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P59539

- T2R45_HUMAN

UniProt

P59539 - T2R45_HUMAN

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Protein

Taste receptor type 2 member 45

Gene

TAS2R45

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. sensory perception of taste Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 45
Short name:
T2R45
Alternative name(s):
G-protein coupled receptor 59
Gene namesi
Name:TAS2R45
Synonyms:GPR59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:18876. TAS2R45.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Taste receptor type 2 member 45PRO_0000082315Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP59539.

PTM databases

PhosphoSiteiP59539.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

CleanExiHS_TAS2R45.
GenevestigatoriP59539.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000410574.

Structurei

3D structure databases

ProteinModelPortaliP59539.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11ExtracellularSequence Analysis
Topological domaini23 – 5533CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini77 – 9822ExtracellularSequence AnalysisAdd
BLAST
Topological domaini120 – 1267CytoplasmicSequence Analysis
Topological domaini148 – 17831ExtracellularSequence AnalysisAdd
BLAST
Topological domaini200 – 22930CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini251 – 2599ExtracellularSequence Analysis
Topological domaini281 – 29919CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG060698.
InParanoidiP59539.
PhylomeDBiP59539.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59539-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITFLPIIFS ILVVVTFVIG NFANGFIALV NSTEWVKRQK ISFADQIVTA
60 70 80 90 100
LAVSRVGLLW VLLLNWYSTV LNPAFCSVEL RTTAYNIWAV TGHFSNWPAT
110 120 130 140 150
SLSIFYLLKI ANFSNLIFLR LKRRVKSVIL VVLLGPLLFL ACHLFVVNMN
160 170 180 190 200
QIVWTKEYEG NMTWKIKLRR AMYLSDTTVT MLANLVPFTV TLISFLLLVC
210 220 230 240 250
SLCKHLKKMQ LHGKGSQDPS TKVHIKVLQT VISFFLLRAI YFVSVIISVW
260 270 280 290
SFKNLENKPV FMFCQAIGFS CSSAHPFILI WGNKKLKQTY LSVLWQMRY
Length:299
Mass (Da):34,278
Last modified:April 11, 2003 - v1
Checksum:i50E181C3C5FCFC6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494226 Genomic DNA. Translation: AAM19317.1.
UniGeneiHs.287378.

Polymorphism databases

DMDMi29839477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494226 Genomic DNA. Translation: AAM19317.1 .
UniGenei Hs.287378.

3D structure databases

ProteinModelPortali P59539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000410574.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P59539.

Polymorphism databases

DMDMi 29839477.

Proteomic databases

PRIDEi P59539.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC12M9R0327.
HGNCi HGNC:18876. TAS2R45.
MIMi 613967. gene.
neXtProti NX_P59539.
PharmGKBi PA38730.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG060698.
InParanoidi P59539.
PhylomeDBi P59539.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 13606992.
PROi P59539.
SOURCEi Search...

Gene expression databases

CleanExi HS_TAS2R45.
Genevestigatori P59539.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: REVIEW.
  3. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  4. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R45_HUMAN
AccessioniPrimary (citable) accession number: P59539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3