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P59537

- T2R43_HUMAN

UniProt

P59537 - T2R43_HUMAN

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Protein
Taste receptor type 2 member 43
Gene
TAS2R43
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways By similarity.

GO - Molecular functioni

  1. bitter taste receptor activity Source: HGNC
  2. taste receptor activity Source: HGNC

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: HGNC
  2. detection of chemical stimulus involved in sensory perception of bitter taste Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 43
Short name:
T2R43
Alternative name(s):
Taste receptor type 2 member 52
Short name:
T2R52
Gene namesi
Name:TAS2R43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:18875. TAS2R43.

Subcellular locationi

Membrane; Multi-pass membrane protein. Cell projectioncilium membrane
Note: In airway epithelial cells, localizes to motile cilia.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11Extracellular Reviewed prediction
Transmembranei2 – 2221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini23 – 4624Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei47 – 6721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini68 – 8619Extracellular Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini108 – 12619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini148 – 17831Extracellular Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini200 – 22930Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei230 – 25021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini251 – 2599Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini281 – 30929Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. ciliary membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: HGNC
  3. motile cilium Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Taste receptor type 2 member 43
PRO_0000082302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi176 – 1761N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59537.
PRIDEiP59537.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in airway epithelia.1 Publication

Gene expression databases

ArrayExpressiP59537.
CleanExiHS_TAS2R43.
GenevestigatoriP59537.

Structurei

3D structure databases

ProteinModelPortaliP59537.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43462.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
KOiK08474.
OMAiKNLENKP.
OrthoDBiEOG7P02JB.
PhylomeDBiP59537.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59537-1 [UniParc]FASTAAdd to Basket

« Hide

MITFLPIIFS SLVVVTFVIG NFANGFIALV NSIEWFKRQK ISFADQILTA    50
LAVSRVGLLW VLLLNWYSTV LNPAFNSVEV RTTAYNIWAV INHFSNWLAT 100
TLSIFYLLKI ANFSNFIFLH LKRRVKSVIL VMLLGPLLFL ACHLFVINMN 150
EIVRTKEFEG NMTWKIKLKS AMYFSNMTVT MVANLVPFTL TLLSFMLLIC 200
SLCKHLKKMQ LHGKGSQDPS TKVHIKALQT VISFLLLCAI YFLSIMISVW 250
SFGSLENKPV FMFCKAIRFS YPSIHPFILI WGNKKLKQTF LSVFWQMRYW 300
VKGEKTSSP 309
Length:309
Mass (Da):35,599
Last modified:January 25, 2012 - v2
Checksum:i3B4FCD1089EB6857
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351W → S in AAM19328. 1 Publication
Sequence conflicti35 – 351W → S in AAU21145. 1 Publication
Sequence conflicti35 – 351W → S in AAI17424. 1 Publication
Sequence conflicti212 – 2121H → R in AAM19328. 1 Publication
Sequence conflicti212 – 2121H → R in AAU21145. 1 Publication
Sequence conflicti212 – 2121H → R in AAI17424. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494237 Genomic DNA. Translation: AAM19328.1.
AY114089 Genomic DNA. Translation: AAM63539.1.
AY724943 Genomic DNA. Translation: AAU21145.1.
AC018630 Genomic DNA. No translation available.
BC117423 mRNA. Translation: AAI17424.1.
CCDSiCCDS53749.1.
RefSeqiNP_795365.2. NM_176884.2.
UniGeneiHs.688195.

Genome annotation databases

EnsembliENST00000531678; ENSP00000431719; ENSG00000255374.
ENST00000571879; ENSP00000458723; ENSG00000262612.
GeneIDi259289.
KEGGihsa:259289.
UCSCiuc001qzq.1. human.

Polymorphism databases

DMDMi374095447.

Cross-referencesi

Web resourcesi

Protein Spotlight

A tail of protection - Issue 119 of July 2010

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494237 Genomic DNA. Translation: AAM19328.1 .
AY114089 Genomic DNA. Translation: AAM63539.1 .
AY724943 Genomic DNA. Translation: AAU21145.1 .
AC018630 Genomic DNA. No translation available.
BC117423 mRNA. Translation: AAI17424.1 .
CCDSi CCDS53749.1.
RefSeqi NP_795365.2. NM_176884.2.
UniGenei Hs.688195.

3D structure databases

ProteinModelPortali P59537.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 374095447.

Proteomic databases

PaxDbi P59537.
PRIDEi P59537.

Protocols and materials databases

DNASUi 259289.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000531678 ; ENSP00000431719 ; ENSG00000255374 .
ENST00000571879 ; ENSP00000458723 ; ENSG00000262612 .
GeneIDi 259289.
KEGGi hsa:259289.
UCSCi uc001qzq.1. human.

Organism-specific databases

CTDi 259289.
GeneCardsi GC12M011243.
HGNCi HGNC:18875. TAS2R43.
MIMi 612668. gene.
neXtProti NX_P59537.
PharmGKBi PA38729.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43462.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
KOi K08474.
OMAi KNLENKP.
OrthoDBi EOG7P02JB.
PhylomeDBi P59537.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R43.
GenomeRNAii 259289.
NextBioi 93115.
PROi P59537.
SOURCEi Search...

Gene expression databases

ArrayExpressi P59537.
CleanExi HS_TAS2R43.
Genevestigatori P59537.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. Cited for: ACTIVATION BY SACCHARIN AND ACESULFAME K.
  10. "Motile cilia of human airway epithelia are chemosensory."
    Shah A.S., Ben-Shahar Y., Moninger T.O., Kline J.N., Welsh M.J.
    Science 325:1131-1134(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiT2R43_HUMAN
AccessioniPrimary (citable) accession number: P59537
Secondary accession number(s): P59546, Q645X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: January 25, 2012
Last modified: September 3, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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