P59551 (T2R60_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 60
Short name=T2R60

Alternative name(s):
Taste receptor type 2 member 56
Short name=T2R56

Gene names

Name:

TAS2R60

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Miscellaneous	Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sensory perception of bitter taste Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	G-protein coupled receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Taste receptor type 2 member 60		PRO_0000082351
Regions
	Topological domain	1 – 7	7	Extracellular Potential
	Transmembrane	8 – 28	21	Helical; Name=1; Potential
	Topological domain	29 – 40	12	Cytoplasmic Potential
	Transmembrane	41 – 61	21	Helical; Name=2; Potential
	Topological domain	62 – 88	27	Extracellular Potential
	Transmembrane	89 – 109	21	Helical; Name=3; Potential
	Topological domain	110 – 128	19	Cytoplasmic Potential
	Transmembrane	129 – 149	21	Helical; Name=4; Potential
	Topological domain	150 – 183	34	Extracellular Potential
	Transmembrane	184 – 204	21	Helical; Name=5; Potential
	Topological domain	205 – 234	30	Cytoplasmic Potential
	Transmembrane	235 – 255	21	Helical; Name=6; Potential
	Topological domain	256 – 264	9	Extracellular Potential
	Transmembrane	265 – 285	21	Helical; Name=7; Potential
	Topological domain	286 – 318	33	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	179	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P59551 [UniParc]. Last modified April 11, 2003. Version 1. Checksum: DEDAB1CC8101764B	FASTA	318	36,337
	10 20 30 40 50 60 MNGDHMVLGS SVTDKKAIIL VTILLLLRLV AIAGNGFITA ALGVEWVLRR MLLPCDKLLV 70 80 90 100 110 120 SLGASRFCLQ SVVMGKTIYV FLHPMAFPYN PVLQFLAFQW DFLNAATLWS STWLSVFYCV 130 140 150 160 170 180 KIATFTHPVF FWLKHKLSGW LPWMLFSSVG LSSFTTILFF IGNHRMYQNY LRNHLQPWNV 190 200 210 220 230 240 TGDSIRSYCE KFYLFPLKMI TWTMPTAVFF ICMILLITSL GRHRKKALLT TSGFREPSVQ 250 260 270 280 290 300 AHIKALLALL SFAMLFISYF LSLVFSAAGI FPPLDFKFWV WESVIYLCAA VHPIILLFSN 310 CRLRAVLKSR RSSRCGTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of human taste receptor genes belonging to the TAS2R family." Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J. Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Adaptive diversification of bitter taste receptor genes in mammalian evolution." Shi P., Zhang J., Yang H., Zhang Y.-P. Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	"Receptors for bitter and sweet taste." Montmayeur J.-P., Matsunami H. Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[7]	"Molecular mechanisms of bitter and sweet taste transduction." Margolskee R.F. J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[8]	"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY114094 Genomic DNA. Translation: AAM63544.1. AY724955 Genomic DNA. Translation: AAU21151.1. CH236959 Genomic DNA. Translation: EAL23790.1. BC100938 mRNA. Translation: AAI00939.1. BC100939 mRNA. Translation: AAI00940.1. BC100940 mRNA. Translation: AAI00941.1. BK001100 Genomic DNA. Translation: DAA01207.1.
IPI	IPI00250364.
RefSeq	NP_803186.1. NM_177437.1.
UniGene	Hs.688222.
3D structure databases
ProteinModelPortal	P59551.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	29839489.
Proteomic databases
PaxDb	P59551.
PeptideAtlas	P59551.
PRIDE	P59551.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332690; ENSP00000327724; ENSG00000185899.
GeneID	338398.
KEGG	hsa:338398.
UCSC	uc011ktg.2. human.
Organism-specific databases
CTD	338398.
GeneCards	GC07P143143.
HGNC	HGNC:20639. TAS2R60.
HPA	HPA030416.
MIM	613968. gene.
neXtProt	NX_P59551.
PharmGKB	PA134879120.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45884.
HOGENOM	HOG000234595.
HOVERGEN	HBG098568.
InParanoid	P59551.
KO	K08474.
OMA	PCDKLLV.
OrthoDB	EOG4P5K9P.
PhylomeDB	P59551.
Gene expression databases
ArrayExpress	P59551.
CleanEx	HS_TAS2R60.
Genevestigator	P59551.
Family and domain databases
InterPro	IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	338398.
NextBio	96978.
SOURCE	Search...

Entry information

Entry name

T2R60_HUMAN

Accession

Primary (citable) accession number: P59551
Secondary accession number(s): A4D2G8, Q645W8, Q7RTR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	April 11, 2003
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.