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P59542 (T2R19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 19
Alternative name(s):
Taste receptor type 2 member 23
Taste receptor type 2 member 48
Short name=T2R48
Gene names
Name:TAS2R19
Synonyms:TAS2R23, TAS2R48
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsensory perception of taste

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Taste receptor type 2 member 19
PRO_0000082328

Regions

Topological domain11Extracellular Potential
Transmembrane2 – 2221Helical; Name=1; Potential
Topological domain23 – 5533Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 8711Extracellular Potential
Transmembrane88 – 10821Helical; Name=3; Potential
Topological domain109 – 12719Cytoplasmic Potential
Transmembrane128 – 14821Helical; Name=4; Potential
Topological domain149 – 18133Extracellular Potential
Transmembrane182 – 20221Helical; Name=5; Potential
Topological domain203 – 22624Cytoplasmic Potential
Transmembrane227 – 24721Helical; Name=6; Potential
Topological domain248 – 25912Extracellular Potential
Transmembrane260 – 28021Helical; Name=7; Potential
Topological domain281 – 29919Cytoplasmic Potential

Amino acid modifications

Glycosylation1611N-linked (GlcNAc...) Potential

Natural variations

Natural variant1261K → Q.
Corresponds to variant rs12424373 [ dbSNP | Ensembl ].
VAR_053354
Natural variant2991R → C.
Corresponds to variant rs10772420 [ dbSNP | Ensembl ].
VAR_053355

Sequences

Sequence LengthMass (Da)Tools
P59542 [UniParc].

Last modified April 11, 2003. Version 1.
Checksum: 843EAEF42105EBE0

FASTA29933,908
        10         20         30         40         50         60 
MMCFLLIISS ILVVFAFVLG NVANGFIALV NVIDWVNTRK ISSAEQILTA LVVSRIGLLW 

        70         80         90        100        110        120 
VMLFLWYATV FNSALYGLEV RIVASNAWAV TNHFSMWLAA SLSIFCLLKI ANFSNLISLH 

       130        140        150        160        170        180 
LKKRIKSVVL VILLGPLVFL ICNLAVITMD ERVWTKEYEG NVTWKIKLRN AIHLSSLTVT 

       190        200        210        220        230        240 
TLANLIPFTL SLICFLLLIC SLCKHLKKMR LHSKGSQDPS TKVHIKALQT VTSFLMLFAI 

       250        260        270        280        290 
YFLCIITSTW NLRTQQSKLV LLLCQTVAIM YPSFHSFILI MGSRKLKQTF LSVLWQMTR 

« Hide

References

« Hide 'large scale' references
[1]"The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[5]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[6]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF494234 Genomic DNA. Translation: AAM19325.1.
AY724939 Genomic DNA. Translation: AAU21141.1.
BC101804 mRNA. Translation: AAI01805.1.
BC111998 mRNA. Translation: AAI11999.1.
RefSeqNP_795369.1. NM_176888.1.
UniGeneHs.687025.
Hs.688196.

3D structure databases

ProteinModelPortalP59542.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB9.A.14.17.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

Polymorphism databases

DMDM29839480.

Proteomic databases

PaxDbP59542.
PRIDEP59542.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000390673; ENSP00000375091; ENSG00000212124.
ENST00000573562; ENSP00000461533; ENSG00000263028.
GeneID259294.
KEGGhsa:259294.
UCSCuc010shj.2. human.

Organism-specific databases

CTD259294.
GeneCardsGC12M011174.
HGNCHGNC:19108. TAS2R19.
MIM613961. gene.
neXtProtNX_P59542.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG130344.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidP59542.
KOK08474.
OMAGNITWET.
OrthoDBEOG7P02JB.
PhylomeDBP59542.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP59542.
CleanExHS_TAS2R48.
GenevestigatorP59542.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R19.
GenomeRNAi259294.
NextBio93137.
PROP59542.
SOURCESearch...

Entry information

Entry nameT2R19_HUMAN
AccessionPrimary (citable) accession number: P59542
Secondary accession number(s): Q3MIJ4, Q645X8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries