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P59538

- T2R31_HUMAN

UniProt

P59538 - T2R31_HUMAN

Protein

Taste receptor type 2 member 31

Gene

TAS2R31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.By similarity

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 31
    Short name:
    T2R31
    Alternative name(s):
    Taste receptor type 2 member 44
    Short name:
    T2R44
    Taste receptor type 2 member 53
    Short name:
    T2R53
    Gene namesi
    Name:TAS2R31
    Synonyms:TAS2R44
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:19113. TAS2R31.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Taste receptor type 2 member 31PRO_0000082309Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP59538.

    PTM databases

    PhosphoSiteiP59538.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

    Gene expression databases

    CleanExiHS_TAS2R44.
    GenevestigatoriP59538.

    Structurei

    3D structure databases

    ProteinModelPortaliP59538.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 22ExtracellularSequence Analysis
    Topological domaini24 – 5532CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 1265CytoplasmicSequence Analysis
    Topological domaini148 – 18134ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini203 – 22927CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 2599ExtracellularSequence Analysis
    Topological domaini281 – 30929CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK08474.
    OMAiCANGFIA.
    OrthoDBiEOG7P02JB.
    PhylomeDBiP59538.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59538-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTFIPIIFS SVVVVLFVIG NFANGFIALV NSIERVKRQK ISFADQILTA    50
    LAVSRVGLLW VLLLNWYSTV FNPAFYSVEV RTTAYNVWAV TGHFSNWLAT 100
    SLSIFYLLKI ANFSNLIFLH LKRRVKSVIL VMLLGPLLFL ACQLFVINMK 150
    EIVRTKEYEG NLTWKIKLRS AVYLSDATVT TLGNLVPFTL TLLCFLLLIC 200
    SLCKHLKKMQ LHGKGSQDPS TKVHIKALQT VIFFLLLCAV YFLSIMISVW 250
    SFGSLENKPV FMFCKAIRFS YPSIHPFILI WGNKKLKQTF LSVLRQVRYW 300
    VKGEKPSSP 309
    Length:309
    Mass (Da):35,278
    Last modified:June 28, 2011 - v2
    Checksum:i56926C025E4C6358
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351R → W.
    Corresponds to variant rs10845295 [ dbSNP | Ensembl ].
    VAR_030684
    Natural varianti162 – 1621L → M.2 Publications
    Corresponds to variant rs10743938 [ dbSNP | Ensembl ].
    VAR_030685
    Natural varianti217 – 2171Q → E.
    Corresponds to variant rs10845294 [ dbSNP | Ensembl ].
    VAR_030686
    Natural varianti227 – 2271A → V.1 Publication
    Corresponds to variant rs10845293 [ dbSNP | Ensembl ].
    VAR_030687
    Natural varianti240 – 2401V → I.1 Publication
    Corresponds to variant rs10772423 [ dbSNP | Ensembl ].
    VAR_030688
    Natural varianti276 – 2761P → R.
    Corresponds to variant rs12318612 [ dbSNP | Ensembl ].
    VAR_062090

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494228 Genomic DNA. Translation: AAM19319.1.
    AY114090 Genomic DNA. Translation: AAM63540.1.
    AY724942 Genomic DNA. Translation: AAU21144.1.
    AC018630 Genomic DNA. No translation available.
    BC117421 mRNA. Translation: AAI17422.1.
    CCDSiCCDS53747.1.
    RefSeqiNP_795366.2. NM_176885.2.
    UniGeneiHs.688197.

    Genome annotation databases

    EnsembliENST00000390675; ENSP00000375093; ENSG00000256436.
    ENST00000572376; ENSP00000459810; ENSG00000263097.
    GeneIDi259290.
    KEGGihsa:259290.
    UCSCiuc001qzo.1. human.

    Polymorphism databases

    DMDMi338817946.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494228 Genomic DNA. Translation: AAM19319.1 .
    AY114090 Genomic DNA. Translation: AAM63540.1 .
    AY724942 Genomic DNA. Translation: AAU21144.1 .
    AC018630 Genomic DNA. No translation available.
    BC117421 mRNA. Translation: AAI17422.1 .
    CCDSi CCDS53747.1.
    RefSeqi NP_795366.2. NM_176885.2.
    UniGenei Hs.688197.

    3D structure databases

    ProteinModelPortali P59538.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2034804.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P59538.

    Polymorphism databases

    DMDMi 338817946.

    Proteomic databases

    PRIDEi P59538.

    Protocols and materials databases

    DNASUi 259290.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000390675 ; ENSP00000375093 ; ENSG00000256436 .
    ENST00000572376 ; ENSP00000459810 ; ENSG00000263097 .
    GeneIDi 259290.
    KEGGi hsa:259290.
    UCSCi uc001qzo.1. human.

    Organism-specific databases

    CTDi 259290.
    GeneCardsi GC12M011183.
    HGNCi HGNC:19113. TAS2R31.
    MIMi 612669. gene.
    neXtProti NX_P59538.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K08474.
    OMAi CANGFIA.
    OrthoDBi EOG7P02JB.
    PhylomeDBi P59538.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R31.
    GenomeRNAii 259290.
    NextBioi 93119.
    PROi P59538.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_TAS2R44.
    Genevestigatori P59538.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-162.
    2. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
      Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
      Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-162; VAL-227 AND ILE-240.
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: REVIEW.
    7. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. Cited for: ACTIVATION BY SACCHARIN AND ACESULFAME K.

    Entry informationi

    Entry nameiT2R31_HUMAN
    AccessioniPrimary (citable) accession number: P59538
    Secondary accession number(s): P59547, Q17R84, Q645X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3