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P59540

- T2R46_HUMAN

UniProt

P59540 - T2R46_HUMAN

Protein

Taste receptor type 2 member 46

Gene

TAS2R46

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency By similarity.By similarity

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 46
    Short name:
    T2R46
    Alternative name(s):
    Taste receptor type 2 member 54
    Short name:
    T2R54
    Gene namesi
    Name:TAS2R46
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:18877. TAS2R46.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell projectioncilium membrane 1 Publication
    Note: In airway epithelial cells, localizes to motile cilia.

    GO - Cellular componenti

    1. ciliary membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProt
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38731.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Taste receptor type 2 member 46PRO_0000082318Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP59540.

    PTM databases

    PhosphoSiteiP59540.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium.1 Publication

    Gene expression databases

    ArrayExpressiP59540.
    CleanExiHS_TAS2R46.
    GenevestigatoriP59540.

    Structurei

    3D structure databases

    ProteinModelPortaliP59540.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 11ExtracellularSequence Analysis
    Topological domaini23 – 4624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 12619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini148 – 17831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 22930CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 2599ExtracellularSequence Analysis
    Topological domaini281 – 30929CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG060698.
    KOiK08474.
    OMAiFMFCEAI.
    OrthoDBiEOG7P02JB.
    PhylomeDBiP59540.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59540-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITFLPIIFS ILIVVTFVIG NFANGFIALV NSIEWFKRQK ISFADQILTA    50
    LAVSRVGLLW VLVLNWYATE LNPAFNSIEV RITAYNVWAV INHFSNWLAT 100
    SLSIFYLLKI ANFSNLIFLH LKRRVKSVVL VILLGPLLFL VCHLFVINMN 150
    QIIWTKEYEG NMTWKIKLRS AMYLSNTTVT ILANLVPFTL TLISFLLLIC 200
    SLCKHLKKMQ LHGKGSQDPS MKVHIKALQT VTSFLLLCAI YFLSIIMSVW 250
    SFESLENKPV FMFCEAIAFS YPSTHPFILI WGNKKLKQTF LSVLWHVRYW 300
    VKGEKPSSS 309
    Length:309
    Mass (Da):35,523
    Last modified:November 23, 2004 - v2
    Checksum:iFF4D7747F0CE47EF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti296 – 2972HV → QM(PubMed:12379855)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti228 – 2281L → M.1 Publication
    Corresponds to variant rs2708380 [ dbSNP | Ensembl ].
    VAR_062091

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114091 Genomic DNA. Translation: AAM63541.1.
    AY724941 Genomic DNA. Translation: AAU21143.1.
    AF494227 Genomic DNA. Translation: AAM19318.1.
    CCDSiCCDS53748.1.
    RefSeqiNP_795368.2. NM_176887.2.
    UniGeneiHs.688193.

    Genome annotation databases

    EnsembliENST00000533467; ENSP00000436450; ENSG00000226761.
    ENST00000574263; ENSP00000460229; ENSG00000262525.
    GeneIDi259292.
    KEGGihsa:259292.
    UCSCiuc001qzp.1. human.

    Polymorphism databases

    DMDMi55977809.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A tail of protection - Issue 119 of July 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114091 Genomic DNA. Translation: AAM63541.1 .
    AY724941 Genomic DNA. Translation: AAU21143.1 .
    AF494227 Genomic DNA. Translation: AAM19318.1 .
    CCDSi CCDS53748.1.
    RefSeqi NP_795368.2. NM_176887.2.
    UniGenei Hs.688193.

    3D structure databases

    ProteinModelPortali P59540.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P59540.

    Polymorphism databases

    DMDMi 55977809.

    Proteomic databases

    PRIDEi P59540.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000533467 ; ENSP00000436450 ; ENSG00000226761 .
    ENST00000574263 ; ENSP00000460229 ; ENSG00000262525 .
    GeneIDi 259292.
    KEGGi hsa:259292.
    UCSCi uc001qzp.1. human.

    Organism-specific databases

    CTDi 259292.
    GeneCardsi GC12M011214.
    HGNCi HGNC:18877. TAS2R46.
    MIMi 612774. gene.
    neXtProti NX_P59540.
    PharmGKBi PA38731.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG060698.
    KOi K08474.
    OMAi FMFCEAI.
    OrthoDBi EOG7P02JB.
    PhylomeDBi P59540.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R46.
    GenomeRNAii 259292.
    NextBioi 93127.
    PROi P59540.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P59540.
    CleanExi HS_TAS2R46.
    Genevestigatori P59540.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
      Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
      Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-228.
    3. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-299.
    4. Cited for: REVIEW.
    5. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. "Motile cilia of human airway epithelia are chemosensory."
      Shah A.S., Ben-Shahar Y., Moninger T.O., Kline J.N., Welsh M.J.
      Science 325:1131-1134(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiT2R46_HUMAN
    AccessioniPrimary (citable) accession number: P59540
    Secondary accession number(s): P59548, Q645X6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3