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P59636

- ORF9B_CVHSA

UniProt

P59636 - ORF9B_CVHSA

Protein

Protein 9b

Gene

9b

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein 9b
    Alternative name(s):
    Accessory protein 9b
    ORF-9b
    Gene namesi
    ORF Names:9b
    OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
    Taxonomic identifieri227859 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Paguma larvata (Masked palm civet) [TaxID: 9675]
    ProteomesiUP000000354: Genome

    Subcellular locationi

    Host cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication. Host cytoplasm 1 Publication
    Note: Binds non-covalently to intracellular lipid bilayers.

    GO - Cellular componenti

    1. host cell cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host cytoplasm, Host cytoplasmic vesicle, Host membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9898Protein 9bPRO_0000106137Add
    BLAST

    Proteomic databases

    PRIDEiP59636.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    Secondary structure

    1
    98
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi14 – 2310
    Beta strandi42 – 476
    Beta strandi54 – 607
    Beta strandi65 – 673
    Beta strandi69 – 746
    Helixi85 – 873
    Beta strandi90 – 978

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CMEX-ray2.80A/B9-98[»]
    C/D/F/H10-98[»]
    E/G9-98[»]
    ProteinModelPortaliP59636.
    SMRiP59636. Positions 9-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP59636.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR018542. SARS_lipid-bd.
    [Graphical view]
    PfamiPF09399. SARS_lipid_bind. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59636-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPNQTNVVP PALHLVDPQI QLTITRMEDA MGQGQNSADP KVYPIILRLG   50
    SQLSLSMARR NLDSLEARAF QSTPIVVQMT KLATTEELPD EFVVVTAK 98
    Length:98
    Mass (Da):10,802
    Last modified:April 23, 2003 - v1
    Checksum:i5166F22872915FCB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581A → V in strain: Isolate TWK.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY278741 Genomic RNA. No translation available.
    AY274119 Genomic RNA. Translation: AAP41048.1.
    AY282752 Genomic RNA. No translation available.
    AY278554 Genomic RNA. Translation: AAP13574.1.
    AY278491 Genomic RNA. No translation available.
    AY278487 Genomic RNA. No translation available.
    AY278488 Genomic RNA. Translation: AAP30038.1.
    AY278489 Genomic RNA. Translation: AAP51235.1.
    AY278490 Genomic RNA. No translation available.
    AY279354 Genomic RNA. No translation available.
    AY291451 Genomic RNA. Translation: AAP37025.1.
    AY310120 Genomic RNA. Translation: AAP50496.1.
    AY291315 Genomic RNA. Translation: AAP33708.1.
    AY290752 Genomic RNA. Translation: AAP69659.1.
    AP006557 Genomic RNA. Translation: BAC81359.1.
    AP006558 Genomic RNA. Translation: BAC81373.1.
    AP006559 Genomic RNA. Translation: BAC81387.1.
    AP006560 Genomic RNA. Translation: BAC81401.1.
    AP006561 Genomic RNA. Translation: BAC81415.1.
    AY323977 Genomic RNA. Translation: AAP72985.1.
    AY427439 Genomic RNA. Translation: AAQ94071.1.
    RefSeqiNP_828859.1. NC_004718.3.

    Genome annotation databases

    GeneIDi1489679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY278741 Genomic RNA. No translation available.
    AY274119 Genomic RNA. Translation: AAP41048.1 .
    AY282752 Genomic RNA. No translation available.
    AY278554 Genomic RNA. Translation: AAP13574.1 .
    AY278491 Genomic RNA. No translation available.
    AY278487 Genomic RNA. No translation available.
    AY278488 Genomic RNA. Translation: AAP30038.1 .
    AY278489 Genomic RNA. Translation: AAP51235.1 .
    AY278490 Genomic RNA. No translation available.
    AY279354 Genomic RNA. No translation available.
    AY291451 Genomic RNA. Translation: AAP37025.1 .
    AY310120 Genomic RNA. Translation: AAP50496.1 .
    AY291315 Genomic RNA. Translation: AAP33708.1 .
    AY290752 Genomic RNA. Translation: AAP69659.1 .
    AP006557 Genomic RNA. Translation: BAC81359.1 .
    AP006558 Genomic RNA. Translation: BAC81373.1 .
    AP006559 Genomic RNA. Translation: BAC81387.1 .
    AP006560 Genomic RNA. Translation: BAC81401.1 .
    AP006561 Genomic RNA. Translation: BAC81415.1 .
    AY323977 Genomic RNA. Translation: AAP72985.1 .
    AY427439 Genomic RNA. Translation: AAQ94071.1 .
    RefSeqi NP_828859.1. NC_004718.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CME X-ray 2.80 A/B 9-98 [» ]
    C/D/F/H 10-98 [» ]
    E/G 9-98 [» ]
    ProteinModelPortali P59636.
    SMRi P59636. Positions 9-98.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P59636.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1489679.

    Miscellaneous databases

    EvolutionaryTracei P59636.

    Family and domain databases

    InterProi IPR018542. SARS_lipid-bd.
    [Graphical view ]
    Pfami PF09399. SARS_lipid_bind. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Urbani.
    2. "The genome sequence of the SARS-associated coronavirus."
      Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A., Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y., Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R., Mayo M., McDonald H.
      , Montgomery S.B., Pandoh P.K., Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M., Skowronski D.M., Upton C., Roper R.L.
      Science 300:1399-1404(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Tor2.
    3. "Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome."
      Tsui S.K.W., Chim S.S.C., Lo Y.M.D.
      N. Engl. J. Med. 349:187-188(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate CUHK-Su10 and Isolate CUHK-W1.
    4. "The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39)."
      Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C., Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.
      Exp. Biol. Med. 228:866-873(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate HKU-39849.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate GD01.
    6. "The complete genome of SARS coronavirus clone TW1."
      Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate TW1.
    7. "SARS virus is a close relative of type II coronaviruses."
      Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K., Censini S., Guidotti S., Masignani V., Scarselli M., Mora M., Donati C., Han J., Song H.C., Abrignani S., Covacci A., Rappuoli R.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate FRA.
    8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Frankfurt 1.
    9. "Severe acute respiratory syndrome-associated coronavirus genotype and its characterization."
      Li L., Wang Z., Lu Y., Bao Q., Chen S., Wu N., Cheng S., Weng J., Zhang Y., Yan J., Mei L., Wang X., Zhu H., Yu Y., Zhang M., Li M., Yao J., Lu Q.
      , Yao P., Bo X., Wo J., Wang S., Hu S.
      Chin. Med. J. 116:1288-1292(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate ZJ01.
    10. "The complete genome of SARS coronavirus TWH."
      Shu H.Y., Wu K.M., Tsai S.F.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS and Isolate TWY.
    11. Canducci F., Clementi M., Poli G., Vicenzi E.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate HSR 1.
    12. Balotta C., Corvasce S., Violin M., Galli M., Moroni M., Vigevani G.M., Ruan Y.J., Salemi M.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate AS.
    13. "The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus."
      Meier C., Aricescu A.R., Assenberg R., Aplin R.T., Gilbert R.J.C., Grimes J.M., Stuart D.I.
      Structure 14:1157-1165(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-98, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiORF9B_CVHSA
    AccessioniPrimary (citable) accession number: P59636
    Secondary accession number(s): Q7T6R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: April 23, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The gene encoding this protein is included within the N gene (alternative ORF).

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3