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P59535 (T2R40_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 40

Short name=T2R40
Alternative name(s):
G-protein coupled receptor 60
Taste receptor type 2 member 58
Short name=T2R58
Gene names
Name:TAS2R40
Synonyms:GPR60
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Taste receptor type 2 member 40
PRO_0000082288

Regions

Topological domain1 – 1414Extracellular Potential
Transmembrane15 – 3521Helical; Name=1; Potential
Topological domain36 – 5823Cytoplasmic Potential
Transmembrane59 – 7921Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 16222Helical; Name=4; Potential
Topological domain163 – 19028Extracellular Potential
Transmembrane191 – 21121Helical; Name=5; Potential
Topological domain212 – 24736Cytoplasmic Potential
Transmembrane248 – 26821Helical; Name=6; Potential
Topological domain269 – 2768Extracellular Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 32326Cytoplasmic Potential

Amino acid modifications

Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential

Natural variations

Natural variant231V → L.
Corresponds to variant rs17164164 [ dbSNP | Ensembl ].
VAR_053350
Natural variant1871S → Y.
Corresponds to variant rs10260248 [ dbSNP | Ensembl ].
VAR_053351

Sequences

Sequence LengthMass (Da)Tools
P59535 [UniParc].

Last modified April 11, 2003. Version 1.
Checksum: 605E66397EE04E77

FASTA32336,812
        10         20         30         40         50         60 
MATVNTDATD KDISKFKVTF TLVVSGIECI TGILGSGFIT AIYGAEWARG KTLPTGDRIM 

        70         80         90        100        110        120 
LMLSFSRLLL QIWMMLENIF SLLFRIVYNQ NSVYILFKVI TVFLNHSNLW FAAWLKVFYC 

       130        140        150        160        170        180 
LRIANFNHPL FFLMKRKIIV LMPWLLRLSV LVSLSFSFPL SRDVFNVYVN SSIPIPSSNS 

       190        200        210        220        230        240 
TEKKYFSETN MVNLVFFYNM GIFVPLIMFI LAATLLILSL KRHTLHMGSN ATGSRDPSMK 

       250        260        270        280        290        300 
AHIGAIKATS YFLILYIFNA IALFLSTSNI FDTYSSWNIL CKIIMAAYPA GHSVQLILGN 

       310        320 
PGLRRAWKRF QHQVPLYLKG QTL 

« Hide

References

« Hide 'large scale' references
[1]"The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[8]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF494229 Genomic DNA. Translation: AAM19320.1.
AY724957 Genomic DNA. Translation: AAU21153.1.
CH236959 Genomic DNA. Translation: EAL23782.1.
CH471198 Genomic DNA. Translation: EAW51882.1.
BC101795 mRNA. Translation: AAI01796.1.
BC101797 mRNA. Translation: AAI01798.1.
CCDSCCDS43662.1.
RefSeqNP_795363.1. NM_176882.1.
UniGeneHs.352241.

3D structure databases

ProteinModelPortalP59535.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP59535.

Polymorphism databases

DMDM29839473.

Proteomic databases

PaxDbP59535.
PRIDEP59535.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000408947; ENSP00000386210; ENSG00000221937.
GeneID259286.
KEGGhsa:259286.
UCSCuc011ksx.2. human.

Organism-specific databases

CTD259286.
GeneCardsGC07P142919.
H-InvDBHIX0033892.
HGNCHGNC:18885. TAS2R40.
MIM613964. gene.
neXtProtNX_P59535.
PharmGKBPA38738.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28890.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidP59535.
KOK08474.
OMASNIFDTY.
OrthoDBEOG76MK91.
PhylomeDBP59535.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP59535.
CleanExHS_TAS2R40.
GenevestigatorP59535.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R40.
GenomeRNAi259286.
NextBio93107.
PROP59535.
SOURCESearch...

Entry information

Entry nameT2R40_HUMAN
AccessionPrimary (citable) accession number: P59535
Secondary accession number(s): A4D2I2, Q645W6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries