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P59534

- T2R39_HUMAN

UniProt

P59534 - T2R39_HUMAN

Protein

Taste receptor type 2 member 39

Gene

TAS2R39

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 39
    Short name:
    T2R39
    Alternative name(s):
    Taste receptor type 2 member 57
    Short name:
    T2R57
    Gene namesi
    Name:TAS2R39
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:18886. TAS2R39.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38739.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Taste receptor type 2 member 39PRO_0000082281Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP59534.
    PRIDEiP59534.

    PTM databases

    PhosphoSiteiP59534.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiP59534.
    BgeeiP59534.
    CleanExiHS_TAS2R39.
    GenevestigatoriP59534.

    Organism-specific databases

    HPAiHPA053456.
    HPA060680.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000405095.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GFZmodel-A1-332[»]
    ProteinModelPortaliP59534.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 7423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 11621ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 26236CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini284 – 2918ExtracellularSequence Analysis
    Topological domaini313 – 33826CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG132005.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    KOiK08474.
    OMAiFYSEDAV.
    OrthoDBiEOG76MK91.
    PhylomeDBiP59534.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59534-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGRCFPPDT KEKQQLRMTK LCDPAESELS PFLITLILAV LLAEYLIGII    50
    ANGFIMAIHA AEWVQNKAVS TSGRILVFLS VSRIALQSLM MLEITISSTS 100
    LSFYSEDAVY YAFKISFIFL NFCSLWFAAW LSFFYFVKIA NFSYPLFLKL 150
    RWRITGLIPW LLWLSVFISF SHSMFCINIC TVYCNNSFPI HSSNSTKKTY 200
    LSEINVVGLA FFFNLGIVTP LIMFILTATL LILSLKRHTL HMGSNATGSN 250
    DPSMEAHMGA IKAISYFLIL YIFNAVALFI YLSNMFDINS LWNNLCQIIM 300
    AAYPASHSIL LIQDNPGLRR AWKRLQLRLH LYPKEWTL 338
    Length:338
    Mass (Da):38,626
    Last modified:November 23, 2004 - v3
    Checksum:iF9CD1860008198AB
    GO

    Sequence cautioni

    The sequence AAM19321.1 differs from that shown. Reason: Frameshift at position 323.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti193 – 1931S → F.
    Corresponds to variant rs35474877 [ dbSNP | Ensembl ].
    VAR_053348
    Natural varianti197 – 1971K → E.
    Corresponds to variant rs34169190 [ dbSNP | Ensembl ].
    VAR_053349

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494230 Genomic DNA. Translation: AAM19321.1. Frameshift.
    AY724959 Genomic DNA. Translation: AAU21155.1.
    BC100947 mRNA. Translation: AAI00948.1.
    BC100948 mRNA. Translation: AAI00949.1.
    BC114952 mRNA. Translation: AAI14953.1.
    CCDSiCCDS47729.1.
    RefSeqiNP_795362.2. NM_176881.2.
    UniGeneiHs.553660.

    Genome annotation databases

    EnsembliENST00000446620; ENSP00000405095; ENSG00000236398.
    GeneIDi259285.
    KEGGihsa:259285.
    UCSCiuc011ksw.2. human.

    Polymorphism databases

    DMDMi55977808.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494230 Genomic DNA. Translation: AAM19321.1 . Frameshift.
    AY724959 Genomic DNA. Translation: AAU21155.1 .
    BC100947 mRNA. Translation: AAI00948.1 .
    BC100948 mRNA. Translation: AAI00949.1 .
    BC114952 mRNA. Translation: AAI14953.1 .
    CCDSi CCDS47729.1.
    RefSeqi NP_795362.2. NM_176881.2.
    UniGenei Hs.553660.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GFZ model - A 1-332 [» ]
    ProteinModelPortali P59534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000405095.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P59534.

    Polymorphism databases

    DMDMi 55977808.

    Proteomic databases

    PaxDbi P59534.
    PRIDEi P59534.

    Protocols and materials databases

    DNASUi 259285.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000446620 ; ENSP00000405095 ; ENSG00000236398 .
    GeneIDi 259285.
    KEGGi hsa:259285.
    UCSCi uc011ksw.2. human.

    Organism-specific databases

    CTDi 259285.
    GeneCardsi GC07P142880.
    HGNCi HGNC:18886. TAS2R39.
    HPAi HPA053456.
    HPA060680.
    neXtProti NX_P59534.
    PharmGKBi PA38739.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG132005.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    KOi K08474.
    OMAi FYSEDAV.
    OrthoDBi EOG76MK91.
    PhylomeDBi P59534.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R39.
    GenomeRNAii 259285.
    NextBioi 93103.
    PROi P59534.

    Gene expression databases

    ArrayExpressi P59534.
    Bgeei P59534.
    CleanExi HS_TAS2R39.
    Genevestigatori P59534.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: REVIEW.
    5. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R39_HUMAN
    AccessioniPrimary (citable) accession number: P59534
    Secondary accession number(s): A4FUI7, Q3ZCN6, Q645W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3