain-containing ion transport regulator 5

Gene

Fxyd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ion channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FXYD domain-containing ion transport regulator 5
    Gene namesi
    Name:Fxyd5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi620827. Fxyd5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 178157FXYD domain-containing ion transport regulator 5PRO_0000010371Add
    BLAST

    Proteomic databases

    PaxDbiP59647.

    Expressioni

    Tissue specificityi

    Spleen, lung, skeletal muscle, and testis.

    Gene expression databases

    GenevestigatoriP59647.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028597.

    Structurei

    3D structure databases

    ProteinModelPortaliP59647.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 146125ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini165 – 17814CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei147 – 16418HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi88 – 13447Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FXYD family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43413.
    GeneTreeiENSGT00410000026316.
    HOGENOMiHOG000112679.
    HOVERGENiHBG051678.
    InParanoidiP59647.
    KOiK13362.
    OMAiFYYDEAT.
    OrthoDBiEOG7MKW85.
    PhylomeDBiP59647.
    TreeFamiTF338182.

    Family and domain databases

    InterProiIPR000272. Ion-transport_regulator_FXYD.
    [Graphical view]
    PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
    [Graphical view]
    ProDomiPD005989. PD005989. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS01310. FXYD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59647-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPPSQLCLL TIVALILPSE GQTPEKPRSS FTAHQSSVTT HVPVPDQTSP    50
    GVQTTPPIWT SEAGEATGSQ TAAKTKTQQL TEMATANPVT DPGPLTSSEK 100
    GTPALSRIKS PSPPKGYMPP SYIENPLDPN ENSPFYYDNT TLRKRGLLVA 150
    AVLFITGIII LTSGKCRQFS QLCLNRHR 178
    Length:178
    Mass (Da):19,128
    Last modified:September 5, 2006 - v2
    Checksum:i99B30D88B928FF4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060571 mRNA. Translation: AAH60571.1.
    RefSeqiNP_001257617.1. NM_001270688.1.
    NP_001257618.1. NM_001270689.1.
    NP_068709.2. NM_021909.2.
    UniGeneiRn.234281.
    Rn.24997.

    Genome annotation databases

    EnsembliENSRNOT00000028597; ENSRNOP00000028597; ENSRNOG00000021062.
    GeneIDi60338.
    KEGGirno:60338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060571 mRNA. Translation: AAH60571.1 .
    RefSeqi NP_001257617.1. NM_001270688.1.
    NP_001257618.1. NM_001270689.1.
    NP_068709.2. NM_021909.2.
    UniGenei Rn.234281.
    Rn.24997.

    3D structure databases

    ProteinModelPortali P59647.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028597.

    Proteomic databases

    PaxDbi P59647.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028597 ; ENSRNOP00000028597 ; ENSRNOG00000021062 .
    GeneIDi 60338.
    KEGGi rno:60338.

    Organism-specific databases

    CTDi 53827.
    RGDi 620827. Fxyd5.

    Phylogenomic databases

    eggNOGi NOG43413.
    GeneTreei ENSGT00410000026316.
    HOGENOMi HOG000112679.
    HOVERGENi HBG051678.
    InParanoidi P59647.
    KOi K13362.
    OMAi FYYDEAT.
    OrthoDBi EOG7MKW85.
    PhylomeDBi P59647.
    TreeFami TF338182.

    Miscellaneous databases

    PROi P59647.

    Gene expression databases

    Genevestigatori P59647.

    Family and domain databases

    InterProi IPR000272. Ion-transport_regulator_FXYD.
    [Graphical view ]
    Pfami PF02038. ATP1G1_PLM_MAT8. 1 hit.
    [Graphical view ]
    ProDomi PD005989. PD005989. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS01310. FXYD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    2. "The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression."
      Sweadner K.J., Rael E.
      Genomics 68:41-56(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiFXYD5_RAT
    AccessioniPrimary (citable) accession number: P59647
    Secondary accession number(s): Q6P9W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3