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P59499

- GLMS_BUCBP

UniProt

P59499 - GLMS_BUCBP

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei605 – 6051For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-28-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:bbp_028
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135313Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224915.bbp028.

    Structurei

    3D structure databases

    ProteinModelPortaliP59499.
    SMRiP59499. Positions 2-610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 220219Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini289 – 429141SIS 1UniRule annotationAdd
    BLAST
    Domaini461 – 600140SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59499-1 [UniParc]FASTAAdd to Basket

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    MCGIISAISK KNVTNILIEG MKRLEYRGYD SSGLAIINKK KEIIRLRSQG    50
    KIKNIINLIH KTKQLIGNIG IAHTRWATHG LALKKNAHPH VSKNIAIVHN 100
    GIIENYLNIK TKLQKNGYIF TSDTDTEVIA HLIHYEQNKN NKSLLKTIQT 150
    VILKLTGSYS MVIMDRYHPN ILIAIRSGSP LLIGLGKQEN FISSDQLSLL 200
    KITKKFIYLN EGDIAILSHK KITIFNKNSI LVHRPIVISN IQNDSITKGH 250
    YQHYMKKEIY EQPYAIKNAI RNRITKNEKI QFSELNNNAH ALLLKIEHID 300
    IIACGTSYNA GMVSKYWFES LSKISCNVEI ASEFCHRKFI VKKNSLLLIL 350
    SQSGETADSL TALRNSKKHE YLGSLVICNS SSSSLVYESN FSILTNAGIE 400
    IGVASTKSFT TQLTILLMIA AKINNLKTND EKIENKVAKT LRLLPEITKN 450
    VLKCDSLIYS LAKELSDKNN IIFIGRGHNY PIAMEGALKL KEISYTHAEA 500
    YAAGELKHGP LALVDSSTQI IVIAPNDNLI DKIKLNISEI RTRGGVLHIF 550
    SDNLTKFNDN TNVIRLPYDG ILLSPIIYVI PLQLLAYYVA LIKGKNIDKP 600
    RNLAKSVTVE 610
    Length:610
    Mass (Da):68,386
    Last modified:January 23, 2007 - v2
    Checksum:i795DDDC357D0FF57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO26771.1.
    RefSeqiNP_777666.1. NC_004545.1.
    WP_011091172.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO26771; AAO26771; bbp_028.
    GeneIDi1058365.
    KEGGibab:bbp028.
    PATRICi21244827. VBIBucAph80364_0028.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO26771.1 .
    RefSeqi NP_777666.1. NC_004545.1.
    WP_011091172.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali P59499.
    SMRi P59499. Positions 2-610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp028.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO26771 ; AAO26771 ; bbp_028 .
    GeneIDi 1058365.
    KEGGi bab:bbp028.
    PATRICi 21244827. VBIBucAph80364_0028.

    Phylogenomic databases

    eggNOGi COG0449.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci BAPH224915:GJ9D-28-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiGLMS_BUCBP
    AccessioniPrimary (citable) accession number: P59499
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3