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P59523 (UPPP_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:bbp_058
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151124

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane247 – 26721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P59523 [UniParc].

Last modified April 11, 2003. Version 1.
Checksum: 9827B94F40E54FA6

FASTA26830,326
        10         20         30         40         50         60 
MTMTTNIFNA IILGIVEGIT EFFPISSSGH LLIFTNILEM KNNEIKILNT IIQTGAALSI 

        70         80         90        100        110        120 
LLHFKEKFVI FLEQIFICKQ ITKKNDLIYH HIILGNIPII FIGLCIYQYI KYLSNFYSII 

       130        140        150        160        170        180 
YALIFGTILL ILTEISKTKI SSNKNIETPQ ILIIGIFQCL ALWPGFSRSC ATISAGILSG 

       190        200        210        220        230        240 
LKQSKSVEFS FILSVPIFFG ASVLDVINNF YDISINNIPM LFSGFLSAFI TSNIVIKRCL 

       250        260 
NTMKNCSLIP FIIYRSILSI IIYLFFMH 

« Hide

References

[1]"Reductive genome evolution in Buchnera aphidicola."
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016826 Genomic DNA. Translation: AAO26797.1.
RefSeqNP_777692.1. NC_004545.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224915.bbp058.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO26797; AAO26797; bbp_058.
GeneID1058524.
KEGGbab:bbp058.
PATRIC21244889. VBIBucAph80364_0055.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycBAPH224915:GJ9D-58-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_BUCBP
AccessionPrimary (citable) accession number: P59523
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families