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Protein

FXYD domain-containing ion transport regulator 4

Gene

FXYD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 4
Gene namesi
Name:FXYD4
ORF Names:UNQ526/PRO1069
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:4028. FXYD4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 3818ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Topological domaini60 – 8930CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28444.

Polymorphism and mutation databases

BioMutaiFXYD4.
DMDMi114152806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 8969FXYD domain-containing ion transport regulator 4PRO_0000010366Add
BLAST

Proteomic databases

PaxDbiP59646.
PRIDEiP59646.

PTM databases

PhosphoSiteiP59646.

Expressioni

Gene expression databases

BgeeiP59646.
CleanExiHS_FXYD4.
GenevisibleiP59646. HS.

Organism-specific databases

HPAiHPA014839.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363575.

Structurei

3D structure databases

ProteinModelPortaliP59646.
SMRiP59646. Positions 25-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
InParanoidiP59646.
KOiK13359.
OMAiPGSASTC.
OrthoDBiEOG7WDN61.
PhylomeDBiP59646.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVTLALLL LAGLTALEAN DPFANKDDPF YYDWKNLQLS GLICGGLLAI
60 70 80
AGIAAVLSGK CKCKSSQKQH SPVPEKAIPL ITPGSATTC
Length:89
Mass (Da):9,373
Last modified:September 5, 2006 - v2
Checksum:iC5935929A22449B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631C → Y in AAQ88947 (PubMed:12975309).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358584 mRNA. Translation: AAQ88947.1.
AL512654 Genomic DNA. Translation: CAI17065.1.
BC054876 mRNA. Translation: AAH54876.1.
CCDSiCCDS7203.1.
RefSeqiNP_001171892.1. NM_001184963.1.
NP_775183.1. NM_173160.2.
UniGeneiHs.130497.

Genome annotation databases

EnsembliENST00000476166; ENSP00000473361; ENSG00000150201.
ENST00000616495; ENSP00000483791; ENSG00000150201.
GeneIDi53828.
KEGGihsa:53828.
UCSCiuc001jaq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358584 mRNA. Translation: AAQ88947.1.
AL512654 Genomic DNA. Translation: CAI17065.1.
BC054876 mRNA. Translation: AAH54876.1.
CCDSiCCDS7203.1.
RefSeqiNP_001171892.1. NM_001184963.1.
NP_775183.1. NM_173160.2.
UniGeneiHs.130497.

3D structure databases

ProteinModelPortaliP59646.
SMRiP59646. Positions 25-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363575.

PTM databases

PhosphoSiteiP59646.

Polymorphism and mutation databases

BioMutaiFXYD4.
DMDMi114152806.

Proteomic databases

PaxDbiP59646.
PRIDEiP59646.

Protocols and materials databases

DNASUi53828.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000476166; ENSP00000473361; ENSG00000150201.
ENST00000616495; ENSP00000483791; ENSG00000150201.
GeneIDi53828.
KEGGihsa:53828.
UCSCiuc001jaq.2. human.

Organism-specific databases

CTDi53828.
GeneCardsiFXYD4.
HGNCiHGNC:4028. FXYD4.
HPAiHPA014839.
neXtProtiNX_P59646.
PharmGKBiPA28444.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
InParanoidiP59646.
KOiK13359.
OMAiPGSASTC.
OrthoDBiEOG7WDN61.
PhylomeDBiP59646.
TreeFamiTF333443.

Enzyme and pathway databases

ReactomeiR-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii53828.
NextBioi56148.
PROiP59646.

Gene expression databases

BgeeiP59646.
CleanExiHS_FXYD4.
GenevisibleiP59646. HS.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression."
    Sweadner K.J., Rael E.
    Genomics 68:41-56(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiFXYD4_HUMAN
AccessioniPrimary (citable) accession number: P59646
Secondary accession number(s): Q6UWZ1, Q7Z4M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 5, 2006
Last modified: March 16, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.