Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P59607

- ASSY_BRADU

UniProt

P59607 - ASSY_BRADU

Protein

Argininosuccinate synthase

Gene

argG

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (23 Apr 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei99 – 991CitrullineBy similarity
    Binding sitei129 – 1291ATP; via amide nitrogenBy similarity
    Binding sitei131 – 1311AspartateBy similarity
    Binding sitei131 – 1311ATPBy similarity
    Binding sitei135 – 1351AspartateBy similarity
    Binding sitei135 – 1351CitrullineBy similarity
    Binding sitei136 – 1361AspartateBy similarity
    Binding sitei136 – 1361ATPBy similarity
    Binding sitei139 – 1391CitrullineBy similarity
    Binding sitei192 – 1921CitrullineBy similarity
    Binding sitei194 – 1941ATPBy similarity
    Binding sitei201 – 2011CitrullineBy similarity
    Binding sitei203 – 2031CitrullineBy similarity
    Binding sitei280 – 2801CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-525-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:argG
    Ordered Locus Names:bll0522
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Argininosuccinate synthasePRO_0000148693Add
    BLAST

    Proteomic databases

    PRIDEiP59607.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi224911.bll0522.

    Structurei

    3D structure databases

    ProteinModelPortaliP59607.
    SMRiP59607. Positions 2-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OrthoDBiEOG6K9QCV.
    PhylomeDBiP59607.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59607-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTILKSLPK GEKVGIAFSG GLDTSAALLW MKQKGARCYA YTANLGQPDE    50
    ADYNEIPRKA QEFGAEKAVL VDCRTQLVHE GIAAIQSGAF HISTGGITYF 100
    NTTPLGRAVT GTMLVAAMKE DGVNIWGDGS TFKGNDIERF YRYGLLTNPS 150
    LRIYKPWLDQ QFIDELGGRA EMSAFMTAQG FAYKMSAEKA YSTDSNLLGA 200
    THEAKDLESL DSGIKIVNPI MGVPFWREDC NVKAEKVVVR FEEGQPTALN 250
    GQTFTDPVAL FLEANAIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL 300
    HIAYERLVTG IHNEDTIEQY RISGMRLGRL LYQGRWFDSQ ALMLRETAQR 350
    WVARAVTGEV TLELRRGNDY SILNTESPNL TYAPERLSME KVEDAAFTPA 400
    DRIGQLTMRN LDIADTRTKL KLYTDTGLLS GSEGSQIFRL ENDKG 445
    Length:445
    Mass (Da):49,231
    Last modified:April 23, 2003 - v1
    Checksum:i7A5112563C7A8529
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC45787.1.
    RefSeqiNP_767162.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC45787; BAC45787; BAC45787.
    GeneIDi1049678.
    KEGGibja:bll0522.
    PATRICi21184521. VBIBraJap65052_0538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC45787.1 .
    RefSeqi NP_767162.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali P59607.
    SMRi P59607. Positions 2-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.bll0522.

    Proteomic databases

    PRIDEi P59607.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC45787 ; BAC45787 ; BAC45787 .
    GeneIDi 1049678.
    KEGGi bja:bll0522.
    PATRICi 21184521. VBIBraJap65052_0538.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OrthoDBi EOG6K9QCV.
    PhylomeDBi P59607.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci BJAP224911:GJEJ-525-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiASSY_BRADU
    AccessioniPrimary (citable) accession number: P59607
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: April 23, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3