P59536 (T2R41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 41
Short name=T2R41

Alternative name(s):
Taste receptor type 2 member 59
Short name=T2R59

Gene names

Name:

TAS2R41

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Miscellaneous	Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sensory perception of taste Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Taste receptor type 2 member 41		PRO_0000082295
Regions
	Topological domain	1 – 7	7	Extracellular Potential
	Transmembrane	8 – 28	21	Helical; Name=1; Potential
	Topological domain	29 – 40	12	Cytoplasmic Potential
	Transmembrane	41 – 61	21	Helical; Name=2; Potential
	Topological domain	62 – 88	27	Extracellular Potential
	Transmembrane	89 – 109	21	Helical; Name=3; Potential
	Topological domain	110 – 129	20	Cytoplasmic Potential
	Transmembrane	130 – 150	21	Helical; Name=4; Potential
	Topological domain	151 – 183	33	Extracellular Potential
	Transmembrane	184 – 204	21	Helical; Name=5; Potential
	Topological domain	205 – 234	30	Cytoplasmic Potential
	Transmembrane	235 – 255	21	Helical; Name=6; Potential
	Topological domain	256 – 264	9	Extracellular Potential
	Transmembrane	265 – 285	21	Helical; Name=7; Potential
	Topological domain	286 – 307	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	127	1	P → L. Ref.2 Ref.3 Corresponds to variant rs10278721 [ dbSNP | Ensembl ].		VAR_060211
Experimental info
	Sequence conflict	207	1	L → M in BAD98053. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P59536 [UniParc]. Last modified October 13, 2009. Version 2. Checksum: 7A33E3ED3E44E563	FASTA	307	35,896
	10 20 30 40 50 60 MQAALTAFFV LLFSLLSLLG IAANGFIVLV LGREWLRYGR LLPLDMILIS LGASRFCLQL 70 80 90 100 110 120 VGTVHNFYYS AQKVEYSGGL GRQFFHLHWH FLNSATFWFC SWLSVLFCVK IANITHSTFL 130 140 150 160 170 180 WLKWRFPGWV PWLLLGSVLI SFIITLLFFW VNYPVYQEFL IRKFSGNMTY KWNTRIETYY 190 200 210 220 230 240 FPSLKLVIWS IPFSVFLVSI MLLINSLRRH TQRMQHNGHS LQDPSTQAHT RALKSLISFL 250 260 270 280 290 300 ILYALSFLSL IIDAAKFISM QNDFYWPWQI AVYLCISVHP FILIFSNLKL RSVFSQLLLL ARGFWVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of human taste receptor genes belonging to the TAS2R family." Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J. Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides." Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W. Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-127.
[3]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-127.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates." Go Y., Satta Y., Takenaka O., Takahata N. Genetics 170:313-326(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-291.
[7]	"Receptors for bitter and sweet taste." Montmayeur J.-P., Matsunami H. Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[8]	"Molecular mechanisms of bitter and sweet taste transduction." Margolskee R.F. J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[9]	"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY114093 Genomic DNA. Translation: AAM63543.1. AF494232 Genomic DNA. Translation: AAM19323.1. AY724956 Genomic DNA. Translation: AAU21152.1. AC073264 Genomic DNA. No translation available. BC101157 mRNA. Translation: AAI01158.1. BC101158 mRNA. Translation: AAI01159.1. AB199177 Genomic DNA. Translation: BAD98051.1. AB199178 Genomic DNA. Translation: BAD98052.1. AB199179 Genomic DNA. Translation: BAD98053.1.
IPI	IPI00221132.
RefSeq	NP_795364.2. NM_176883.2.
UniGene	Hs.650648.
3D structure databases
ProteinModelPortal	P59536.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	261260079.
Proteomic databases
PaxDb	P59536.
PRIDE	P59536.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000408916; ENSP00000386201; ENSG00000221855.
GeneID	259287.
KEGG	hsa:259287.
UCSC	uc003wdc.1. human.
Organism-specific databases
CTD	259287.
GeneCards	GC07P143174.
HGNC	HGNC:18883. TAS2R41.
MIM	613965. gene.
neXtProt	NX_P59536.
PharmGKB	PA38737.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG29380.
HOVERGEN	HBG098568.
InParanoid	P59536.
KO	K08474.
OMA	WHFLNSA.
OrthoDB	EOG4P5K9P.
PhylomeDB	P59536.
Gene expression databases
Bgee	P59536.
CleanEx	HS_TAS2R41.
Genevestigator	P59536.
Family and domain databases
InterPro	IPR007960. TAS2_rcpt. [Graphical view]
Pfam	PF05296. TAS2R. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	259287.
NextBio	93111.
SOURCE	Search...

Entry information

Entry name

T2R41_HUMAN

Accession

Primary (citable) accession number: P59536
Secondary accession number(s): P59550 , Q495I2, Q50KJ5, Q50KJ6, Q50KJ7, Q645W7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	October 13, 2009
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.