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P59542

- T2R19_HUMAN

UniProt

P59542 - T2R19_HUMAN

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Protein

Taste receptor type 2 member 19

Gene

TAS2R19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. sensory perception of taste Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Protein family/group databases

TCDBi9.A.14.17.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 19
Alternative name(s):
Taste receptor type 2 member 23
Taste receptor type 2 member 48
Short name:
T2R48
Gene namesi
Name:TAS2R19
Synonyms:TAS2R23, TAS2R48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:19108. TAS2R19.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Taste receptor type 2 member 19PRO_0000082328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59542.
PRIDEiP59542.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

CleanExiHS_TAS2R48.
ExpressionAtlasiP59542. baseline.
GenevestigatoriP59542.

Structurei

3D structure databases

ProteinModelPortaliP59542.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11ExtracellularSequence Analysis
Topological domaini23 – 5533CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini77 – 8711ExtracellularSequence AnalysisAdd
BLAST
Topological domaini109 – 12719CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini149 – 18133ExtracellularSequence AnalysisAdd
BLAST
Topological domaini203 – 22624CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini248 – 25912ExtracellularSequence AnalysisAdd
BLAST
Topological domaini281 – 29919CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei128 – 14821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG130344.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59542.
KOiK08474.
OMAiGNITWET.
OrthoDBiEOG7P02JB.
PhylomeDBiP59542.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59542-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMCFLLIISS ILVVFAFVLG NVANGFIALV NVIDWVNTRK ISSAEQILTA
60 70 80 90 100
LVVSRIGLLW VMLFLWYATV FNSALYGLEV RIVASNAWAV TNHFSMWLAA
110 120 130 140 150
SLSIFCLLKI ANFSNLISLH LKKRIKSVVL VILLGPLVFL ICNLAVITMD
160 170 180 190 200
ERVWTKEYEG NVTWKIKLRN AIHLSSLTVT TLANLIPFTL SLICFLLLIC
210 220 230 240 250
SLCKHLKKMR LHSKGSQDPS TKVHIKALQT VTSFLMLFAI YFLCIITSTW
260 270 280 290
NLRTQQSKLV LLLCQTVAIM YPSFHSFILI MGSRKLKQTF LSVLWQMTR
Length:299
Mass (Da):33,908
Last modified:April 11, 2003 - v1
Checksum:i843EAEF42105EBE0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti126 – 1261K → Q.
Corresponds to variant rs12424373 [ dbSNP | Ensembl ].
VAR_053354
Natural varianti299 – 2991R → C.
Corresponds to variant rs10772420 [ dbSNP | Ensembl ].
VAR_053355

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494234 Genomic DNA. Translation: AAM19325.1.
AY724939 Genomic DNA. Translation: AAU21141.1.
BC101804 mRNA. Translation: AAI01805.1.
BC111998 mRNA. Translation: AAI11999.1.
CCDSiCCDS8640.1.
RefSeqiNP_795369.1. NM_176888.1.
UniGeneiHs.687025.
Hs.688196.

Genome annotation databases

EnsembliENST00000390673; ENSP00000375091; ENSG00000212124.
ENST00000573562; ENSP00000461533; ENSG00000263028.
GeneIDi259294.
KEGGihsa:259294.
UCSCiuc010shj.2. human.

Polymorphism databases

DMDMi29839480.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494234 Genomic DNA. Translation: AAM19325.1 .
AY724939 Genomic DNA. Translation: AAU21141.1 .
BC101804 mRNA. Translation: AAI01805.1 .
BC111998 mRNA. Translation: AAI11999.1 .
CCDSi CCDS8640.1.
RefSeqi NP_795369.1. NM_176888.1.
UniGenei Hs.687025.
Hs.688196.

3D structure databases

ProteinModelPortali P59542.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 9.A.14.17.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

Polymorphism databases

DMDMi 29839480.

Proteomic databases

PaxDbi P59542.
PRIDEi P59542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000390673 ; ENSP00000375091 ; ENSG00000212124 .
ENST00000573562 ; ENSP00000461533 ; ENSG00000263028 .
GeneIDi 259294.
KEGGi hsa:259294.
UCSCi uc010shj.2. human.

Organism-specific databases

CTDi 259294.
GeneCardsi GC12M011174.
HGNCi HGNC:19108. TAS2R19.
MIMi 613961. gene.
neXtProti NX_P59542.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG130344.
GeneTreei ENSGT00760000119096.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi P59542.
KOi K08474.
OMAi GNITWET.
OrthoDBi EOG7P02JB.
PhylomeDBi P59542.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R19.
GenomeRNAii 259294.
NextBioi 93137.
PROi P59542.
SOURCEi Search...

Gene expression databases

CleanExi HS_TAS2R48.
ExpressionAtlasi P59542. baseline.
Genevestigatori P59542.

Family and domain databases

InterProi IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: REVIEW.
  5. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R19_HUMAN
AccessioniPrimary (citable) accession number: P59542
Secondary accession number(s): Q3MIJ4, Q645X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3