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Protein

Taste receptor type 2 member 20

Gene

TAS2R20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

BioCyciZFISH:G66-32588-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 20
Alternative name(s):
Taste receptor type 2 member 49
Short name:
T2R49
Taste receptor type 2 member 56
Short name:
T2R56
Gene namesi
Name:TAS2R20
Synonyms:TAS2R49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:19109. TAS2R20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini28 – 46CytoplasmicSequence analysisAdd BLAST19
Transmembranei47 – 67Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini68 – 79ExtracellularSequence analysisAdd BLAST12
Transmembranei80 – 100Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini101 – 125CytoplasmicSequence analysisAdd BLAST25
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 178ExtracellularSequence analysisAdd BLAST32
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 229CytoplasmicSequence analysisAdd BLAST30
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 259ExtracellularSequence analysis9
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 309CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255837.
ENSG00000273092.

Polymorphism and mutation databases

BioMutaiTAS2R20.
DMDMi55977811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000823311 – 309Taste receptor type 2 member 20Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59543.
PRIDEiP59543.

PTM databases

iPTMnetiP59543.
PhosphoSitePlusiP59543.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiENSG00000272873.
CleanExiHS_TAS2R49.

Structurei

3D structure databases

ProteinModelPortaliP59543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9F7. Eukaryota.
ENOG4111BEG. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59543.
KOiK08474.
OMAiCWAKGQN.
OrthoDBiEOG091G0HMB.
PhylomeDBiP59543.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSFLHIVFS ILVVVAFILG NFANGFIALI NFIAWVKRQK ISSADQIIAA
60 70 80 90 100
LAVSRVGLLW VILLHWYSTV LNPTSSNLKV IIFISNAWAV TNHFSIWLAT
110 120 130 140 150
SLSIFYLLKI VNFSRLIFHH LKRKAKSVVL VIVLGSLFFL VCHLVMKHTY
160 170 180 190 200
INVWTEECEG NVTWKIKLRN AMHLSNLTVA MLANLIPFTL TLISFLLLIY
210 220 230 240 250
SLCKHLKKMQ LHGKGSQDPS TKIHIKALQT VTSFLILLAI YFLCLIISFW
260 270 280 290 300
NFKMRPKEIV LMLCQAFGII YPSFHSFILI WGNKTLKQTF LSVLWQVTCW

AKGQNQSTP
Length:309
Mass (Da):35,358
Last modified:November 23, 2004 - v2
Checksum:iAB200710EE19361C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33I → V in AAU21140 (PubMed:15496549).Curated1
Sequence conflicti55R → K in AAM19327 (PubMed:12379855).Curated1
Sequence conflicti141 – 143VCH → ICQ in AAU21140 (PubMed:15496549).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05335679K → E.1 PublicationCorresponds to variant rs7135018dbSNPEnsembl.1
Natural variantiVAR_053357143H → Q.Corresponds to variant rs12226920dbSNPEnsembl.1
Natural variantiVAR_053358148H → N.1 PublicationCorresponds to variant rs12226919dbSNPEnsembl.1
Natural variantiVAR_053359236I → V.1 PublicationCorresponds to variant rs10845281dbSNPEnsembl.1
Natural variantiVAR_053360252F → S.1 PublicationCorresponds to variant rs10845280dbSNPEnsembl.1
Natural variantiVAR_053361255R → L.1 PublicationCorresponds to variant rs10845279dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494236 Genomic DNA. Translation: AAM19327.1.
AY114092 Genomic DNA. Translation: AAM63542.1.
AY724938 Genomic DNA. Translation: AAU21140.1.
BC100915 mRNA. Translation: AAI00916.1.
BC100916 mRNA. Translation: AAI00917.1.
BC100918 mRNA. Translation: AAI00919.1.
BC113843 mRNA. Translation: AAI13844.1.
CCDSiCCDS8639.1.
RefSeqiNP_795370.2. NM_176889.3.
UniGeneiHs.686384.

Genome annotation databases

EnsembliENST00000538986; ENSP00000441624; ENSG00000255837.
ENST00000570941; ENSP00000459353; ENSG00000273092.
GeneIDi259295.
KEGGihsa:259295.
UCSCiuc001qzm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494236 Genomic DNA. Translation: AAM19327.1.
AY114092 Genomic DNA. Translation: AAM63542.1.
AY724938 Genomic DNA. Translation: AAU21140.1.
BC100915 mRNA. Translation: AAI00916.1.
BC100916 mRNA. Translation: AAI00917.1.
BC100918 mRNA. Translation: AAI00919.1.
BC113843 mRNA. Translation: AAI13844.1.
CCDSiCCDS8639.1.
RefSeqiNP_795370.2. NM_176889.3.
UniGeneiHs.686384.

3D structure databases

ProteinModelPortaliP59543.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP59543.
PhosphoSitePlusiP59543.

Polymorphism and mutation databases

BioMutaiTAS2R20.
DMDMi55977811.

Proteomic databases

PaxDbiP59543.
PRIDEiP59543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000538986; ENSP00000441624; ENSG00000255837.
ENST00000570941; ENSP00000459353; ENSG00000273092.
GeneIDi259295.
KEGGihsa:259295.
UCSCiuc001qzm.3. human.

Organism-specific databases

CTDi259295.
GeneCardsiTAS2R20.
HGNCiHGNC:19109. TAS2R20.
MIMi613962. gene.
neXtProtiNX_P59543.
OpenTargetsiENSG00000255837.
ENSG00000273092.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9F7. Eukaryota.
ENOG4111BEG. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59543.
KOiK08474.
OMAiCWAKGQN.
OrthoDBiEOG091G0HMB.
PhylomeDBiP59543.
TreeFamiTF335891.

Enzyme and pathway databases

BioCyciZFISH:G66-32588-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikiiTAS2R20.
GenomeRNAii259295.
PROiP59543.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000272873.
CleanExiHS_TAS2R49.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT2R20_HUMAN
AccessioniPrimary (citable) accession number: P59543
Secondary accession number(s): P59549
, Q2HIZ4, Q496D8, Q645X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.