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Protein

FXYD domain-containing ion transport regulator 3

Gene

Fxyd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: RGD
  • regulation of catalytic activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 3
Gene namesi
Name:Fxyd3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620825. Fxyd3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 3818ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Topological domaini60 – 8829CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 8868FXYD domain-containing ion transport regulator 3PRO_0000010365Add
BLAST

Proteomic databases

PaxDbiP59645.

Expressioni

Gene expression databases

GenevisibleiP59645. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028637.

Structurei

3D structure databases

ProteinModelPortaliP59645.
SMRiP59645. Positions 21-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiP59645.
KOiK13361.
OMAiYDWHSLR.
OrthoDBiEOG7H7956.
PhylomeDBiP59645.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEFALSLLV LLAGLPTLDA NDPEDKDSPF YYDWHSLRVG GLICAGILCA
60 70 80
LGIIVLMSGK CKCKFSQKPS HRPGDGPPLI TPGSAHNC
Length:88
Mass (Da):9,411
Last modified:April 30, 2003 - v1
Checksum:i45AFE872FD1AF944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA801365 mRNA. No translation available.
RefSeqiNP_758528.1. NM_172317.2.
XP_006228882.1. XM_006228820.2.
UniGeneiRn.3896.

Genome annotation databases

EnsembliENSRNOT00000028637; ENSRNOP00000028637; ENSRNOG00000021095.
GeneIDi116831.
KEGGirno:116831.
UCSCiRGD:620825. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA801365 mRNA. No translation available.
RefSeqiNP_758528.1. NM_172317.2.
XP_006228882.1. XM_006228820.2.
UniGeneiRn.3896.

3D structure databases

ProteinModelPortaliP59645.
SMRiP59645. Positions 21-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028637.

Proteomic databases

PaxDbiP59645.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028637; ENSRNOP00000028637; ENSRNOG00000021095.
GeneIDi116831.
KEGGirno:116831.
UCSCiRGD:620825. rat.

Organism-specific databases

CTDi5349.
RGDi620825. Fxyd3.

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiP59645.
KOiK13361.
OMAiYDWHSLR.
OrthoDBiEOG7H7956.
PhylomeDBiP59645.
TreeFamiTF333443.

Enzyme and pathway databases

ReactomeiR-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiP59645.

Gene expression databases

GenevisibleiP59645. RN.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Lee N.H., Glodek A., Chandra I., Mason T.M., Quackenbush J., Kerlavage A.R., Adams M.D.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression."
    Sweadner K.J., Rael E.
    Genomics 68:41-56(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECONSTRUCTION FROM ESTS, CONCEPTUAL TRANSLATION.

Entry informationi

Entry nameiFXYD3_RAT
AccessioniPrimary (citable) accession number: P59645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.