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P59608

- ASSY_BURM1

UniProt

P59608 - ASSY_BURM1

Protein

Argininosuccinate synthase

Gene

argG

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (23 Apr 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei99 – 991CitrullineBy similarity
    Binding sitei129 – 1291ATP; via amide nitrogenBy similarity
    Binding sitei131 – 1311AspartateBy similarity
    Binding sitei131 – 1311ATPBy similarity
    Binding sitei135 – 1351AspartateBy similarity
    Binding sitei135 – 1351CitrullineBy similarity
    Binding sitei136 – 1361AspartateBy similarity
    Binding sitei136 – 1361ATPBy similarity
    Binding sitei139 – 1391CitrullineBy similarity
    Binding sitei192 – 1921CitrullineBy similarity
    Binding sitei194 – 1941ATPBy similarity
    Binding sitei201 – 2011CitrullineBy similarity
    Binding sitei203 – 2031CitrullineBy similarity
    Binding sitei280 – 2801CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBMUL395019:GIYO-3497-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:argG
    Ordered Locus Names:Bmul_5014, BMULJ_03499
    OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
    Taxonomic identifieri395019 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000007064: Chromosome 2, UP000008815: Chromosome 2

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Argininosuccinate synthasePRO_0000148694Add
    BLAST

    Proteomic databases

    PRIDEiP59608.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi395019.Bmul_5014.

    Structurei

    3D structure databases

    ProteinModelPortaliP59608.
    SMRiP59608. Positions 2-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OMAiRQEMSEF.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59608-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTILESLPT GQKVGIAFSG GLDTSAALHW MKLKGAVPYA YTANLGQPDE    50
    DDYDAIPKRA LEYGAAGARL IDCRAQLVAE GIAALQSGAF HITTAGVTYF 100
    NTTPIGRAVT GTMLVAAMKE DGVNIWGDGS TYKGNDIERF YRYGLLVNPD 150
    LKIYKPWLDQ TFIDELGGRA EMSEFMRQSG FAYKMSAEKA YSTDSNLLGA 200
    THEAKDLESL ESGIKIVNPI MGVAFWRDDV KIAAEEVTVR FEAGQPVALN 250
    GVEFKDQVEL LLEANRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGLALL 300
    YIAYERLVTG IHNEDTIEQY RENGRRLGRL LYQGRWFDPQ AIMLRETAQR 350
    WVARAITGEV KIELRRGNDY SILSTKSPNL TYQPERLSME KVASTFSPRD 400
    RIGQLTMRNL DITDTRDKLR VYTQVGLLTP GEASALPQIK GDSGE 445
    Length:445
    Mass (Da):49,252
    Last modified:April 23, 2003 - v1
    Checksum:i67581060BC11267F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB091438 Genomic DNA. Translation: BAC65286.1.
    CP000869 Genomic DNA. Translation: ABX18685.1.
    AP009386 Genomic DNA. Translation: BAG45371.1.
    RefSeqiYP_001584977.1. NC_010086.1.
    YP_001947907.1. NC_010805.1.

    Genome annotation databases

    EnsemblBacteriaiABX18685; ABX18685; Bmul_5014.
    BAG45371; BAG45371; BMULJ_03499.
    GeneIDi5768979.
    6360599.
    KEGGibmj:BMULJ_03499.
    bmu:Bmul_5014.
    PATRICi19169038. VBIBurMul203716_4556.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB091438 Genomic DNA. Translation: BAC65286.1 .
    CP000869 Genomic DNA. Translation: ABX18685.1 .
    AP009386 Genomic DNA. Translation: BAG45371.1 .
    RefSeqi YP_001584977.1. NC_010086.1.
    YP_001947907.1. NC_010805.1.

    3D structure databases

    ProteinModelPortali P59608.
    SMRi P59608. Positions 2-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395019.Bmul_5014.

    Proteomic databases

    PRIDEi P59608.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX18685 ; ABX18685 ; Bmul_5014 .
    BAG45371 ; BAG45371 ; BMULJ_03499 .
    GeneIDi 5768979.
    6360599.
    KEGGi bmj:BMULJ_03499.
    bmu:Bmul_5014.
    PATRICi 19169038. VBIBurMul203716_4556.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OMAi RQEMSEF.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci BMUL395019:GIYO-3497-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distribution and organization of auxotrophic genes on the multichromosomal genome of Burkholderia multivorans ATCC 17616."
      Komatsu H., Imura Y., Ohori A., Nagata Y., Tsuda M.
      J. Bacteriol. 185:3333-3343(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of chromosome 2 of Burkholderia multivorans ATCC 17616."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17616 / 249.
    3. "Complete genome sequence of Burkholderia multivorans ATCC 17616."
      Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N., Hattori M., Tsuda M.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17616 / 249.

    Entry informationi

    Entry nameiASSY_BURM1
    AccessioniPrimary (citable) accession number: P59608
    Secondary accession number(s): A9APH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: April 23, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3