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P59544

- T2R50_HUMAN

UniProt

P59544 - T2R50_HUMAN

Protein

Taste receptor type 2 member 50

Gene

TAS2R50

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 50
    Short name:
    T2R50
    Alternative name(s):
    Taste receptor type 2 member 51
    Short name:
    T2R51
    Gene namesi
    Name:TAS2R50
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:18882. TAS2R50.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38736.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Taste receptor type 2 member 50PRO_0000082337Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP59544.
    PRIDEiP59544.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiP59544.
    BgeeiP59544.
    CleanExiHS_TAS2R50.
    GenevestigatoriP59544.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000375093.

    Structurei

    3D structure databases

    ProteinModelPortaliP59544.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 11ExtracellularSequence Analysis
    Topological domaini23 – 5533CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 8711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini109 – 12618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini148 – 18134ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini203 – 22927CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 2599ExtracellularSequence Analysis
    Topological domaini281 – 29919CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74690.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiP59544.
    KOiK08474.
    OMAiDSFILIW.
    OrthoDBiEOG7P02JB.
    PhylomeDBiP59544.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59544-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITFLYIFFS ILIMVLFVLG NFANGFIALV NFIDWVKRKK ISSADQILTA    50
    LAVSRIGLLW ALLLNWYLTV LNPAFYSVEL RITSYNAWVV TNHFSMWLAA 100
    NLSIFYLLKI ANFSNLLFLH LKRRVRSVIL VILLGTLIFL VCHLLVANMD 150
    ESMWAEEYEG NMTGKMKLRN TVHLSYLTVT TLWSFIPFTL SLISFLMLIC 200
    SLCKHLKKMQ LHGEGSQDLS TKVHIKALQT LISFLLLCAI FFLFLIVSVW 250
    SPRRLRNDPV VMVSKAVGNI YLAFDSFILI WRTKKLKHTF LLILCQIRC 299
    Length:299
    Mass (Da):34,558
    Last modified:May 18, 2010 - v2
    Checksum:iD5C3E41E1B370E6A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti203 – 2031C → Y.1 Publication
    Corresponds to variant rs1376251 [ dbSNP | Ensembl ].
    VAR_024187

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494235 Genomic DNA. Translation: AAM19326.1.
    AY114088 Genomic DNA. Translation: AAM63538.1.
    AY724937 Genomic DNA. Translation: AAU21139.1.
    AC018630 Genomic DNA. No translation available.
    BC112100 mRNA. Translation: AAI12101.1.
    CCDSiCCDS8638.1.
    RefSeqiNP_795371.2. NM_176890.2.
    UniGeneiHs.688194.

    Genome annotation databases

    EnsembliENST00000506868; ENSP00000424040; ENSG00000212126.
    ENST00000575654; ENSP00000458551; ENSG00000273431.
    GeneIDi259296.
    KEGGihsa:259296.
    UCSCiuc001qzl.2. human.

    Polymorphism databases

    DMDMi296452919.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494235 Genomic DNA. Translation: AAM19326.1 .
    AY114088 Genomic DNA. Translation: AAM63538.1 .
    AY724937 Genomic DNA. Translation: AAU21139.1 .
    AC018630 Genomic DNA. No translation available.
    BC112100 mRNA. Translation: AAI12101.1 .
    CCDSi CCDS8638.1.
    RefSeqi NP_795371.2. NM_176890.2.
    UniGenei Hs.688194.

    3D structure databases

    ProteinModelPortali P59544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000375093.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 296452919.

    Proteomic databases

    PaxDbi P59544.
    PRIDEi P59544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000506868 ; ENSP00000424040 ; ENSG00000212126 .
    ENST00000575654 ; ENSP00000458551 ; ENSG00000273431 .
    GeneIDi 259296.
    KEGGi hsa:259296.
    UCSCi uc001qzl.2. human.

    Organism-specific databases

    CTDi 259296.
    GeneCardsi GC12M011138.
    HGNCi HGNC:18882. TAS2R50.
    MIMi 609627. gene.
    neXtProti NX_P59544.
    PharmGKBi PA38736.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74690.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi P59544.
    KOi K08474.
    OMAi DSFILIW.
    OrthoDBi EOG7P02JB.
    PhylomeDBi P59544.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R50.
    GenomeRNAii 259296.
    NextBioi 93145.
    PROi P59544.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P59544.
    Bgeei P59544.
    CleanExi HS_TAS2R50.
    Genevestigatori P59544.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TYR-203.
    2. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
      Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
      Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: REVIEW.
    7. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R50_HUMAN
    AccessioniPrimary (citable) accession number: P59544
    Secondary accession number(s): P59545, Q2M255, Q645Y0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3