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P59556

- RIBB_BUCBP

UniProt

P59556 - RIBB_BUCBP

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Protein

3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene

ribB

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.UniRule annotation

Catalytic activityi

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Magnesium or manganese.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Magnesium or manganese 1UniRule annotation
Metal bindingi38 – 381Magnesium or manganese 2UniRule annotation
Binding sitei42 – 421SubstrateUniRule annotation
Sitei136 – 1361Essential for catalytic activityUniRule annotation
Metal bindingi153 – 1531Magnesium or manganese 2UniRule annotation
Binding sitei174 – 1741SubstrateUniRule annotation
Sitei174 – 1741Essential for catalytic activityUniRule annotation

GO - Molecular functioni

  1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-56-MONOMER.
UniPathwayiUPA00275; UER00399.

Names & Taxonomyi

Protein namesi
Recommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthaseUniRule annotation (EC:4.1.99.12UniRule annotation)
Short name:
DHBP synthaseUniRule annotation
Gene namesi
Name:ribBUniRule annotation
Ordered Locus Names:bbp_056
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2112113,4-dihydroxy-2-butanone 4-phosphate synthasePRO_0000151793Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224915.bbp056.

Structurei

3D structure databases

ProteinModelPortaliP59556.
SMRiP59556. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 382Substrate bindingUniRule annotation
Regioni150 – 1545Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the DHBP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0108.
KOiK02858.
OMAiQMAKLIR.
OrthoDBiEOG679TK8.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
HAMAPiMF_00180. RibB.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view]
PfamiPF00926. DHBP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00506. ribB. 1 hit.

Sequencei

Sequence statusi: Complete.

P59556-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQNLLDQFG TPKTRVKNAI SALRYGHGII VLDNEDRENE GDLIFSGETM
60 70 80 90 100
TTEQMALTIR YGSGIVCLCI TESKRKQLKL PMMVQNNTSK FGTNFTVTIE
110 120 130 140 150
AAEGISTGVS AKDRLTTIRA AINDNAKPSD LNRPGHIFPL QAHKNGILGR
160 170 180 190 200
IGHTEAAIEF VTLAGFKPAG IICELTNRNG TMSKVPDIIK FSKLKKMTIV
210
TIRDLIQYIS R
Length:211
Mass (Da):23,239
Last modified:April 11, 2003 - v1
Checksum:iDC5A5B905265A97D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26795.1.
RefSeqiNP_777690.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26795; AAO26795; bbp_056.
GeneIDi1058191.
KEGGibab:bbp056.
PATRICi21244885. VBIBucAph80364_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26795.1 .
RefSeqi NP_777690.1. NC_004545.1.

3D structure databases

ProteinModelPortali P59556.
SMRi P59556. Positions 1-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO26795 ; AAO26795 ; bbp_056 .
GeneIDi 1058191.
KEGGi bab:bbp056.
PATRICi 21244885. VBIBucAph80364_0053.

Phylogenomic databases

eggNOGi COG0108.
KOi K02858.
OMAi QMAKLIR.
OrthoDBi EOG679TK8.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00399 .
BioCyci BAPH224915:GJ9D-56-MONOMER.

Family and domain databases

Gene3Di 3.90.870.10. 1 hit.
HAMAPi MF_00180. RibB.
InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view ]
Pfami PF00926. DHBP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55821. SSF55821. 1 hit.
TIGRFAMsi TIGR00506. ribB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiRIBB_BUCBP
AccessioniPrimary (citable) accession number: P59556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3