P59613 (ARLY_BRAJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	blr1381

Organism

Bradyrhizobium japonicum

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Sequence caution	The sequence BAC46646.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137745

Sequences

	Sequence		Length	Mass (Da)
	P59613 [UniParc]. Last modified April 23, 2003. Version 1. Checksum: 88B07A5CBB595C1A	FASTA	465	50,418
	10 20 30 40 50 60 MSNKMWGGRF SERPDEIMEE INVSIDVDRH LYAQDIAASK AHAAMLATQG IITASDAKNI 70 80 90 100 110 120 GKGLDTILSE IGKGGFTFKR ALEDIHMNVE SRLSELIGPA AGRLHTARSR NDQVATDFRL 130 140 150 160 170 180 YVRDVIDETD AALAAFQQAL VARALEHAGT VMPGFTHLQT AQPVTFGHHL LAYVEMAARD 190 200 210 220 230 240 RGRFQDARKR LNESPLGAAA LAGTSFPIDR HATAKALLFD RPMANSLDAV SDRDFVLETL 250 260 270 280 290 300 SAASICAVHM SRFAEEIVIW TSPLVGLIRL SDKFTTGSSI MPQKRNPDAA ELVRAKTGRV 310 320 330 340 350 360 IGALNGLLIV MKGLPLAYQK DMQEDKQGAM EGFAALSLAI RAMTGMVRDL APDEAKMKAA 370 380 390 400 410 420 AGEGYATATD LADWLVRTLK MPFREAHHVT GRIVAKAAEG GVALHELPLK EMQAIEPRIT 430 440 450 460 KDVLGVLSVE SSVKSRTSFG GTAPKNVASQ AKSWAKRLEK ERKLG

References

[1]

"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000040 Genomic DNA. Translation: BAC46646.1. Different initiation.
RefSeq	NP_768021.1. NC_004463.1.
3D structure databases
ProteinModelPortal	P59613.
SMR	P59613. Positions 14-460.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1055126.
GenomeReviews	Gene locus blr1381 in contig BA000040_GR.
KEGG	bja:blr1381.
NMPDR	fig|224911.1.peg.1381.
PATRIC	21186336. VBIBraJap65052_1435.
Phylogenomic databases
HOGENOM	HBG539632.
OMA	MAEDLIF.
PhylomeDB	P59613.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR1381-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BRAJA

Accession

Primary (citable) accession number: P59613

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	April 23, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program