P59490 (PTH_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	bbp_179

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]

Taxonomic identifier

224915 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_0000187709

Sequences

	Sequence		Length	Mass (Da)
	P59490 [UniParc]. Last modified April 4, 2003. Version 1. Checksum: C75F4F690C55633C	FASTA	207	23,466
	10 20 30 40 50 60 MKEIKLIVGL ANPIKKYNDT RHNVGSWLVN SLVTQQNKKL KKNNKFLGYS TEINILSKNI 70 80 90 100 110 120 HVLVPDTFMN LSGISVLAIS NFYNIKLHEI LVVHDELDLK PGNVKFRLRS SHNGHNGIRN 130 140 150 160 170 180 VLAVLGTNIK FLRIQIGIGR PINSGYKISK FVLSKPNVSE KLLINRAILC AIRVIYDSIN 190 200 QRNVIMTESS LNSMLDHYMN SCVIHHN

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016826 Genomic DNA. Translation: AAO26911.1.
RefSeq	NP_777806.1. NC_004545.1.
3D structure databases
ProteinModelPortal	P59490.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000002445; EBBUCP00000002269; EBBUCG00000002445.
GeneID	1058578.
GenomeReviews	Gene locus bbp_179 in contig AE016826_GR.
KEGG	bab:bbp179.
PATRIC	21245133. VBIBucAph80364_0173.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000008081.
HOGENOM	HBG610927.
OMA	FNILMNG.
PhylomeDB	P59490.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_179-MONOMER.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_BUCBP

Accession

Primary (citable) accession number: P59490

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
Last sequence update:	April 4, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program