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Protein

Taste receptor type 2 member 40

Gene

TAS2R40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 40
Short name:
T2R40
Alternative name(s):
G-protein coupled receptor 60
Taste receptor type 2 member 58
Short name:
T2R58
Gene namesi
Name:TAS2R40
Synonyms:GPR60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:18885. TAS2R40.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei15 – 3521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini36 – 5823CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16222Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19028ExtracellularSequence AnalysisAdd
BLAST
Transmembranei191 – 21121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini212 – 24736CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 2768ExtracellularSequence Analysis
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini298 – 32326CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Taste receptor type 2 member 40PRO_0000082288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59535.
PRIDEiP59535.

PTM databases

PhosphoSiteiP59535.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiP59535.
CleanExiHS_TAS2R40.
GenevestigatoriP59535.

Structurei

3D structure databases

ProteinModelPortaliP59535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28890.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59535.
KOiK08474.
OMAiSNIFDTY.
OrthoDBiEOG76MK91.
PhylomeDBiP59535.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59535-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATVNTDATD KDISKFKVTF TLVVSGIECI TGILGSGFIT AIYGAEWARG
60 70 80 90 100
KTLPTGDRIM LMLSFSRLLL QIWMMLENIF SLLFRIVYNQ NSVYILFKVI
110 120 130 140 150
TVFLNHSNLW FAAWLKVFYC LRIANFNHPL FFLMKRKIIV LMPWLLRLSV
160 170 180 190 200
LVSLSFSFPL SRDVFNVYVN SSIPIPSSNS TEKKYFSETN MVNLVFFYNM
210 220 230 240 250
GIFVPLIMFI LAATLLILSL KRHTLHMGSN ATGSRDPSMK AHIGAIKATS
260 270 280 290 300
YFLILYIFNA IALFLSTSNI FDTYSSWNIL CKIIMAAYPA GHSVQLILGN
310 320
PGLRRAWKRF QHQVPLYLKG QTL
Length:323
Mass (Da):36,812
Last modified:April 11, 2003 - v1
Checksum:i605E66397EE04E77
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231V → L.
Corresponds to variant rs17164164 [ dbSNP | Ensembl ].
VAR_053350
Natural varianti187 – 1871S → Y.
Corresponds to variant rs10260248 [ dbSNP | Ensembl ].
VAR_053351

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494229 Genomic DNA. Translation: AAM19320.1.
AY724957 Genomic DNA. Translation: AAU21153.1.
CH236959 Genomic DNA. Translation: EAL23782.1.
CH471198 Genomic DNA. Translation: EAW51882.1.
BC101795 mRNA. Translation: AAI01796.1.
BC101797 mRNA. Translation: AAI01798.1.
CCDSiCCDS43662.1.
RefSeqiNP_795363.1. NM_176882.1.
UniGeneiHs.352241.

Genome annotation databases

EnsembliENST00000408947; ENSP00000386210; ENSG00000221937.
GeneIDi259286.
KEGGihsa:259286.
UCSCiuc011ksx.2. human.

Polymorphism databases

DMDMi29839473.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494229 Genomic DNA. Translation: AAM19320.1.
AY724957 Genomic DNA. Translation: AAU21153.1.
CH236959 Genomic DNA. Translation: EAL23782.1.
CH471198 Genomic DNA. Translation: EAW51882.1.
BC101795 mRNA. Translation: AAI01796.1.
BC101797 mRNA. Translation: AAI01798.1.
CCDSiCCDS43662.1.
RefSeqiNP_795363.1. NM_176882.1.
UniGeneiHs.352241.

3D structure databases

ProteinModelPortaliP59535.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP59535.

Polymorphism databases

DMDMi29839473.

Proteomic databases

PaxDbiP59535.
PRIDEiP59535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408947; ENSP00000386210; ENSG00000221937.
GeneIDi259286.
KEGGihsa:259286.
UCSCiuc011ksx.2. human.

Organism-specific databases

CTDi259286.
GeneCardsiGC07P142919.
H-InvDBHIX0033892.
HGNCiHGNC:18885. TAS2R40.
MIMi613964. gene.
neXtProtiNX_P59535.
PharmGKBiPA38738.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28890.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59535.
KOiK08474.
OMAiSNIFDTY.
OrthoDBiEOG76MK91.
PhylomeDBiP59535.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiTAS2R40.
GenomeRNAii259286.
NextBioi93107.
PROiP59535.
SOURCEiSearch...

Gene expression databases

BgeeiP59535.
CleanExiHS_TAS2R40.
GenevestigatoriP59535.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: REVIEW.
  7. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R40_HUMAN
AccessioniPrimary (citable) accession number: P59535
Secondary accession number(s): A4D2I2, Q645W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: January 7, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.