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P59530

- TA2R7_MOUSE

UniProt

P59530 - TA2R7_MOUSE

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Protein

Taste receptor type 2 member 7

Gene

Tas2r7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: Ensembl

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 7
Short name:
T2R7
Alternative name(s):
STC7-4
T2R30
T2R6
mT2R42
Gene namesi
Name:Tas2r7
Synonyms:Tas2r130, Tas2r6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2681278. Tas2r130.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence Analysis
Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini31 – 4919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini71 – 10131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 1286CytoplasmicSequence Analysis
Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini150 – 18738ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 23527CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini257 – 26610ExtracellularSequence Analysis
Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini288 – 31225CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Taste receptor type 2 member 7PRO_0000082217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP59530.

PTM databases

PhosphoSiteiP59530.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues.

Gene expression databases

GenevestigatoriP59530.

Structurei

3D structure databases

ProteinModelPortaliP59530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45213.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59530.
KOiK08474.
OMAiWIKWRID.
OrthoDBiEOG72C512.
PhylomeDBiP59530.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59530-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTYETDTTLM LVAVGEALVG ILGNAFIALV NFMGWMKNRK IASIDLILSS
60 70 80 90 100
VAMSRICLQC IILLDCIILV QYPDTYNRGK EMRTVDFFWT LTNHLSVWFA
110 120 130 140 150
TCLSIFYLFK IANFFHPLFL WIKWRIDKLI LRTLLACVII SLCFSLPVTE
160 170 180 190 200
NLSDDFRRCV KTKERINSTL RCKVNKAGHA SVKVNLNLVM LFPFSVSLVS
210 220 230 240 250
FLLLILSLWR HTRQIQLSVT GYKDPSTTAH VKAMKAVISF LALFVVYCLA
260 270 280 290 300
FLIATSSYFM PESELAVIWG ELIALIYPSS HSFILILGSS KLKQASVRVL
310
CRVKTMLKGK KY
Length:312
Mass (Da):35,510
Last modified:April 11, 2003 - v1
Checksum:i73EBE2CA794AAF22
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661C → G in AAL85200. (PubMed:11854532)Curated
Sequence conflicti84 – 852TV → II in AAL85200. (PubMed:11854532)Curated
Sequence conflicti107 – 1082YL → HF in AAL85200. (PubMed:11854532)Curated
Sequence conflicti138 – 1403VII → LIL in AAL85200. (PubMed:11854532)Curated
Sequence conflicti153 – 1531S → T in AAL85200. (PubMed:11854532)Curated
Sequence conflicti174 – 1741V → L in AAL85200. (PubMed:11854532)Curated
Sequence conflicti179 – 1791H → Y in AAL85200. (PubMed:11854532)Curated
Sequence conflicti215 – 2151I → M in AAL85200. (PubMed:11854532)Curated
Sequence conflicti218 – 2181S → N in AAL85200. (PubMed:11854532)Curated
Sequence conflicti223 – 2231K → N in AAL85200. (PubMed:11854532)Curated
Sequence conflicti234 – 2341M → T in AAL85200. (PubMed:11854532)Curated
Sequence conflicti242 – 2421A → V in AAL85200. (PubMed:11854532)Curated
Sequence conflicti245 – 2451V → I in AAL85200. (PubMed:11854532)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462604 Genomic DNA. Translation: AAO14564.1.
AX097857 Genomic DNA. No translation available.
AC140204 Genomic DNA. No translation available.
BC119329 mRNA. Translation: AAI19330.1.
AF412303 mRNA. Translation: AAL85200.1.
BK001071 Genomic DNA. Translation: DAA01210.1.
CCDSiCCDS20608.1.
RefSeqiNP_954607.1. NM_199156.1.
UniGeneiMm.377916.

Genome annotation databases

EnsembliENSMUST00000067597; ENSMUSP00000063954; ENSMUSG00000054497.
GeneIDi387355.
KEGGimmu:387355.
UCSCiuc009eiv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462604 Genomic DNA. Translation: AAO14564.1 .
AX097857 Genomic DNA. No translation available.
AC140204 Genomic DNA. No translation available.
BC119329 mRNA. Translation: AAI19330.1 .
AF412303 mRNA. Translation: AAL85200.1 .
BK001071 Genomic DNA. Translation: DAA01210.1 .
CCDSi CCDS20608.1.
RefSeqi NP_954607.1. NM_199156.1.
UniGenei Mm.377916.

3D structure databases

ProteinModelPortali P59530.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P59530.

Proteomic databases

PRIDEi P59530.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067597 ; ENSMUSP00000063954 ; ENSMUSG00000054497 .
GeneIDi 387355.
KEGGi mmu:387355.
UCSCi uc009eiv.1. mouse.

Organism-specific databases

CTDi 387355.
MGIi MGI:2681278. Tas2r130.

Phylogenomic databases

eggNOGi NOG45213.
GeneTreei ENSGT00760000119096.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi P59530.
KOi K08474.
OMAi WIKWRID.
OrthoDBi EOG72C512.
PhylomeDBi P59530.
TreeFami TF335891.

Enzyme and pathway databases

Reactomei REACT_250376. G alpha (i) signalling events.
REACT_262510. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi 405886.
PROi P59530.
SOURCEi Search...

Gene expression databases

Genevestigatori P59530.

Family and domain databases

InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus."
    Scalzo A.A., Wheat R., Dubbelde C., Stone L., Clark P., Du Y., Dong N., Stoll J., Yokoyama W.M., Brown M.G.
    Immunogenetics 55:370-378(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells."
    Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.
    Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-280.
  6. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: REVIEW.
  8. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R7_MOUSE
AccessioniPrimary (citable) accession number: P59530
Secondary accession number(s): Q0VE81, Q7M726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3