Reviewed, UniProtKB/Swiss-Prot P59601 (ARGE_VIBPA)

Names and origin

Protein names

Recommended name:
    Acetylornithine deacetylase
      Short name=Acetylornithinase
      Short name=AO
    EC=3.5.1.16
Alternative name(s):
    N-acetylornithinase
      Short name=NAO

Gene names

Name:	argE
Ordered Locus Names:	VP2760

Organism

Vibrio parahaemolyticus [Complete proteome] [HAMAP]

Taxonomic identifier

670 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine. HAMAP MF_01108
Cofactor	Binds 2 zinc or cobalt ions per subunit By similarity. Glutathione By similarity.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. HAMAP MF_01108
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the peptidase M20A family. ArgE subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Ligand	Cobalt Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	acetylornithine deacetylase activity Inferred from electronic annotation. Source: HAMAP cobalt ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Acetylornithine deacetylase HAMAP MF_01108		PRO_0000185252
Sites
	Active site	78	1	By similarity
	Active site	140	1	Proton acceptor By similarity
	Metal binding	76	1	Cobalt or zinc 1 By similarity
	Metal binding	108	1	Cobalt or zinc 1 By similarity
	Metal binding	108	1	Cobalt or zinc 2 By similarity
	Metal binding	141	1	Cobalt or zinc 2 By similarity
	Metal binding	165	1	Cobalt or zinc 1 By similarity
	Metal binding	351	1	Cobalt or zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59601-1 [UniParc]. Last modified April 23, 2003. Version 1. Checksum: F4B912E0E0137DA2	FASTA	378	41,882
	10 20 30 40 50 60 MQLPTFLEVY EGLISTSSIS STDPSWDQGN AKVIEKLATW FKDLGFHVEV IEVESGKHNM 70 80 90 100 110 120 IARMGEGEGG LLLAGHSDTV PFDEGRWSFD PHKLTEKDNR FYGLGTADMK GFFAFIYEAV 130 140 150 160 170 180 KKVDWSKQNK PLYVLATCDE ETTMLGARHF TTNAPFKPDY CIIGEPTSLV PIRGHKGHVA 190 200 210 220 230 240 NAIRVTGKSG HSSDPALGVN AIEIMHEVLF AMMQLRDKLI KEYHHPGFAI PSPTLNLGHI 250 260 270 280 290 300 HGGDSANRIC GCCELHYDVR PLPGISLDGL ENMLRSALQE VEAKWPGRID IVPLHEPIPG 310 320 330 340 350 360 YECQHDHPFI GGVEEICQTS SQTVNYCTEA PFLQQLCPTL VLGPGSIEQA HQPDEFLSFD 370 FIDPTIDVLS KAMVKYCC

References

[1]

"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000031 Genomic DNA. Translation: BAC61023.1.
RefSeq	NP_799139.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M20.974.
Genome annotation databases
GeneID	1190310.
GenomeReviews	Gene locus VP2760 in contig BA000031_GR.
KEGG	vpa:VP2760.
NMPDR	fig|223926.1.peg.2760.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P59601.
OMA	QPLMILA.
Enzyme and pathway databases
BioCyc	VPAR223926:VP2760-MON.
BRENDA	3.5.1.16. 3063.
Family and domain databases
HAMAP	MF_01108. [Tree]
InterPro	IPR010169. AcOrn-deacetyl. IPR001261. ArgE/DapE_CS. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
TIGRFAMs	TIGR01892. AcOrn-deacetyl. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. 1 hit. PS00759. ARGE_DAPE_CPG2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGE_VIBPA

Accession

Primary (citable) accession number: P59601

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	April 23, 2003
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)