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P59540

- T2R46_HUMAN

UniProt

P59540 - T2R46_HUMAN

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Protein
Taste receptor type 2 member 46
Gene
TAS2R46
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency By similarity.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 46
Short name:
T2R46
Alternative name(s):
Taste receptor type 2 member 54
Short name:
T2R54
Gene namesi
Name:TAS2R46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:18877. TAS2R46.

Subcellular locationi

Membrane; Multi-pass membrane protein. Cell projectioncilium membrane
Note: In airway epithelial cells, localizes to motile cilia.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11Extracellular Reviewed prediction
Transmembranei2 – 2221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini23 – 4624Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei47 – 6721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini68 – 8619Extracellular Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini108 – 12619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini148 – 17831Extracellular Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini200 – 22930Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei230 – 25021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini251 – 2599Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini281 – 30929Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. ciliary membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProt
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Taste receptor type 2 member 46
PRO_0000082318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi176 – 1761N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP59540.

PTM databases

PhosphoSiteiP59540.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium.1 Publication

Gene expression databases

ArrayExpressiP59540.
CleanExiHS_TAS2R46.
GenevestigatoriP59540.

Structurei

3D structure databases

ProteinModelPortaliP59540.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG060698.
KOiK08474.
OMAiFMFCEAI.
OrthoDBiEOG7P02JB.
PhylomeDBiP59540.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59540-1 [UniParc]FASTAAdd to Basket

« Hide

MITFLPIIFS ILIVVTFVIG NFANGFIALV NSIEWFKRQK ISFADQILTA    50
LAVSRVGLLW VLVLNWYATE LNPAFNSIEV RITAYNVWAV INHFSNWLAT 100
SLSIFYLLKI ANFSNLIFLH LKRRVKSVVL VILLGPLLFL VCHLFVINMN 150
QIIWTKEYEG NMTWKIKLRS AMYLSNTTVT ILANLVPFTL TLISFLLLIC 200
SLCKHLKKMQ LHGKGSQDPS MKVHIKALQT VTSFLLLCAI YFLSIIMSVW 250
SFESLENKPV FMFCEAIAFS YPSTHPFILI WGNKKLKQTF LSVLWHVRYW 300
VKGEKPSSS 309
Length:309
Mass (Da):35,523
Last modified:November 23, 2004 - v2
Checksum:iFF4D7747F0CE47EF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281L → M.1 Publication
Corresponds to variant rs2708380 [ dbSNP | Ensembl ].
VAR_062091

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2972HV → QM1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY114091 Genomic DNA. Translation: AAM63541.1.
AY724941 Genomic DNA. Translation: AAU21143.1.
AF494227 Genomic DNA. Translation: AAM19318.1.
CCDSiCCDS53748.1.
RefSeqiNP_795368.2. NM_176887.2.
UniGeneiHs.688193.

Genome annotation databases

EnsembliENST00000533467; ENSP00000436450; ENSG00000226761.
ENST00000574263; ENSP00000460229; ENSG00000262525.
GeneIDi259292.
KEGGihsa:259292.
UCSCiuc001qzp.1. human.

Polymorphism databases

DMDMi55977809.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

A tail of protection - Issue 119 of July 2010

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY114091 Genomic DNA. Translation: AAM63541.1 .
AY724941 Genomic DNA. Translation: AAU21143.1 .
AF494227 Genomic DNA. Translation: AAM19318.1 .
CCDSi CCDS53748.1.
RefSeqi NP_795368.2. NM_176887.2.
UniGenei Hs.688193.

3D structure databases

ProteinModelPortali P59540.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P59540.

Polymorphism databases

DMDMi 55977809.

Proteomic databases

PRIDEi P59540.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000533467 ; ENSP00000436450 ; ENSG00000226761 .
ENST00000574263 ; ENSP00000460229 ; ENSG00000262525 .
GeneIDi 259292.
KEGGi hsa:259292.
UCSCi uc001qzp.1. human.

Organism-specific databases

CTDi 259292.
GeneCardsi GC12M011214.
HGNCi HGNC:18877. TAS2R46.
MIMi 612774. gene.
neXtProti NX_P59540.
PharmGKBi PA38731.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG060698.
KOi K08474.
OMAi FMFCEAI.
OrthoDBi EOG7P02JB.
PhylomeDBi P59540.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R46.
GenomeRNAii 259292.
NextBioi 93127.
PROi P59540.
SOURCEi Search...

Gene expression databases

ArrayExpressi P59540.
CleanExi HS_TAS2R46.
Genevestigatori P59540.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-228.
  3. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-299.
  4. Cited for: REVIEW.
  5. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Motile cilia of human airway epithelia are chemosensory."
    Shah A.S., Ben-Shahar Y., Moninger T.O., Kline J.N., Welsh M.J.
    Science 325:1131-1134(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiT2R46_HUMAN
AccessioniPrimary (citable) accession number: P59540
Secondary accession number(s): P59548, Q645X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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