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P59551

- T2R60_HUMAN

UniProt

P59551 - T2R60_HUMAN

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Protein
Taste receptor type 2 member 60
Gene
TAS2R60
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  1. sensory perception of bitter taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 60
Short name:
T2R60
Alternative name(s):
Taste receptor type 2 member 56
Short name:
T2R56
Gene namesi
Name:TAS2R60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:20639. TAS2R60.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Extracellular Reviewed prediction
Transmembranei8 – 2821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini29 – 4012Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei41 – 6121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini62 – 8827Extracellular Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini110 – 12819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei129 – 14921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini150 – 18334Extracellular Reviewed prediction
Add
BLAST
Transmembranei184 – 20421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini205 – 23430Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei235 – 25521Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini256 – 2649Extracellular Reviewed prediction
Transmembranei265 – 28521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini286 – 31833Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Taste receptor type 2 member 60
PRO_0000082351Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59551.
PeptideAtlasiP59551.
PRIDEiP59551.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

CleanExiHS_TAS2R60.
GenevestigatoriP59551.

Organism-specific databases

HPAiHPA030416.

Structurei

3D structure databases

ProteinModelPortaliP59551.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45884.
HOGENOMiHOG000234595.
HOVERGENiHBG098568.
InParanoidiP59551.
KOiK08474.
OMAiPCDKLLV.
OrthoDBiEOG77Q4X4.
PhylomeDBiP59551.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59551-1 [UniParc]FASTAAdd to Basket

« Hide

MNGDHMVLGS SVTDKKAIIL VTILLLLRLV AIAGNGFITA ALGVEWVLRR    50
MLLPCDKLLV SLGASRFCLQ SVVMGKTIYV FLHPMAFPYN PVLQFLAFQW 100
DFLNAATLWS STWLSVFYCV KIATFTHPVF FWLKHKLSGW LPWMLFSSVG 150
LSSFTTILFF IGNHRMYQNY LRNHLQPWNV TGDSIRSYCE KFYLFPLKMI 200
TWTMPTAVFF ICMILLITSL GRHRKKALLT TSGFREPSVQ AHIKALLALL 250
SFAMLFISYF LSLVFSAAGI FPPLDFKFWV WESVIYLCAA VHPIILLFSN 300
CRLRAVLKSR RSSRCGTP 318
Length:318
Mass (Da):36,337
Last modified:April 11, 2003 - v1
Checksum:iDEDAB1CC8101764B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY114094 Genomic DNA. Translation: AAM63544.1.
AY724955 Genomic DNA. Translation: AAU21151.1.
CH236959 Genomic DNA. Translation: EAL23790.1.
BC100938 mRNA. Translation: AAI00939.1.
BC100939 mRNA. Translation: AAI00940.1.
BC100940 mRNA. Translation: AAI00941.1.
BK001100 Genomic DNA. Translation: DAA01207.1.
CCDSiCCDS5885.1.
RefSeqiNP_803186.1. NM_177437.1.
UniGeneiHs.688222.

Genome annotation databases

EnsembliENST00000332690; ENSP00000327724; ENSG00000185899.
GeneIDi338398.
KEGGihsa:338398.
UCSCiuc011ktg.2. human.

Polymorphism databases

DMDMi29839489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY114094 Genomic DNA. Translation: AAM63544.1 .
AY724955 Genomic DNA. Translation: AAU21151.1 .
CH236959 Genomic DNA. Translation: EAL23790.1 .
BC100938 mRNA. Translation: AAI00939.1 .
BC100939 mRNA. Translation: AAI00940.1 .
BC100940 mRNA. Translation: AAI00941.1 .
BK001100 Genomic DNA. Translation: DAA01207.1 .
CCDSi CCDS5885.1.
RefSeqi NP_803186.1. NM_177437.1.
UniGenei Hs.688222.

3D structure databases

ProteinModelPortali P59551.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 29839489.

Proteomic databases

PaxDbi P59551.
PeptideAtlasi P59551.
PRIDEi P59551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332690 ; ENSP00000327724 ; ENSG00000185899 .
GeneIDi 338398.
KEGGi hsa:338398.
UCSCi uc011ktg.2. human.

Organism-specific databases

CTDi 338398.
GeneCardsi GC07P143143.
HGNCi HGNC:20639. TAS2R60.
HPAi HPA030416.
MIMi 613968. gene.
neXtProti NX_P59551.
PharmGKBi PA134879120.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45884.
HOGENOMi HOG000234595.
HOVERGENi HBG098568.
InParanoidi P59551.
KOi K08474.
OMAi PCDKLLV.
OrthoDBi EOG77Q4X4.
PhylomeDBi P59551.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R60.
GenomeRNAii 338398.
NextBioi 96978.
PROi P59551.
SOURCEi Search...

Gene expression databases

CleanExi HS_TAS2R60.
Genevestigatori P59551.

Family and domain databases

InterProi IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R60_HUMAN
AccessioniPrimary (citable) accession number: P59551
Secondary accession number(s): A4D2G8, Q645W8, Q7RTR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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