Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Taste receptor type 2 member 60

Gene

TAS2R60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  1. sensory perception of bitter taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 60
Short name:
T2R60
Alternative name(s):
Taste receptor type 2 member 56
Short name:
T2R56
Gene namesi
Name:TAS2R60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:20639. TAS2R60.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularSequence Analysis
Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini29 – 4012CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei41 – 6121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini62 – 8827ExtracellularSequence AnalysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini110 – 12819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini150 – 18334ExtracellularSequence AnalysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini205 – 23430CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini256 – 2649ExtracellularSequence Analysis
Transmembranei265 – 28521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini286 – 31833CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Taste receptor type 2 member 60PRO_0000082351Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59551.
PeptideAtlasiP59551.
PRIDEiP59551.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

CleanExiHS_TAS2R60.
ExpressionAtlasiP59551. baseline and differential.
GenevestigatoriP59551.

Organism-specific databases

HPAiHPA030416.

Interactioni

Protein-protein interaction databases

BioGridi130733. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP59551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45884.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG098568.
InParanoidiP59551.
KOiK08474.
OMAiFICMILL.
OrthoDBiEOG77Q4X4.
PhylomeDBiP59551.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59551-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGDHMVLGS SVTDKKAIIL VTILLLLRLV AIAGNGFITA ALGVEWVLRR
60 70 80 90 100
MLLPCDKLLV SLGASRFCLQ SVVMGKTIYV FLHPMAFPYN PVLQFLAFQW
110 120 130 140 150
DFLNAATLWS STWLSVFYCV KIATFTHPVF FWLKHKLSGW LPWMLFSSVG
160 170 180 190 200
LSSFTTILFF IGNHRMYQNY LRNHLQPWNV TGDSIRSYCE KFYLFPLKMI
210 220 230 240 250
TWTMPTAVFF ICMILLITSL GRHRKKALLT TSGFREPSVQ AHIKALLALL
260 270 280 290 300
SFAMLFISYF LSLVFSAAGI FPPLDFKFWV WESVIYLCAA VHPIILLFSN
310
CRLRAVLKSR RSSRCGTP
Length:318
Mass (Da):36,337
Last modified:April 11, 2003 - v1
Checksum:iDEDAB1CC8101764B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114094 Genomic DNA. Translation: AAM63544.1.
AY724955 Genomic DNA. Translation: AAU21151.1.
CH236959 Genomic DNA. Translation: EAL23790.1.
BC100938 mRNA. Translation: AAI00939.1.
BC100939 mRNA. Translation: AAI00940.1.
BC100940 mRNA. Translation: AAI00941.1.
BK001100 Genomic DNA. Translation: DAA01207.1.
CCDSiCCDS5885.1.
RefSeqiNP_803186.1. NM_177437.1.
UniGeneiHs.688222.

Genome annotation databases

EnsembliENST00000332690; ENSP00000327724; ENSG00000185899.
GeneIDi338398.
KEGGihsa:338398.
UCSCiuc011ktg.2. human.

Polymorphism databases

DMDMi29839489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114094 Genomic DNA. Translation: AAM63544.1.
AY724955 Genomic DNA. Translation: AAU21151.1.
CH236959 Genomic DNA. Translation: EAL23790.1.
BC100938 mRNA. Translation: AAI00939.1.
BC100939 mRNA. Translation: AAI00940.1.
BC100940 mRNA. Translation: AAI00941.1.
BK001100 Genomic DNA. Translation: DAA01207.1.
CCDSiCCDS5885.1.
RefSeqiNP_803186.1. NM_177437.1.
UniGeneiHs.688222.

3D structure databases

ProteinModelPortaliP59551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130733. 1 interaction.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi29839489.

Proteomic databases

PaxDbiP59551.
PeptideAtlasiP59551.
PRIDEiP59551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332690; ENSP00000327724; ENSG00000185899.
GeneIDi338398.
KEGGihsa:338398.
UCSCiuc011ktg.2. human.

Organism-specific databases

CTDi338398.
GeneCardsiGC07P143143.
HGNCiHGNC:20639. TAS2R60.
HPAiHPA030416.
MIMi613968. gene.
neXtProtiNX_P59551.
PharmGKBiPA134879120.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45884.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG098568.
InParanoidiP59551.
KOiK08474.
OMAiFICMILL.
OrthoDBiEOG77Q4X4.
PhylomeDBiP59551.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiTAS2R60.
GenomeRNAii338398.
NextBioi96978.
PROiP59551.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TAS2R60.
ExpressionAtlasiP59551. baseline and differential.
GenevestigatoriP59551.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R60_HUMAN
AccessioniPrimary (citable) accession number: P59551
Secondary accession number(s): A4D2G8, Q645W8, Q7RTR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.