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P59636 (ORF9B_CVHSA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer.

Subcellular location

Host cytoplasmic vesicle membrane; Peripheral membrane protein. Host cytoplasm. Note: Binds non-covalently to intracellular lipid bilayers. Ref.13

Miscellaneous

The gene encoding this protein is included within the N gene (alternative ORF).

Sequence similarities

Belongs to the coronavirus group 2 protein 9b family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9898Protein 9b
PRO_0000106137

Natural variations

Natural variant581A → V in strain: Isolate TWK.

Secondary structure

............... 98
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P59636 [UniParc].

Last modified April 23, 2003. Version 1.
Checksum: 5166F22872915FCB

FASTA9810,802
        10         20         30         40         50         60 
MDPNQTNVVP PALHLVDPQI QLTITRMEDA MGQGQNSADP KVYPIILRLG SQLSLSMARR 

        70         80         90 
NLDSLEARAF QSTPIVVQMT KLATTEELPD EFVVVTAK 

« Hide

References

[1]"Characterization of a novel coronavirus associated with severe acute respiratory syndrome."
Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R., Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H., Tong S., Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D., Erdman D.D. expand/collapse author list , Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E., Sanchez A., Liffick S., Holloway B., Limor J., McCaustland K., Olsen-Rasmussen M., Fouchier R., Guenther S., Osterhaus A.D.M.E., Drosten C., Pallansch M.A., Anderson L.J., Bellini W.J.
Science 300:1394-1399(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Urbani.
[2]"The genome sequence of the SARS-associated coronavirus."
Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A., Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y., Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R., Mayo M., McDonald H. expand/collapse author list , Montgomery S.B., Pandoh P.K., Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M., Skowronski D.M., Upton C., Roper R.L.
Science 300:1399-1404(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Tor2.
[3]"Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome."
Tsui S.K.W., Chim S.S.C., Lo Y.M.D.
N. Engl. J. Med. 349:187-188(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate CUHK-Su10 and Isolate CUHK-W1.
[4]"The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39)."
Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C., Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.
Exp. Biol. Med. 228:866-873(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate HKU-39849.
[5]Qin E., Zhu Q., Yu M., Fan B., Chang G., Si B., Yang B., Peng W., Jiang T., Liu B., Deng Y., Liu H., Zhang Y., Wang C., Li Y., Gan Y., Li X., Lu F. expand/collapse author list , Tan G., Yang R., Cao W.S., Wang J., Chen W., Cong L., Deng Y., Dong W., Han Y., Hu W., Lei M., Li C., Li G., Li G., Li H., Li S., Li S., Li W., Li W., Lin W., Liu J., Liu Z., Lu H., Ni P., Qi Q., Sun Y., Tang L., Tong Z., Wang J., Wang X., Wu Q., Xi Y., Xu Z., Yang L., Ye C., Ye J., Zhang B., Zhang F., Zhang J., Zhang X., Zhou J., Yang H.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate GD01.
[6]"The complete genome of SARS coronavirus clone TW1."
Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate TW1.
[7]"SARS virus is a close relative of type II coronaviruses."
Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K., Censini S., Guidotti S., Masignani V., Scarselli M., Mora M., Donati C., Han J., Song H.C., Abrignani S., Covacci A., Rappuoli R.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate FRA.
[8]"Mechanisms and enzymes involved in SARS coronavirus genome expression."
Thiel V., Ivanov K.A., Putics A., Hertzig T., Schelle B., Bayer S., Weissbrich B., Snijder E.J., Rabenau H., Doerr H.W., Gorbalenya A.E., Ziebuhr J.
J. Gen. Virol. 84:2305-2315(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate Frankfurt 1.
[9]"Severe acute respiratory syndrome-associated coronavirus genotype and its characterization."
Li L., Wang Z., Lu Y., Bao Q., Chen S., Wu N., Cheng S., Weng J., Zhang Y., Yan J., Mei L., Wang X., Zhu H., Yu Y., Zhang M., Li M., Yao J., Lu Q. expand/collapse author list , Yao P., Bo X., Wo J., Wang S., Hu S.
Chin. Med. J. 116:1288-1292(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate ZJ01.
[10]"The complete genome of SARS coronavirus TWH."
Shu H.Y., Wu K.M., Tsai S.F.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS and Isolate TWY.
[11]Canducci F., Clementi M., Poli G., Vicenzi E.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate HSR 1.
[12]Balotta C., Corvasce S., Violin M., Galli M., Moroni M., Vigevani G.M., Ruan Y.J., Salemi M.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate AS.
[13]"The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus."
Meier C., Aricescu A.R., Assenberg R., Aplin R.T., Gilbert R.J.C., Grimes J.M., Stuart D.I.
Structure 14:1157-1165(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-98, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY278741 Genomic RNA. No translation available.
AY274119 Genomic RNA. Translation: AAP41048.1.
AY282752 Genomic RNA. No translation available.
AY278554 Genomic RNA. Translation: AAP13574.1.
AY278491 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. Translation: AAP30038.1.
AY278489 Genomic RNA. Translation: AAP51235.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37025.1.
AY310120 Genomic RNA. Translation: AAP50496.1.
AY291315 Genomic RNA. Translation: AAP33708.1.
AY290752 Genomic RNA. Translation: AAP69659.1.
AP006557 Genomic RNA. Translation: BAC81359.1.
AP006558 Genomic RNA. Translation: BAC81373.1.
AP006559 Genomic RNA. Translation: BAC81387.1.
AP006560 Genomic RNA. Translation: BAC81401.1.
AP006561 Genomic RNA. Translation: BAC81415.1.
AY323977 Genomic RNA. Translation: AAP72985.1.
AY427439 Genomic RNA. Translation: AAQ94071.1.
RefSeqNP_828859.1. NC_004718.3.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CMEX-ray2.80A/B9-98[»]
C/D/F/H10-98[»]
E/G9-98[»]
ProteinModelPortalP59636.
SMRP59636. Positions 9-98.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP59636.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1489679.

Family and domain databases

InterProIPR018542. SARS_lipid-bd.
[Graphical view]
PfamPF09399. SARS_lipid_bind. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP59636.

Entry information

Entry nameORF9B_CVHSA
AccessionPrimary (citable) accession number: P59636
Secondary accession number(s): Q7T6R2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: November 13, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references