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P59556

- RIBB_BUCBP

UniProt

P59556 - RIBB_BUCBP

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Protein
3,4-dihydroxy-2-butanone 4-phosphate synthase
Gene
ribB, bbp_056
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity.UniRule annotation

Catalytic activityi

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Magnesium or manganese 1 By similarity
Metal bindingi38 – 381Magnesium or manganese 2 By similarity
Binding sitei42 – 421Substrate By similarity
Sitei136 – 1361Essential for catalytic activity By similarity
Metal bindingi153 – 1531Magnesium or manganese 2 By similarity
Binding sitei174 – 1741Substrate By similarity
Sitei174 – 1741Essential for catalytic activity By similarity

GO - Molecular functioni

  1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-56-MONOMER.
UniPathwayiUPA00275; UER00399.

Names & Taxonomyi

Protein namesi
Recommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthase (EC:4.1.99.12)
Short name:
DHBP synthase
Gene namesi
Name:ribB
Ordered Locus Names:bbp_056
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2112113,4-dihydroxy-2-butanone 4-phosphate synthaseUniRule annotation
PRO_0000151793Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224915.bbp056.

Structurei

3D structure databases

ProteinModelPortaliP59556.
SMRiP59556. Positions 1-208.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 382Substrate binding By similarity
Regioni150 – 1545Substrate binding By similarity

Sequence similaritiesi

Belongs to the DHBP synthase family.

Phylogenomic databases

eggNOGiCOG0108.
KOiK02858.
OMAiQMAKLIR.
OrthoDBiEOG679TK8.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
HAMAPiMF_00180. RibB.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view]
PfamiPF00926. DHBP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00506. ribB. 1 hit.

Sequencei

Sequence statusi: Complete.

P59556-1 [UniParc]FASTAAdd to Basket

« Hide

MTQNLLDQFG TPKTRVKNAI SALRYGHGII VLDNEDRENE GDLIFSGETM    50
TTEQMALTIR YGSGIVCLCI TESKRKQLKL PMMVQNNTSK FGTNFTVTIE 100
AAEGISTGVS AKDRLTTIRA AINDNAKPSD LNRPGHIFPL QAHKNGILGR 150
IGHTEAAIEF VTLAGFKPAG IICELTNRNG TMSKVPDIIK FSKLKKMTIV 200
TIRDLIQYIS R 211
Length:211
Mass (Da):23,239
Last modified:April 11, 2003 - v1
Checksum:iDC5A5B905265A97D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26795.1.
RefSeqiNP_777690.1. NC_004545.1.
WP_011091196.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26795; AAO26795; bbp_056.
GeneIDi1058191.
KEGGibab:bbp056.
PATRICi21244885. VBIBucAph80364_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26795.1 .
RefSeqi NP_777690.1. NC_004545.1.
WP_011091196.1. NC_004545.1.

3D structure databases

ProteinModelPortali P59556.
SMRi P59556. Positions 1-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO26795 ; AAO26795 ; bbp_056 .
GeneIDi 1058191.
KEGGi bab:bbp056.
PATRICi 21244885. VBIBucAph80364_0053.

Phylogenomic databases

eggNOGi COG0108.
KOi K02858.
OMAi QMAKLIR.
OrthoDBi EOG679TK8.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00399 .
BioCyci BAPH224915:GJ9D-56-MONOMER.

Family and domain databases

Gene3Di 3.90.870.10. 1 hit.
HAMAPi MF_00180. RibB.
InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view ]
Pfami PF00926. DHBP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55821. SSF55821. 1 hit.
TIGRFAMsi TIGR00506. ribB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiRIBB_BUCBP
AccessioniPrimary (citable) accession number: P59556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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