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P59551

- T2R60_HUMAN

UniProt

P59551 - T2R60_HUMAN

Protein

Taste receptor type 2 member 60

Gene

TAS2R60

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB

    GO - Biological processi

    1. sensory perception of bitter taste Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 60
    Short name:
    T2R60
    Alternative name(s):
    Taste receptor type 2 member 56
    Short name:
    T2R56
    Gene namesi
    Name:TAS2R60
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:20639. TAS2R60.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134879120.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Taste receptor type 2 member 60PRO_0000082351Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP59551.
    PeptideAtlasiP59551.
    PRIDEiP59551.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

    Gene expression databases

    CleanExiHS_TAS2R60.
    GenevestigatoriP59551.

    Organism-specific databases

    HPAiHPA030416.

    Structurei

    3D structure databases

    ProteinModelPortaliP59551.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77ExtracellularSequence Analysis
    Topological domaini29 – 4012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini62 – 8827ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini110 – 12819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 18334ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini205 – 23430CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 2649ExtracellularSequence Analysis
    Topological domaini286 – 31833CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei41 – 6121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45884.
    HOGENOMiHOG000234595.
    HOVERGENiHBG098568.
    InParanoidiP59551.
    KOiK08474.
    OMAiPCDKLLV.
    OrthoDBiEOG77Q4X4.
    PhylomeDBiP59551.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59551-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGDHMVLGS SVTDKKAIIL VTILLLLRLV AIAGNGFITA ALGVEWVLRR    50
    MLLPCDKLLV SLGASRFCLQ SVVMGKTIYV FLHPMAFPYN PVLQFLAFQW 100
    DFLNAATLWS STWLSVFYCV KIATFTHPVF FWLKHKLSGW LPWMLFSSVG 150
    LSSFTTILFF IGNHRMYQNY LRNHLQPWNV TGDSIRSYCE KFYLFPLKMI 200
    TWTMPTAVFF ICMILLITSL GRHRKKALLT TSGFREPSVQ AHIKALLALL 250
    SFAMLFISYF LSLVFSAAGI FPPLDFKFWV WESVIYLCAA VHPIILLFSN 300
    CRLRAVLKSR RSSRCGTP 318
    Length:318
    Mass (Da):36,337
    Last modified:April 11, 2003 - v1
    Checksum:iDEDAB1CC8101764B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114094 Genomic DNA. Translation: AAM63544.1.
    AY724955 Genomic DNA. Translation: AAU21151.1.
    CH236959 Genomic DNA. Translation: EAL23790.1.
    BC100938 mRNA. Translation: AAI00939.1.
    BC100939 mRNA. Translation: AAI00940.1.
    BC100940 mRNA. Translation: AAI00941.1.
    BK001100 Genomic DNA. Translation: DAA01207.1.
    CCDSiCCDS5885.1.
    RefSeqiNP_803186.1. NM_177437.1.
    UniGeneiHs.688222.

    Genome annotation databases

    EnsembliENST00000332690; ENSP00000327724; ENSG00000185899.
    GeneIDi338398.
    KEGGihsa:338398.
    UCSCiuc011ktg.2. human.

    Polymorphism databases

    DMDMi29839489.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114094 Genomic DNA. Translation: AAM63544.1 .
    AY724955 Genomic DNA. Translation: AAU21151.1 .
    CH236959 Genomic DNA. Translation: EAL23790.1 .
    BC100938 mRNA. Translation: AAI00939.1 .
    BC100939 mRNA. Translation: AAI00940.1 .
    BC100940 mRNA. Translation: AAI00941.1 .
    BK001100 Genomic DNA. Translation: DAA01207.1 .
    CCDSi CCDS5885.1.
    RefSeqi NP_803186.1. NM_177437.1.
    UniGenei Hs.688222.

    3D structure databases

    ProteinModelPortali P59551.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 29839489.

    Proteomic databases

    PaxDbi P59551.
    PeptideAtlasi P59551.
    PRIDEi P59551.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332690 ; ENSP00000327724 ; ENSG00000185899 .
    GeneIDi 338398.
    KEGGi hsa:338398.
    UCSCi uc011ktg.2. human.

    Organism-specific databases

    CTDi 338398.
    GeneCardsi GC07P143143.
    HGNCi HGNC:20639. TAS2R60.
    HPAi HPA030416.
    MIMi 613968. gene.
    neXtProti NX_P59551.
    PharmGKBi PA134879120.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45884.
    HOGENOMi HOG000234595.
    HOVERGENi HBG098568.
    InParanoidi P59551.
    KOi K08474.
    OMAi PCDKLLV.
    OrthoDBi EOG77Q4X4.
    PhylomeDBi P59551.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R60.
    GenomeRNAii 338398.
    NextBioi 96978.
    PROi P59551.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_TAS2R60.
    Genevestigatori P59551.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
      Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
      Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
      Shi P., Zhang J., Yang H., Zhang Y.-P.
      Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    6. Cited for: REVIEW.
    7. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R60_HUMAN
    AccessioniPrimary (citable) accession number: P59551
    Secondary accession number(s): A4D2G8, Q645W8, Q7RTR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3