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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei605For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:bbp_028
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353132 – 610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST609

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224915.bbp028.

Structurei

3D structure databases

ProteinModelPortaliP59499.
SMRiP59499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 220Glutamine amidotransferase type-2UniRule annotationAdd BLAST219
Domaini289 – 429SIS 1UniRule annotationAdd BLAST141
Domaini461 – 600SIS 2UniRule annotationAdd BLAST140

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiASEYRYA.
OrthoDBiPOG091H0061.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIISAISK KNVTNILIEG MKRLEYRGYD SSGLAIINKK KEIIRLRSQG
60 70 80 90 100
KIKNIINLIH KTKQLIGNIG IAHTRWATHG LALKKNAHPH VSKNIAIVHN
110 120 130 140 150
GIIENYLNIK TKLQKNGYIF TSDTDTEVIA HLIHYEQNKN NKSLLKTIQT
160 170 180 190 200
VILKLTGSYS MVIMDRYHPN ILIAIRSGSP LLIGLGKQEN FISSDQLSLL
210 220 230 240 250
KITKKFIYLN EGDIAILSHK KITIFNKNSI LVHRPIVISN IQNDSITKGH
260 270 280 290 300
YQHYMKKEIY EQPYAIKNAI RNRITKNEKI QFSELNNNAH ALLLKIEHID
310 320 330 340 350
IIACGTSYNA GMVSKYWFES LSKISCNVEI ASEFCHRKFI VKKNSLLLIL
360 370 380 390 400
SQSGETADSL TALRNSKKHE YLGSLVICNS SSSSLVYESN FSILTNAGIE
410 420 430 440 450
IGVASTKSFT TQLTILLMIA AKINNLKTND EKIENKVAKT LRLLPEITKN
460 470 480 490 500
VLKCDSLIYS LAKELSDKNN IIFIGRGHNY PIAMEGALKL KEISYTHAEA
510 520 530 540 550
YAAGELKHGP LALVDSSTQI IVIAPNDNLI DKIKLNISEI RTRGGVLHIF
560 570 580 590 600
SDNLTKFNDN TNVIRLPYDG ILLSPIIYVI PLQLLAYYVA LIKGKNIDKP
610
RNLAKSVTVE
Length:610
Mass (Da):68,386
Last modified:January 23, 2007 - v2
Checksum:i795DDDC357D0FF57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO26771.1.
RefSeqiWP_011091172.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26771; AAO26771; bbp_028.
KEGGibab:bbp_028.

Similar proteinsi

Entry informationi

Entry nameiGLMS_BUCBP
AccessioniPrimary (citable) accession number: P59499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome