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P59533

- T2R38_HUMAN

UniProt

P59533 - T2R38_HUMAN

Protein

Taste receptor type 2 member 38

Gene

TAS2R38

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.By similarity

    GO - Molecular functioni

    1. bitter taste receptor activity Source: UniProt

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Enzyme and pathway databases

    ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 38
    Short name:
    T2R38
    Alternative name(s):
    PTC bitter taste receptor
    Taste receptor type 2 member 61
    Short name:
    T2R61
    Gene namesi
    Name:TAS2R38
    Synonyms:PTC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:9584. TAS2R38.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProt
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi171200. phenotype.
    PharmGKBiPA33936.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Taste receptor type 2 member 38PRO_0000082273Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP59533.
    PRIDEiP59533.

    PTM databases

    PhosphoSiteiP59533.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

    Gene expression databases

    ArrayExpressiP59533.
    CleanExiHS_TAS2R38.
    GenevestigatoriP59533.

    Organism-specific databases

    HPAiHPA043862.
    HPA054366.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000331291.

    Structurei

    3D structure databases

    ProteinModelPortaliP59533.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini39 – 5517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 9418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini116 – 14227CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 19027ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini212 – 25140CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 2764ExtracellularSequence Analysis
    Topological domaini298 – 33336CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43295.
    HOGENOMiHOG000041379.
    HOVERGENiHBG098741.
    InParanoidiP59533.
    KOiK08474.
    OMAiHMRTMKV.
    OrthoDBiEOG7J447B.
    PhylomeDBiP59533.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59533-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTLTRIRTV SYEVRSTFLF ISVLEFAVGF LTNAFVFLVN FWDVVKRQAL    50
    SNSDCVLLCL SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAIIMLWM 100
    IANQANLWLA ACLSLLYCSK LIRFSHTFLI CLASWVSRKI SQMLLGIILC 150
    SCICTVLCVW CFFSRPHFTV TTVLFMNNNT RLNWQIKDLN LFYSFLFCYL 200
    WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRNSRDPSLE AHIKALKSLV 250
    SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAILISG 300
    NAKLRRAVMT ILLWAQSSLK VRADHKADSR TLC 333
    Length:333
    Mass (Da):37,892
    Last modified:June 21, 2005 - v3
    Checksum:iE3B5EDD5AB99994C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti186 – 1861I → N in AAM19322. (PubMed:12379855)Curated

    Polymorphismi

    Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting) [MIMi:171200]; also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless. Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti49 – 491A → P.1 Publication
    Corresponds to variant rs713598 [ dbSNP | Ensembl ].
    VAR_017860
    Natural varianti262 – 2621A → V.5 Publications
    Corresponds to variant rs1726866 [ dbSNP | Ensembl ].
    VAR_017861
    Natural varianti296 – 2961I → V.1 Publication
    Corresponds to variant rs10246939 [ dbSNP | Ensembl ].
    VAR_017862

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494231 Genomic DNA. Translation: AAM19322.1.
    AY114095 Genomic DNA. Translation: AAM63545.1.
    AY258598 Genomic DNA. Translation: AAP14667.1.
    AY724960 Genomic DNA. Translation: AAU21156.1.
    CH236950 Genomic DNA. Translation: EAL24011.1.
    CH471070 Genomic DNA. Translation: EAW83993.1.
    BC104933 mRNA. Translation: AAI04934.1.
    BC104937 mRNA. Translation: AAI04938.1.
    CCDSiCCDS34765.1.
    RefSeqiNP_789787.4. NM_176817.4.
    UniGeneiHs.647085.

    Genome annotation databases

    EnsembliENST00000547270; ENSP00000448219; ENSG00000257138.
    GeneIDi5726.
    KEGGihsa:5726.
    UCSCiuc003vwx.1. human.

    Polymorphism databases

    DMDMi68068016.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A tail of protection - Issue 119 of July 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494231 Genomic DNA. Translation: AAM19322.1 .
    AY114095 Genomic DNA. Translation: AAM63545.1 .
    AY258598 Genomic DNA. Translation: AAP14667.1 .
    AY724960 Genomic DNA. Translation: AAU21156.1 .
    CH236950 Genomic DNA. Translation: EAL24011.1 .
    CH471070 Genomic DNA. Translation: EAW83993.1 .
    BC104933 mRNA. Translation: AAI04934.1 .
    BC104937 mRNA. Translation: AAI04938.1 .
    CCDSi CCDS34765.1.
    RefSeqi NP_789787.4. NM_176817.4.
    UniGenei Hs.647085.

    3D structure databases

    ProteinModelPortali P59533.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000331291.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P59533.

    Polymorphism databases

    DMDMi 68068016.

    Proteomic databases

    PaxDbi P59533.
    PRIDEi P59533.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000547270 ; ENSP00000448219 ; ENSG00000257138 .
    GeneIDi 5726.
    KEGGi hsa:5726.
    UCSCi uc003vwx.1. human.

    Organism-specific databases

    CTDi 5726.
    GeneCardsi GC07M141672.
    H-InvDB HIX0033729.
    HGNCi HGNC:9584. TAS2R38.
    HPAi HPA043862.
    HPA054366.
    MIMi 171200. phenotype.
    607751. gene.
    neXtProti NX_P59533.
    PharmGKBi PA33936.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43295.
    HOGENOMi HOG000041379.
    HOVERGENi HBG098741.
    InParanoidi P59533.
    KOi K08474.
    OMAi HMRTMKV.
    OrthoDBi EOG7J447B.
    PhylomeDBi P59533.
    TreeFami TF335891.

    Enzyme and pathway databases

    Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii TAS2R38.
    GenomeRNAii 5726.
    NextBioi 22262.
    PROi P59533.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P59533.
    CleanExi HS_TAS2R38.
    Genevestigatori P59533.

    Family and domain databases

    InterProi IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
      Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
      Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-262.
    2. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
      Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
      Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide."
      Kim U.-K., Jorgenson E., Coon H., Leppert M., Risch N., Drayna D.T.
      Science 299:1221-1225(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-49 AND VAL-296.
    4. "Evolution of bitter taste receptors in humans and apes."
      Fischer A., Gilad Y., Man O., Paeaebo S.
      Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-262.
    5. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-262.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-262.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-262.
    8. Cited for: REVIEW.
    9. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiT2R38_HUMAN
    AccessioniPrimary (citable) accession number: P59533
    Secondary accession number(s): A4D1U6
    , P59552, Q2M3E8, Q645W3, Q86UK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3