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P59536

- T2R41_HUMAN

UniProt

P59536 - T2R41_HUMAN

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Protein

Taste receptor type 2 member 41

Gene

TAS2R41

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. sensory perception of taste Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 41
Short name:
T2R41
Alternative name(s):
Taste receptor type 2 member 59
Short name:
T2R59
Gene namesi
Name:TAS2R41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:18883. TAS2R41.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Taste receptor type 2 member 41PRO_0000082295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59536.
PRIDEiP59536.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiP59536.
CleanExiHS_TAS2R41.
GenevestigatoriP59536.

Organism-specific databases

HPAiHPA057063.

Interactioni

Protein-protein interaction databases

BioGridi129242. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliP59536.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77ExtracellularSequence Analysis
Topological domaini29 – 4012CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini62 – 8827ExtracellularSequence AnalysisAdd
BLAST
Topological domaini110 – 12920CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini151 – 18333ExtracellularSequence AnalysisAdd
BLAST
Topological domaini205 – 23430CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini256 – 2649ExtracellularSequence Analysis
Topological domaini286 – 30722CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei41 – 6121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei265 – 28521Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG29380.
GeneTreeiENSGT00760000119096.
HOVERGENiHBG098568.
InParanoidiP59536.
KOiK08474.
OMAiDWYWPWQ.
OrthoDBiEOG7CK37R.
PhylomeDBiP59536.
TreeFamiTF335891.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59536-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQAALTAFFV LLFSLLSLLG IAANGFIVLV LGREWLRYGR LLPLDMILIS
60 70 80 90 100
LGASRFCLQL VGTVHNFYYS AQKVEYSGGL GRQFFHLHWH FLNSATFWFC
110 120 130 140 150
SWLSVLFCVK IANITHSTFL WLKWRFPGWV PWLLLGSVLI SFIITLLFFW
160 170 180 190 200
VNYPVYQEFL IRKFSGNMTY KWNTRIETYY FPSLKLVIWS IPFSVFLVSI
210 220 230 240 250
MLLINSLRRH TQRMQHNGHS LQDPSTQAHT RALKSLISFL ILYALSFLSL
260 270 280 290 300
IIDAAKFISM QNDFYWPWQI AVYLCISVHP FILIFSNLKL RSVFSQLLLL

ARGFWVA
Length:307
Mass (Da):35,896
Last modified:October 13, 2009 - v2
Checksum:i7A33E3ED3E44E563
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti207 – 2071L → M in BAD98053. (PubMed:15744053)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti127 – 1271P → L.2 Publications
Corresponds to variant rs10278721 [ dbSNP | Ensembl ].
VAR_060211

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY114093 Genomic DNA. Translation: AAM63543.1.
AF494232 Genomic DNA. Translation: AAM19323.1.
AY724956 Genomic DNA. Translation: AAU21152.1.
AC073264 Genomic DNA. No translation available.
BC101157 mRNA. Translation: AAI01158.1.
BC101158 mRNA. Translation: AAI01159.1.
AB199177 Genomic DNA. Translation: BAD98051.1.
AB199178 Genomic DNA. Translation: BAD98052.1.
AB199179 Genomic DNA. Translation: BAD98053.1.
CCDSiCCDS43663.1.
RefSeqiNP_795364.2. NM_176883.2.
UniGeneiHs.650648.

Genome annotation databases

EnsembliENST00000408916; ENSP00000386201; ENSG00000221855.
GeneIDi259287.
KEGGihsa:259287.
UCSCiuc003wdc.1. human.

Polymorphism databases

DMDMi261260079.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY114093 Genomic DNA. Translation: AAM63543.1 .
AF494232 Genomic DNA. Translation: AAM19323.1 .
AY724956 Genomic DNA. Translation: AAU21152.1 .
AC073264 Genomic DNA. No translation available.
BC101157 mRNA. Translation: AAI01158.1 .
BC101158 mRNA. Translation: AAI01159.1 .
AB199177 Genomic DNA. Translation: BAD98051.1 .
AB199178 Genomic DNA. Translation: BAD98052.1 .
AB199179 Genomic DNA. Translation: BAD98053.1 .
CCDSi CCDS43663.1.
RefSeqi NP_795364.2. NM_176883.2.
UniGenei Hs.650648.

3D structure databases

ProteinModelPortali P59536.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129242. 8 interactions.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 261260079.

Proteomic databases

PaxDbi P59536.
PRIDEi P59536.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000408916 ; ENSP00000386201 ; ENSG00000221855 .
GeneIDi 259287.
KEGGi hsa:259287.
UCSCi uc003wdc.1. human.

Organism-specific databases

CTDi 259287.
GeneCardsi GC07P143174.
HGNCi HGNC:18883. TAS2R41.
HPAi HPA057063.
MIMi 613965. gene.
neXtProti NX_P59536.
PharmGKBi PA38737.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG29380.
GeneTreei ENSGT00760000119096.
HOVERGENi HBG098568.
InParanoidi P59536.
KOi K08474.
OMAi DWYWPWQ.
OrthoDBi EOG7CK37R.
PhylomeDBi P59536.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R41.
GenomeRNAii 259287.
NextBioi 93111.
PROi P59536.
SOURCEi Search...

Gene expression databases

Bgeei P59536.
CleanExi HS_TAS2R41.
Genevestigatori P59536.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-127.
  3. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-127.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates."
    Go Y., Satta Y., Takenaka O., Takahata N.
    Genetics 170:313-326(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-291.
  7. Cited for: REVIEW.
  8. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R41_HUMAN
AccessioniPrimary (citable) accession number: P59536
Secondary accession number(s): P59550
, Q495I2, Q50KJ5, Q50KJ6, Q50KJ7, Q645W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 13, 2009
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3