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Protein

Protein 7a

Gene

7a

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-structural protein which is dispensable for virus replication in cell culture.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

G0/G1 host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Protein 7a
Alternative name(s):
Accessory protein 7a
Protein U122
Protein X4
Gene namesi
ORF Names:7a
OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Taxonomic identifieri227859 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]
Proteomesi
  • UP000000354 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 9681Virion surfaceSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence analysisAdd
BLAST
Topological domaini118 – 1225IntravirionSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi14 – 185SCELY → LLLLL: Complete loss of signal sequence cleavage. 1 Publication
Mutagenesisi118 – 1203KRK → ERE: Induces rapid exit from the endoplasmic reticulum. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Add
BLAST
Chaini16 – 122107Protein 7aPRO_0000037435Add
BLAST

Proteomic databases

PRIDEiP59635.

Interactioni

Subunit structurei

Interacts with the spike glycoprotein, M protein, E protein and the accessory protein 3a. Interacts with human SGT.3 Publications

Structurei

Secondary structure

1
122
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 249Combined sources
Beta strandi27 – 326Combined sources
Beta strandi34 – 374Combined sources
Beta strandi39 – 446Combined sources
Turni50 – 523Combined sources
Beta strandi53 – 575Combined sources
Beta strandi60 – 667Combined sources
Beta strandi72 – 809Combined sources
Beta strandi82 – 843Combined sources
Beta strandi89 – 935Combined sources
Beta strandi95 – 973Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XAKX-ray1.80A14-96[»]
1YO4NMR-A16-99[»]
ProteinModelPortaliP59635.
SMRiP59635. Positions 16-99.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59635.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi118 – 1225Di-lysine motif

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.1550. 1 hit.
InterProiIPR014888. SARS_X4.
[Graphical view]
PfamiPF08779. SARS_X4. 1 hit.
[Graphical view]
SUPFAMiSSF117066. SSF117066. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIILFLTLI VFTSCELYHY QECVRGTTVL LKEPCPSGTY EGNSPFHPLA
60 70 80 90 100
DNKFALTCTS THFAFACADG TRHTYQLRAR SVSPKLFIRQ EEVQQELYSP
110 120
LFLIVAALVF LILCFTIKRK TE
Length:122
Mass (Da):13,941
Last modified:April 23, 2003 - v1
Checksum:i6D8D8D949B0DB4B5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381G → A in strain: Isolate Shanghai LY.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA. Translation: AAP13449.1.
AY274119 Genomic RNA. Translation: AAP41043.1.
AY282752 Genomic RNA. No translation available.
AY278554 Genomic RNA. Translation: AAP13573.1.
AY278491 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. Translation: AAP30036.1.
AY278489 Genomic RNA. Translation: AAP51233.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37023.1.
AY310120 Genomic RNA. Translation: AAP50491.1.
AY291315 Genomic RNA. Translation: AAP33703.1.
AY338174 Genomic RNA. Translation: AAQ01603.1.
AY338175 Genomic RNA. Translation: AAQ01615.1.
AY348314 Genomic RNA. Translation: AAP97888.1.
AP006557 Genomic RNA. Translation: BAC81354.1.
AP006558 Genomic RNA. Translation: BAC81368.1.
AP006559 Genomic RNA. Translation: BAC81382.1.
AP006560 Genomic RNA. Translation: BAC81396.1.
AP006561 Genomic RNA. Translation: BAC81410.1.
AY323977 Genomic RNA. Translation: AAP72980.1.
AY427439 Genomic RNA. Translation: AAQ94066.1.
AY463059 Genomic RNA. Translation: AAP82982.2.
AY322208 Genomic RNA. Translation: AAP82970.1.
RefSeqiNP_828857.1. NC_004718.3.

Genome annotation databases

GeneIDi1489674.
KEGGivg:1489674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA. Translation: AAP13449.1.
AY274119 Genomic RNA. Translation: AAP41043.1.
AY282752 Genomic RNA. No translation available.
AY278554 Genomic RNA. Translation: AAP13573.1.
AY278491 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. Translation: AAP30036.1.
AY278489 Genomic RNA. Translation: AAP51233.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37023.1.
AY310120 Genomic RNA. Translation: AAP50491.1.
AY291315 Genomic RNA. Translation: AAP33703.1.
AY338174 Genomic RNA. Translation: AAQ01603.1.
AY338175 Genomic RNA. Translation: AAQ01615.1.
AY348314 Genomic RNA. Translation: AAP97888.1.
AP006557 Genomic RNA. Translation: BAC81354.1.
AP006558 Genomic RNA. Translation: BAC81368.1.
AP006559 Genomic RNA. Translation: BAC81382.1.
AP006560 Genomic RNA. Translation: BAC81396.1.
AP006561 Genomic RNA. Translation: BAC81410.1.
AY323977 Genomic RNA. Translation: AAP72980.1.
AY427439 Genomic RNA. Translation: AAQ94066.1.
AY463059 Genomic RNA. Translation: AAP82982.2.
AY322208 Genomic RNA. Translation: AAP82970.1.
RefSeqiNP_828857.1. NC_004718.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XAKX-ray1.80A14-96[»]
1YO4NMR-A16-99[»]
ProteinModelPortaliP59635.
SMRiP59635. Positions 16-99.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP59635.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489674.
KEGGivg:1489674.

Miscellaneous databases

EvolutionaryTraceiP59635.

Family and domain databases

Gene3Di2.60.40.1550. 1 hit.
InterProiIPR014888. SARS_X4.
[Graphical view]
PfamiPF08779. SARS_X4. 1 hit.
[Graphical view]
SUPFAMiSSF117066. SSF117066. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNS7A_CVHSA
AccessioniPrimary (citable) accession number: P59635
Secondary accession number(s): Q7TA11, Q7TA17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: April 13, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.