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P59536 (T2R41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 41

Short name=T2R41
Alternative name(s):
Taste receptor type 2 member 59
Short name=T2R59
Gene names
Name:TAS2R41
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsensory perception of taste

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from direct assay PubMed 20022913. Source: UniProt

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Taste receptor type 2 member 41
PRO_0000082295

Regions

Topological domain1 – 77Extracellular Potential
Transmembrane8 – 2821Helical; Name=1; Potential
Topological domain29 – 4012Cytoplasmic Potential
Transmembrane41 – 6121Helical; Name=2; Potential
Topological domain62 – 8827Extracellular Potential
Transmembrane89 – 10921Helical; Name=3; Potential
Topological domain110 – 12920Cytoplasmic Potential
Transmembrane130 – 15021Helical; Name=4; Potential
Topological domain151 – 18333Extracellular Potential
Transmembrane184 – 20421Helical; Name=5; Potential
Topological domain205 – 23430Cytoplasmic Potential
Transmembrane235 – 25521Helical; Name=6; Potential
Topological domain256 – 2649Extracellular Potential
Transmembrane265 – 28521Helical; Name=7; Potential
Topological domain286 – 30722Cytoplasmic Potential

Amino acid modifications

Glycosylation1671N-linked (GlcNAc...) Potential

Natural variations

Natural variant1271P → L. Ref.2 Ref.3
Corresponds to variant rs10278721 [ dbSNP | Ensembl ].
VAR_060211

Experimental info

Sequence conflict2071L → M in BAD98053. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P59536 [UniParc].

Last modified October 13, 2009. Version 2.
Checksum: 7A33E3ED3E44E563

FASTA30735,896
        10         20         30         40         50         60 
MQAALTAFFV LLFSLLSLLG IAANGFIVLV LGREWLRYGR LLPLDMILIS LGASRFCLQL 

        70         80         90        100        110        120 
VGTVHNFYYS AQKVEYSGGL GRQFFHLHWH FLNSATFWFC SWLSVLFCVK IANITHSTFL 

       130        140        150        160        170        180 
WLKWRFPGWV PWLLLGSVLI SFIITLLFFW VNYPVYQEFL IRKFSGNMTY KWNTRIETYY 

       190        200        210        220        230        240 
FPSLKLVIWS IPFSVFLVSI MLLINSLRRH TQRMQHNGHS LQDPSTQAHT RALKSLISFL 

       250        260        270        280        290        300 
ILYALSFLSL IIDAAKFISM QNDFYWPWQI AVYLCISVHP FILIFSNLKL RSVFSQLLLL 


ARGFWVA 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of human taste receptor genes belonging to the TAS2R family."
Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-127.
[3]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-127.
[4]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates."
Go Y., Satta Y., Takenaka O., Takahata N.
Genetics 170:313-326(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-291.
[7]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[8]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[9]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY114093 Genomic DNA. Translation: AAM63543.1.
AF494232 Genomic DNA. Translation: AAM19323.1.
AY724956 Genomic DNA. Translation: AAU21152.1.
AC073264 Genomic DNA. No translation available.
BC101157 mRNA. Translation: AAI01158.1.
BC101158 mRNA. Translation: AAI01159.1.
AB199177 Genomic DNA. Translation: BAD98051.1.
AB199178 Genomic DNA. Translation: BAD98052.1.
AB199179 Genomic DNA. Translation: BAD98053.1.
CCDSCCDS43663.1.
RefSeqNP_795364.2. NM_176883.2.
UniGeneHs.650648.

3D structure databases

ProteinModelPortalP59536.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM261260079.

Proteomic databases

PaxDbP59536.
PRIDEP59536.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000408916; ENSP00000386201; ENSG00000221855.
GeneID259287.
KEGGhsa:259287.
UCSCuc003wdc.1. human.

Organism-specific databases

CTD259287.
GeneCardsGC07P143174.
HGNCHGNC:18883. TAS2R41.
HPAHPA057063.
MIM613965. gene.
neXtProtNX_P59536.
PharmGKBPA38737.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG29380.
HOVERGENHBG098568.
InParanoidP59536.
KOK08474.
OMADWYWPWQ.
OrthoDBEOG7CK37R.
PhylomeDBP59536.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP59536.
CleanExHS_TAS2R41.
GenevestigatorP59536.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R41.
GenomeRNAi259287.
NextBio93111.
PROP59536.
SOURCESearch...

Entry information

Entry nameT2R41_HUMAN
AccessionPrimary (citable) accession number: P59536
Secondary accession number(s): P59550 expand/collapse secondary AC list , Q495I2, Q50KJ5, Q50KJ6, Q50KJ7, Q645W7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 13, 2009
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries