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P59510

- ATS20_HUMAN

UniProt

P59510 - ATS20_HUMAN

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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 20

Gene

ADAMTS20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi403 – 4031Zinc; catalyticBy similarity
Active sitei404 – 4041PROSITE-ProRule annotation
Metal bindingi407 – 4071Zinc; catalyticBy similarity
Metal bindingi413 – 4131Zinc; catalyticBy similarity

GO - Molecular functioni

  1. metalloendopeptidase activity Source: Ensembl
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. extracellular matrix organization Source: Ensembl
  2. negative regulation of apoptotic process Source: Ensembl
  3. positive regulation of melanocyte differentiation Source: Ensembl
  4. positive regulation of signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

Protein family/group databases

MEROPSiM12.246.

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 20 (EC:3.4.24.-)
Short name:
ADAM-TS 20
Short name:
ADAM-TS20
Short name:
ADAMTS-20
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17178. ADAMTS20.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 253232By similarityPRO_0000029206Add
BLAST
Chaini254 – 19101657A disintegrin and metalloproteinase with thrombospondin motifs 20PRO_0000029207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi334 ↔ 387By similarity
Disulfide bondi363 ↔ 369By similarity
Disulfide bondi381 ↔ 462By similarity
Disulfide bondi419 ↔ 446By similarity
Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi489 ↔ 511By similarity
Disulfide bondi500 ↔ 521By similarity
Disulfide bondi506 ↔ 540By similarity
Disulfide bondi534 ↔ 545By similarity
Disulfide bondi568 ↔ 605By similarity
Disulfide bondi572 ↔ 610By similarity
Disulfide bondi583 ↔ 595By similarity
Glycosylationi702 – 7021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi717 – 7171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi728 – 7281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi809 – 8091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi870 – 8701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1061 – 10611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1456 – 14561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1542 – 15421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1572 – 15721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1763 – 17631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1781 – 17811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1852 – 18521N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP59510.
PRIDEiP59510.

PTM databases

PhosphoSiteiP59510.

Expressioni

Tissue specificityi

Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas.

Gene expression databases

BgeeiP59510.
CleanExiHS_ADAMTS20.
ExpressionAtlasiP59510. baseline.
GenevestigatoriP59510.

Organism-specific databases

HPAiHPA027608.
HPA027609.

Interactioni

Protein-protein interaction databases

IntActiP59510. 1 interaction.
STRINGi9606.ENSP00000374071.

Structurei

3D structure databases

ProteinModelPortaliP59510.
SMRiP59510. Positions 259-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 467209Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini468 – 55588DisintegrinAdd
BLAST
Domaini556 – 61156TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini846 – 90459TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini905 – 96157TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini966 – 102358TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini1024 – 107350TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini1076 – 113560TSP type-1 6PROSITE-ProRule annotationAdd
BLAST
Domaini1152 – 120655TSP type-1 7PROSITE-ProRule annotationAdd
BLAST
Domaini1207 – 126458TSP type-1 8PROSITE-ProRule annotationAdd
BLAST
Domaini1304 – 135653TSP type-1 9PROSITE-ProRule annotationAdd
BLAST
Domaini1358 – 141659TSP type-1 10PROSITE-ProRule annotationAdd
BLAST
Domaini1417 – 147559TSP type-1 11PROSITE-ProRule annotationAdd
BLAST
Domaini1476 – 153156TSP type-1 12PROSITE-ProRule annotationAdd
BLAST
Domaini1535 – 158854TSP type-1 13PROSITE-ProRule annotationAdd
BLAST
Domaini1589 – 165264TSP type-1 14PROSITE-ProRule annotationAdd
BLAST
Domaini1654 – 171057TSP type-1 15PROSITE-ProRule annotationAdd
BLAST
Domaini1711 – 1910200GONPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni724 – 846123SpacerAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi612 – 723112Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.Curated
Contains 1 GON domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation
Contains 15 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG237764.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000004798.
HOVERGENiHBG037334.
InParanoidiP59510.
KOiK09609.
OMAiPWGPYSS.
OrthoDBiEOG7WDN1M.
PhylomeDBiP59510.
TreeFamiTF331949.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR012314. Pept_M12B_GON-ADAMTSs.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08685. GON. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 11 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 13 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 12 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS51046. GON. 1 hit.
PS50092. TSP1. 12 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59510-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVAKWLTGL LYHLSLFITR SWEVDFHPRQ EALVRTLTSY EVVIPERVNE
60 70 80 90 100
FGEVFPQSHH FSRQKRSSEA LEPMPFRTHY RFTAYGQLFQ LNLTADASFL
110 120 130 140 150
AAGYTEVHLG TPERGAWESD AGPSDLRHCF YRGQVNSQED YKAVVSLCGG
160 170 180 190 200
LTGTFKGQNG EYFLEPIMKA DGNEYEDGHN KPHLIYRQDL NNSFLQTLKY
210 220 230 240 250
CSVSESQIKE TSLPFHTYSN MNEDLNVMKE RVLGHTSKNV PLKDERRHSR
260 270 280 290 300
KKRLISYPRY IEIMVTADAK VVSAHGSNLQ NYILTLMSIV ATIYKDPSIG
310 320 330 340 350
NLIHIVVVKL VMIHREEEGP VINFDGATTL KNFCSWQQTQ NDLDDVHPSH
360 370 380 390 400
HDTAVLITRE DICSSKEKCN MLGLSYLGTI CDPLQSCFIN EEKGLISAFT
410 420 430 440 450
IAHELGHTLG VQHDDNPRCK EMKVTKYHVM APALSFHMSP WSWSNCSRKY
460 470 480 490 500
VTEFLDTGYG ECLLDKPDEE IYNLPSELPG SRYDGNKQCE LAFGPGSQMC
510 520 530 540 550
PHINICMHLW CTSTEKLHKG CFTQHVPPAD GTDCGPGMHC RHGLCVNKET
560 570 580 590 600
ETRPVNGEWG PWEPYSSCSR TCGGGIESAT RRCNRPEPRN GGNYCVGRRM
610 620 630 640 650
KFRSCNTDSC PKGTQDFREK QCSDFNGKHL DISGIPSNVR WLPRYSGIGT
660 670 680 690 700
KDRCKLYCQV AGTNYFYLLK DMVEDGTPCG TETHDICVQG QCMAAGCDHV
710 720 730 740 750
LNSSAKIDKC GVCGGDNSSC KTITGVFNSS HYGYNVVVKI PAGATNVDIR
760 770 780 790 800
QYSYSGQPDD SYLALSDAEG NFLFNGNFLL STSKKEINVQ GTRTVIEYSG
810 820 830 840 850
SNNAVERINS TNRQEKEILI EVLCVGNLYN PDVHYSFNIP LEERSDMFTW
860 870 880 890 900
DPYGPWEGCT KMCQGLQRRN ITCIHKSDHS VVSDKECDHL PLPSFVTQSC
910 920 930 940 950
NTDCELRWHV IGKSECSSQC GQGYRTLDIH CMKYSIHEGQ TVQVDDHYCG
960 970 980 990 1000
DQLKPPTQEL CHGNCVFTRW HYSEWSQCSR SCGGGERSRE SYCMNNFGHR
1010 1020 1030 1040 1050
LADNECQELS RVTRENCNEF SCPSWAASEW SECLVTCGKG TKQRQVWCQL
1060 1070 1080 1090 1100
NVDHLSDGFC NSSTKPESLS PCELHTCASW QVGPWGPCTT TCGHGYQMRD
1110 1120 1130 1140 1150
VKCVNELASA VLEDTECHEA SRPSDRQSCV LTPCSFISKL ETALLPTVLI
1160 1170 1180 1190 1200
KKMAQWRHGS WTPCSVSCGR GTQARYVSCR DALDRIADES YCAHLPRPAE
1210 1220 1230 1240 1250
IWDCFTPCGE WQAGDWSPCS ASCGHGKTTR QVLCMNYHQP IDENYCDPEV
1260 1270 1280 1290 1300
RPLMEQECSL AACPPAHSHF PSSPVQPSYY LSTNLPLTQK LEDNENQVVH
1310 1320 1330 1340 1350
PSVRGNQWRT GPWGSCSSSC SGGLQHRAVV CQDENGQSAS YCDAASKPPE
1360 1370 1380 1390 1400
LQQCGPGPCP QWNYGNWGEC SQTCGGGIKS RLVICQFPNG QILEDHNCEI
1410 1420 1430 1440 1450
VNKPPSVIQC HMHACPADVS WHQEPWTSCS ASCGKGRKYR EVFCIDQFQR
1460 1470 1480 1490 1500
KLEDTNCSQV QKPPTHKACR SVRCPSWKAN SWNECSVTCG SGVQQRDVYC
1510 1520 1530 1540 1550
RLKGVGQVVE EMCDQSTRPC SQRRCWSQDC VQHKGMERGR LNCSTSCERK
1560 1570 1580 1590 1600
DSHQRMECTD NQIRQVNEIV YNSSTISLTS KNCRNPPCNY IVVTADSSQC
1610 1620 1630 1640 1650
ANNCGFSYRQ RITYCTEIPS TKKHKLHRLR PIVYQECPVV PSSQVYQCIN
1660 1670 1680 1690 1700
SCLHLATWKV GKWSKCSVTC GIGIMKRQVK CITKHGLSSD LCLNHLKPGA
1710 1720 1730 1740 1750
QKKCYANDCK SFTTCKEIQV KNHIRKDGDY YLNIKGRIIK IYCADMYLEN
1760 1770 1780 1790 1800
PKEYLTLVQG EENFSEVYGF RLKNPYQCPF NGSRREDCEC DNGHLAAGYT
1810 1820 1830 1840 1850
VFSKIRIDLT SMQIKTTDLL FSKTIFGNAV PFATAGDCYS AFRCPQGQFS
1860 1870 1880 1890 1900
INLSGTGMKI SSTAKWLTQG SYTSVSIRRS EDGTRFFGKC GGYCGKCLPH
1910
MTTGLPIQVI
Length:1,910
Mass (Da):214,721
Last modified:December 16, 2008 - v2
Checksum:iD7FFCB0D56F4B6D9
GO
Isoform 2 (identifier: P59510-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     683-693: THDICVQGQCM → SYNIDCNCVLK
     1429-1504: CSASCGKGRK...QRDVYCRLKG → EDLKVKLLPQ...GDLKYYKNSL
     1505-1910: Missing.

Show »
Length:1,504
Mass (Da):169,506
Checksum:i2F9D75248EE885DF
GO
Isoform 3 (identifier: P59510-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: ILIE → LILQ

Show »
Length:1,910
Mass (Da):214,720
Checksum:i93AA3B0AC1B9C6D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521T → V in CAD56159. (PubMed:12562771)Curated
Sequence conflicti152 – 1521T → V in CAD56160. (PubMed:12562771)Curated
Sequence conflicti360 – 3601E → Y in CAD56159. (PubMed:12562771)Curated
Sequence conflicti360 – 3601E → Y in CAD56160. (PubMed:12562771)Curated
Sequence conflicti371 – 3711M → T in AAO15766. (PubMed:12514189)Curated
Sequence conflicti456 – 4561D → E in CAD56159. (PubMed:12562771)Curated
Sequence conflicti456 – 4561D → E in CAD56160. (PubMed:12562771)Curated
Sequence conflicti648 – 6481I → V in CAD56159. (PubMed:12562771)Curated
Sequence conflicti648 – 6481I → V in CAD56160. (PubMed:12562771)Curated
Sequence conflicti792 – 7932Missing in CAD56159. (PubMed:12562771)Curated
Sequence conflicti792 – 7932Missing in CAD56160. (PubMed:12562771)Curated
Sequence conflicti908 – 9125WHVIG → GMLLAK in AAO15766. (PubMed:12514189)Curated
Sequence conflicti1315 – 13151S → Q in CAD56159. (PubMed:12562771)Curated
Sequence conflicti1315 – 13151S → Q in CAD56160. (PubMed:12562771)Curated
Sequence conflicti1327 – 13271R → T in AAO15766. (PubMed:12514189)Curated
Sequence conflicti1816 – 18161T → A in CAD56159. (PubMed:12562771)Curated
Sequence conflicti1881 – 18811E → Q in CAD56159. (PubMed:12562771)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti876 – 8761K → M.
Corresponds to variant rs7302446 [ dbSNP | Ensembl ].
VAR_057088
Natural varianti1000 – 10001R → H.
Corresponds to variant rs7297737 [ dbSNP | Ensembl ].
VAR_057089
Natural varianti1273 – 12731S → F.
Corresponds to variant rs7310011 [ dbSNP | Ensembl ].
VAR_057090

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei683 – 69311THDICVQGQCM → SYNIDCNCVLK in isoform 2. 1 PublicationVSP_007106Add
BLAST
Alternative sequencei818 – 8214ILIE → LILQ in isoform 3. 1 PublicationVSP_047084
Alternative sequencei1429 – 150476CSASC…CRLKG → EDLKVKLLPQRTIILWELMK NIFCHGKHSHMYLINVVTDH LLYPRHCDPETIETYFLSLW SLQFTWGDLKYYKNSL in isoform 2. 1 PublicationVSP_007107Add
BLAST
Alternative sequencei1505 – 1910406Missing in isoform 2. 1 PublicationVSP_007108Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF488804 mRNA. Translation: AAO15766.1.
AJ515153 mRNA. Translation: CAD56159.3.
AJ515154 mRNA. Translation: CAD56160.2.
AC090525 Genomic DNA. No translation available.
AC107018 Genomic DNA. No translation available.
AC120104 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57861.1.
CCDSiCCDS31778.2. [P59510-3]
RefSeqiNP_079279.3. NM_025003.3.
UniGeneiHs.287554.

Genome annotation databases

EnsembliENST00000389420; ENSP00000374071; ENSG00000173157. [P59510-3]
ENST00000615814; ENSP00000484172; ENSG00000173157. [P59510-1]
GeneIDi80070.
KEGGihsa:80070.
UCSCiuc010skx.2. human.

Polymorphism databases

DMDMi218511943.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF488804 mRNA. Translation: AAO15766.1 .
AJ515153 mRNA. Translation: CAD56159.3 .
AJ515154 mRNA. Translation: CAD56160.2 .
AC090525 Genomic DNA. No translation available.
AC107018 Genomic DNA. No translation available.
AC120104 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57861.1 .
CCDSi CCDS31778.2. [P59510-3 ]
RefSeqi NP_079279.3. NM_025003.3.
UniGenei Hs.287554.

3D structure databases

ProteinModelPortali P59510.
SMRi P59510. Positions 259-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P59510. 1 interaction.
STRINGi 9606.ENSP00000374071.

Protein family/group databases

MEROPSi M12.246.

PTM databases

PhosphoSitei P59510.

Polymorphism databases

DMDMi 218511943.

Proteomic databases

PaxDbi P59510.
PRIDEi P59510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389420 ; ENSP00000374071 ; ENSG00000173157 . [P59510-3 ]
ENST00000615814 ; ENSP00000484172 ; ENSG00000173157 . [P59510-1 ]
GeneIDi 80070.
KEGGi hsa:80070.
UCSCi uc010skx.2. human.

Organism-specific databases

CTDi 80070.
GeneCardsi GC12M043715.
HGNCi HGNC:17178. ADAMTS20.
HPAi HPA027608.
HPA027609.
MIMi 611681. gene.
neXtProti NX_P59510.
PharmGKBi PA134901626.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237764.
GeneTreei ENSGT00760000118885.
HOGENOMi HOG000004798.
HOVERGENi HBG037334.
InParanoidi P59510.
KOi K09609.
OMAi PWGPYSS.
OrthoDBi EOG7WDN1M.
PhylomeDBi P59510.
TreeFami TF331949.

Enzyme and pathway databases

Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii 80070.
NextBioi 35537418.
PROi P59510.
SOURCEi Search...

Gene expression databases

Bgeei P59510.
CleanExi HS_ADAMTS20.
ExpressionAtlasi P59510. baseline.
Genevestigatori P59510.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR012314. Pept_M12B_GON-ADAMTSs.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF08685. GON. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 11 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00209. TSP1. 13 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 12 hits.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS51046. GON. 1 hit.
PS50092. TSP1. 12 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1."
    Somerville R.P., Longpre J.-M., Jungers K.A., Engle J.M., Ross M., Evanko S., Wight T.N., Leduc R., Apte S.S.
    J. Biol. Chem. 278:9503-9513(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain."
    Llamazares M., Cal S., Quesada V., Lopez-Otin C.
    J. Biol. Chem. 278:13382-13389(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiATS20_HUMAN
AccessioniPrimary (citable) accession number: P59510
Secondary accession number(s): A6NNC9, J3QT00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3