Skip Header

Contribute Send feedback
Read comments (?) or add your own

P59614 (ARLY_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:bbp_049
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Argininosuccinate lyase HAMAP MF_00006
PRO_0000137750

Sequences

Sequence LengthMass (Da)Tools
P59614 [UniParc].

Last modified April 23, 2003. Version 1.
Checksum: 4F37B6EE0B85D4ED

FASTA45851,710
        10         20         30         40         50         60 
MKLWGGRFVH ESNSFFKKFN SSIQTDYKLV EQDIFSSMSW ADALLKSGVL IKSECNEIKN 

        70         80         90        100        110        120 
ALQKLLCIVK KTPNIVLDSN LEDVHSWVET QLILLVGDLG KKLHTGRSRN DQIATDLKLW 

       130        140        150        160        170        180 
CKHKIKDLFN RIIEFKIELI KISDNTQSVI MPGYTHLQRA QPITFSFWCL AYLEMIKRDE 

       190        200        210        220        230        240 
DRLKDALKRL NSSPLGCGAI SGTTWNIDRE NLAKSMGFKS ATNNSLDSVS DRDYVVELAS 

       250        260        270        280        290        300 
VASISMMHLS RFAEDLIFFN SSESKFVELS DTITSGSSLM PQKKNPDSLE LIRAKSGRVF 

       310        320        330        340        350        360 
GFLVSILVVL KGLPLSYNKD MQEDKKGLFD ALNTWSKCLF MSSLVLKNLH INSINCLKAS 

       370        380        390        400        410        420 
KKSYSNATEL ADYLVNKGIT FRDAHHITGQ IVLEALKLNV PLEKLDLSIF KKYSSSIELD 

       430        440        450 
VYNFLDVISL LEKRNSKGGV APKIVSKAII CEKKQLKI

« Hide

References

[1]"Reductive genome evolution in Buchnera aphidicola."
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016826 Genomic DNA. Translation: AAO26788.1.
RefSeqNP_777683.1. NC_004545.1.

3D structure databases

ProteinModelPortalP59614.
SMRP59614. Positions 3-454.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002625; EBBUCP00000002449; EBBUCG00000002625.
GeneID1058128.
GenomeReviewsGene locus bbp_049 in contig AE016826_GR.
KEGGbab:bbp049.
PATRIC21244871. VBIBucAph80364_0046.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007810.
HOGENOMHBG539632.
OMAMAEDLIF.
PhylomeDBP59614.
ProtClustDBPRK04833.

Enzyme and pathway databases

BioCycBAPH224915:BBP_049-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_BUCBP
AccessionPrimary (citable) accession number: P59614
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents