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P59533

- T2R38_HUMAN

UniProt

P59533 - T2R38_HUMAN

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Protein
Taste receptor type 2 member 38
Gene
TAS2R38, PTC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 By similarity.

GO - Molecular functioni

  1. bitter taste receptor activity Source: UniProt
Complete GO annotation...

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 38
Short name:
T2R38
Alternative name(s):
PTC bitter taste receptor
Taste receptor type 2 member 61
Short name:
T2R61
Gene namesi
Name:TAS2R38
Synonyms:PTC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:9584. TAS2R38.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717Extracellular Reviewed prediction
Add
BLAST
Transmembranei18 – 3821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini39 – 5517Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei56 – 7621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini77 – 9418Extracellular Reviewed prediction
Add
BLAST
Transmembranei95 – 11521Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini116 – 14227Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini164 – 19027Extracellular Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini212 – 25140Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini273 – 2764Extracellular Reviewed prediction
Transmembranei277 – 29721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini298 – 33336Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

MIMi171200. phenotype.
PharmGKBiPA33936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Taste receptor type 2 member 38
PRO_0000082273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59533.
PRIDEiP59533.

PTM databases

PhosphoSiteiP59533.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Gene expression databases

ArrayExpressiP59533.
CleanExiHS_TAS2R38.
GenevestigatoriP59533.

Organism-specific databases

HPAiHPA043862.
HPA054366.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331291.

Structurei

3D structure databases

ProteinModelPortaliP59533.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43295.
HOGENOMiHOG000041379.
HOVERGENiHBG098741.
InParanoidiP59533.
KOiK08474.
OMAiHMRTMKV.
OrthoDBiEOG7J447B.
PhylomeDBiP59533.
TreeFamiTF335891.

Family and domain databases

InterProiIPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59533-1 [UniParc]FASTAAdd to Basket

« Hide

MLTLTRIRTV SYEVRSTFLF ISVLEFAVGF LTNAFVFLVN FWDVVKRQAL    50
SNSDCVLLCL SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAIIMLWM 100
IANQANLWLA ACLSLLYCSK LIRFSHTFLI CLASWVSRKI SQMLLGIILC 150
SCICTVLCVW CFFSRPHFTV TTVLFMNNNT RLNWQIKDLN LFYSFLFCYL 200
WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRNSRDPSLE AHIKALKSLV 250
SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAILISG 300
NAKLRRAVMT ILLWAQSSLK VRADHKADSR TLC 333
Length:333
Mass (Da):37,892
Last modified:June 21, 2005 - v3
Checksum:iE3B5EDD5AB99994C
GO

Polymorphismi

Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting) [MIMi:171200]; also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled. Genetic studies have demonstrated complex inheritance for this trait. For some people (and some chimpanzees also), the chemical PTC tastes very bitter. For others, it is tasteless. Actually, substantial variation in taste sensitivity exists in human. Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491A → P.1 Publication
Corresponds to variant rs713598 [ dbSNP | Ensembl ].
VAR_017860
Natural varianti262 – 2621A → V.5 Publications
Corresponds to variant rs1726866 [ dbSNP | Ensembl ].
VAR_017861
Natural varianti296 – 2961I → V.1 Publication
Corresponds to variant rs10246939 [ dbSNP | Ensembl ].
VAR_017862

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti186 – 1861I → N in AAM19322. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494231 Genomic DNA. Translation: AAM19322.1.
AY114095 Genomic DNA. Translation: AAM63545.1.
AY258598 Genomic DNA. Translation: AAP14667.1.
AY724960 Genomic DNA. Translation: AAU21156.1.
CH236950 Genomic DNA. Translation: EAL24011.1.
CH471070 Genomic DNA. Translation: EAW83993.1.
BC104933 mRNA. Translation: AAI04934.1.
BC104937 mRNA. Translation: AAI04938.1.
CCDSiCCDS34765.1.
RefSeqiNP_789787.4. NM_176817.4.
UniGeneiHs.647085.

Genome annotation databases

EnsembliENST00000547270; ENSP00000448219; ENSG00000257138.
ENST00000567903; ENSP00000455619; ENSG00000260696.
GeneIDi5726.
KEGGihsa:5726.
UCSCiuc003vwx.1. human.

Polymorphism databases

DMDMi68068016.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

A tail of protection - Issue 119 of July 2010

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF494231 Genomic DNA. Translation: AAM19322.1 .
AY114095 Genomic DNA. Translation: AAM63545.1 .
AY258598 Genomic DNA. Translation: AAP14667.1 .
AY724960 Genomic DNA. Translation: AAU21156.1 .
CH236950 Genomic DNA. Translation: EAL24011.1 .
CH471070 Genomic DNA. Translation: EAW83993.1 .
BC104933 mRNA. Translation: AAI04934.1 .
BC104937 mRNA. Translation: AAI04938.1 .
CCDSi CCDS34765.1.
RefSeqi NP_789787.4. NM_176817.4.
UniGenei Hs.647085.

3D structure databases

ProteinModelPortali P59533.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331291.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P59533.

Polymorphism databases

DMDMi 68068016.

Proteomic databases

PaxDbi P59533.
PRIDEi P59533.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000547270 ; ENSP00000448219 ; ENSG00000257138 .
ENST00000567903 ; ENSP00000455619 ; ENSG00000260696 .
GeneIDi 5726.
KEGGi hsa:5726.
UCSCi uc003vwx.1. human.

Organism-specific databases

CTDi 5726.
GeneCardsi GC07M141672.
H-InvDB HIX0033729.
HGNCi HGNC:9584. TAS2R38.
HPAi HPA043862.
HPA054366.
MIMi 171200. phenotype.
607751. gene.
neXtProti NX_P59533.
PharmGKBi PA33936.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43295.
HOGENOMi HOG000041379.
HOVERGENi HBG098741.
InParanoidi P59533.
KOi K08474.
OMAi HMRTMKV.
OrthoDBi EOG7J447B.
PhylomeDBi P59533.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_18319. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii TAS2R38.
GenomeRNAii 5726.
NextBioi 22262.
PROi P59533.
SOURCEi Search...

Gene expression databases

ArrayExpressi P59533.
CleanExi HS_TAS2R38.
Genevestigatori P59533.

Family and domain databases

InterProi IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."
    Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.
    Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-262.
  2. "Identification and characterization of human taste receptor genes belonging to the TAS2R family."
    Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.
    Cytogenet. Genome Res. 98:45-53(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide."
    Kim U.-K., Jorgenson E., Coon H., Leppert M., Risch N., Drayna D.T.
    Science 299:1221-1225(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-49 AND VAL-296.
  4. "Evolution of bitter taste receptors in humans and apes."
    Fischer A., Gilad Y., Man O., Paeaebo S.
    Mol. Biol. Evol. 22:432-436(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-262.
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-262.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-262.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-262.
  8. Cited for: REVIEW.
  9. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiT2R38_HUMAN
AccessioniPrimary (citable) accession number: P59533
Secondary accession number(s): A4D1U6
, P59552, Q2M3E8, Q645W3, Q86UK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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