Reviewed, UniProtKB/Swiss-Prot P59614 (ARLY_BUCBP)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	bbp_049

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137750

Sequences

	Sequence		Length	Mass (Da)
	P59614-1 [UniParc]. Last modified April 23, 2003. Version 1. Checksum: 4F37B6EE0B85D4ED	FASTA	458	51,710
	10 20 30 40 50 60 MKLWGGRFVH ESNSFFKKFN SSIQTDYKLV EQDIFSSMSW ADALLKSGVL IKSECNEIKN 70 80 90 100 110 120 ALQKLLCIVK KTPNIVLDSN LEDVHSWVET QLILLVGDLG KKLHTGRSRN DQIATDLKLW 130 140 150 160 170 180 CKHKIKDLFN RIIEFKIELI KISDNTQSVI MPGYTHLQRA QPITFSFWCL AYLEMIKRDE 190 200 210 220 230 240 DRLKDALKRL NSSPLGCGAI SGTTWNIDRE NLAKSMGFKS ATNNSLDSVS DRDYVVELAS 250 260 270 280 290 300 VASISMMHLS RFAEDLIFFN SSESKFVELS DTITSGSSLM PQKKNPDSLE LIRAKSGRVF 310 320 330 340 350 360 GFLVSILVVL KGLPLSYNKD MQEDKKGLFD ALNTWSKCLF MSSLVLKNLH INSINCLKAS 370 380 390 400 410 420 KKSYSNATEL ADYLVNKGIT FRDAHHITGQ IVLEALKLNV PLEKLDLSIF KKYSSSIELD 430 440 450 VYNFLDVISL LEKRNSKGGV APKIVSKAII CEKKQLKI

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016826 Genomic DNA. Translation: AAO26788.1.
RefSeq	NP_777683.1.
3D structure databases
HSSP	HSSP built from PDB template 1K7W based on UniProtKB P24058.
ModBase	Search...
Genome annotation databases
GeneID	1058128.
GenomeReviews	Gene locus bbp_049 in contig AE016826_GR.
KEGG	bab:bbp049.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P59614.
OMA	MAEDLIF.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_049-MON.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BUCBP

Accession

Primary (citable) accession number: P59614

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	April 23, 2003
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)