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Protein

Membrane protein

Gene

M

Organism
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein
Short name:
M protein
Alternative name(s):
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Gene namesi
Name:M
ORF Names:5
OrganismiHuman SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
Taxonomic identifieri227859 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Paguma larvata (Masked palm civet) [TaxID: 9675]
Proteomesi
  • UP000000354 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818Virion surfaceSequence analysisAdd
BLAST
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Topological domaini40 – 4910IntravirionSequence analysis
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Topological domaini71 – 788Virion surfaceSequence analysis
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Topological domaini100 – 221122IntravirionSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Membrane proteinPRO_0000106035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...); by hostSequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP59596.

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus (By similarity). Interacts with the accessory proteins 3a and 7a.By similarity3 Publications

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I6GX-ray2.20C/F88-96[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59596.

Family & Domainsi

Sequence similaritiesi

Belongs to the coronaviruses M protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR002574. Corona_M.
[Graphical view]
PfamiPF01635. Corona_M. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNGTITVE ELKQLLEQWN LVIGFLFLAW IMLLQFAYSN RNRFLYIIKL
60 70 80 90 100
VFLWLLWPVT LACFVLAAVY RINWVTGGIA IAMACIVGLM WLSYFVASFR
110 120 130 140 150
LFARTRSMWS FNPETNILLN VPLRGTIVTR PLMESELVIG AVIIRGHLRM
160 170 180 190 200
AGHSLGRCDI KDLPKEITVA TSRTLSYYKL GASQRVGTDS GFAAYNRYRI
210 220
GNYKLNTDHA GSNDNIALLV Q
Length:221
Mass (Da):25,061
Last modified:April 23, 2003 - v1
Checksum:i275C37085A0215A8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111E → K in strain: Isolate Sin2500.
Natural varianti27 – 271F → C in strain: Isolate CUHK-Su10, Isolate TWC2, Isolate TWC3, Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS, Isolate TWY, Isolate Taiwan TC1, Isolate Taiwan TC2 and Isolate Taiwan TC3.
Natural varianti68 – 681A → V in strain: Isolate HKU-39849, Isolate FRA and Isolate Frankfurt 1.
Natural varianti73 – 731N → T in strain: Isolate TC3.
Natural varianti119 – 1191L → P in strain: Isolate Shanghai QXC1.
Natural varianti154 – 1541S → P in strain: Isolate Urbani.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA. Translation: AAP13444.1.
AY274119 Genomic RNA. Translation: AAP41041.1.
AY278554 Genomic RNA. Translation: AAP13571.1.
AY282752 Genomic RNA. No translation available.
AY304492 Genomic RNA. No translation available.
AY304495 Genomic RNA. No translation available.
AY278491 Genomic RNA. No translation available.
AY283794 Genomic RNA. No translation available.
AY283795 Genomic RNA. No translation available.
AY283796 Genomic RNA. No translation available.
AY283797 Genomic RNA. No translation available.
AY283798 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. Translation: AAP30034.1.
AY278489 Genomic RNA. Translation: AAP51231.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37021.1.
AY310120 Genomic RNA. Translation: AAP50489.1.
AY291315 Genomic RNA. Translation: AAP33701.1.
AY463059 Genomic RNA. Translation: AAR86790.1.
AY323974 mRNA. Translation: AAP73415.1.
AY321118 Genomic RNA. No translation available.
AY338174 Genomic RNA. Translation: AAQ01601.1.
AY338175 Genomic RNA. Translation: AAQ01613.1.
AY348314 Genomic RNA. Translation: AAP97886.1.
AP006557 Genomic RNA. Translation: BAC81352.1.
AP006558 Genomic RNA. Translation: BAC81366.1.
AP006559 Genomic RNA. Translation: BAC81380.1.
AP006560 Genomic RNA. Translation: BAC81394.1.
AP006561 Genomic RNA. Translation: BAC81408.1.
AY323977 Genomic RNA. Translation: AAP72978.1.
AY362698 Genomic RNA. No translation available.
AY362699 Genomic RNA. No translation available.
AY427439 Genomic RNA. Translation: AAQ94064.1.
RefSeqiNP_828855.1. NC_004718.3.

Genome annotation databases

GeneIDi1489672.
KEGGivg:1489672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278741 Genomic RNA. Translation: AAP13444.1.
AY274119 Genomic RNA. Translation: AAP41041.1.
AY278554 Genomic RNA. Translation: AAP13571.1.
AY282752 Genomic RNA. No translation available.
AY304492 Genomic RNA. No translation available.
AY304495 Genomic RNA. No translation available.
AY278491 Genomic RNA. No translation available.
AY283794 Genomic RNA. No translation available.
AY283795 Genomic RNA. No translation available.
AY283796 Genomic RNA. No translation available.
AY283797 Genomic RNA. No translation available.
AY283798 Genomic RNA. No translation available.
AY278487 Genomic RNA. No translation available.
AY278488 Genomic RNA. Translation: AAP30034.1.
AY278489 Genomic RNA. Translation: AAP51231.1.
AY278490 Genomic RNA. No translation available.
AY279354 Genomic RNA. No translation available.
AY291451 Genomic RNA. Translation: AAP37021.1.
AY310120 Genomic RNA. Translation: AAP50489.1.
AY291315 Genomic RNA. Translation: AAP33701.1.
AY463059 Genomic RNA. Translation: AAR86790.1.
AY323974 mRNA. Translation: AAP73415.1.
AY321118 Genomic RNA. No translation available.
AY338174 Genomic RNA. Translation: AAQ01601.1.
AY338175 Genomic RNA. Translation: AAQ01613.1.
AY348314 Genomic RNA. Translation: AAP97886.1.
AP006557 Genomic RNA. Translation: BAC81352.1.
AP006558 Genomic RNA. Translation: BAC81366.1.
AP006559 Genomic RNA. Translation: BAC81380.1.
AP006560 Genomic RNA. Translation: BAC81394.1.
AP006561 Genomic RNA. Translation: BAC81408.1.
AY323977 Genomic RNA. Translation: AAP72978.1.
AY362698 Genomic RNA. No translation available.
AY362699 Genomic RNA. No translation available.
AY427439 Genomic RNA. Translation: AAQ94064.1.
RefSeqiNP_828855.1. NC_004718.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I6GX-ray2.20C/F88-96[»]
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP59596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489672.
KEGGivg:1489672.

Miscellaneous databases

EvolutionaryTraceiP59596.

Family and domain databases

InterProiIPR002574. Corona_M.
[Graphical view]
PfamiPF01635. Corona_M. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVME1_CVHSA
AccessioniPrimary (citable) accession number: P59596
Secondary accession number(s): Q6S8E5
, Q7T6Q8, Q7T6R1, Q7T6R5, Q7T6S0, Q7T6S3, Q7T726, Q7T7P6, Q7T7S6, Q7TA12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.