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Protein

Anti-sigma F factor

Gene

spoIIAB

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processSporulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-sigma F factorUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Stage II sporulation protein ABUniRule annotation
Gene namesi
Name:spoIIABUniRule annotation
Ordered Locus Names:CTC_02247
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001412 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002035641 – 141Anti-sigma F factorAdd BLAST141

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC02247

Structurei

3D structure databases

ProteinModelPortaliP59623
SMRiP59623
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBE Bacteria
COG2172 LUCA
KOiK06379
OMAiHAYEDKI
OrthoDBiPOG091H0LCB

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00637 Anti_sigma_F, 1 hit
InterProiView protein in InterPro
IPR010194 Anti-sigma_F
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
PANTHERiPTHR35526:SF2 PTHR35526:SF2, 1 hit
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01925 spIIAB, 1 hit

Sequencei

Sequence statusi: Complete.

P59623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDNMMKLEI LSKSENESFA RATVAAFASQ LDPTLNELTD IKTAVSEAVT
60 70 80 90 100
NSIIHGYENK GDKTVKIEAY IKDKELTVII WDEGIGIENV NLAMQPLYTS
110 120 130 140
RPDLERSGMG FTVMQSFMDE LEVKSEKNKG TKIIMKKIFN N
Length:141
Mass (Da):15,888
Last modified:April 23, 2003 - v1
Checksum:iD97464725A7112FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA Translation: AAO36729.1
RefSeqiWP_011100390.1, NC_004557.1

Genome annotation databases

EnsemblBacteriaiAAO36729; AAO36729; CTC_02247
GeneIDi24252975
KEGGictc:CTC_02247

Similar proteinsi

Entry informationi

Entry nameiSP2AB_CLOTE
AccessioniPrimary (citable) accession number: P59623
Secondary accession number(s): Q891W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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