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P59544

- T2R50_HUMAN

UniProt

P59544 - T2R50_HUMAN

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Protein

Taste receptor type 2 member 50

Gene
TAS2R50
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 50
Short name:
T2R50
Alternative name(s):
Taste receptor type 2 member 51
Short name:
T2R51
Gene namesi
Name:TAS2R50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:18882. TAS2R50.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11Extracellular Reviewed prediction
Transmembranei2 – 2221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini23 – 5533Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei56 – 7621Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini77 – 8711Extracellular Reviewed predictionAdd
BLAST
Transmembranei88 – 10821Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini109 – 12618Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini148 – 18134Extracellular Reviewed predictionAdd
BLAST
Transmembranei182 – 20221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini203 – 22927Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei230 – 25021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini251 – 2599Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini281 – 29919Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38736.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Taste receptor type 2 member 50PRO_0000082337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59544.
PRIDEiP59544.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

ArrayExpressiP59544.
BgeeiP59544.
CleanExiHS_TAS2R50.
GenevestigatoriP59544.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375093.

Structurei

3D structure databases

ProteinModelPortaliP59544.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74690.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59544.
KOiK08474.
OMAiDSFILIW.
OrthoDBiEOG7P02JB.
PhylomeDBiP59544.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59544-1 [UniParc]FASTAAdd to Basket

« Hide

MITFLYIFFS ILIMVLFVLG NFANGFIALV NFIDWVKRKK ISSADQILTA    50
LAVSRIGLLW ALLLNWYLTV LNPAFYSVEL RITSYNAWVV TNHFSMWLAA 100
NLSIFYLLKI ANFSNLLFLH LKRRVRSVIL VILLGTLIFL VCHLLVANMD 150
ESMWAEEYEG NMTGKMKLRN TVHLSYLTVT TLWSFIPFTL SLISFLMLIC 200
SLCKHLKKMQ LHGEGSQDLS TKVHIKALQT LISFLLLCAI FFLFLIVSVW 250
SPRRLRNDPV VMVSKAVGNI YLAFDSFILI WRTKKLKHTF LLILCQIRC 299
Length:299
Mass (Da):34,558
Last modified:May 18, 2010 - v2
Checksum:iD5C3E41E1B370E6A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti203 – 2031C → Y.1 Publication
Corresponds to variant rs1376251 [ dbSNP | Ensembl ].
VAR_024187

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494235 Genomic DNA. Translation: AAM19326.1.
AY114088 Genomic DNA. Translation: AAM63538.1.
AY724937 Genomic DNA. Translation: AAU21139.1.
AC018630 Genomic DNA. No translation available.
BC112100 mRNA. Translation: AAI12101.1.
CCDSiCCDS8638.1.
RefSeqiNP_795371.2. NM_176890.2.
UniGeneiHs.688194.

Genome annotation databases

EnsembliENST00000506868; ENSP00000424040; ENSG00000212126.
ENST00000570541; ENSP00000458427; ENSG00000272952.
ENST00000575654; ENSP00000458551; ENSG00000273431.
GeneIDi259296.
KEGGihsa:259296.
UCSCiuc001qzl.2. human.

Polymorphism databases

DMDMi296452919.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494235 Genomic DNA. Translation: AAM19326.1 .
AY114088 Genomic DNA. Translation: AAM63538.1 .
AY724937 Genomic DNA. Translation: AAU21139.1 .
AC018630 Genomic DNA. No translation available.
BC112100 mRNA. Translation: AAI12101.1 .
CCDSi CCDS8638.1.
RefSeqi NP_795371.2. NM_176890.2.
UniGenei Hs.688194.

3D structure databases

ProteinModelPortali P59544.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000375093.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 296452919.

Proteomic databases

PaxDbi P59544.
PRIDEi P59544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000506868 ; ENSP00000424040 ; ENSG00000212126 .
ENST00000570541 ; ENSP00000458427 ; ENSG00000272952 .
ENST00000575654 ; ENSP00000458551 ; ENSG00000273431 .
GeneIDi 259296.
KEGGi hsa:259296.
UCSCi uc001qzl.2. human.

Organism-specific databases

CTDi 259296.
GeneCardsi GC12M011138.
HGNCi HGNC:18882. TAS2R50.
MIMi 609627. gene.
neXtProti NX_P59544.
PharmGKBi PA38736.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74690.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi P59544.
KOi K08474.
OMAi DSFILIW.
OrthoDBi EOG7P02JB.
PhylomeDBi P59544.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R50.
GenomeRNAii 259296.
NextBioi 93145.
PROi P59544.
SOURCEi Search...

Gene expression databases

ArrayExpressi P59544.
Bgeei P59544.
CleanExi HS_TAS2R50.
Genevestigatori P59544.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-203.
  2. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R50_HUMAN
AccessioniPrimary (citable) accession number: P59544
Secondary accession number(s): P59545, Q2M255, Q645Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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