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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 20

Gene

ADAMTS20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi403Zinc; catalyticBy similarity1
Active sitei404PROSITE-ProRule annotation1
Metal bindingi407Zinc; catalyticBy similarity1
Metal bindingi413Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Protein family/group databases

MEROPSiM12.246.

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 20 (EC:3.4.24.-)
Short name:
ADAM-TS 20
Short name:
ADAM-TS20
Short name:
ADAMTS-20
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17178. ADAMTS20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi80070.
OpenTargetsiENSG00000173157.
PharmGKBiPA134901626.

Polymorphism and mutation databases

BioMutaiADAMTS20.
DMDMi218511943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002920622 – 253By similarityAdd BLAST232
ChainiPRO_0000029207254 – 1910A disintegrin and metalloproteinase with thrombospondin motifs 20Add BLAST1657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi334 ↔ 387By similarity
Disulfide bondi363 ↔ 369By similarity
Disulfide bondi381 ↔ 462By similarity
Disulfide bondi419 ↔ 446By similarity
Glycosylationi445N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi489 ↔ 511By similarity
Disulfide bondi500 ↔ 521By similarity
Disulfide bondi506 ↔ 540By similarity
Disulfide bondi534 ↔ 545By similarity
Disulfide bondi568 ↔ 605By similarity
Disulfide bondi572 ↔ 610By similarity
Disulfide bondi583 ↔ 595By similarity
Glycosylationi702N-linked (GlcNAc...)Sequence analysis1
Glycosylationi717N-linked (GlcNAc...)Sequence analysis1
Glycosylationi728N-linked (GlcNAc...)Sequence analysis1
Glycosylationi809N-linked (GlcNAc...)Sequence analysis1
Glycosylationi870N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1061N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1456N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1542N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1572N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1763N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1781N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1852N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP59510.
PeptideAtlasiP59510.
PRIDEiP59510.

PTM databases

iPTMnetiP59510.
PhosphoSitePlusiP59510.

Expressioni

Tissue specificityi

Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas.

Gene expression databases

BgeeiENSG00000173157.
CleanExiHS_ADAMTS20.
ExpressionAtlasiP59510. baseline and differential.
GenevisibleiP59510. HS.

Organism-specific databases

HPAiHPA027608.
HPA027609.

Interactioni

Protein-protein interaction databases

IntActiP59510. 1 interactor.
STRINGi9606.ENSP00000374071.

Structurei

3D structure databases

ProteinModelPortaliP59510.
SMRiP59510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 467Peptidase M12BPROSITE-ProRule annotationAdd BLAST209
Domaini468 – 555DisintegrinAdd BLAST88
Domaini556 – 611TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini846 – 904TSP type-1 2PROSITE-ProRule annotationAdd BLAST59
Domaini905 – 961TSP type-1 3PROSITE-ProRule annotationAdd BLAST57
Domaini966 – 1023TSP type-1 4PROSITE-ProRule annotationAdd BLAST58
Domaini1024 – 1073TSP type-1 5PROSITE-ProRule annotationAdd BLAST50
Domaini1076 – 1135TSP type-1 6PROSITE-ProRule annotationAdd BLAST60
Domaini1152 – 1206TSP type-1 7PROSITE-ProRule annotationAdd BLAST55
Domaini1207 – 1264TSP type-1 8PROSITE-ProRule annotationAdd BLAST58
Domaini1304 – 1356TSP type-1 9PROSITE-ProRule annotationAdd BLAST53
Domaini1358 – 1416TSP type-1 10PROSITE-ProRule annotationAdd BLAST59
Domaini1417 – 1475TSP type-1 11PROSITE-ProRule annotationAdd BLAST59
Domaini1476 – 1531TSP type-1 12PROSITE-ProRule annotationAdd BLAST56
Domaini1535 – 1588TSP type-1 13PROSITE-ProRule annotationAdd BLAST54
Domaini1589 – 1652TSP type-1 14PROSITE-ProRule annotationAdd BLAST64
Domaini1654 – 1710TSP type-1 15PROSITE-ProRule annotationAdd BLAST57
Domaini1711 – 1910GONPROSITE-ProRule annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni724 – 846SpacerAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi612 – 723Cys-richAdd BLAST112

Sequence similaritiesi

Contains 1 disintegrin domain.Curated
Contains 1 GON domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation
Contains 15 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XPKZ. LUCA.
GeneTreeiENSGT00760000118880.
HOGENOMiHOG000004798.
HOVERGENiHBG037334.
InParanoidiP59510.
KOiK09609.
OMAiCGPGMHC.
OrthoDBiEOG091G00AX.
PhylomeDBiP59510.
TreeFamiTF331949.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR012314. Pept_M12B_GON-ADAMTSs.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08685. GON. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 11 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 13 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 12 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS51046. GON. 1 hit.
PS50092. TSP1. 12 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59510-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVAKWLTGL LYHLSLFITR SWEVDFHPRQ EALVRTLTSY EVVIPERVNE
60 70 80 90 100
FGEVFPQSHH FSRQKRSSEA LEPMPFRTHY RFTAYGQLFQ LNLTADASFL
110 120 130 140 150
AAGYTEVHLG TPERGAWESD AGPSDLRHCF YRGQVNSQED YKAVVSLCGG
160 170 180 190 200
LTGTFKGQNG EYFLEPIMKA DGNEYEDGHN KPHLIYRQDL NNSFLQTLKY
210 220 230 240 250
CSVSESQIKE TSLPFHTYSN MNEDLNVMKE RVLGHTSKNV PLKDERRHSR
260 270 280 290 300
KKRLISYPRY IEIMVTADAK VVSAHGSNLQ NYILTLMSIV ATIYKDPSIG
310 320 330 340 350
NLIHIVVVKL VMIHREEEGP VINFDGATTL KNFCSWQQTQ NDLDDVHPSH
360 370 380 390 400
HDTAVLITRE DICSSKEKCN MLGLSYLGTI CDPLQSCFIN EEKGLISAFT
410 420 430 440 450
IAHELGHTLG VQHDDNPRCK EMKVTKYHVM APALSFHMSP WSWSNCSRKY
460 470 480 490 500
VTEFLDTGYG ECLLDKPDEE IYNLPSELPG SRYDGNKQCE LAFGPGSQMC
510 520 530 540 550
PHINICMHLW CTSTEKLHKG CFTQHVPPAD GTDCGPGMHC RHGLCVNKET
560 570 580 590 600
ETRPVNGEWG PWEPYSSCSR TCGGGIESAT RRCNRPEPRN GGNYCVGRRM
610 620 630 640 650
KFRSCNTDSC PKGTQDFREK QCSDFNGKHL DISGIPSNVR WLPRYSGIGT
660 670 680 690 700
KDRCKLYCQV AGTNYFYLLK DMVEDGTPCG TETHDICVQG QCMAAGCDHV
710 720 730 740 750
LNSSAKIDKC GVCGGDNSSC KTITGVFNSS HYGYNVVVKI PAGATNVDIR
760 770 780 790 800
QYSYSGQPDD SYLALSDAEG NFLFNGNFLL STSKKEINVQ GTRTVIEYSG
810 820 830 840 850
SNNAVERINS TNRQEKEILI EVLCVGNLYN PDVHYSFNIP LEERSDMFTW
860 870 880 890 900
DPYGPWEGCT KMCQGLQRRN ITCIHKSDHS VVSDKECDHL PLPSFVTQSC
910 920 930 940 950
NTDCELRWHV IGKSECSSQC GQGYRTLDIH CMKYSIHEGQ TVQVDDHYCG
960 970 980 990 1000
DQLKPPTQEL CHGNCVFTRW HYSEWSQCSR SCGGGERSRE SYCMNNFGHR
1010 1020 1030 1040 1050
LADNECQELS RVTRENCNEF SCPSWAASEW SECLVTCGKG TKQRQVWCQL
1060 1070 1080 1090 1100
NVDHLSDGFC NSSTKPESLS PCELHTCASW QVGPWGPCTT TCGHGYQMRD
1110 1120 1130 1140 1150
VKCVNELASA VLEDTECHEA SRPSDRQSCV LTPCSFISKL ETALLPTVLI
1160 1170 1180 1190 1200
KKMAQWRHGS WTPCSVSCGR GTQARYVSCR DALDRIADES YCAHLPRPAE
1210 1220 1230 1240 1250
IWDCFTPCGE WQAGDWSPCS ASCGHGKTTR QVLCMNYHQP IDENYCDPEV
1260 1270 1280 1290 1300
RPLMEQECSL AACPPAHSHF PSSPVQPSYY LSTNLPLTQK LEDNENQVVH
1310 1320 1330 1340 1350
PSVRGNQWRT GPWGSCSSSC SGGLQHRAVV CQDENGQSAS YCDAASKPPE
1360 1370 1380 1390 1400
LQQCGPGPCP QWNYGNWGEC SQTCGGGIKS RLVICQFPNG QILEDHNCEI
1410 1420 1430 1440 1450
VNKPPSVIQC HMHACPADVS WHQEPWTSCS ASCGKGRKYR EVFCIDQFQR
1460 1470 1480 1490 1500
KLEDTNCSQV QKPPTHKACR SVRCPSWKAN SWNECSVTCG SGVQQRDVYC
1510 1520 1530 1540 1550
RLKGVGQVVE EMCDQSTRPC SQRRCWSQDC VQHKGMERGR LNCSTSCERK
1560 1570 1580 1590 1600
DSHQRMECTD NQIRQVNEIV YNSSTISLTS KNCRNPPCNY IVVTADSSQC
1610 1620 1630 1640 1650
ANNCGFSYRQ RITYCTEIPS TKKHKLHRLR PIVYQECPVV PSSQVYQCIN
1660 1670 1680 1690 1700
SCLHLATWKV GKWSKCSVTC GIGIMKRQVK CITKHGLSSD LCLNHLKPGA
1710 1720 1730 1740 1750
QKKCYANDCK SFTTCKEIQV KNHIRKDGDY YLNIKGRIIK IYCADMYLEN
1760 1770 1780 1790 1800
PKEYLTLVQG EENFSEVYGF RLKNPYQCPF NGSRREDCEC DNGHLAAGYT
1810 1820 1830 1840 1850
VFSKIRIDLT SMQIKTTDLL FSKTIFGNAV PFATAGDCYS AFRCPQGQFS
1860 1870 1880 1890 1900
INLSGTGMKI SSTAKWLTQG SYTSVSIRRS EDGTRFFGKC GGYCGKCLPH
1910
MTTGLPIQVI
Length:1,910
Mass (Da):214,721
Last modified:December 16, 2008 - v2
Checksum:iD7FFCB0D56F4B6D9
GO
Isoform 2 (identifier: P59510-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     683-693: THDICVQGQCM → SYNIDCNCVLK
     1429-1504: CSASCGKGRK...QRDVYCRLKG → EDLKVKLLPQ...GDLKYYKNSL
     1505-1910: Missing.

Show »
Length:1,504
Mass (Da):169,506
Checksum:i2F9D75248EE885DF
GO
Isoform 3 (identifier: P59510-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: ILIE → LILQ

Show »
Length:1,910
Mass (Da):214,720
Checksum:i93AA3B0AC1B9C6D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152T → V in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti152T → V in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti360E → Y in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti360E → Y in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti371M → T in AAO15766 (PubMed:12514189).Curated1
Sequence conflicti456D → E in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti456D → E in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti648I → V in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti648I → V in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti792 – 793Missing in CAD56159 (PubMed:12562771).Curated2
Sequence conflicti792 – 793Missing in CAD56160 (PubMed:12562771).Curated2
Sequence conflicti908 – 912WHVIG → GMLLAK in AAO15766 (PubMed:12514189).Curated5
Sequence conflicti1315S → Q in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti1315S → Q in CAD56160 (PubMed:12562771).Curated1
Sequence conflicti1327R → T in AAO15766 (PubMed:12514189).Curated1
Sequence conflicti1816T → A in CAD56159 (PubMed:12562771).Curated1
Sequence conflicti1881E → Q in CAD56159 (PubMed:12562771).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057088876K → M.Corresponds to variant rs7302446dbSNPEnsembl.1
Natural variantiVAR_0570891000R → H.Corresponds to variant rs7297737dbSNPEnsembl.1
Natural variantiVAR_0570901273S → F.Corresponds to variant rs7310011dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007106683 – 693THDICVQGQCM → SYNIDCNCVLK in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_047084818 – 821ILIE → LILQ in isoform 3. 1 Publication4
Alternative sequenceiVSP_0071071429 – 1504CSASC…CRLKG → EDLKVKLLPQRTIILWELMK NIFCHGKHSHMYLINVVTDH LLYPRHCDPETIETYFLSLW SLQFTWGDLKYYKNSL in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_0071081505 – 1910Missing in isoform 2. 1 PublicationAdd BLAST406

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488804 mRNA. Translation: AAO15766.1.
AJ515153 mRNA. Translation: CAD56159.3.
AJ515154 mRNA. Translation: CAD56160.2.
AC090525 Genomic DNA. No translation available.
AC107018 Genomic DNA. No translation available.
AC120104 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57861.1.
CCDSiCCDS31778.2. [P59510-3]
RefSeqiNP_079279.3. NM_025003.3.
UniGeneiHs.287554.

Genome annotation databases

EnsembliENST00000389420; ENSP00000374071; ENSG00000173157. [P59510-3]
GeneIDi80070.
KEGGihsa:80070.
UCSCiuc010skx.3. human. [P59510-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488804 mRNA. Translation: AAO15766.1.
AJ515153 mRNA. Translation: CAD56159.3.
AJ515154 mRNA. Translation: CAD56160.2.
AC090525 Genomic DNA. No translation available.
AC107018 Genomic DNA. No translation available.
AC120104 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57861.1.
CCDSiCCDS31778.2. [P59510-3]
RefSeqiNP_079279.3. NM_025003.3.
UniGeneiHs.287554.

3D structure databases

ProteinModelPortaliP59510.
SMRiP59510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP59510. 1 interactor.
STRINGi9606.ENSP00000374071.

Protein family/group databases

MEROPSiM12.246.

PTM databases

iPTMnetiP59510.
PhosphoSitePlusiP59510.

Polymorphism and mutation databases

BioMutaiADAMTS20.
DMDMi218511943.

Proteomic databases

PaxDbiP59510.
PeptideAtlasiP59510.
PRIDEiP59510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389420; ENSP00000374071; ENSG00000173157. [P59510-3]
GeneIDi80070.
KEGGihsa:80070.
UCSCiuc010skx.3. human. [P59510-1]

Organism-specific databases

CTDi80070.
DisGeNETi80070.
GeneCardsiADAMTS20.
HGNCiHGNC:17178. ADAMTS20.
HPAiHPA027608.
HPA027609.
MIMi611681. gene.
neXtProtiNX_P59510.
OpenTargetsiENSG00000173157.
PharmGKBiPA134901626.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XPKZ. LUCA.
GeneTreeiENSGT00760000118880.
HOGENOMiHOG000004798.
HOVERGENiHBG037334.
InParanoidiP59510.
KOiK09609.
OMAiCGPGMHC.
OrthoDBiEOG091G00AX.
PhylomeDBiP59510.
TreeFamiTF331949.

Enzyme and pathway databases

ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

GenomeRNAii80070.
PROiP59510.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173157.
CleanExiHS_ADAMTS20.
ExpressionAtlasiP59510. baseline and differential.
GenevisibleiP59510. HS.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR012314. Pept_M12B_GON-ADAMTSs.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08685. GON. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 11 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 13 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 12 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS51046. GON. 1 hit.
PS50092. TSP1. 12 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATS20_HUMAN
AccessioniPrimary (citable) accession number: P59510
Secondary accession number(s): A6NNC9, J3QT00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.