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P59534 (T2R39_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 39

Short name=T2R39
Alternative name(s):
Taste receptor type 2 member 57
Short name=T2R57
Gene names
Name:TAS2R39
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence caution

The sequence AAM19321.1 differs from that shown. Reason: Frameshift at position 323.

Ontologies

Keywords
   Biological processSensory transduction
Taste
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsensory perception of taste

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Taste receptor type 2 member 39
PRO_0000082281

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 7423Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=2; Potential
Topological domain96 – 11621Extracellular Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 15619Cytoplasmic Potential
Transmembrane157 – 17721Helical; Name=4; Potential
Topological domain178 – 20528Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 26236Cytoplasmic Potential
Transmembrane263 – 28321Helical; Name=6; Potential
Topological domain284 – 2918Extracellular Potential
Transmembrane292 – 31221Helical; Name=7; Potential
Topological domain313 – 33826Cytoplasmic Potential

Amino acid modifications

Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential

Natural variations

Natural variant1931S → F.
Corresponds to variant rs35474877 [ dbSNP | Ensembl ].
VAR_053348
Natural variant1971K → E.
Corresponds to variant rs34169190 [ dbSNP | Ensembl ].
VAR_053349

Sequences

Sequence LengthMass (Da)Tools
P59534 [UniParc].

Last modified November 23, 2004. Version 3.
Checksum: F9CD1860008198AB

FASTA33838,626
        10         20         30         40         50         60 
MLGRCFPPDT KEKQQLRMTK LCDPAESELS PFLITLILAV LLAEYLIGII ANGFIMAIHA 

        70         80         90        100        110        120 
AEWVQNKAVS TSGRILVFLS VSRIALQSLM MLEITISSTS LSFYSEDAVY YAFKISFIFL 

       130        140        150        160        170        180 
NFCSLWFAAW LSFFYFVKIA NFSYPLFLKL RWRITGLIPW LLWLSVFISF SHSMFCINIC 

       190        200        210        220        230        240 
TVYCNNSFPI HSSNSTKKTY LSEINVVGLA FFFNLGIVTP LIMFILTATL LILSLKRHTL 

       250        260        270        280        290        300 
HMGSNATGSN DPSMEAHMGA IKAISYFLIL YIFNAVALFI YLSNMFDINS LWNNLCQIIM 

       310        320        330 
AAYPASHSIL LIQDNPGLRR AWKRLQLRLH LYPKEWTL 

« Hide

References

« Hide 'large scale' references
[1]"The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evolution of bitter taste receptors in humans and apes."
Fischer A., Gilad Y., Man O., Paeaebo S.
Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[5]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[6]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF494230 Genomic DNA. Translation: AAM19321.1. Frameshift.
AY724959 Genomic DNA. Translation: AAU21155.1.
BC100947 mRNA. Translation: AAI00948.1.
BC100948 mRNA. Translation: AAI00949.1.
BC114952 mRNA. Translation: AAI14953.1.
RefSeqNP_795362.2. NM_176881.2.
UniGeneHs.553660.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2GFZmodel-A1-332[»]
ProteinModelPortalP59534.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000405095.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP59534.

Polymorphism databases

DMDM55977808.

Proteomic databases

PaxDbP59534.
PRIDEP59534.

Protocols and materials databases

DNASU259285.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000446620; ENSP00000405095; ENSG00000236398.
GeneID259285.
KEGGhsa:259285.
UCSCuc011ksw.2. human.

Organism-specific databases

CTD259285.
GeneCardsGC07P142880.
HGNCHGNC:18886. TAS2R39.
HPAHPA053456.
HPA060680.
neXtProtNX_P59534.
PharmGKBPA38739.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG132005.
HOGENOMHOG000234595.
HOVERGENHBG060698.
KOK08474.
OMAFYSEDAV.
OrthoDBEOG76MK91.
PhylomeDBP59534.
TreeFamTF335891.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP59534.
BgeeP59534.
CleanExHS_TAS2R39.
GenevestigatorP59534.

Family and domain databases

InterProIPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTAS2R39.
GenomeRNAi259285.
NextBio93103.
PROP59534.

Entry information

Entry nameT2R39_HUMAN
AccessionPrimary (citable) accession number: P59534
Secondary accession number(s): A4FUI7, Q3ZCN6, Q645W4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries