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P59633

- NS3B_CVHSA

UniProt

P59633 - NS3B_CVHSA

Protein

Non-structural protein 3b

Gene

3b

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    Induces host cell G0/G1 arrest and apoptosis.2 Publications

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. regulation of cytokine production Source: CACAO

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 3b
    Short name:
    ns3b
    Alternative name(s):
    Accessory protein 3b
    Protein X2
    Gene namesi
    ORF Names:3b
    OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
    Taxonomic identifieri227859 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Paguma larvata (Masked palm civet) [TaxID: 9675]
    ProteomesiUP000000354: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell mitochondrion Source: UniProtKB-SubCell
    2. host cell nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host mitochondrion, Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 154154Non-structural protein 3bPRO_0000106132Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 13859Mitochondrial targeting signalAdd
    BLAST
    Regioni134 – 15421Nucleolar targetingAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi135 – 15319Bipartite nuclear localization signalSequence AnalysisAdd
    BLAST

    Family and domain databases

    InterProiIPR022117. SARS_3b.
    [Graphical view]
    PfamiPF12383. SARS_3b. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59633-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMPTTLFAGT HITMTTVYHI TVSQIQLSLL KVTAFQHQNS KKTTKLVVIL    50
    RIGTQVLKTM SLYMAISPKF TTSLSLHKLL QTLVLKMLHS SSLTSLLKTH 100
    RMCKYTQSTA LQELLIQQWI QFMMSRRRLL ACLCKHKKVS TNLCTHSFRK 150
    KQVR 154
    Length:154
    Mass (Da):17,750
    Last modified:April 23, 2003 - v1
    Checksum:i82AB0B68F11060A8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311K → Q in strain: Isolate GD01.
    Natural varianti99 – 991T → I in strain: Isolate BJ02.
    Natural varianti115 – 1151L → Q in strain: Isolate GD01.
    Natural varianti121 – 1211Q → P in strain: Isolate BJ01 and Isolate BJ04.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY278741 Genomic RNA. Translation: AAP13447.1.
    AY274119 Genomic RNA. Translation: AAP41039.1.
    AY282752 Genomic RNA. No translation available.
    AY278554 Genomic RNA. Translation: AAP13569.1.
    AY278491 Genomic RNA. No translation available.
    AY278487 Genomic RNA. No translation available.
    AY278488 Genomic RNA. Translation: AAP30032.1.
    AY278489 Genomic RNA. Translation: AAP51229.1.
    AY278490 Genomic RNA. No translation available.
    AY279354 Genomic RNA. No translation available.
    AY291451 Genomic RNA. Translation: AAP37019.1.
    AY310120 Genomic RNA. Translation: AAP50487.1.
    AY291315 Genomic RNA. Translation: AAP33699.1.
    AY463059 Genomic RNA. Translation: AAR86789.1.
    AY338174 Genomic RNA. Translation: AAQ01599.1.
    AY338175 Genomic RNA. Translation: AAQ01611.1.
    AY348314 Genomic RNA. Translation: AAP97884.1.
    AP006557 Genomic RNA. Translation: BAC81350.1.
    AP006558 Genomic RNA. Translation: BAC81364.1.
    AP006559 Genomic RNA. Translation: BAC81378.1.
    AP006560 Genomic RNA. Translation: BAC81392.1.
    AP006561 Genomic RNA. Translation: BAC81406.1.
    AY323977 Genomic RNA. Translation: AAP72976.1.
    AY427439 Genomic RNA. Translation: AAQ94062.1.
    RefSeqiNP_828853.1. NC_004718.3.

    Genome annotation databases

    GeneIDi1489670.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY278741 Genomic RNA. Translation: AAP13447.1 .
    AY274119 Genomic RNA. Translation: AAP41039.1 .
    AY282752 Genomic RNA. No translation available.
    AY278554 Genomic RNA. Translation: AAP13569.1 .
    AY278491 Genomic RNA. No translation available.
    AY278487 Genomic RNA. No translation available.
    AY278488 Genomic RNA. Translation: AAP30032.1 .
    AY278489 Genomic RNA. Translation: AAP51229.1 .
    AY278490 Genomic RNA. No translation available.
    AY279354 Genomic RNA. No translation available.
    AY291451 Genomic RNA. Translation: AAP37019.1 .
    AY310120 Genomic RNA. Translation: AAP50487.1 .
    AY291315 Genomic RNA. Translation: AAP33699.1 .
    AY463059 Genomic RNA. Translation: AAR86789.1 .
    AY338174 Genomic RNA. Translation: AAQ01599.1 .
    AY338175 Genomic RNA. Translation: AAQ01611.1 .
    AY348314 Genomic RNA. Translation: AAP97884.1 .
    AP006557 Genomic RNA. Translation: BAC81350.1 .
    AP006558 Genomic RNA. Translation: BAC81364.1 .
    AP006559 Genomic RNA. Translation: BAC81378.1 .
    AP006560 Genomic RNA. Translation: BAC81392.1 .
    AP006561 Genomic RNA. Translation: BAC81406.1 .
    AY323977 Genomic RNA. Translation: AAP72976.1 .
    AY427439 Genomic RNA. Translation: AAQ94062.1 .
    RefSeqi NP_828853.1. NC_004718.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1489670.

    Family and domain databases

    InterProi IPR022117. SARS_3b.
    [Graphical view ]
    Pfami PF12383. SARS_3b. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Urbani.
    2. "The genome sequence of the SARS-associated coronavirus."
      Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A., Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y., Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R., Mayo M., McDonald H.
      , Montgomery S.B., Pandoh P.K., Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M., Skowronski D.M., Upton C., Roper R.L.
      Science 300:1399-1404(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Tor2.
    3. "Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome."
      Tsui S.K.W., Chim S.S.C., Lo Y.M.D.
      N. Engl. J. Med. 349:187-188(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate CUHK-Su10 and Isolate CUHK-W1.
    4. "The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39)."
      Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C., Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.
      Exp. Biol. Med. 228:866-873(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate HKU-39849.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04 and Isolate GD01.
    6. "The complete genome of SARS coronavirus clone TW1."
      Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate TW1.
    7. "SARS virus is a close relative of type II coronaviruses."
      Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K., Censini S., Guidotti S., Masignani V., Scarselli M., Mora M., Donati C., Han J., Song H.C., Abrignani S., Covacci A., Rappuoli R.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate FRA.
    8. Thiel V., Hertzig T., Putics A., Ivanov K.A., Schelle B., Bayer S., Scheiner B., Weinand H., Weissbrich B., Ziebuhr J.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Frankfurt 1.
    9. "Analysis of SARS coronavirus genome in Shanghai isolates."
      Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Shanghai QXC1.
    10. Chang J.-G.C., Lin T.-H., Chen C.-M., Lin C.-S., Chan W.-L., Shih M.-C.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Taiwan TC1, Isolate Taiwan TC2 and Isolate Taiwan TC3.
    11. "The complete genome of SARS coronavirus TWH."
      Shu H.Y., Wu K.M., Tsai S.F.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS and Isolate TWY.
    12. Canducci F., Clementi M., Poli G., Vicenzi E.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate HSR 1.
    13. Balotta C., Corvasce S., Violin M., Galli M., Moroni M., Vigevani G.M., Ruan Y.J., Salemi M.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate AS.
    14. "G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells."
      Yuan X., Shan Y., Zhao Z., Chen J., Cong Y.
      Virol. J. 2:66-66(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus."
      Yuan X., Yao Z., Shan Y., Chen B., Yang Z., Wu J., Zhao Z., Chen J., Cong Y.
      Virus Res. 114:70-79(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    16. "Mitochondrial location of severe acute respiratory syndrome coronavirus 3b protein."
      Yuan X., Shan Y., Yao Z., Li J., Zhao Z., Chen J., Cong Y.
      Mol. Cells 21:186-191(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiNS3B_CVHSA
    AccessioniPrimary (citable) accession number: P59633
    Secondary accession number(s): Q7TFA9, Q80BV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: April 23, 2003
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3