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Protein

Taste receptor type 2 member 19

Gene

TAS2R19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

BioCyciZFISH:G66-31604-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Protein family/group databases

TCDBi9.A.14.17.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 19
Alternative name(s):
Taste receptor type 2 member 23
Taste receptor type 2 member 48
Short name:
T2R48
Gene namesi
Name:TAS2R19
Synonyms:TAS2R23, TAS2R48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:19108. TAS2R19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1ExtracellularSequence analysis1
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini23 – 55CytoplasmicSequence analysisAdd BLAST33
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 87ExtracellularSequence analysisAdd BLAST11
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini109 – 127CytoplasmicSequence analysisAdd BLAST19
Transmembranei128 – 148Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini149 – 181ExtracellularSequence analysisAdd BLAST33
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini203 – 226CytoplasmicSequence analysisAdd BLAST24
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 259ExtracellularSequence analysisAdd BLAST12
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 299CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212124.
ENSG00000263028.

Polymorphism and mutation databases

BioMutaiTAS2R19.
DMDMi29839480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000823281 – 299Taste receptor type 2 member 19Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59542.
PeptideAtlasiP59542.
PRIDEiP59542.

PTM databases

iPTMnetiP59542.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

CleanExiHS_TAS2R48.

Structurei

3D structure databases

ProteinModelPortaliP59542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUZ6. Eukaryota.
ENOG4110PRM. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59542.
KOiK08474.
OMAiKMRLHSK.
OrthoDBiEOG091G0HMB.
PhylomeDBiP59542.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCFLLIISS ILVVFAFVLG NVANGFIALV NVIDWVNTRK ISSAEQILTA
60 70 80 90 100
LVVSRIGLLW VMLFLWYATV FNSALYGLEV RIVASNAWAV TNHFSMWLAA
110 120 130 140 150
SLSIFCLLKI ANFSNLISLH LKKRIKSVVL VILLGPLVFL ICNLAVITMD
160 170 180 190 200
ERVWTKEYEG NVTWKIKLRN AIHLSSLTVT TLANLIPFTL SLICFLLLIC
210 220 230 240 250
SLCKHLKKMR LHSKGSQDPS TKVHIKALQT VTSFLMLFAI YFLCIITSTW
260 270 280 290
NLRTQQSKLV LLLCQTVAIM YPSFHSFILI MGSRKLKQTF LSVLWQMTR
Length:299
Mass (Da):33,908
Last modified:April 11, 2003 - v1
Checksum:i843EAEF42105EBE0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053354126K → Q.Corresponds to variant rs12424373dbSNPEnsembl.1
Natural variantiVAR_053355299R → C.Corresponds to variant rs10772420dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494234 Genomic DNA. Translation: AAM19325.1.
AY724939 Genomic DNA. Translation: AAU21141.1.
BC101804 mRNA. Translation: AAI01805.1.
BC111998 mRNA. Translation: AAI11999.1.
CCDSiCCDS8640.1.
RefSeqiNP_795369.1. NM_176888.2.
UniGeneiHs.687025.
Hs.688196.

Genome annotation databases

EnsembliENST00000390673; ENSP00000375091; ENSG00000212124.
ENST00000573562; ENSP00000461533; ENSG00000263028.
GeneIDi259294.
KEGGihsa:259294.
UCSCiuc010shj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494234 Genomic DNA. Translation: AAM19325.1.
AY724939 Genomic DNA. Translation: AAU21141.1.
BC101804 mRNA. Translation: AAI01805.1.
BC111998 mRNA. Translation: AAI11999.1.
CCDSiCCDS8640.1.
RefSeqiNP_795369.1. NM_176888.2.
UniGeneiHs.687025.
Hs.688196.

3D structure databases

ProteinModelPortaliP59542.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi9.A.14.17.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP59542.

Polymorphism and mutation databases

BioMutaiTAS2R19.
DMDMi29839480.

Proteomic databases

PaxDbiP59542.
PeptideAtlasiP59542.
PRIDEiP59542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390673; ENSP00000375091; ENSG00000212124.
ENST00000573562; ENSP00000461533; ENSG00000263028.
GeneIDi259294.
KEGGihsa:259294.
UCSCiuc010shj.3. human.

Organism-specific databases

CTDi259294.
GeneCardsiTAS2R19.
HGNCiHGNC:19108. TAS2R19.
MIMi613961. gene.
neXtProtiNX_P59542.
OpenTargetsiENSG00000212124.
ENSG00000263028.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUZ6. Eukaryota.
ENOG4110PRM. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59542.
KOiK08474.
OMAiKMRLHSK.
OrthoDBiEOG091G0HMB.
PhylomeDBiP59542.
TreeFamiTF335891.

Enzyme and pathway databases

BioCyciZFISH:G66-31604-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

GeneWikiiTAS2R19.
GenomeRNAii259294.
PROiP59542.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TAS2R48.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT2R19_HUMAN
AccessioniPrimary (citable) accession number: P59542
Secondary accession number(s): Q3MIJ4, Q645X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.