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Protein

Taste receptor type 2 member 39

Gene

TAS2R39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

GO - Molecular functioni

  • bitter taste receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 39
Short name:
T2R39
Alternative name(s):
Taste receptor type 2 member 57
Short name:
T2R57
Gene namesi
Name:TAS2R39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18886. TAS2R39.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini52 – 7423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini96 – 11621ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini138 – 15619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 20528ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini227 – 26236CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini284 – 2918ExtracellularSequence Analysis
Transmembranei292 – 31221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini313 – 33826CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38739.

Polymorphism and mutation databases

BioMutaiTAS2R39.
DMDMi55977808.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Taste receptor type 2 member 39PRO_0000082281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59534.
PRIDEiP59534.

PTM databases

PhosphoSiteiP59534.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

BgeeiP59534.
CleanExiHS_TAS2R39.
GenevisibleiP59534. HS.

Organism-specific databases

HPAiHPA053456.
HPA060680.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000405095.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GFZmodel-A1-332[»]
ProteinModelPortaliP59534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG132005.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59534.
KOiK08474.
OMAiYAFKISF.
OrthoDBiEOG76MK91.
PhylomeDBiP59534.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGRCFPPDT KEKQQLRMTK LCDPAESELS PFLITLILAV LLAEYLIGII
60 70 80 90 100
ANGFIMAIHA AEWVQNKAVS TSGRILVFLS VSRIALQSLM MLEITISSTS
110 120 130 140 150
LSFYSEDAVY YAFKISFIFL NFCSLWFAAW LSFFYFVKIA NFSYPLFLKL
160 170 180 190 200
RWRITGLIPW LLWLSVFISF SHSMFCINIC TVYCNNSFPI HSSNSTKKTY
210 220 230 240 250
LSEINVVGLA FFFNLGIVTP LIMFILTATL LILSLKRHTL HMGSNATGSN
260 270 280 290 300
DPSMEAHMGA IKAISYFLIL YIFNAVALFI YLSNMFDINS LWNNLCQIIM
310 320 330
AAYPASHSIL LIQDNPGLRR AWKRLQLRLH LYPKEWTL
Length:338
Mass (Da):38,626
Last modified:November 23, 2004 - v3
Checksum:iF9CD1860008198AB
GO

Sequence cautioni

The sequence AAM19321.1 differs from that shown. Reason: Frameshift at position 323. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931S → F.
Corresponds to variant rs35474877 [ dbSNP | Ensembl ].
VAR_053348
Natural varianti197 – 1971K → E.
Corresponds to variant rs34169190 [ dbSNP | Ensembl ].
VAR_053349

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494230 Genomic DNA. Translation: AAM19321.1. Frameshift.
AY724959 Genomic DNA. Translation: AAU21155.1.
BC100947 mRNA. Translation: AAI00948.1.
BC100948 mRNA. Translation: AAI00949.1.
BC114952 mRNA. Translation: AAI14953.1.
CCDSiCCDS47729.1.
RefSeqiNP_795362.2. NM_176881.2.
UniGeneiHs.553660.

Genome annotation databases

EnsembliENST00000446620; ENSP00000405095; ENSG00000236398.
GeneIDi259285.
KEGGihsa:259285.
UCSCiuc011ksw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494230 Genomic DNA. Translation: AAM19321.1. Frameshift.
AY724959 Genomic DNA. Translation: AAU21155.1.
BC100947 mRNA. Translation: AAI00948.1.
BC100948 mRNA. Translation: AAI00949.1.
BC114952 mRNA. Translation: AAI14953.1.
CCDSiCCDS47729.1.
RefSeqiNP_795362.2. NM_176881.2.
UniGeneiHs.553660.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GFZmodel-A1-332[»]
ProteinModelPortaliP59534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000405095.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP59534.

Polymorphism and mutation databases

BioMutaiTAS2R39.
DMDMi55977808.

Proteomic databases

PaxDbiP59534.
PRIDEiP59534.

Protocols and materials databases

DNASUi259285.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446620; ENSP00000405095; ENSG00000236398.
GeneIDi259285.
KEGGihsa:259285.
UCSCiuc011ksw.2. human.

Organism-specific databases

CTDi259285.
GeneCardsiGC07P142880.
HGNCiHGNC:18886. TAS2R39.
HPAiHPA053456.
HPA060680.
neXtProtiNX_P59534.
PharmGKBiPA38739.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG132005.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59534.
KOiK08474.
OMAiYAFKISF.
OrthoDBiEOG76MK91.
PhylomeDBiP59534.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiTAS2R39.
GenomeRNAii259285.
NextBioi93103.
PROiP59534.

Gene expression databases

BgeeiP59534.
CleanExiHS_TAS2R39.
GenevisibleiP59534. HS.

Family and domain databases

InterProiIPR007960. T2R.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: REVIEW.
  5. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R39_HUMAN
AccessioniPrimary (citable) accession number: P59534
Secondary accession number(s): A4FUI7, Q3ZCN6, Q645W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 23, 2004
Last modified: July 22, 2015
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.