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P59535

- T2R40_HUMAN

UniProt

P59535 - T2R40_HUMAN

Protein

Taste receptor type 2 member 40

Gene

TAS2R40

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 40
    Short name:
    T2R40
    Alternative name(s):
    G-protein coupled receptor 60
    Taste receptor type 2 member 58
    Short name:
    T2R58
    Gene namesi
    Name:TAS2R40
    Synonyms:GPR60
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:18885. TAS2R40.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38738.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Taste receptor type 2 member 40PRO_0000082288Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP59535.
    PRIDEiP59535.

    PTM databases

    PhosphoSiteiP59535.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

    Gene expression databases

    BgeeiP59535.
    CleanExiHS_TAS2R40.
    GenevestigatoriP59535.

    Structurei

    3D structure databases

    ProteinModelPortaliP59535.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini36 – 5823CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19028ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini212 – 24736CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 2768ExtracellularSequence Analysis
    Topological domaini298 – 32326CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16222Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG28890.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiP59535.
    KOiK08474.
    OMAiSNIFDTY.
    OrthoDBiEOG76MK91.
    PhylomeDBiP59535.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59535-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATVNTDATD KDISKFKVTF TLVVSGIECI TGILGSGFIT AIYGAEWARG    50
    KTLPTGDRIM LMLSFSRLLL QIWMMLENIF SLLFRIVYNQ NSVYILFKVI 100
    TVFLNHSNLW FAAWLKVFYC LRIANFNHPL FFLMKRKIIV LMPWLLRLSV 150
    LVSLSFSFPL SRDVFNVYVN SSIPIPSSNS TEKKYFSETN MVNLVFFYNM 200
    GIFVPLIMFI LAATLLILSL KRHTLHMGSN ATGSRDPSMK AHIGAIKATS 250
    YFLILYIFNA IALFLSTSNI FDTYSSWNIL CKIIMAAYPA GHSVQLILGN 300
    PGLRRAWKRF QHQVPLYLKG QTL 323
    Length:323
    Mass (Da):36,812
    Last modified:April 11, 2003 - v1
    Checksum:i605E66397EE04E77
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231V → L.
    Corresponds to variant rs17164164 [ dbSNP | Ensembl ].
    VAR_053350
    Natural varianti187 – 1871S → Y.
    Corresponds to variant rs10260248 [ dbSNP | Ensembl ].
    VAR_053351

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494229 Genomic DNA. Translation: AAM19320.1.
    AY724957 Genomic DNA. Translation: AAU21153.1.
    CH236959 Genomic DNA. Translation: EAL23782.1.
    CH471198 Genomic DNA. Translation: EAW51882.1.
    BC101795 mRNA. Translation: AAI01796.1.
    BC101797 mRNA. Translation: AAI01798.1.
    CCDSiCCDS43662.1.
    RefSeqiNP_795363.1. NM_176882.1.
    UniGeneiHs.352241.

    Genome annotation databases

    EnsembliENST00000408947; ENSP00000386210; ENSG00000221937.
    GeneIDi259286.
    KEGGihsa:259286.
    UCSCiuc011ksx.2. human.

    Polymorphism databases

    DMDMi29839473.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494229 Genomic DNA. Translation: AAM19320.1 .
    AY724957 Genomic DNA. Translation: AAU21153.1 .
    CH236959 Genomic DNA. Translation: EAL23782.1 .
    CH471198 Genomic DNA. Translation: EAW51882.1 .
    BC101795 mRNA. Translation: AAI01796.1 .
    BC101797 mRNA. Translation: AAI01798.1 .
    CCDSi CCDS43662.1.
    RefSeqi NP_795363.1. NM_176882.1.
    UniGenei Hs.352241.

    3D structure databases

    ProteinModelPortali P59535.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P59535.

    Polymorphism databases

    DMDMi 29839473.

    Proteomic databases

    PaxDbi P59535.
    PRIDEi P59535.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000408947 ; ENSP00000386210 ; ENSG00000221937 .
    GeneIDi 259286.
    KEGGi hsa:259286.
    UCSCi uc011ksx.2. human.

    Organism-specific databases

    CTDi 259286.
    GeneCardsi GC07P142919.
    H-InvDB HIX0033892.
    HGNCi HGNC:18885. TAS2R40.
    MIMi 613964. gene.
    neXtProti NX_P59535.
    PharmGKBi PA38738.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28890.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi P59535.
    KOi K08474.
    OMAi SNIFDTY.
    OrthoDBi EOG76MK91.
    PhylomeDBi P59535.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R40.
    GenomeRNAii 259286.
    NextBioi 93107.
    PROi P59535.
    SOURCEi Search...

    Gene expression databases

    Bgeei P59535.
    CleanExi HS_TAS2R40.
    Genevestigatori P59535.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: REVIEW.
    7. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R40_HUMAN
    AccessioniPrimary (citable) accession number: P59535
    Secondary accession number(s): A4D2I2, Q645W6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3