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P59530

- TA2R7_MOUSE

UniProt

P59530 - TA2R7_MOUSE

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Protein
Taste receptor type 2 member 7
Gene
Tas2r7, Tas2r130, Tas2r6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 7
Short name:
T2R7
Alternative name(s):
STC7-4
T2R30
T2R6
mT2R42
Gene namesi
Name:Tas2r7
Synonyms:Tas2r130, Tas2r6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2681278. Tas2r130.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Extracellular Reviewed prediction
Transmembranei10 – 3021Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini31 – 4919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei50 – 7021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini71 – 10131Extracellular Reviewed prediction
Add
BLAST
Transmembranei102 – 12221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini123 – 1286Cytoplasmic Reviewed prediction
Transmembranei129 – 14921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini150 – 18738Extracellular Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini209 – 23527Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei236 – 25621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini257 – 26610Extracellular Reviewed prediction
Transmembranei267 – 28721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini288 – 31225Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Taste receptor type 2 member 7
PRO_0000082217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP59530.

PTM databases

PhosphoSiteiP59530.

Expressioni

Tissue specificityi

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues.

Gene expression databases

GenevestigatoriP59530.

Structurei

3D structure databases

ProteinModelPortaliP59530.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45213.
GeneTreeiENSGT00560000076963.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ0VE81.
KOiK08474.
OMAiWIKWRID.
OrthoDBiEOG72C512.
PhylomeDBiP59530.
TreeFamiTF335891.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view]
PfamiPF05296. TAS2R. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59530-1 [UniParc]FASTAAdd to Basket

« Hide

MTYETDTTLM LVAVGEALVG ILGNAFIALV NFMGWMKNRK IASIDLILSS    50
VAMSRICLQC IILLDCIILV QYPDTYNRGK EMRTVDFFWT LTNHLSVWFA 100
TCLSIFYLFK IANFFHPLFL WIKWRIDKLI LRTLLACVII SLCFSLPVTE 150
NLSDDFRRCV KTKERINSTL RCKVNKAGHA SVKVNLNLVM LFPFSVSLVS 200
FLLLILSLWR HTRQIQLSVT GYKDPSTTAH VKAMKAVISF LALFVVYCLA 250
FLIATSSYFM PESELAVIWG ELIALIYPSS HSFILILGSS KLKQASVRVL 300
CRVKTMLKGK KY 312
Length:312
Mass (Da):35,510
Last modified:April 11, 2003 - v1
Checksum:i73EBE2CA794AAF22
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661C → G in AAL85200. 1 Publication
Sequence conflicti84 – 852TV → II in AAL85200. 1 Publication
Sequence conflicti107 – 1082YL → HF in AAL85200. 1 Publication
Sequence conflicti138 – 1403VII → LIL in AAL85200. 1 Publication
Sequence conflicti153 – 1531S → T in AAL85200. 1 Publication
Sequence conflicti174 – 1741V → L in AAL85200. 1 Publication
Sequence conflicti179 – 1791H → Y in AAL85200. 1 Publication
Sequence conflicti215 – 2151I → M in AAL85200. 1 Publication
Sequence conflicti218 – 2181S → N in AAL85200. 1 Publication
Sequence conflicti223 – 2231K → N in AAL85200. 1 Publication
Sequence conflicti234 – 2341M → T in AAL85200. 1 Publication
Sequence conflicti242 – 2421A → V in AAL85200. 1 Publication
Sequence conflicti245 – 2451V → I in AAL85200. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462604 Genomic DNA. Translation: AAO14564.1.
AX097857 Genomic DNA. No translation available.
AC140204 Genomic DNA. No translation available.
BC119329 mRNA. Translation: AAI19330.1.
AF412303 mRNA. Translation: AAL85200.1.
BK001071 Genomic DNA. Translation: DAA01210.1.
CCDSiCCDS20608.1.
RefSeqiNP_954607.1. NM_199156.1.
UniGeneiMm.377916.

Genome annotation databases

EnsembliENSMUST00000067597; ENSMUSP00000063954; ENSMUSG00000054497.
GeneIDi387355.
KEGGimmu:387355.
UCSCiuc009eiv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF462604 Genomic DNA. Translation: AAO14564.1 .
AX097857 Genomic DNA. No translation available.
AC140204 Genomic DNA. No translation available.
BC119329 mRNA. Translation: AAI19330.1 .
AF412303 mRNA. Translation: AAL85200.1 .
BK001071 Genomic DNA. Translation: DAA01210.1 .
CCDSi CCDS20608.1.
RefSeqi NP_954607.1. NM_199156.1.
UniGenei Mm.377916.

3D structure databases

ProteinModelPortali P59530.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P59530.

Proteomic databases

PRIDEi P59530.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067597 ; ENSMUSP00000063954 ; ENSMUSG00000054497 .
GeneIDi 387355.
KEGGi mmu:387355.
UCSCi uc009eiv.1. mouse.

Organism-specific databases

CTDi 387355.
MGIi MGI:2681278. Tas2r130.

Phylogenomic databases

eggNOGi NOG45213.
GeneTreei ENSGT00560000076963.
HOGENOMi HOG000234595.
HOVERGENi HBG060698.
InParanoidi Q0VE81.
KOi K08474.
OMAi WIKWRID.
OrthoDBi EOG72C512.
PhylomeDBi P59530.
TreeFami TF335891.

Miscellaneous databases

NextBioi 405886.
PROi P59530.
SOURCEi Search...

Gene expression databases

Genevestigatori P59530.

Family and domain databases

InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. TAS2_rcpt.
[Graphical view ]
Pfami PF05296. TAS2R. 1 hit.
[Graphical view ]
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus."
    Scalzo A.A., Wheat R., Dubbelde C., Stone L., Clark P., Du Y., Dong N., Stoll J., Yokoyama W.M., Brown M.G.
    Immunogenetics 55:370-378(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells."
    Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.
    Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-280.
  6. "Adaptive diversification of bitter taste receptor genes in mammalian evolution."
    Shi P., Zhang J., Yang H., Zhang Y.-P.
    Mol. Biol. Evol. 20:805-814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: REVIEW.
  8. "Molecular mechanisms of bitter and sweet taste transduction."
    Margolskee R.F.
    J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."
    Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.
    Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTA2R7_MOUSE
AccessioniPrimary (citable) accession number: P59530
Secondary accession number(s): Q0VE81, Q7M726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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