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P59537

- T2R43_HUMAN

UniProt

P59537 - T2R43_HUMAN

Protein

Taste receptor type 2 member 43

Gene

TAS2R43

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways By similarity.By similarity

    GO - Molecular functioni

    1. bitter taste receptor activity Source: HGNC
    2. taste receptor activity Source: HGNC

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: HGNC
    2. G-protein coupled receptor signaling pathway Source: HGNC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 43
    Short name:
    T2R43
    Alternative name(s):
    Taste receptor type 2 member 52
    Short name:
    T2R52
    Gene namesi
    Name:TAS2R43
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:18875. TAS2R43.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell projectioncilium membrane 1 Publication
    Note: In airway epithelial cells, localizes to motile cilia.

    GO - Cellular componenti

    1. ciliary membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: HGNC
    3. motile cilium Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38729.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Taste receptor type 2 member 43PRO_0000082302Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP59537.
    PRIDEiP59537.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in airway epithelia.1 Publication

    Gene expression databases

    ArrayExpressiP59537.
    CleanExiHS_TAS2R43.
    GenevestigatoriP59537.

    Structurei

    3D structure databases

    ProteinModelPortaliP59537.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 11ExtracellularSequence Analysis
    Topological domaini23 – 4624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 12619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini148 – 17831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 22930CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 2599ExtracellularSequence Analysis
    Topological domaini281 – 30929CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43462.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    KOiK08474.
    OMAiKNLENKP.
    OrthoDBiEOG7P02JB.
    PhylomeDBiP59537.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59537-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITFLPIIFS SLVVVTFVIG NFANGFIALV NSIEWFKRQK ISFADQILTA    50
    LAVSRVGLLW VLLLNWYSTV LNPAFNSVEV RTTAYNIWAV INHFSNWLAT 100
    TLSIFYLLKI ANFSNFIFLH LKRRVKSVIL VMLLGPLLFL ACHLFVINMN 150
    EIVRTKEFEG NMTWKIKLKS AMYFSNMTVT MVANLVPFTL TLLSFMLLIC 200
    SLCKHLKKMQ LHGKGSQDPS TKVHIKALQT VISFLLLCAI YFLSIMISVW 250
    SFGSLENKPV FMFCKAIRFS YPSIHPFILI WGNKKLKQTF LSVFWQMRYW 300
    VKGEKTSSP 309
    Length:309
    Mass (Da):35,599
    Last modified:January 25, 2012 - v2
    Checksum:i3B4FCD1089EB6857
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351W → S in AAM19328. (PubMed:12379855)Curated
    Sequence conflicti35 – 351W → S in AAU21145. (PubMed:15496549)Curated
    Sequence conflicti35 – 351W → S in AAI17424. (PubMed:15489334)Curated
    Sequence conflicti212 – 2121H → R in AAM19328. (PubMed:12379855)Curated
    Sequence conflicti212 – 2121H → R in AAU21145. (PubMed:15496549)Curated
    Sequence conflicti212 – 2121H → R in AAI17424. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494237 Genomic DNA. Translation: AAM19328.1.
    AY114089 Genomic DNA. Translation: AAM63539.1.
    AY724943 Genomic DNA. Translation: AAU21145.1.
    AC018630 Genomic DNA. No translation available.
    BC117423 mRNA. Translation: AAI17424.1.
    CCDSiCCDS53749.1.
    RefSeqiNP_795365.2. NM_176884.2.
    UniGeneiHs.688195.

    Genome annotation databases

    EnsembliENST00000531678; ENSP00000431719; ENSG00000255374.
    ENST00000571879; ENSP00000458723; ENSG00000262612.
    GeneIDi259289.
    KEGGihsa:259289.
    UCSCiuc001qzq.1. human.

    Polymorphism databases

    DMDMi374095447.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A tail of protection - Issue 119 of July 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494237 Genomic DNA. Translation: AAM19328.1 .
    AY114089 Genomic DNA. Translation: AAM63539.1 .
    AY724943 Genomic DNA. Translation: AAU21145.1 .
    AC018630 Genomic DNA. No translation available.
    BC117423 mRNA. Translation: AAI17424.1 .
    CCDSi CCDS53749.1.
    RefSeqi NP_795365.2. NM_176884.2.
    UniGenei Hs.688195.

    3D structure databases

    ProteinModelPortali P59537.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 374095447.

    Proteomic databases

    PaxDbi P59537.
    PRIDEi P59537.

    Protocols and materials databases

    DNASUi 259289.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000531678 ; ENSP00000431719 ; ENSG00000255374 .
    ENST00000571879 ; ENSP00000458723 ; ENSG00000262612 .
    GeneIDi 259289.
    KEGGi hsa:259289.
    UCSCi uc001qzq.1. human.

    Organism-specific databases

    CTDi 259289.
    GeneCardsi GC12M011243.
    HGNCi HGNC:18875. TAS2R43.
    MIMi 612668. gene.
    neXtProti NX_P59537.
    PharmGKBi PA38729.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43462.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    KOi K08474.
    OMAi KNLENKP.
    OrthoDBi EOG7P02JB.
    PhylomeDBi P59537.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R43.
    GenomeRNAii 259289.
    NextBioi 93115.
    PROi P59537.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P59537.
    CleanExi HS_TAS2R43.
    Genevestigatori P59537.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
      Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
      Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: REVIEW.
    7. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. Cited for: ACTIVATION BY SACCHARIN AND ACESULFAME K.
    10. "Motile cilia of human airway epithelia are chemosensory."
      Shah A.S., Ben-Shahar Y., Moninger T.O., Kline J.N., Welsh M.J.
      Science 325:1131-1134(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiT2R43_HUMAN
    AccessioniPrimary (citable) accession number: P59537
    Secondary accession number(s): P59546, Q645X4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3