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P59536

- T2R41_HUMAN

UniProt

P59536 - T2R41_HUMAN

Protein

Taste receptor type 2 member 41

Gene

TAS2R41

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. sensory perception of taste Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 41
    Short name:
    T2R41
    Alternative name(s):
    Taste receptor type 2 member 59
    Short name:
    T2R59
    Gene namesi
    Name:TAS2R41
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:18883. TAS2R41.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38737.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Taste receptor type 2 member 41PRO_0000082295Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP59536.
    PRIDEiP59536.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

    Gene expression databases

    BgeeiP59536.
    CleanExiHS_TAS2R41.
    GenevestigatoriP59536.

    Organism-specific databases

    HPAiHPA057063.

    Structurei

    3D structure databases

    ProteinModelPortaliP59536.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77ExtracellularSequence Analysis
    Topological domaini29 – 4012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini62 – 8827ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini110 – 12920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini151 – 18333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini205 – 23430CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 2649ExtracellularSequence Analysis
    Topological domaini286 – 30722CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei41 – 6121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG29380.
    HOVERGENiHBG098568.
    InParanoidiP59536.
    KOiK08474.
    OMAiDWYWPWQ.
    OrthoDBiEOG7CK37R.
    PhylomeDBiP59536.
    TreeFamiTF335891.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59536-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAALTAFFV LLFSLLSLLG IAANGFIVLV LGREWLRYGR LLPLDMILIS    50
    LGASRFCLQL VGTVHNFYYS AQKVEYSGGL GRQFFHLHWH FLNSATFWFC 100
    SWLSVLFCVK IANITHSTFL WLKWRFPGWV PWLLLGSVLI SFIITLLFFW 150
    VNYPVYQEFL IRKFSGNMTY KWNTRIETYY FPSLKLVIWS IPFSVFLVSI 200
    MLLINSLRRH TQRMQHNGHS LQDPSTQAHT RALKSLISFL ILYALSFLSL 250
    IIDAAKFISM QNDFYWPWQI AVYLCISVHP FILIFSNLKL RSVFSQLLLL 300
    ARGFWVA 307
    Length:307
    Mass (Da):35,896
    Last modified:October 13, 2009 - v2
    Checksum:i7A33E3ED3E44E563
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti207 – 2071L → M in BAD98053. (PubMed:15744053)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti127 – 1271P → L.2 Publications
    Corresponds to variant rs10278721 [ dbSNP | Ensembl ].
    VAR_060211

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114093 Genomic DNA. Translation: AAM63543.1.
    AF494232 Genomic DNA. Translation: AAM19323.1.
    AY724956 Genomic DNA. Translation: AAU21152.1.
    AC073264 Genomic DNA. No translation available.
    BC101157 mRNA. Translation: AAI01158.1.
    BC101158 mRNA. Translation: AAI01159.1.
    AB199177 Genomic DNA. Translation: BAD98051.1.
    AB199178 Genomic DNA. Translation: BAD98052.1.
    AB199179 Genomic DNA. Translation: BAD98053.1.
    CCDSiCCDS43663.1.
    RefSeqiNP_795364.2. NM_176883.2.
    UniGeneiHs.650648.

    Genome annotation databases

    EnsembliENST00000408916; ENSP00000386201; ENSG00000221855.
    GeneIDi259287.
    KEGGihsa:259287.
    UCSCiuc003wdc.1. human.

    Polymorphism databases

    DMDMi261260079.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY114093 Genomic DNA. Translation: AAM63543.1 .
    AF494232 Genomic DNA. Translation: AAM19323.1 .
    AY724956 Genomic DNA. Translation: AAU21152.1 .
    AC073264 Genomic DNA. No translation available.
    BC101157 mRNA. Translation: AAI01158.1 .
    BC101158 mRNA. Translation: AAI01159.1 .
    AB199177 Genomic DNA. Translation: BAD98051.1 .
    AB199178 Genomic DNA. Translation: BAD98052.1 .
    AB199179 Genomic DNA. Translation: BAD98053.1 .
    CCDSi CCDS43663.1.
    RefSeqi NP_795364.2. NM_176883.2.
    UniGenei Hs.650648.

    3D structure databases

    ProteinModelPortali P59536.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 261260079.

    Proteomic databases

    PaxDbi P59536.
    PRIDEi P59536.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000408916 ; ENSP00000386201 ; ENSG00000221855 .
    GeneIDi 259287.
    KEGGi hsa:259287.
    UCSCi uc003wdc.1. human.

    Organism-specific databases

    CTDi 259287.
    GeneCardsi GC07P143174.
    HGNCi HGNC:18883. TAS2R41.
    HPAi HPA057063.
    MIMi 613965. gene.
    neXtProti NX_P59536.
    PharmGKBi PA38737.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG29380.
    HOVERGENi HBG098568.
    InParanoidi P59536.
    KOi K08474.
    OMAi DWYWPWQ.
    OrthoDBi EOG7CK37R.
    PhylomeDBi P59536.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R41.
    GenomeRNAii 259287.
    NextBioi 93111.
    PROi P59536.
    SOURCEi Search...

    Gene expression databases

    Bgeei P59536.
    CleanExi HS_TAS2R41.
    Genevestigatori P59536.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
      Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
      Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-127.
    3. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-127.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates."
      Go Y., Satta Y., Takenaka O., Takahata N.
      Genetics 170:313-326(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-291.
    7. Cited for: REVIEW.
    8. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R41_HUMAN
    AccessioniPrimary (citable) accession number: P59536
    Secondary accession number(s): P59550
    , Q495I2, Q50KJ5, Q50KJ6, Q50KJ7, Q645W7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3