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P59499

- GLMS_BUCBP

UniProt

P59499 - GLMS_BUCBP

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, bbp_028
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei605 – 6051For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-28-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:bbp_028
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135313Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224915.bbp028.

Structurei

3D structure databases

ProteinModelPortaliP59499.
SMRiP59499. Positions 2-610.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 220219Glutamine amidotransferase type-2
Add
BLAST
Domaini289 – 429141SIS 1
Add
BLAST
Domaini461 – 600140SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59499-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIISAISK KNVTNILIEG MKRLEYRGYD SSGLAIINKK KEIIRLRSQG    50
KIKNIINLIH KTKQLIGNIG IAHTRWATHG LALKKNAHPH VSKNIAIVHN 100
GIIENYLNIK TKLQKNGYIF TSDTDTEVIA HLIHYEQNKN NKSLLKTIQT 150
VILKLTGSYS MVIMDRYHPN ILIAIRSGSP LLIGLGKQEN FISSDQLSLL 200
KITKKFIYLN EGDIAILSHK KITIFNKNSI LVHRPIVISN IQNDSITKGH 250
YQHYMKKEIY EQPYAIKNAI RNRITKNEKI QFSELNNNAH ALLLKIEHID 300
IIACGTSYNA GMVSKYWFES LSKISCNVEI ASEFCHRKFI VKKNSLLLIL 350
SQSGETADSL TALRNSKKHE YLGSLVICNS SSSSLVYESN FSILTNAGIE 400
IGVASTKSFT TQLTILLMIA AKINNLKTND EKIENKVAKT LRLLPEITKN 450
VLKCDSLIYS LAKELSDKNN IIFIGRGHNY PIAMEGALKL KEISYTHAEA 500
YAAGELKHGP LALVDSSTQI IVIAPNDNLI DKIKLNISEI RTRGGVLHIF 550
SDNLTKFNDN TNVIRLPYDG ILLSPIIYVI PLQLLAYYVA LIKGKNIDKP 600
RNLAKSVTVE 610
Length:610
Mass (Da):68,386
Last modified:January 23, 2007 - v2
Checksum:i795DDDC357D0FF57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26771.1.
RefSeqiNP_777666.1. NC_004545.1.
WP_011091172.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26771; AAO26771; bbp_028.
GeneIDi1058365.
KEGGibab:bbp028.
PATRICi21244827. VBIBucAph80364_0028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26771.1 .
RefSeqi NP_777666.1. NC_004545.1.
WP_011091172.1. NC_004545.1.

3D structure databases

ProteinModelPortali P59499.
SMRi P59499. Positions 2-610.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224915.bbp028.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO26771 ; AAO26771 ; bbp_028 .
GeneIDi 1058365.
KEGGi bab:bbp028.
PATRICi 21244827. VBIBucAph80364_0028.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci BAPH224915:GJ9D-28-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiGLMS_BUCBP
AccessioniPrimary (citable) accession number: P59499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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