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P59534

- T2R39_HUMAN

UniProt

P59534 - T2R39_HUMAN

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Protein
Taste receptor type 2 member 39
Gene
TAS2R39
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt
Complete GO annotation...

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 39
Short name:
T2R39
Alternative name(s):
Taste receptor type 2 member 57
Short name:
T2R57
Gene namesi
Name:TAS2R39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:18886. TAS2R39.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Extracellular Reviewed prediction
Add
BLAST
Transmembranei31 – 5121Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini52 – 7423Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei75 – 9521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini96 – 11621Extracellular Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini138 – 15619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei157 – 17721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini178 – 20528Extracellular Reviewed prediction
Add
BLAST
Transmembranei206 – 22621Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini227 – 26236Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei263 – 28321Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini284 – 2918Extracellular Reviewed prediction
Transmembranei292 – 31221Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini313 – 33826Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Taste receptor type 2 member 39
PRO_0000082281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59534.
PRIDEiP59534.

PTM databases

PhosphoSiteiP59534.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

ArrayExpressiP59534.
BgeeiP59534.
CleanExiHS_TAS2R39.
GenevestigatoriP59534.

Organism-specific databases

HPAiHPA053456.
HPA060680.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000405095.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GFZmodel-A1-332[»]
ProteinModelPortaliP59534.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG132005.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
KOiK08474.
OMAiFYSEDAV.
OrthoDBiEOG76MK91.
PhylomeDBiP59534.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59534-1 [UniParc]FASTAAdd to Basket

« Hide

MLGRCFPPDT KEKQQLRMTK LCDPAESELS PFLITLILAV LLAEYLIGII    50
ANGFIMAIHA AEWVQNKAVS TSGRILVFLS VSRIALQSLM MLEITISSTS 100
LSFYSEDAVY YAFKISFIFL NFCSLWFAAW LSFFYFVKIA NFSYPLFLKL 150
RWRITGLIPW LLWLSVFISF SHSMFCINIC TVYCNNSFPI HSSNSTKKTY 200
LSEINVVGLA FFFNLGIVTP LIMFILTATL LILSLKRHTL HMGSNATGSN 250
DPSMEAHMGA IKAISYFLIL YIFNAVALFI YLSNMFDINS LWNNLCQIIM 300
AAYPASHSIL LIQDNPGLRR AWKRLQLRLH LYPKEWTL 338
Length:338
Mass (Da):38,626
Last modified:November 23, 2004 - v3
Checksum:iF9CD1860008198AB
GO

Sequence cautioni

The sequence AAM19321.1 differs from that shown. Reason: Frameshift at position 323.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931S → F.
Corresponds to variant rs35474877 [ dbSNP | Ensembl ].
VAR_053348
Natural varianti197 – 1971K → E.
Corresponds to variant rs34169190 [ dbSNP | Ensembl ].
VAR_053349

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494230 Genomic DNA. Translation: AAM19321.1. Frameshift.
AY724959 Genomic DNA. Translation: AAU21155.1.
BC100947 mRNA. Translation: AAI00948.1.
BC100948 mRNA. Translation: AAI00949.1.
BC114952 mRNA. Translation: AAI14953.1.
CCDSiCCDS47729.1.
RefSeqiNP_795362.2. NM_176881.2.
UniGeneiHs.553660.

Genome annotation databases

EnsembliENST00000446620; ENSP00000405095; ENSG00000236398.
GeneIDi259285.
KEGGihsa:259285.
UCSCiuc011ksw.2. human.

Polymorphism databases

DMDMi55977808.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494230 Genomic DNA. Translation: AAM19321.1 . Frameshift.
AY724959 Genomic DNA. Translation: AAU21155.1 .
BC100947 mRNA. Translation: AAI00948.1 .
BC100948 mRNA. Translation: AAI00949.1 .
BC114952 mRNA. Translation: AAI14953.1 .
CCDSi CCDS47729.1.
RefSeqi NP_795362.2. NM_176881.2.
UniGenei Hs.553660.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GFZ model - A 1-332 [» ]
ProteinModelPortali P59534.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000405095.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P59534.

Polymorphism databases

DMDMi 55977808.

Proteomic databases

PaxDbi P59534.
PRIDEi P59534.

Protocols and materials databases

DNASUi 259285.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000446620 ; ENSP00000405095 ; ENSG00000236398 .
GeneIDi 259285.
KEGGi hsa:259285.
UCSCi uc011ksw.2. human.

Organism-specific databases

CTDi 259285.
GeneCardsi GC07P142880.
HGNCi HGNC:18886. TAS2R39.
HPAi HPA053456.
HPA060680.
neXtProti NX_P59534.
PharmGKBi PA38739.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG132005.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
KOi K08474.
OMAi FYSEDAV.
OrthoDBi EOG76MK91.
PhylomeDBi P59534.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R39.
GenomeRNAii 259285.
NextBioi 93103.
PROi P59534.

Gene expression databases

ArrayExpressi P59534.
Bgeei P59534.
CleanExi HS_TAS2R39.
Genevestigatori P59534.

Family and domain databases

InterProi IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: REVIEW.
  5. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R39_HUMAN
AccessioniPrimary (citable) accession number: P59534
Secondary accession number(s): A4FUI7, Q3ZCN6, Q645W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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