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P59603 (ASSY_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:lp_0775
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000148602

Regions

Nucleotide binding11 – 199ATP By similarity

Sites

Binding site881Citrulline By similarity
Binding site1181ATP; via amide nitrogen By similarity
Binding site1201Aspartate By similarity
Binding site1241Aspartate By similarity
Binding site1241Citrulline By similarity
Binding site1251Aspartate By similarity
Binding site1281Citrulline By similarity
Binding site1761Citrulline By similarity
Binding site2611Citrulline By similarity
Binding site2731Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
P59603 [UniParc].

Last modified April 23, 2003. Version 1.
Checksum: 4198183D3BFF93E5

FASTA41145,154
        10         20         30         40         50         60 
MVKQNDKIIL AYSGGLDTSV AISWLKDKGY DVVACGIDVG EGKDMDAIKE KALKLGAVSS 

        70         80         90        100        110        120 
YMIDAKQEFA EEYALIALQG HTLYEGEYPL VSALSRPLIA KKLVTLAKQE HAVAIAHGCT 

       130        140        150        160        170        180 
GKGNDQVRFE VAIHALAPDI KIEAPVRDWH WSREEEIDYA KEHNIPVPIN LDSPYSIDEN 

       190        200        210        220        230        240 
LWGRANECGI LEDPWQGAPA DAFDRTKALA DTPDTPTTLE ITFEAGVPVA LDGESLNLAD 

       250        260        270        280        290        300 
LIIKLDQIAG EHGIGRIDHI ENRLVGIKSR EVYEAPAATV LLKAHKDLED LTFERELAHF 

       310        320        330        340        350        360 
KPIIEQKLAD TIYNGLWFSP LMEAMVAFLK QTQQVVNGVV RVQLFKGNVI TEGRKSPNSL 

       370        380        390        400        410 
YDTNLATYTS ADSFDQQAAV GFIKLWGLPT QVNAQVQAKA QAEAKTDKAH A 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC78238.1.
RefSeqYP_004888752.1. NC_004567.2.

3D structure databases

ProteinModelPortalP59603.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_0775.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC78238; CCC78238; lp_0775.
GeneID1063757.
KEGGlpl:lp_0775.
PATRIC22247965. VBILacPla27411_0655.

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMAKANALYM.

Enzyme and pathway databases

BioCycLPLA220668-WGS:GSPK-673-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_LACPL
AccessionPrimary (citable) accession number: P59603
Secondary accession number(s): F9ULZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways