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P59551 (T2R60_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 60

Short name=T2R60
Alternative name(s):
Taste receptor type 2 member 56
Short name=T2R56
Gene names
Name:TAS2R60
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsensory perception of bitter taste

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled receptor activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Taste receptor type 2 member 60
PRO_0000082351

Regions

Topological domain1 – 77Extracellular Potential
Transmembrane8 – 2821Helical; Name=1; Potential
Topological domain29 – 4012Cytoplasmic Potential
Transmembrane41 – 6121Helical; Name=2; Potential
Topological domain62 – 8827Extracellular Potential
Transmembrane89 – 10921Helical; Name=3; Potential
Topological domain110 – 12819Cytoplasmic Potential
Transmembrane129 – 14921Helical; Name=4; Potential
Topological domain150 – 18334Extracellular Potential
Transmembrane184 – 20421Helical; Name=5; Potential
Topological domain205 – 23430Cytoplasmic Potential
Transmembrane235 – 25521Helical; Name=6; Potential
Topological domain256 – 2649Extracellular Potential
Transmembrane265 – 28521Helical; Name=7; Potential
Topological domain286 – 31833Cytoplasmic Potential

Amino acid modifications

Glycosylation1791N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P59551 [UniParc].

Last modified April 11, 2003. Version 1.
Checksum: DEDAB1CC8101764B

FASTA31836,337
        10         20         30         40         50         60 
MNGDHMVLGS SVTDKKAIIL VTILLLLRLV AIAGNGFITA ALGVEWVLRR MLLPCDKLLV 

        70         80         90        100        110        120 
SLGASRFCLQ SVVMGKTIYV FLHPMAFPYN PVLQFLAFQW DFLNAATLWS STWLSVFYCV 

       130        140        150        160        170        180 
KIATFTHPVF FWLKHKLSGW LPWMLFSSVG LSSFTTILFF IGNHRMYQNY LRNHLQPWNV 

       190        200        210        220        230        240 
TGDSIRSYCE KFYLFPLKMI TWTMPTAVFF ICMILLITSL GRHRKKALLT TSGFREPSVQ 

       250        260        270        280        290        300 
AHIKALLALL SFAMLFISYF LSLVFSAAGI FPPLDFKFWV WESVIYLCAA VHPIILLFSN 

       310 
CRLRAVLKSR RSSRCGTP 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of human taste receptor genes belonging to the TAS2R family."
Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Adaptive diversification of bitter taste receptor genes in mammalian evolution."
Shi P., Zhang J., Yang H., Zhang Y.-P.
Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[8]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY114094 Genomic DNA. Translation: AAM63544.1.
AY724955 Genomic DNA. Translation: AAU21151.1.
CH236959 Genomic DNA. Translation: EAL23790.1.
BC100938 mRNA. Translation: AAI00939.1.
BC100939 mRNA. Translation: AAI00940.1.
BC100940 mRNA. Translation: AAI00941.1.
BK001100 Genomic DNA. Translation: DAA01207.1.
RefSeqNP_803186.1. NM_177437.1.
UniGeneHs.688222.

3D structure databases

ProteinModelPortalP59551.
SMRP59551. Positions 277-313.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM29839489.

Proteomic databases

PaxDbP59551.
PeptideAtlasP59551.
PRIDEP59551.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332690; ENSP00000327724; ENSG00000185899.
GeneID338398.
KEGGhsa:338398.
UCSCuc011ktg.2. human.

Organism-specific databases

CTD338398.
GeneCardsGC07P143143.
HGNCHGNC:20639. TAS2R60.
HPAHPA030416.
MIM613968. gene.
neXtProtNX_P59551.
PharmGKBPA134879120.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45884.
HOGENOMHOG000234595.
HOVERGENHBG098568.
InParanoidP59551.
KOK08474.
OMAPCDKLLV.
OrthoDBEOG77Q4X4.
PhylomeDBP59551.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_TAS2R60.
GenevestigatorP59551.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R60.
GenomeRNAi338398.
NextBio96978.
PROP59551.
SOURCESearch...

Entry information

Entry nameT2R60_HUMAN
AccessionPrimary (citable) accession number: P59551
Secondary accession number(s): A4D2G8, Q645W8, Q7RTR7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries