Taste receptor type 2 member 39 - Homo sapiens (Human)

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P59534 (T2R39_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Taste receptor type 2 member 39
Short name=T2R39

Alternative name(s):
Taste receptor type 2 member 57
Short name=T2R57

Gene names

Name:

TAS2R39

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Miscellaneous	Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
Sequence similarities	Belongs to the G-protein coupled receptor T2R family.
Sequence caution	The sequence AAM19321.1 differs from that shown. Reason: Frameshift at position 323.

Ontologies

Keywords
Biological process	Sensory transduction Taste
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sensory perception of taste Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 338

338

Taste receptor type 2 member 39

PRO_0000082281

Regions

Topological domain

1 – 30

Extracellular Potential

Transmembrane

31 – 51

Helical; Name=1; Potential

Topological domain

52 – 74

Cytoplasmic Potential

Transmembrane

75 – 95

Helical; Name=2; Potential

Topological domain

96 – 116

Extracellular Potential

Transmembrane

117 – 137

Helical; Name=3; Potential

Topological domain

138 – 156

Cytoplasmic Potential

Transmembrane

157 – 177

Helical; Name=4; Potential

Topological domain

178 – 205

Extracellular Potential

Transmembrane

206 – 226

Helical; Name=5; Potential

Topological domain

227 – 262

Cytoplasmic Potential

Transmembrane

263 – 283

Helical; Name=6; Potential

Topological domain

284 – 291

Extracellular Potential

Transmembrane

292 – 312

Helical; Name=7; Potential

Topological domain

313 – 338

Cytoplasmic Potential

Amino acid modifications

Glycosylation

185

N-linked (GlcNAc...) Potential

Glycosylation

194

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

193

S → F.
Corresponds to variant rs35474877 [ dbSNP | Ensembl ].

VAR_053348

Natural variant

197

K → E.
Corresponds to variant rs34169190 [ dbSNP | Ensembl ].

VAR_053349

Sequences

Sequence

Length

Mass (Da)

Tools

P59534 [UniParc].

Last modified November 23, 2004. Version 3.
Checksum: F9CD1860008198AB
Show »

FASTA

338

38,626

        10         20         30         40         50         60 
MLGRCFPPDT KEKQQLRMTK LCDPAESELS PFLITLILAV LLAEYLIGII ANGFIMAIHA 

        70         80         90        100        110        120 
AEWVQNKAVS TSGRILVFLS VSRIALQSLM MLEITISSTS LSFYSEDAVY YAFKISFIFL 

       130        140        150        160        170        180 
NFCSLWFAAW LSFFYFVKIA NFSYPLFLKL RWRITGLIPW LLWLSVFISF SHSMFCINIC 

       190        200        210        220        230        240 
TVYCNNSFPI HSSNSTKKTY LSEINVVGLA FFFNLGIVTP LIMFILTATL LILSLKRHTL 

       250        260        270        280        290        300 
HMGSNATGSN DPSMEAHMGA IKAISYFLIL YIFNAVALFI YLSNMFDINS LWNNLCQIIM 

       310        320        330 
AAYPASHSIL LIQDNPGLRR AWKRLQLRLH LYPKEWTL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides." Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W. Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of bitter taste receptors in humans and apes." Fischer A., Gilad Y., Man O., Paeaebo S. Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Receptors for bitter and sweet taste." Montmayeur J.-P., Matsunami H. Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[5]	"Molecular mechanisms of bitter and sweet taste transduction." Margolskee R.F. J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[6]	"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF494230 Genomic DNA. Translation: AAM19321.1. Frameshift.
AY724959 Genomic DNA. Translation: AAU21155.1.
BC100947 mRNA. Translation: AAI00948.1.
BC100948 mRNA. Translation: AAI00949.1.
BC114952 mRNA. Translation: AAI14953.1.

IPI

IPI00470540.

RefSeq

NP_795362.2. NM_176881.2.

UniGene

Hs.553660.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GFZ	model	-	A	1-332	[»]

ProteinModelPortal

P59534.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000405095.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P59534.

Polymorphism databases

DMDM

55977808.

Proteomic databases

PaxDb

P59534.

PRIDE

P59534.

Protocols and materials databases

DNASU

259285.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000446620; ENSP00000405095; ENSG00000236398.

GeneID

259285.

KEGG

hsa:259285.

UCSC

uc011ksw.2. human.

Organism-specific databases

CTD

259285.

GeneCards

GC07P142880.

HGNC

HGNC:18886. TAS2R39.

neXtProt

NX_P59534.

PharmGKB

PA38739.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG132005.

HOGENOM

HOG000234595.

HOVERGEN

HBG060698.

K08474.

OMA

IPWLLWL.

OrthoDB

EOG4T4CVX.

Gene expression databases

ArrayExpress

P59534.

Bgee

P59534.

CleanEx

HS_TAS2R39.

Genevestigator

P59534.

Family and domain databases

InterPro

IPR007960. TAS2_rcpt.
[Graphical view]

Pfam

PF05296. TAS2R. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

259285.

NextBio

93103.

Entry information

Entry name

T2R39_HUMAN

Accession

Primary (citable) accession number: P59534
Secondary accession number(s): A4FUI7, Q3ZCN6, Q645W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	November 23, 2004
Last modified:	April 3, 2013
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 7: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents