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P59636

- ORF9B_CVHSA

UniProt

P59636 - ORF9B_CVHSA

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Protein

Protein 9b

Gene

9b

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein 9b
Alternative name(s):
Accessory protein 9b
ORF-9b
Gene namesi
ORF Names:9b
OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Taxonomic identifieri227859 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]
ProteomesiUP000000354: Genome

Subcellular locationi

Host cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication. Host cytoplasm 1 Publication
Note: Binds non-covalently to intracellular lipid bilayers.

GO - Cellular componenti

  1. host cell cytoplasmic vesicle Source: UniProtKB-KW
  2. host cell membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host cytoplasmic vesicle, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Protein 9bPRO_0000106137Add
BLAST

Proteomic databases

PRIDEiP59636.

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1
98
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 2310Combined sources
Beta strandi42 – 476Combined sources
Beta strandi54 – 607Combined sources
Beta strandi65 – 673Combined sources
Beta strandi69 – 746Combined sources
Helixi85 – 873Combined sources
Beta strandi90 – 978Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CMEX-ray2.80A/B9-98[»]
C/D/F/H10-98[»]
E/G9-98[»]
ProteinModelPortaliP59636.
SMRiP59636. Positions 9-98.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59636.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR018542. SARS_lipid-bd.
[Graphical view]
PfamiPF09399. SARS_lipid_bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59636-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPNQTNVVP PALHLVDPQI QLTITRMEDA MGQGQNSADP KVYPIILRLG
60 70 80 90
SQLSLSMARR NLDSLEARAF QSTPIVVQMT KLATTEELPD EFVVVTAK
Length:98
Mass (Da):10,802
Last modified:April 23, 2003 - v1
Checksum:i5166F22872915FCB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581A → V in strain: Isolate TWK.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA. No translation available.
AY274119 Genomic RNA. Translation: AAP41048.1.
AY282752 Genomic RNA. No translation available.
AY278554 Genomic RNA. Translation: AAP13574.1.
AY278491 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. Translation: AAP30038.1.
AY278489 Genomic RNA. Translation: AAP51235.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37025.1.
AY310120 Genomic RNA. Translation: AAP50496.1.
AY291315 Genomic RNA. Translation: AAP33708.1.
AY290752 Genomic RNA. Translation: AAP69659.1.
AP006557 Genomic RNA. Translation: BAC81359.1.
AP006558 Genomic RNA. Translation: BAC81373.1.
AP006559 Genomic RNA. Translation: BAC81387.1.
AP006560 Genomic RNA. Translation: BAC81401.1.
AP006561 Genomic RNA. Translation: BAC81415.1.
AY323977 Genomic RNA. Translation: AAP72985.1.
AY427439 Genomic RNA. Translation: AAQ94071.1.
RefSeqiNP_828859.1. NC_004718.3.

Genome annotation databases

GeneIDi1489679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA. No translation available.
AY274119 Genomic RNA. Translation: AAP41048.1 .
AY282752 Genomic RNA. No translation available.
AY278554 Genomic RNA. Translation: AAP13574.1 .
AY278491 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. Translation: AAP30038.1 .
AY278489 Genomic RNA. Translation: AAP51235.1 .
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37025.1 .
AY310120 Genomic RNA. Translation: AAP50496.1 .
AY291315 Genomic RNA. Translation: AAP33708.1 .
AY290752 Genomic RNA. Translation: AAP69659.1 .
AP006557 Genomic RNA. Translation: BAC81359.1 .
AP006558 Genomic RNA. Translation: BAC81373.1 .
AP006559 Genomic RNA. Translation: BAC81387.1 .
AP006560 Genomic RNA. Translation: BAC81401.1 .
AP006561 Genomic RNA. Translation: BAC81415.1 .
AY323977 Genomic RNA. Translation: AAP72985.1 .
AY427439 Genomic RNA. Translation: AAQ94071.1 .
RefSeqi NP_828859.1. NC_004718.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CME X-ray 2.80 A/B 9-98 [» ]
C/D/F/H 10-98 [» ]
E/G 9-98 [» ]
ProteinModelPortali P59636.
SMRi P59636. Positions 9-98.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P59636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1489679.

Miscellaneous databases

EvolutionaryTracei P59636.

Family and domain databases

InterProi IPR018542. SARS_lipid-bd.
[Graphical view ]
Pfami PF09399. SARS_lipid_bind. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Urbani.
  2. "The genome sequence of the SARS-associated coronavirus."
    Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A., Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y., Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R., Mayo M., McDonald H.
    , Montgomery S.B., Pandoh P.K., Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M., Skowronski D.M., Upton C., Roper R.L.
    Science 300:1399-1404(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Tor2.
  3. "Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome."
    Tsui S.K.W., Chim S.S.C., Lo Y.M.D.
    N. Engl. J. Med. 349:187-188(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate CUHK-Su10 and Isolate CUHK-W1.
  4. "The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39)."
    Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C., Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.
    Exp. Biol. Med. 228:866-873(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate HKU-39849.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate GD01.
  6. "The complete genome of SARS coronavirus clone TW1."
    Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate TW1.
  7. "SARS virus is a close relative of type II coronaviruses."
    Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K., Censini S., Guidotti S., Masignani V., Scarselli M., Mora M., Donati C., Han J., Song H.C., Abrignani S., Covacci A., Rappuoli R.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate FRA.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Frankfurt 1.
  9. "Severe acute respiratory syndrome-associated coronavirus genotype and its characterization."
    Li L., Wang Z., Lu Y., Bao Q., Chen S., Wu N., Cheng S., Weng J., Zhang Y., Yan J., Mei L., Wang X., Zhu H., Yu Y., Zhang M., Li M., Yao J., Lu Q.
    , Yao P., Bo X., Wo J., Wang S., Hu S.
    Chin. Med. J. 116:1288-1292(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate ZJ01.
  10. "The complete genome of SARS coronavirus TWH."
    Shu H.Y., Wu K.M., Tsai S.F.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS and Isolate TWY.
  11. Canducci F., Clementi M., Poli G., Vicenzi E.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate HSR 1.
  12. Balotta C., Corvasce S., Violin M., Galli M., Moroni M., Vigevani G.M., Ruan Y.J., Salemi M.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate AS.
  13. "The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus."
    Meier C., Aricescu A.R., Assenberg R., Aplin R.T., Gilbert R.J.C., Grimes J.M., Stuart D.I.
    Structure 14:1157-1165(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-98, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiORF9B_CVHSA
AccessioniPrimary (citable) accession number: P59636
Secondary accession number(s): Q7T6R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

The gene encoding this protein is included within the N gene (alternative ORF).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3