Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Taste receptor type 2 member 60

Gene

TAS2R60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: Reactome
  • sensory perception of bitter taste Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 60
Short name:
T2R60
Alternative name(s):
Taste receptor type 2 member 56
Short name:
T2R56
Gene namesi
Name:TAS2R60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000185899.1
HGNCiHGNC:20639 TAS2R60
MIMi613968 gene
neXtProtiNX_P59551

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 28Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini29 – 40CytoplasmicSequence analysisAdd BLAST12
Transmembranei41 – 61Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini62 – 88ExtracellularSequence analysisAdd BLAST27
Transmembranei89 – 109Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini110 – 128CytoplasmicSequence analysisAdd BLAST19
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 183ExtracellularSequence analysisAdd BLAST34
Transmembranei184 – 204Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini205 – 234CytoplasmicSequence analysisAdd BLAST30
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 264ExtracellularSequence analysis9
Transmembranei265 – 285Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini286 – 318CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi338398
PharmGKBiPA134879120

Chemistry databases

ChEMBLiCHEMBL3309109

Polymorphism and mutation databases

BioMutaiTAS2R60
DMDMi29839489

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000823511 – 318Taste receptor type 2 member 60Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59551
PeptideAtlasiP59551
PRIDEiP59551
ProteomicsDBi57152

PTM databases

PhosphoSitePlusiP59551

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000185899
CleanExiHS_TAS2R60

Organism-specific databases

HPAiHPA030416

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327724

Chemistry databases

BindingDBiP59551

Structurei

3D structure databases

ProteinModelPortaliP59551
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW8Z Eukaryota
ENOG411156S LUCA
GeneTreeiENSGT00760000119096
HOGENOMiHOG000234595
HOVERGENiHBG098568
InParanoidiP59551
KOiK08474
OMAiYCVKIAT
OrthoDBiEOG091G0FRD
PhylomeDBiP59551
TreeFamiTF335891

Family and domain databases

InterProiView protein in InterPro
IPR007960 T2R
PANTHERiPTHR11394 PTHR11394, 1 hit
PfamiView protein in Pfam
PF05296 TAS2R, 1 hit

Sequencei

Sequence statusi: Complete.

P59551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGDHMVLGS SVTDKKAIIL VTILLLLRLV AIAGNGFITA ALGVEWVLRR
60 70 80 90 100
MLLPCDKLLV SLGASRFCLQ SVVMGKTIYV FLHPMAFPYN PVLQFLAFQW
110 120 130 140 150
DFLNAATLWS STWLSVFYCV KIATFTHPVF FWLKHKLSGW LPWMLFSSVG
160 170 180 190 200
LSSFTTILFF IGNHRMYQNY LRNHLQPWNV TGDSIRSYCE KFYLFPLKMI
210 220 230 240 250
TWTMPTAVFF ICMILLITSL GRHRKKALLT TSGFREPSVQ AHIKALLALL
260 270 280 290 300
SFAMLFISYF LSLVFSAAGI FPPLDFKFWV WESVIYLCAA VHPIILLFSN
310
CRLRAVLKSR RSSRCGTP
Length:318
Mass (Da):36,337
Last modified:April 11, 2003 - v1
Checksum:iDEDAB1CC8101764B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114094 Genomic DNA Translation: AAM63544.1
AY724955 Genomic DNA Translation: AAU21151.1
CH236959 Genomic DNA Translation: EAL23790.1
BC100938 mRNA Translation: AAI00939.1
BC100939 mRNA Translation: AAI00940.1
BC100940 mRNA Translation: AAI00941.1
BK001100 Genomic DNA Translation: DAA01207.1
CCDSiCCDS5885.1
RefSeqiNP_803186.1, NM_177437.1
UniGeneiHs.688222

Genome annotation databases

EnsembliENST00000332690; ENSP00000327724; ENSG00000185899
ENST00000642941; ENSP00000494922; ENSG00000285341
GeneIDi338398
KEGGihsa:338398
UCSCiuc011ktg.2 human

Similar proteinsi

Entry informationi

Entry nameiT2R60_HUMAN
AccessioniPrimary (citable) accession number: P59551
Secondary accession number(s): A4D2G8, Q645W8, Q7RTR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health