ID T2R45_HUMAN Reviewed; 299 AA. AC P59539; DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot. DT 11-APR-2003, sequence version 1. DT 24-JAN-2024, entry version 113. DE RecName: Full=Taste receptor type 2 member 45; DE Short=T2R45; DE AltName: Full=G-protein coupled receptor 59; GN Name=TAS2R45; Synonyms=GPR59; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=12379855; DOI=10.1038/ng1014; RA Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.; RT "The human TAS2R16 receptor mediates bitter taste in response to beta- RT glucopyranosides."; RL Nat. Genet. 32:397-401(2002). RN [2] RP REVIEW. RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8; RA Montmayeur J.-P., Matsunami H.; RT "Receptors for bitter and sweet taste."; RL Curr. Opin. Neurobiol. 12:366-371(2002). RN [3] RP REVIEW. RX PubMed=11696554; DOI=10.1074/jbc.r100054200; RA Margolskee R.F.; RT "Molecular mechanisms of bitter and sweet taste transduction."; RL J. Biol. Chem. 277:1-4(2002). RN [4] RP REVIEW. RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0; RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., RA Zuker C.S., Ryba N.J.; RT "Coding of sweet, bitter, and umami tastes: different receptor cells RT sharing similar signaling pathways."; RL Cell 112:293-301(2003). CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness CC and is gustducin-linked. May play a role in sensing the chemical CC composition of the gastrointestinal content. The activity of this CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation CC and lead to the gating of TRPM5 (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the CC tongue and exclusively in gustducin-positive cells. CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of CC bitter compounds; individual taste cells can discriminate among bitter CC stimuli. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF494226; AAM19317.1; -; Genomic_DNA. DR AlphaFoldDB; P59539; -. DR SMR; P59539; -. DR ChEMBL; CHEMBL4523252; -. DR GlyCosmos; P59539; 1 site, No reported glycans. DR GlyGen; P59539; 1 site. DR iPTMnet; P59539; -. DR PhosphoSitePlus; P59539; -. DR BioMuta; HGNC:18876; -. DR DMDM; 29839477; -. DR MassIVE; P59539; -. DR AGR; HGNC:18876; -. DR GeneCards; TAS2R45; -. DR HGNC; HGNC:18876; TAS2R45. DR MIM; 613967; gene. DR neXtProt; NX_P59539; -. DR PharmGKB; PA38730; -. DR InParanoid; P59539; -. DR PhylomeDB; P59539; -. DR PathwayCommons; P59539; -. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors). DR Pharos; P59539; Tchem. DR PRO; PR:P59539; -. DR Proteomes; UP000005640; Unplaced. DR RNAct; P59539; Protein. DR GO; GO:0016020; C:membrane; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW. DR CDD; cd15027; 7tm_TAS2R43-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR007960; TAS2R. DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1. DR PANTHER; PTHR11394:SF134; TASTE RECEPTOR TYPE 2 MEMBER 45; 1. DR Pfam; PF05296; TAS2R; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. PE 2: Evidence at transcript level; KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..299 FT /note="Taste receptor type 2 member 45" FT /id="PRO_0000082315" FT TOPO_DOM 1 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 2..22 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 23..55 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 56..76 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 77..98 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 99..119 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 120..126 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 127..147 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 148..178 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 179..199 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 200..229 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 230..250 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 251..259 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 260..280 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 281..299 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 161 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" SQ SEQUENCE 299 AA; 34278 MW; 50E181C3C5FCFC6B CRC64; MITFLPIIFS ILVVVTFVIG NFANGFIALV NSTEWVKRQK ISFADQIVTA LAVSRVGLLW VLLLNWYSTV LNPAFCSVEL RTTAYNIWAV TGHFSNWPAT SLSIFYLLKI ANFSNLIFLR LKRRVKSVIL VVLLGPLLFL ACHLFVVNMN QIVWTKEYEG NMTWKIKLRR AMYLSDTTVT MLANLVPFTV TLISFLLLVC SLCKHLKKMQ LHGKGSQDPS TKVHIKVLQT VISFFLLRAI YFVSVIISVW SFKNLENKPV FMFCQAIGFS CSSAHPFILI WGNKKLKQTY LSVLWQMRY //