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P59535

- T2R40_HUMAN

UniProt

P59535 - T2R40_HUMAN

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Protein
Taste receptor type 2 member 40
Gene
TAS2R40, GPR60
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt
Complete GO annotation...

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 40
Short name:
T2R40
Alternative name(s):
G-protein coupled receptor 60
Taste receptor type 2 member 58
Short name:
T2R58
Gene namesi
Name:TAS2R40
Synonyms:GPR60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:18885. TAS2R40.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414Extracellular Reviewed prediction
Add
BLAST
Transmembranei15 – 3521Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini36 – 5823Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini80 – 10021Extracellular Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini122 – 14019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei141 – 16222Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini163 – 19028Extracellular Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini212 – 24736Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini269 – 2768Extracellular Reviewed prediction
Transmembranei277 – 29721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini298 – 32326Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Taste receptor type 2 member 40
PRO_0000082288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59535.
PRIDEiP59535.

PTM databases

PhosphoSiteiP59535.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiP59535.
CleanExiHS_TAS2R40.
GenevestigatoriP59535.

Structurei

3D structure databases

ProteinModelPortaliP59535.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28890.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59535.
KOiK08474.
OMAiSNIFDTY.
OrthoDBiEOG76MK91.
PhylomeDBiP59535.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59535-1 [UniParc]FASTAAdd to Basket

« Hide

MATVNTDATD KDISKFKVTF TLVVSGIECI TGILGSGFIT AIYGAEWARG    50
KTLPTGDRIM LMLSFSRLLL QIWMMLENIF SLLFRIVYNQ NSVYILFKVI 100
TVFLNHSNLW FAAWLKVFYC LRIANFNHPL FFLMKRKIIV LMPWLLRLSV 150
LVSLSFSFPL SRDVFNVYVN SSIPIPSSNS TEKKYFSETN MVNLVFFYNM 200
GIFVPLIMFI LAATLLILSL KRHTLHMGSN ATGSRDPSMK AHIGAIKATS 250
YFLILYIFNA IALFLSTSNI FDTYSSWNIL CKIIMAAYPA GHSVQLILGN 300
PGLRRAWKRF QHQVPLYLKG QTL 323
Length:323
Mass (Da):36,812
Last modified:April 11, 2003 - v1
Checksum:i605E66397EE04E77
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231V → L.
Corresponds to variant rs17164164 [ dbSNP | Ensembl ].
VAR_053350
Natural varianti187 – 1871S → Y.
Corresponds to variant rs10260248 [ dbSNP | Ensembl ].
VAR_053351

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494229 Genomic DNA. Translation: AAM19320.1.
AY724957 Genomic DNA. Translation: AAU21153.1.
CH236959 Genomic DNA. Translation: EAL23782.1.
CH471198 Genomic DNA. Translation: EAW51882.1.
BC101795 mRNA. Translation: AAI01796.1.
BC101797 mRNA. Translation: AAI01798.1.
CCDSiCCDS43662.1.
RefSeqiNP_795363.1. NM_176882.1.
UniGeneiHs.352241.

Genome annotation databases

EnsembliENST00000408947; ENSP00000386210; ENSG00000221937.
GeneIDi259286.
KEGGihsa:259286.
UCSCiuc011ksx.2. human.

Polymorphism databases

DMDMi29839473.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494229 Genomic DNA. Translation: AAM19320.1 .
AY724957 Genomic DNA. Translation: AAU21153.1 .
CH236959 Genomic DNA. Translation: EAL23782.1 .
CH471198 Genomic DNA. Translation: EAW51882.1 .
BC101795 mRNA. Translation: AAI01796.1 .
BC101797 mRNA. Translation: AAI01798.1 .
CCDSi CCDS43662.1.
RefSeqi NP_795363.1. NM_176882.1.
UniGenei Hs.352241.

3D structure databases

ProteinModelPortali P59535.
ModBasei Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P59535.

Polymorphism databases

DMDMi 29839473.

Proteomic databases

PaxDbi P59535.
PRIDEi P59535.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000408947 ; ENSP00000386210 ; ENSG00000221937 .
GeneIDi 259286.
KEGGi hsa:259286.
UCSCi uc011ksx.2. human.

Organism-specific databases

CTDi 259286.
GeneCardsi GC07P142919.
H-InvDB HIX0033892.
HGNCi HGNC:18885. TAS2R40.
MIMi 613964. gene.
neXtProti NX_P59535.
PharmGKBi PA38738.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28890.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi P59535.
KOi K08474.
OMAi SNIFDTY.
OrthoDBi EOG76MK91.
PhylomeDBi P59535.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R40.
GenomeRNAii 259286.
NextBioi 93107.
PROi P59535.
SOURCEi Search...

Gene expression databases

Bgeei P59535.
CleanExi HS_TAS2R40.
Genevestigatori P59535.

Family and domain databases

InterProi IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R40_HUMAN
AccessioniPrimary (citable) accession number: P59535
Secondary accession number(s): A4D2I2, Q645W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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