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Protein

Taste receptor type 2 member 50

Gene

TAS2R50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

BioCyciZFISH:G66-33047-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 50
Short name:
T2R50
Alternative name(s):
Taste receptor type 2 member 51
Short name:
T2R51
Gene namesi
Name:TAS2R50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18882. TAS2R50.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1ExtracellularSequence analysis1
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini23 – 55CytoplasmicSequence analysisAdd BLAST33
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 87ExtracellularSequence analysisAdd BLAST11
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini109 – 126CytoplasmicSequence analysisAdd BLAST18
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 181ExtracellularSequence analysisAdd BLAST34
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini203 – 229CytoplasmicSequence analysisAdd BLAST27
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 259ExtracellularSequence analysis9
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 299CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi259296.
OpenTargetsiENSG00000212126.
ENSG00000273431.
ENSG00000276167.
PharmGKBiPA38736.

Polymorphism and mutation databases

BioMutaiTAS2R50.
DMDMi296452919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000823371 – 299Taste receptor type 2 member 50Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59544.
PRIDEiP59544.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000212126.
CleanExiHS_TAS2R50.
GenevisibleiP59544. HS.

Organism-specific databases

HPAiCAB016204.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000424040.

Structurei

3D structure databases

ProteinModelPortaliP59544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0YF. Eukaryota.
ENOG410YMY3. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59544.
KOiK08474.
OMAiWSFIPFT.
OrthoDBiEOG091G0HMB.
PhylomeDBiP59544.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITFLYIFFS ILIMVLFVLG NFANGFIALV NFIDWVKRKK ISSADQILTA
60 70 80 90 100
LAVSRIGLLW ALLLNWYLTV LNPAFYSVEL RITSYNAWVV TNHFSMWLAA
110 120 130 140 150
NLSIFYLLKI ANFSNLLFLH LKRRVRSVIL VILLGTLIFL VCHLLVANMD
160 170 180 190 200
ESMWAEEYEG NMTGKMKLRN TVHLSYLTVT TLWSFIPFTL SLISFLMLIC
210 220 230 240 250
SLCKHLKKMQ LHGEGSQDLS TKVHIKALQT LISFLLLCAI FFLFLIVSVW
260 270 280 290
SPRRLRNDPV VMVSKAVGNI YLAFDSFILI WRTKKLKHTF LLILCQIRC
Length:299
Mass (Da):34,558
Last modified:May 18, 2010 - v2
Checksum:iD5C3E41E1B370E6A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024187203C → Y.1 PublicationCorresponds to variant rs1376251dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494235 Genomic DNA. Translation: AAM19326.1.
AY114088 Genomic DNA. Translation: AAM63538.1.
AY724937 Genomic DNA. Translation: AAU21139.1.
AC018630 Genomic DNA. No translation available.
BC112100 mRNA. Translation: AAI12101.1.
CCDSiCCDS8638.1.
RefSeqiNP_795371.2. NM_176890.2.
UniGeneiHs.688194.

Genome annotation databases

EnsembliENST00000506868; ENSP00000424040; ENSG00000212126.
ENST00000575654; ENSP00000458551; ENSG00000273431.
ENST00000613831; ENSP00000479785; ENSG00000276167.
GeneIDi259296.
KEGGihsa:259296.
UCSCiuc001qzl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494235 Genomic DNA. Translation: AAM19326.1.
AY114088 Genomic DNA. Translation: AAM63538.1.
AY724937 Genomic DNA. Translation: AAU21139.1.
AC018630 Genomic DNA. No translation available.
BC112100 mRNA. Translation: AAI12101.1.
CCDSiCCDS8638.1.
RefSeqiNP_795371.2. NM_176890.2.
UniGeneiHs.688194.

3D structure databases

ProteinModelPortaliP59544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000424040.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiTAS2R50.
DMDMi296452919.

Proteomic databases

PaxDbiP59544.
PRIDEiP59544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000506868; ENSP00000424040; ENSG00000212126.
ENST00000575654; ENSP00000458551; ENSG00000273431.
ENST00000613831; ENSP00000479785; ENSG00000276167.
GeneIDi259296.
KEGGihsa:259296.
UCSCiuc001qzl.2. human.

Organism-specific databases

CTDi259296.
DisGeNETi259296.
GeneCardsiTAS2R50.
HGNCiHGNC:18882. TAS2R50.
HPAiCAB016204.
MIMi609627. gene.
neXtProtiNX_P59544.
OpenTargetsiENSG00000212126.
ENSG00000273431.
ENSG00000276167.
PharmGKBiPA38736.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0YF. Eukaryota.
ENOG410YMY3. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59544.
KOiK08474.
OMAiWSFIPFT.
OrthoDBiEOG091G0HMB.
PhylomeDBiP59544.
TreeFamiTF335891.

Enzyme and pathway databases

BioCyciZFISH:G66-33047-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikiiTAS2R50.
GenomeRNAii259296.
PROiP59544.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000212126.
CleanExiHS_TAS2R50.
GenevisibleiP59544. HS.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT2R50_HUMAN
AccessioniPrimary (citable) accession number: P59544
Secondary accession number(s): P59545, Q2M255, Q645Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.