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P59633

- NS3B_CVHSA

UniProt

P59633 - NS3B_CVHSA

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Protein

Non-structural protein 3b

Gene
3b
Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

Induces host cell G0/G1 arrest and apoptosis.2 Publications

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. regulation of cytokine production Source: CACAO
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 3b
Short name:
ns3b
Alternative name(s):
Accessory protein 3b
Protein X2
Gene namesi
ORF Names:3b
OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Taxonomic identifieri227859 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]
ProteomesiUP000000354: Genome

Subcellular locationi

Host nucleushost nucleolus. Host mitochondrion 2 Publications

GO - Cellular componenti

  1. host cell mitochondrion Source: UniProtKB-SubCell
  2. host cell nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host mitochondrion, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Non-structural protein 3bPRO_0000106132Add
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 13859Mitochondrial targeting signalAdd
BLAST
Regioni134 – 15421Nucleolar targetingAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi135 – 15319Bipartite nuclear localization signal Reviewed predictionAdd
BLAST

Family and domain databases

InterProiIPR022117. SARS_3b.
[Graphical view]
PfamiPF12383. SARS_3b. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59633-1 [UniParc]FASTAAdd to Basket

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MMPTTLFAGT HITMTTVYHI TVSQIQLSLL KVTAFQHQNS KKTTKLVVIL    50
RIGTQVLKTM SLYMAISPKF TTSLSLHKLL QTLVLKMLHS SSLTSLLKTH 100
RMCKYTQSTA LQELLIQQWI QFMMSRRRLL ACLCKHKKVS TNLCTHSFRK 150
KQVR 154
Length:154
Mass (Da):17,750
Last modified:April 23, 2003 - v1
Checksum:i82AB0B68F11060A8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311K → Q in strain: Isolate GD01.
Natural varianti99 – 991T → I in strain: Isolate BJ02.
Natural varianti115 – 1151L → Q in strain: Isolate GD01.
Natural varianti121 – 1211Q → P in strain: Isolate BJ01 and Isolate BJ04.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY278741 Genomic RNA. Translation: AAP13447.1.
AY274119 Genomic RNA. Translation: AAP41039.1.
AY282752 Genomic RNA. No translation available.
AY278554 Genomic RNA. Translation: AAP13569.1.
AY278491 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. Translation: AAP30032.1.
AY278489 Genomic RNA. Translation: AAP51229.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37019.1.
AY310120 Genomic RNA. Translation: AAP50487.1.
AY291315 Genomic RNA. Translation: AAP33699.1.
AY463059 Genomic RNA. Translation: AAR86789.1.
AY338174 Genomic RNA. Translation: AAQ01599.1.
AY338175 Genomic RNA. Translation: AAQ01611.1.
AY348314 Genomic RNA. Translation: AAP97884.1.
AP006557 Genomic RNA. Translation: BAC81350.1.
AP006558 Genomic RNA. Translation: BAC81364.1.
AP006559 Genomic RNA. Translation: BAC81378.1.
AP006560 Genomic RNA. Translation: BAC81392.1.
AP006561 Genomic RNA. Translation: BAC81406.1.
AY323977 Genomic RNA. Translation: AAP72976.1.
AY427439 Genomic RNA. Translation: AAQ94062.1.
RefSeqiNP_828853.1. NC_004718.3.

Genome annotation databases

GeneIDi1489670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY278741 Genomic RNA. Translation: AAP13447.1 .
AY274119 Genomic RNA. Translation: AAP41039.1 .
AY282752 Genomic RNA. No translation available.
AY278554 Genomic RNA. Translation: AAP13569.1 .
AY278491 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. Translation: AAP30032.1 .
AY278489 Genomic RNA. Translation: AAP51229.1 .
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37019.1 .
AY310120 Genomic RNA. Translation: AAP50487.1 .
AY291315 Genomic RNA. Translation: AAP33699.1 .
AY463059 Genomic RNA. Translation: AAR86789.1 .
AY338174 Genomic RNA. Translation: AAQ01599.1 .
AY338175 Genomic RNA. Translation: AAQ01611.1 .
AY348314 Genomic RNA. Translation: AAP97884.1 .
AP006557 Genomic RNA. Translation: BAC81350.1 .
AP006558 Genomic RNA. Translation: BAC81364.1 .
AP006559 Genomic RNA. Translation: BAC81378.1 .
AP006560 Genomic RNA. Translation: BAC81392.1 .
AP006561 Genomic RNA. Translation: BAC81406.1 .
AY323977 Genomic RNA. Translation: AAP72976.1 .
AY427439 Genomic RNA. Translation: AAQ94062.1 .
RefSeqi NP_828853.1. NC_004718.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1489670.

Family and domain databases

InterProi IPR022117. SARS_3b.
[Graphical view ]
Pfami PF12383. SARS_3b. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Urbani.
  2. "The genome sequence of the SARS-associated coronavirus."
    Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A., Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y., Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R., Mayo M., McDonald H.
    , Montgomery S.B., Pandoh P.K., Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M., Skowronski D.M., Upton C., Roper R.L.
    Science 300:1399-1404(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Tor2.
  3. "Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome."
    Tsui S.K.W., Chim S.S.C., Lo Y.M.D.
    N. Engl. J. Med. 349:187-188(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate CUHK-Su10 and Isolate CUHK-W1.
  4. "The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39)."
    Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C., Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.
    Exp. Biol. Med. 228:866-873(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate HKU-39849.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate GD01.
  6. "The complete genome of SARS coronavirus clone TW1."
    Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate TW1.
  7. "SARS virus is a close relative of type II coronaviruses."
    Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K., Censini S., Guidotti S., Masignani V., Scarselli M., Mora M., Donati C., Han J., Song H.C., Abrignani S., Covacci A., Rappuoli R.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate FRA.
  8. Thiel V., Hertzig T., Putics A., Ivanov K.A., Schelle B., Bayer S., Scheiner B., Weinand H., Weissbrich B., Ziebuhr J.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Frankfurt 1.
  9. "Analysis of SARS coronavirus genome in Shanghai isolates."
    Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Shanghai QXC1.
  10. Chang J.-G.C., Lin T.-H., Chen C.-M., Lin C.-S., Chan W.-L., Shih M.-C.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Taiwan TC1, Isolate Taiwan TC2 and Isolate Taiwan TC3.
  11. "The complete genome of SARS coronavirus TWH."
    Shu H.Y., Wu K.M., Tsai S.F.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS and Isolate TWY.
  12. Canducci F., Clementi M., Poli G., Vicenzi E.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate HSR 1.
  13. Balotta C., Corvasce S., Violin M., Galli M., Moroni M., Vigevani G.M., Ruan Y.J., Salemi M.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate AS.
  14. "G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells."
    Yuan X., Shan Y., Zhao Z., Chen J., Cong Y.
    Virol. J. 2:66-66(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus."
    Yuan X., Yao Z., Shan Y., Chen B., Yang Z., Wu J., Zhao Z., Chen J., Cong Y.
    Virus Res. 114:70-79(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  16. "Mitochondrial location of severe acute respiratory syndrome coronavirus 3b protein."
    Yuan X., Shan Y., Yao Z., Li J., Zhao Z., Chen J., Cong Y.
    Mol. Cells 21:186-191(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNS3B_CVHSA
AccessioniPrimary (citable) accession number: P59633
Secondary accession number(s): Q7TFA9, Q80BV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: March 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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