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Protein

FXYD domain-containing ion transport regulator 3

Gene

Fxyd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na+ out of the cell and K+ into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 3
Alternative name(s):
Sodium/potassium-transporting ATPase subunit FXYD3Curated
Gene namesi
Name:Fxyd3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620825. Fxyd3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 38ExtracellularSequence analysisAdd BLAST18
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 88CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001036521 – 88FXYD domain-containing ion transport regulator 3Add BLAST68

Post-translational modificationi

Glutathionylated.By similarity

Keywords - PTMi

Glutathionylation

Proteomic databases

PaxDbiP59645.

PTM databases

PhosphoSitePlusiP59645.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021095.
GenevisibleiP59645. RN.

Interactioni

Subunit structurei

Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic alpha subunit ATP1A1. Also interacts with non-catalytic beta subunit ATP1B1. Interacts with the alpha1-beta1, alpha2-beta1 and alpha3-beta1 NKA isozymes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028637.

Structurei

3D structure databases

ProteinModelPortaliP59645.
SMRiP59645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiP59645.
KOiK13361.
OMAiKPSHRPG.
OrthoDBiEOG091G14HJ.
PhylomeDBiP59645.
TreeFamiTF333443.

Family and domain databases

InterProiView protein in InterPro
IPR000272. Ion-transport_regulator_FXYD.
PfamiView protein in Pfam
PF02038. ATP1G1_PLM_MAT8. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989. PD005989. 1 hit.
PROSITEiView protein in PROSITE
PS01310. FXYD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEFALSLLV LLAGLPTLDA NDPEDKDSPF YYDWHSLRVG GLICAGILCA
60 70 80
LGIIVLMSGK CKCKFSQKPS HRPGDGPPLI TPGSAHNC
Length:88
Mass (Da):9,411
Last modified:April 30, 2003 - v1
Checksum:i45AFE872FD1AF944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA801365 mRNA. No translation available.
RefSeqiNP_758528.1. NM_172317.2.
UniGeneiRn.3896.

Genome annotation databases

EnsembliENSRNOT00000028637; ENSRNOP00000028637; ENSRNOG00000021095.
GeneIDi116831.
KEGGirno:116831.
UCSCiRGD:620825. rat.

Similar proteinsi

Entry informationi

Entry nameiFXYD3_RAT
AccessioniPrimary (citable) accession number: P59645
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 30, 2003
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families