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Protein

Taste receptor type 2 member 7

Gene

Tas2r7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

GO - Molecular functioni

  1. bitter taste receptor activity Source: MGI

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_336829. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 7
Short name:
T2R7
Alternative name(s):
STC7-4
T2R30
T2R6
mT2R42
Gene namesi
Name:Tas2r7
Synonyms:Tas2r130, Tas2r6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2681278. Tas2r130.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence Analysis
Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini31 – 4919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini71 – 10131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 1286CytoplasmicSequence Analysis
Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini150 – 18738ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 23527CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini257 – 26610ExtracellularSequence Analysis
Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini288 – 31225CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Taste receptor type 2 member 7PRO_0000082217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP59530.

PTM databases

PhosphoSiteiP59530.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues.

Gene expression databases

GenevestigatoriP59530.

Structurei

3D structure databases

ProteinModelPortaliP59530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45213.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59530.
KOiK08474.
OMAiWIKWRID.
OrthoDBiEOG72C512.
PhylomeDBiP59530.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
IPR030053. TAS2R7.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PTHR11394:SF58. PTHR11394:SF58. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYETDTTLM LVAVGEALVG ILGNAFIALV NFMGWMKNRK IASIDLILSS
60 70 80 90 100
VAMSRICLQC IILLDCIILV QYPDTYNRGK EMRTVDFFWT LTNHLSVWFA
110 120 130 140 150
TCLSIFYLFK IANFFHPLFL WIKWRIDKLI LRTLLACVII SLCFSLPVTE
160 170 180 190 200
NLSDDFRRCV KTKERINSTL RCKVNKAGHA SVKVNLNLVM LFPFSVSLVS
210 220 230 240 250
FLLLILSLWR HTRQIQLSVT GYKDPSTTAH VKAMKAVISF LALFVVYCLA
260 270 280 290 300
FLIATSSYFM PESELAVIWG ELIALIYPSS HSFILILGSS KLKQASVRVL
310
CRVKTMLKGK KY
Length:312
Mass (Da):35,510
Last modified:April 11, 2003 - v1
Checksum:i73EBE2CA794AAF22
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661C → G in AAL85200 (PubMed:11854532).Curated
Sequence conflicti84 – 852TV → II in AAL85200 (PubMed:11854532).Curated
Sequence conflicti107 – 1082YL → HF in AAL85200 (PubMed:11854532).Curated
Sequence conflicti138 – 1403VII → LIL in AAL85200 (PubMed:11854532).Curated
Sequence conflicti153 – 1531S → T in AAL85200 (PubMed:11854532).Curated
Sequence conflicti174 – 1741V → L in AAL85200 (PubMed:11854532).Curated
Sequence conflicti179 – 1791H → Y in AAL85200 (PubMed:11854532).Curated
Sequence conflicti215 – 2151I → M in AAL85200 (PubMed:11854532).Curated
Sequence conflicti218 – 2181S → N in AAL85200 (PubMed:11854532).Curated
Sequence conflicti223 – 2231K → N in AAL85200 (PubMed:11854532).Curated
Sequence conflicti234 – 2341M → T in AAL85200 (PubMed:11854532).Curated
Sequence conflicti242 – 2421A → V in AAL85200 (PubMed:11854532).Curated
Sequence conflicti245 – 2451V → I in AAL85200 (PubMed:11854532).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462604 Genomic DNA. Translation: AAO14564.1.
AX097857 Genomic DNA. No translation available.
AC140204 Genomic DNA. No translation available.
BC119329 mRNA. Translation: AAI19330.1.
AF412303 mRNA. Translation: AAL85200.1.
BK001071 Genomic DNA. Translation: DAA01210.1.
CCDSiCCDS20608.1.
RefSeqiNP_954607.1. NM_199156.1.
UniGeneiMm.377916.

Genome annotation databases

EnsembliENSMUST00000067597; ENSMUSP00000063954; ENSMUSG00000054497.
GeneIDi387355.
KEGGimmu:387355.
UCSCiuc009eiv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462604 Genomic DNA. Translation: AAO14564.1.
AX097857 Genomic DNA. No translation available.
AC140204 Genomic DNA. No translation available.
BC119329 mRNA. Translation: AAI19330.1.
AF412303 mRNA. Translation: AAL85200.1.
BK001071 Genomic DNA. Translation: DAA01210.1.
CCDSiCCDS20608.1.
RefSeqiNP_954607.1. NM_199156.1.
UniGeneiMm.377916.

3D structure databases

ProteinModelPortaliP59530.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP59530.

Proteomic databases

PRIDEiP59530.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067597; ENSMUSP00000063954; ENSMUSG00000054497.
GeneIDi387355.
KEGGimmu:387355.
UCSCiuc009eiv.1. mouse.

Organism-specific databases

CTDi387355.
MGIiMGI:2681278. Tas2r130.

Phylogenomic databases

eggNOGiNOG45213.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiP59530.
KOiK08474.
OMAiWIKWRID.
OrthoDBiEOG72C512.
PhylomeDBiP59530.
TreeFamiTF335891.

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_336829. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

NextBioi405886.
PROiP59530.
SOURCEiSearch...

Gene expression databases

GenevestigatoriP59530.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
IPR030053. TAS2R7.
[Graphical view]
PANTHERiPTHR11394. PTHR11394. 1 hit.
PTHR11394:SF58. PTHR11394:SF58. 1 hit.
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus."
    Scalzo A.A., Wheat R., Dubbelde C., Stone L., Clark P., Du Y., Dong N., Stoll J., Yokoyama W.M., Brown M.G.
    Immunogenetics 55:370-378(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells."
    Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.
    Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-280.
  6. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: REVIEW.
  8. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R7_MOUSE
AccessioniPrimary (citable) accession number: P59530
Secondary accession number(s): Q0VE81, Q7M726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: April 1, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.