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P59510

- ATS20_HUMAN

UniProt

P59510 - ATS20_HUMAN

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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 20

Gene
ADAMTS20
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi403 – 4031Zinc; catalytic By similarity
Active sitei404 – 4041 By similarity
Metal bindingi407 – 4071Zinc; catalytic By similarity
Metal bindingi413 – 4131Zinc; catalytic By similarity

GO - Molecular functioni

  1. metalloendopeptidase activity Source: Ensembl
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. extracellular matrix organization Source: Ensembl
  2. negative regulation of apoptotic process Source: Ensembl
  3. positive regulation of melanocyte differentiation Source: Ensembl
  4. positive regulation of signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

Protein family/group databases

MEROPSiM12.246.

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 20 (EC:3.4.24.-)
Short name:
ADAM-TS 20
Short name:
ADAM-TS20
Short name:
ADAMTS-20
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17178. ADAMTS20.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Propeptidei22 – 253232 By similarityPRO_0000029206Add
BLAST
Chaini254 – 19101657A disintegrin and metalloproteinase with thrombospondin motifs 20PRO_0000029207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi334 ↔ 387 By similarity
Disulfide bondi363 ↔ 369 By similarity
Disulfide bondi381 ↔ 462 By similarity
Disulfide bondi419 ↔ 446 By similarity
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi489 ↔ 511 By similarity
Disulfide bondi500 ↔ 521 By similarity
Disulfide bondi506 ↔ 540 By similarity
Disulfide bondi534 ↔ 545 By similarity
Disulfide bondi568 ↔ 605 By similarity
Disulfide bondi572 ↔ 610 By similarity
Disulfide bondi583 ↔ 595 By similarity
Glycosylationi702 – 7021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi717 – 7171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi728 – 7281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi809 – 8091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi870 – 8701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1061 – 10611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1456 – 14561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1542 – 15421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1572 – 15721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1763 – 17631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1781 – 17811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1852 – 18521N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase By similarity.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP59510.
PRIDEiP59510.

PTM databases

PhosphoSiteiP59510.

Expressioni

Tissue specificityi

Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas.

Gene expression databases

BgeeiP59510.
CleanExiHS_ADAMTS20.
GenevestigatoriP59510.

Organism-specific databases

HPAiHPA027608.
HPA027609.

Interactioni

Protein-protein interaction databases

IntActiP59510. 1 interaction.
STRINGi9606.ENSP00000374071.

Structurei

3D structure databases

ProteinModelPortaliP59510.
SMRiP59510. Positions 259-729.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 467209Peptidase M12BAdd
BLAST
Domaini468 – 55588DisintegrinAdd
BLAST
Domaini556 – 61156TSP type-1 1Add
BLAST
Domaini846 – 90459TSP type-1 2Add
BLAST
Domaini905 – 96157TSP type-1 3Add
BLAST
Domaini966 – 102358TSP type-1 4Add
BLAST
Domaini1024 – 107350TSP type-1 5Add
BLAST
Domaini1076 – 113560TSP type-1 6Add
BLAST
Domaini1152 – 120655TSP type-1 7Add
BLAST
Domaini1207 – 126458TSP type-1 8Add
BLAST
Domaini1304 – 135653TSP type-1 9Add
BLAST
Domaini1358 – 141659TSP type-1 10Add
BLAST
Domaini1417 – 147559TSP type-1 11Add
BLAST
Domaini1476 – 153156TSP type-1 12Add
BLAST
Domaini1535 – 158854TSP type-1 13Add
BLAST
Domaini1589 – 165264TSP type-1 14Add
BLAST
Domaini1654 – 171057TSP type-1 15Add
BLAST
Domaini1711 – 1910200GONAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni724 – 846123SpacerAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi612 – 723112Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.
Contains 1 GON domain.
Contains 15 TSP type-1 domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG237764.
HOGENOMiHOG000004798.
HOVERGENiHBG037334.
InParanoidiP59510.
KOiK09609.
OMAiPWGPYSS.
OrthoDBiEOG7WDN1M.
PhylomeDBiP59510.
TreeFamiTF331949.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR012314. Pept_M12B_GON-ADAMTSs.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08685. GON. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 11 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 13 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 12 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS51046. GON. 1 hit.
PS50092. TSP1. 12 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59510-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWVAKWLTGL LYHLSLFITR SWEVDFHPRQ EALVRTLTSY EVVIPERVNE     50
FGEVFPQSHH FSRQKRSSEA LEPMPFRTHY RFTAYGQLFQ LNLTADASFL 100
AAGYTEVHLG TPERGAWESD AGPSDLRHCF YRGQVNSQED YKAVVSLCGG 150
LTGTFKGQNG EYFLEPIMKA DGNEYEDGHN KPHLIYRQDL NNSFLQTLKY 200
CSVSESQIKE TSLPFHTYSN MNEDLNVMKE RVLGHTSKNV PLKDERRHSR 250
KKRLISYPRY IEIMVTADAK VVSAHGSNLQ NYILTLMSIV ATIYKDPSIG 300
NLIHIVVVKL VMIHREEEGP VINFDGATTL KNFCSWQQTQ NDLDDVHPSH 350
HDTAVLITRE DICSSKEKCN MLGLSYLGTI CDPLQSCFIN EEKGLISAFT 400
IAHELGHTLG VQHDDNPRCK EMKVTKYHVM APALSFHMSP WSWSNCSRKY 450
VTEFLDTGYG ECLLDKPDEE IYNLPSELPG SRYDGNKQCE LAFGPGSQMC 500
PHINICMHLW CTSTEKLHKG CFTQHVPPAD GTDCGPGMHC RHGLCVNKET 550
ETRPVNGEWG PWEPYSSCSR TCGGGIESAT RRCNRPEPRN GGNYCVGRRM 600
KFRSCNTDSC PKGTQDFREK QCSDFNGKHL DISGIPSNVR WLPRYSGIGT 650
KDRCKLYCQV AGTNYFYLLK DMVEDGTPCG TETHDICVQG QCMAAGCDHV 700
LNSSAKIDKC GVCGGDNSSC KTITGVFNSS HYGYNVVVKI PAGATNVDIR 750
QYSYSGQPDD SYLALSDAEG NFLFNGNFLL STSKKEINVQ GTRTVIEYSG 800
SNNAVERINS TNRQEKEILI EVLCVGNLYN PDVHYSFNIP LEERSDMFTW 850
DPYGPWEGCT KMCQGLQRRN ITCIHKSDHS VVSDKECDHL PLPSFVTQSC 900
NTDCELRWHV IGKSECSSQC GQGYRTLDIH CMKYSIHEGQ TVQVDDHYCG 950
DQLKPPTQEL CHGNCVFTRW HYSEWSQCSR SCGGGERSRE SYCMNNFGHR 1000
LADNECQELS RVTRENCNEF SCPSWAASEW SECLVTCGKG TKQRQVWCQL 1050
NVDHLSDGFC NSSTKPESLS PCELHTCASW QVGPWGPCTT TCGHGYQMRD 1100
VKCVNELASA VLEDTECHEA SRPSDRQSCV LTPCSFISKL ETALLPTVLI 1150
KKMAQWRHGS WTPCSVSCGR GTQARYVSCR DALDRIADES YCAHLPRPAE 1200
IWDCFTPCGE WQAGDWSPCS ASCGHGKTTR QVLCMNYHQP IDENYCDPEV 1250
RPLMEQECSL AACPPAHSHF PSSPVQPSYY LSTNLPLTQK LEDNENQVVH 1300
PSVRGNQWRT GPWGSCSSSC SGGLQHRAVV CQDENGQSAS YCDAASKPPE 1350
LQQCGPGPCP QWNYGNWGEC SQTCGGGIKS RLVICQFPNG QILEDHNCEI 1400
VNKPPSVIQC HMHACPADVS WHQEPWTSCS ASCGKGRKYR EVFCIDQFQR 1450
KLEDTNCSQV QKPPTHKACR SVRCPSWKAN SWNECSVTCG SGVQQRDVYC 1500
RLKGVGQVVE EMCDQSTRPC SQRRCWSQDC VQHKGMERGR LNCSTSCERK 1550
DSHQRMECTD NQIRQVNEIV YNSSTISLTS KNCRNPPCNY IVVTADSSQC 1600
ANNCGFSYRQ RITYCTEIPS TKKHKLHRLR PIVYQECPVV PSSQVYQCIN 1650
SCLHLATWKV GKWSKCSVTC GIGIMKRQVK CITKHGLSSD LCLNHLKPGA 1700
QKKCYANDCK SFTTCKEIQV KNHIRKDGDY YLNIKGRIIK IYCADMYLEN 1750
PKEYLTLVQG EENFSEVYGF RLKNPYQCPF NGSRREDCEC DNGHLAAGYT 1800
VFSKIRIDLT SMQIKTTDLL FSKTIFGNAV PFATAGDCYS AFRCPQGQFS 1850
INLSGTGMKI SSTAKWLTQG SYTSVSIRRS EDGTRFFGKC GGYCGKCLPH 1900
MTTGLPIQVI 1910
Length:1,910
Mass (Da):214,721
Last modified:December 16, 2008 - v2
Checksum:iD7FFCB0D56F4B6D9
GO
Isoform 2 (identifier: P59510-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     683-693: THDICVQGQCM → SYNIDCNCVLK
     1429-1504: CSASCGKGRK...QRDVYCRLKG → EDLKVKLLPQ...GDLKYYKNSL
     1505-1910: Missing.

Show »
Length:1,504
Mass (Da):169,506
Checksum:i2F9D75248EE885DF
GO
Isoform 3 (identifier: P59510-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: ILIE → LILQ

Show »
Length:1,910
Mass (Da):214,720
Checksum:i93AA3B0AC1B9C6D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti876 – 8761K → M.
Corresponds to variant rs7302446 [ dbSNP | Ensembl ].
VAR_057088
Natural varianti1000 – 10001R → H.
Corresponds to variant rs7297737 [ dbSNP | Ensembl ].
VAR_057089
Natural varianti1273 – 12731S → F.
Corresponds to variant rs7310011 [ dbSNP | Ensembl ].
VAR_057090

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei683 – 69311THDICVQGQCM → SYNIDCNCVLK in isoform 2. VSP_007106Add
BLAST
Alternative sequencei818 – 8214ILIE → LILQ in isoform 3. VSP_047084
Alternative sequencei1429 – 150476CSASC…CRLKG → EDLKVKLLPQRTIILWELMK NIFCHGKHSHMYLINVVTDH LLYPRHCDPETIETYFLSLW SLQFTWGDLKYYKNSL in isoform 2. VSP_007107Add
BLAST
Alternative sequencei1505 – 1910406Missing in isoform 2. VSP_007108Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521T → V in CAD56159. 1 Publication
Sequence conflicti152 – 1521T → V in CAD56160. 1 Publication
Sequence conflicti360 – 3601E → Y in CAD56159. 1 Publication
Sequence conflicti360 – 3601E → Y in CAD56160. 1 Publication
Sequence conflicti371 – 3711M → T in AAO15766. 1 Publication
Sequence conflicti456 – 4561D → E in CAD56159. 1 Publication
Sequence conflicti456 – 4561D → E in CAD56160. 1 Publication
Sequence conflicti648 – 6481I → V in CAD56159. 1 Publication
Sequence conflicti648 – 6481I → V in CAD56160. 1 Publication
Sequence conflicti792 – 7932Missing in CAD56159. 1 Publication
Sequence conflicti792 – 7932Missing in CAD56160. 1 Publication
Sequence conflicti908 – 9125WHVIG → GMLLAK in AAO15766. 1 Publication
Sequence conflicti1315 – 13151S → Q in CAD56159. 1 Publication
Sequence conflicti1315 – 13151S → Q in CAD56160. 1 Publication
Sequence conflicti1327 – 13271R → T in AAO15766. 1 Publication
Sequence conflicti1816 – 18161T → A in CAD56159. 1 Publication
Sequence conflicti1881 – 18811E → Q in CAD56159. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF488804 mRNA. Translation: AAO15766.1.
AJ515153 mRNA. Translation: CAD56159.3.
AJ515154 mRNA. Translation: CAD56160.2.
AC090525 Genomic DNA. No translation available.
AC107018 Genomic DNA. No translation available.
AC120104 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57861.1.
CCDSiCCDS31778.2. [P59510-3]
RefSeqiNP_079279.3. NM_025003.3.
UniGeneiHs.287554.

Genome annotation databases

EnsembliENST00000389420; ENSP00000374071; ENSG00000173157. [P59510-3]
GeneIDi80070.
KEGGihsa:80070.
UCSCiuc010skx.2. human.

Polymorphism databases

DMDMi218511943.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF488804 mRNA. Translation: AAO15766.1 .
AJ515153 mRNA. Translation: CAD56159.3 .
AJ515154 mRNA. Translation: CAD56160.2 .
AC090525 Genomic DNA. No translation available.
AC107018 Genomic DNA. No translation available.
AC120104 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57861.1 .
CCDSi CCDS31778.2. [P59510-3 ]
RefSeqi NP_079279.3. NM_025003.3.
UniGenei Hs.287554.

3D structure databases

ProteinModelPortali P59510.
SMRi P59510. Positions 259-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P59510. 1 interaction.
STRINGi 9606.ENSP00000374071.

Protein family/group databases

MEROPSi M12.246.

PTM databases

PhosphoSitei P59510.

Polymorphism databases

DMDMi 218511943.

Proteomic databases

PaxDbi P59510.
PRIDEi P59510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389420 ; ENSP00000374071 ; ENSG00000173157 . [P59510-3 ]
GeneIDi 80070.
KEGGi hsa:80070.
UCSCi uc010skx.2. human.

Organism-specific databases

CTDi 80070.
GeneCardsi GC12M043715.
HGNCi HGNC:17178. ADAMTS20.
HPAi HPA027608.
HPA027609.
MIMi 611681. gene.
neXtProti NX_P59510.
PharmGKBi PA134901626.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237764.
HOGENOMi HOG000004798.
HOVERGENi HBG037334.
InParanoidi P59510.
KOi K09609.
OMAi PWGPYSS.
OrthoDBi EOG7WDN1M.
PhylomeDBi P59510.
TreeFami TF331949.

Enzyme and pathway databases

Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii 80070.
NextBioi 35537418.
PROi P59510.
SOURCEi Search...

Gene expression databases

Bgeei P59510.
CleanExi HS_ADAMTS20.
Genevestigatori P59510.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR012314. Pept_M12B_GON-ADAMTSs.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF08685. GON. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 11 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00209. TSP1. 13 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 12 hits.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS51046. GON. 1 hit.
PS50092. TSP1. 12 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1."
    Somerville R.P., Longpre J.-M., Jungers K.A., Engle J.M., Ross M., Evanko S., Wight T.N., Leduc R., Apte S.S.
    J. Biol. Chem. 278:9503-9513(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain."
    Llamazares M., Cal S., Quesada V., Lopez-Otin C.
    J. Biol. Chem. 278:13382-13389(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiATS20_HUMAN
AccessioniPrimary (citable) accession number: P59510
Secondary accession number(s): A6NNC9, J3QT00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 16, 2008
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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