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P59543

- T2R20_HUMAN

UniProt

P59543 - T2R20_HUMAN

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Protein

Taste receptor type 2 member 20

Gene

TAS2R20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. sensory perception of taste Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 20
Alternative name(s):
Taste receptor type 2 member 49
Short name:
T2R49
Taste receptor type 2 member 56
Short name:
T2R56
Gene namesi
Name:TAS2R20
Synonyms:TAS2R49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:19109. TAS2R20.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularSequence Analysis
Transmembranei7 – 2721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini28 – 4619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei47 – 6721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini68 – 7912ExtracellularSequence AnalysisAdd
BLAST
Transmembranei80 – 10021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini101 – 12525CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini147 – 17832ExtracellularSequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini200 – 22930CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini251 – 2599ExtracellularSequence Analysis
Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini281 – 30929CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Taste receptor type 2 member 20PRO_0000082331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59543.
PRIDEiP59543.

PTM databases

PhosphoSiteiP59543.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

CleanExiHS_TAS2R49.
ExpressionAtlasiP59543. baseline.
GenevestigatoriP59543.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375092.

Structurei

3D structure databases

ProteinModelPortaliP59543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43462.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59543.
KOiK08474.
OMAiPSTKIHI.
OrthoDBiEOG7P02JB.
PhylomeDBiP59543.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59543-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSFLHIVFS ILVVVAFILG NFANGFIALI NFIAWVKRQK ISSADQIIAA
60 70 80 90 100
LAVSRVGLLW VILLHWYSTV LNPTSSNLKV IIFISNAWAV TNHFSIWLAT
110 120 130 140 150
SLSIFYLLKI VNFSRLIFHH LKRKAKSVVL VIVLGSLFFL VCHLVMKHTY
160 170 180 190 200
INVWTEECEG NVTWKIKLRN AMHLSNLTVA MLANLIPFTL TLISFLLLIY
210 220 230 240 250
SLCKHLKKMQ LHGKGSQDPS TKIHIKALQT VTSFLILLAI YFLCLIISFW
260 270 280 290 300
NFKMRPKEIV LMLCQAFGII YPSFHSFILI WGNKTLKQTF LSVLWQVTCW

AKGQNQSTP
Length:309
Mass (Da):35,358
Last modified:November 23, 2004 - v2
Checksum:iAB200710EE19361C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331I → V in AAU21140. (PubMed:15496549)Curated
Sequence conflicti55 – 551R → K in AAM19327. (PubMed:12379855)Curated
Sequence conflicti141 – 1433VCH → ICQ in AAU21140. (PubMed:15496549)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791K → E.1 Publication
Corresponds to variant rs7135018 [ dbSNP | Ensembl ].
VAR_053356
Natural varianti143 – 1431H → Q.
Corresponds to variant rs12226920 [ dbSNP | Ensembl ].
VAR_053357
Natural varianti148 – 1481H → N.1 Publication
Corresponds to variant rs12226919 [ dbSNP | Ensembl ].
VAR_053358
Natural varianti236 – 2361I → V.1 Publication
Corresponds to variant rs10845281 [ dbSNP | Ensembl ].
VAR_053359
Natural varianti252 – 2521F → S.1 Publication
Corresponds to variant rs10845280 [ dbSNP | Ensembl ].
VAR_053360
Natural varianti255 – 2551R → L.1 Publication
Corresponds to variant rs10845279 [ dbSNP | Ensembl ].
VAR_053361

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494236 Genomic DNA. Translation: AAM19327.1.
AY114092 Genomic DNA. Translation: AAM63542.1.
AY724938 Genomic DNA. Translation: AAU21140.1.
BC100915 mRNA. Translation: AAI00916.1.
BC100916 mRNA. Translation: AAI00917.1.
BC100918 mRNA. Translation: AAI00919.1.
BC113843 mRNA. Translation: AAI13844.1.
CCDSiCCDS8639.1.
RefSeqiNP_795370.2. NM_176889.2.
UniGeneiHs.686384.

Genome annotation databases

EnsembliENST00000538986; ENSP00000441624; ENSG00000255837.
ENST00000570941; ENSP00000459353; ENSG00000273092.
GeneIDi259295.
KEGGihsa:259295.
UCSCiuc001qzm.2. human.

Polymorphism databases

DMDMi55977811.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494236 Genomic DNA. Translation: AAM19327.1 .
AY114092 Genomic DNA. Translation: AAM63542.1 .
AY724938 Genomic DNA. Translation: AAU21140.1 .
BC100915 mRNA. Translation: AAI00916.1 .
BC100916 mRNA. Translation: AAI00917.1 .
BC100918 mRNA. Translation: AAI00919.1 .
BC113843 mRNA. Translation: AAI13844.1 .
CCDSi CCDS8639.1.
RefSeqi NP_795370.2. NM_176889.2.
UniGenei Hs.686384.

3D structure databases

ProteinModelPortali P59543.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000375092.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P59543.

Polymorphism databases

DMDMi 55977811.

Proteomic databases

PaxDbi P59543.
PRIDEi P59543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000538986 ; ENSP00000441624 ; ENSG00000255837 .
ENST00000570941 ; ENSP00000459353 ; ENSG00000273092 .
GeneIDi 259295.
KEGGi hsa:259295.
UCSCi uc001qzm.2. human.

Organism-specific databases

CTDi 259295.
GeneCardsi GC12M011148.
HGNCi HGNC:19109. TAS2R20.
MIMi 613962. gene.
neXtProti NX_P59543.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43462.
GeneTreei ENSGT00760000119096.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi P59543.
KOi K08474.
OMAi PSTKIHI.
OrthoDBi EOG7P02JB.
PhylomeDBi P59543.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R20.
GenomeRNAii 259295.
NextBioi 93141.
PROi P59543.
SOURCEi Search...

Gene expression databases

CleanExi HS_TAS2R49.
ExpressionAtlasi P59543. baseline.
Genevestigatori P59543.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-148; VAL-236; SER-252 AND LEU-255.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-79.
  5. Cited for: REVIEW.
  6. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R20_HUMAN
AccessioniPrimary (citable) accession number: P59543
Secondary accession number(s): P59549
, Q2HIZ4, Q496D8, Q645X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3