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P59539

- T2R45_HUMAN

UniProt

P59539 - T2R45_HUMAN

Protein

Taste receptor type 2 member 45

Gene

TAS2R45

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. sensory perception of taste Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 45
    Short name:
    T2R45
    Alternative name(s):
    G-protein coupled receptor 59
    Gene namesi
    Name:TAS2R45
    Synonyms:GPR59
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:18876. TAS2R45.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38730.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Taste receptor type 2 member 45PRO_0000082315Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP59539.

    PTM databases

    PhosphoSiteiP59539.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

    Gene expression databases

    CleanExiHS_TAS2R45.
    GenevestigatoriP59539.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000410574.

    Structurei

    3D structure databases

    ProteinModelPortaliP59539.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 11ExtracellularSequence Analysis
    Topological domaini23 – 5533CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 9822ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 1267CytoplasmicSequence Analysis
    Topological domaini148 – 17831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 22930CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 2599ExtracellularSequence Analysis
    Topological domaini281 – 29919CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG060698.
    PhylomeDBiP59539.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59539-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITFLPIIFS ILVVVTFVIG NFANGFIALV NSTEWVKRQK ISFADQIVTA    50
    LAVSRVGLLW VLLLNWYSTV LNPAFCSVEL RTTAYNIWAV TGHFSNWPAT 100
    SLSIFYLLKI ANFSNLIFLR LKRRVKSVIL VVLLGPLLFL ACHLFVVNMN 150
    QIVWTKEYEG NMTWKIKLRR AMYLSDTTVT MLANLVPFTV TLISFLLLVC 200
    SLCKHLKKMQ LHGKGSQDPS TKVHIKVLQT VISFFLLRAI YFVSVIISVW 250
    SFKNLENKPV FMFCQAIGFS CSSAHPFILI WGNKKLKQTY LSVLWQMRY 299
    Length:299
    Mass (Da):34,278
    Last modified:April 11, 2003 - v1
    Checksum:i50E181C3C5FCFC6B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494226 Genomic DNA. Translation: AAM19317.1.
    UniGeneiHs.287378.

    Polymorphism databases

    DMDMi29839477.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494226 Genomic DNA. Translation: AAM19317.1 .
    UniGenei Hs.287378.

    3D structure databases

    ProteinModelPortali P59539.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000410574.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P59539.

    Polymorphism databases

    DMDMi 29839477.

    Proteomic databases

    PRIDEi P59539.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC12M9R0327.
    HGNCi HGNC:18876. TAS2R45.
    MIMi 613967. gene.
    neXtProti NX_P59539.
    PharmGKBi PA38730.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG060698.
    PhylomeDBi P59539.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    NextBioi 13606992.
    PROi P59539.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_TAS2R45.
    Genevestigatori P59539.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: REVIEW.
    3. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    4. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R45_HUMAN
    AccessioniPrimary (citable) accession number: P59539
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3