Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P59542

- T2R19_HUMAN

UniProt

P59542 - T2R19_HUMAN

Protein

Taste receptor type 2 member 19

Gene

TAS2R19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (11 Apr 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. sensory perception of taste Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Protein family/group databases

    TCDBi9.A.14.17.1. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 19
    Alternative name(s):
    Taste receptor type 2 member 23
    Taste receptor type 2 member 48
    Short name:
    T2R48
    Gene namesi
    Name:TAS2R19
    Synonyms:TAS2R23, TAS2R48
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:19108. TAS2R19.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Taste receptor type 2 member 19PRO_0000082328Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP59542.
    PRIDEiP59542.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiP59542.
    CleanExiHS_TAS2R48.
    GenevestigatoriP59542.

    Structurei

    3D structure databases

    ProteinModelPortaliP59542.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 11ExtracellularSequence Analysis
    Topological domaini23 – 5533CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 8711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini109 – 12719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini149 – 18133ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini203 – 22624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 25912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini281 – 29919CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG130344.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiP59542.
    KOiK08474.
    OMAiGNITWET.
    OrthoDBiEOG7P02JB.
    PhylomeDBiP59542.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59542-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMCFLLIISS ILVVFAFVLG NVANGFIALV NVIDWVNTRK ISSAEQILTA    50
    LVVSRIGLLW VMLFLWYATV FNSALYGLEV RIVASNAWAV TNHFSMWLAA 100
    SLSIFCLLKI ANFSNLISLH LKKRIKSVVL VILLGPLVFL ICNLAVITMD 150
    ERVWTKEYEG NVTWKIKLRN AIHLSSLTVT TLANLIPFTL SLICFLLLIC 200
    SLCKHLKKMR LHSKGSQDPS TKVHIKALQT VTSFLMLFAI YFLCIITSTW 250
    NLRTQQSKLV LLLCQTVAIM YPSFHSFILI MGSRKLKQTF LSVLWQMTR 299
    Length:299
    Mass (Da):33,908
    Last modified:April 11, 2003 - v1
    Checksum:i843EAEF42105EBE0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti126 – 1261K → Q.
    Corresponds to variant rs12424373 [ dbSNP | Ensembl ].
    VAR_053354
    Natural varianti299 – 2991R → C.
    Corresponds to variant rs10772420 [ dbSNP | Ensembl ].
    VAR_053355

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494234 Genomic DNA. Translation: AAM19325.1.
    AY724939 Genomic DNA. Translation: AAU21141.1.
    BC101804 mRNA. Translation: AAI01805.1.
    BC111998 mRNA. Translation: AAI11999.1.
    CCDSiCCDS8640.1.
    RefSeqiNP_795369.1. NM_176888.1.
    UniGeneiHs.687025.
    Hs.688196.

    Genome annotation databases

    EnsembliENST00000390673; ENSP00000375091; ENSG00000212124.
    ENST00000573562; ENSP00000461533; ENSG00000263028.
    GeneIDi259294.
    KEGGihsa:259294.
    UCSCiuc010shj.2. human.

    Polymorphism databases

    DMDMi29839480.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494234 Genomic DNA. Translation: AAM19325.1 .
    AY724939 Genomic DNA. Translation: AAU21141.1 .
    BC101804 mRNA. Translation: AAI01805.1 .
    BC111998 mRNA. Translation: AAI11999.1 .
    CCDSi CCDS8640.1.
    RefSeqi NP_795369.1. NM_176888.1.
    UniGenei Hs.687025.
    Hs.688196.

    3D structure databases

    ProteinModelPortali P59542.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 9.A.14.17.1. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    Polymorphism databases

    DMDMi 29839480.

    Proteomic databases

    PaxDbi P59542.
    PRIDEi P59542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000390673 ; ENSP00000375091 ; ENSG00000212124 .
    ENST00000573562 ; ENSP00000461533 ; ENSG00000263028 .
    GeneIDi 259294.
    KEGGi hsa:259294.
    UCSCi uc010shj.2. human.

    Organism-specific databases

    CTDi 259294.
    GeneCardsi GC12M011174.
    HGNCi HGNC:19108. TAS2R19.
    MIMi 613961. gene.
    neXtProti NX_P59542.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG130344.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi P59542.
    KOi K08474.
    OMAi GNITWET.
    OrthoDBi EOG7P02JB.
    PhylomeDBi P59542.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R19.
    GenomeRNAii 259294.
    NextBioi 93137.
    PROi P59542.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P59542.
    CleanExi HS_TAS2R48.
    Genevestigatori P59542.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: REVIEW.
    5. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R19_HUMAN
    AccessioniPrimary (citable) accession number: P59542
    Secondary accession number(s): Q3MIJ4, Q645X8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3