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P59530

- TA2R7_MOUSE

UniProt

P59530 - TA2R7_MOUSE

Protein

Taste receptor type 2 member 7

Gene

Tas2r7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of bitter taste Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 2 member 7
    Short name:
    T2R7
    Alternative name(s):
    STC7-4
    T2R30
    T2R6
    mT2R42
    Gene namesi
    Name:Tas2r7
    Synonyms:Tas2r130, Tas2r6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2681278. Tas2r130.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Taste receptor type 2 member 7PRO_0000082217Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP59530.

    PTM databases

    PhosphoSiteiP59530.

    Expressioni

    Tissue specificityi

    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues.

    Gene expression databases

    GenevestigatoriP59530.

    Structurei

    3D structure databases

    ProteinModelPortaliP59530.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99ExtracellularSequence Analysis
    Topological domaini31 – 4919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini71 – 10131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 1286CytoplasmicSequence Analysis
    Topological domaini150 – 18738ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 23527CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26610ExtracellularSequence Analysis
    Topological domaini288 – 31225CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei50 – 7021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45213.
    GeneTreeiENSGT00560000076963.
    HOGENOMiHOG000234595.
    HOVERGENiHBG060698.
    InParanoidiQ0VE81.
    KOiK08474.
    OMAiWIKWRID.
    OrthoDBiEOG72C512.
    PhylomeDBiP59530.
    TreeFamiTF335891.

    Family and domain databases

    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view]
    PfamiPF05296. TAS2R. 1 hit.
    [Graphical view]
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59530-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTYETDTTLM LVAVGEALVG ILGNAFIALV NFMGWMKNRK IASIDLILSS    50
    VAMSRICLQC IILLDCIILV QYPDTYNRGK EMRTVDFFWT LTNHLSVWFA 100
    TCLSIFYLFK IANFFHPLFL WIKWRIDKLI LRTLLACVII SLCFSLPVTE 150
    NLSDDFRRCV KTKERINSTL RCKVNKAGHA SVKVNLNLVM LFPFSVSLVS 200
    FLLLILSLWR HTRQIQLSVT GYKDPSTTAH VKAMKAVISF LALFVVYCLA 250
    FLIATSSYFM PESELAVIWG ELIALIYPSS HSFILILGSS KLKQASVRVL 300
    CRVKTMLKGK KY 312
    Length:312
    Mass (Da):35,510
    Last modified:April 11, 2003 - v1
    Checksum:i73EBE2CA794AAF22
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661C → G in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti84 – 852TV → II in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti107 – 1082YL → HF in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti138 – 1403VII → LIL in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti153 – 1531S → T in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti174 – 1741V → L in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti179 – 1791H → Y in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti215 – 2151I → M in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti218 – 2181S → N in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti223 – 2231K → N in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti234 – 2341M → T in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti242 – 2421A → V in AAL85200. (PubMed:11854532)Curated
    Sequence conflicti245 – 2451V → I in AAL85200. (PubMed:11854532)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF462604 Genomic DNA. Translation: AAO14564.1.
    AX097857 Genomic DNA. No translation available.
    AC140204 Genomic DNA. No translation available.
    BC119329 mRNA. Translation: AAI19330.1.
    AF412303 mRNA. Translation: AAL85200.1.
    BK001071 Genomic DNA. Translation: DAA01210.1.
    CCDSiCCDS20608.1.
    RefSeqiNP_954607.1. NM_199156.1.
    UniGeneiMm.377916.

    Genome annotation databases

    EnsembliENSMUST00000067597; ENSMUSP00000063954; ENSMUSG00000054497.
    GeneIDi387355.
    KEGGimmu:387355.
    UCSCiuc009eiv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF462604 Genomic DNA. Translation: AAO14564.1 .
    AX097857 Genomic DNA. No translation available.
    AC140204 Genomic DNA. No translation available.
    BC119329 mRNA. Translation: AAI19330.1 .
    AF412303 mRNA. Translation: AAL85200.1 .
    BK001071 Genomic DNA. Translation: DAA01210.1 .
    CCDSi CCDS20608.1.
    RefSeqi NP_954607.1. NM_199156.1.
    UniGenei Mm.377916.

    3D structure databases

    ProteinModelPortali P59530.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P59530.

    Proteomic databases

    PRIDEi P59530.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067597 ; ENSMUSP00000063954 ; ENSMUSG00000054497 .
    GeneIDi 387355.
    KEGGi mmu:387355.
    UCSCi uc009eiv.1. mouse.

    Organism-specific databases

    CTDi 387355.
    MGIi MGI:2681278. Tas2r130.

    Phylogenomic databases

    eggNOGi NOG45213.
    GeneTreei ENSGT00560000076963.
    HOGENOMi HOG000234595.
    HOVERGENi HBG060698.
    InParanoidi Q0VE81.
    KOi K08474.
    OMAi WIKWRID.
    OrthoDBi EOG72C512.
    PhylomeDBi P59530.
    TreeFami TF335891.

    Miscellaneous databases

    NextBioi 405886.
    PROi P59530.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P59530.

    Family and domain databases

    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR007960. TAS2_rcpt.
    [Graphical view ]
    Pfami PF05296. TAS2R. 1 hit.
    [Graphical view ]
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus."
      Scalzo A.A., Wheat R., Dubbelde C., Stone L., Clark P., Du Y., Dong N., Stoll J., Yokoyama W.M., Brown M.G.
      Immunogenetics 55:370-378(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells."
      Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.
      Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-280.
    6. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
      Shi P., Zhang J., Yang H., Zhang Y.-P.
      Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. Cited for: REVIEW.
    8. "Molecular mechanisms of bitter and sweet taste transduction."
      Margolskee R.F.
      J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
      Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
      Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiTA2R7_MOUSE
    AccessioniPrimary (citable) accession number: P59530
    Secondary accession number(s): Q0VE81, Q7M726
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Several bitter taste receptors are expressed in a single taste receptor cell.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3