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P59530 (TA2R7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Taste receptor type 2 member 7

Short name=T2R7
Alternative name(s):
STC7-4
T2R30
T2R6
mT2R42
Gene names
Name:Tas2r7
Synonyms:Tas2r130, Tas2r6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues.

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Sequence similarities

Belongs to the G-protein coupled receptor T2R family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Taste receptor type 2 member 7
PRO_0000082217

Regions

Topological domain1 – 99Extracellular Potential
Transmembrane10 – 3021Helical; Name=1; Potential
Topological domain31 – 4919Cytoplasmic Potential
Transmembrane50 – 7021Helical; Name=2; Potential
Topological domain71 – 10131Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 1286Cytoplasmic Potential
Transmembrane129 – 14921Helical; Name=4; Potential
Topological domain150 – 18738Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 23527Cytoplasmic Potential
Transmembrane236 – 25621Helical; Name=6; Potential
Topological domain257 – 26610Extracellular Potential
Transmembrane267 – 28721Helical; Name=7; Potential
Topological domain288 – 31225Cytoplasmic Potential

Amino acid modifications

Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict661C → G in AAL85200. Ref.5
Sequence conflict84 – 852TV → II in AAL85200. Ref.5
Sequence conflict107 – 1082YL → HF in AAL85200. Ref.5
Sequence conflict138 – 1403VII → LIL in AAL85200. Ref.5
Sequence conflict1531S → T in AAL85200. Ref.5
Sequence conflict1741V → L in AAL85200. Ref.5
Sequence conflict1791H → Y in AAL85200. Ref.5
Sequence conflict2151I → M in AAL85200. Ref.5
Sequence conflict2181S → N in AAL85200. Ref.5
Sequence conflict2231K → N in AAL85200. Ref.5
Sequence conflict2341M → T in AAL85200. Ref.5
Sequence conflict2421A → V in AAL85200. Ref.5
Sequence conflict2451V → I in AAL85200. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P59530 [UniParc].

Last modified April 11, 2003. Version 1.
Checksum: 73EBE2CA794AAF22

FASTA31235,510
        10         20         30         40         50         60 
MTYETDTTLM LVAVGEALVG ILGNAFIALV NFMGWMKNRK IASIDLILSS VAMSRICLQC 

        70         80         90        100        110        120 
IILLDCIILV QYPDTYNRGK EMRTVDFFWT LTNHLSVWFA TCLSIFYLFK IANFFHPLFL 

       130        140        150        160        170        180 
WIKWRIDKLI LRTLLACVII SLCFSLPVTE NLSDDFRRCV KTKERINSTL RCKVNKAGHA 

       190        200        210        220        230        240 
SVKVNLNLVM LFPFSVSLVS FLLLILSLWR HTRQIQLSVT GYKDPSTTAH VKAMKAVISF 

       250        260        270        280        290        300 
LALFVVYCLA FLIATSSYFM PESELAVIWG ELIALIYPSS HSFILILGSS KLKQASVRVL 

       310 
CRVKTMLKGK KY 

« Hide

References

« Hide 'large scale' references
[1]"Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus."
Scalzo A.A., Wheat R., Dubbelde C., Stone L., Clark P., Du Y., Dong N., Stoll J., Yokoyama W.M., Brown M.G.
Immunogenetics 55:370-378(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"T2r taste receptor family."
Zuker C.S., Adler J.E., Ryba N., Mueller K., Hoon M.
Patent number WO0118050, 15-MAR-2001
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells."
Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.
Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-280.
[6]"Adaptive diversification of bitter taste receptor genes in mammalian evolution."
Shi P., Zhang J., Yang H., Zhang Y.-P.
Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Receptors for bitter and sweet taste."
Montmayeur J.-P., Matsunami H.
Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[8]"Molecular mechanisms of bitter and sweet taste transduction."
Margolskee R.F.
J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[9]"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF462604 Genomic DNA. Translation: AAO14564.1.
AX097857 Genomic DNA. No translation available.
AC140204 Genomic DNA. No translation available.
BC119329 mRNA. Translation: AAI19330.1.
AF412303 mRNA. Translation: AAL85200.1.
BK001071 Genomic DNA. Translation: DAA01210.1.
RefSeqNP_954607.1. NM_199156.1.
UniGeneMm.377916.

3D structure databases

ProteinModelPortalP59530.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP59530.

Proteomic databases

PRIDEP59530.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000067597; ENSMUSP00000063954; ENSMUSG00000054497.
GeneID387355.
KEGGmmu:387355.
UCSCuc009eiv.1. mouse.

Organism-specific databases

CTD387355.
MGIMGI:2681278. Tas2r130.

Phylogenomic databases

eggNOGNOG45213.
GeneTreeENSGT00560000076963.
HOGENOMHOG000234595.
HOVERGENHBG060698.
InParanoidQ0VE81.
KOK08474.
OMAWIKWRID.
OrthoDBEOG72C512.
PhylomeDBP59530.
TreeFamTF335891.

Gene expression databases

GenevestigatorP59530.

Family and domain databases

InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio405886.
PROP59530.
SOURCESearch...

Entry information

Entry nameTA2R7_MOUSE
AccessionPrimary (citable) accession number: P59530
Secondary accession number(s): Q0VE81, Q7M726
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries