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P59487 (AROB_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:bbp_480
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3553553-dehydroquinate synthase HAMAP MF_00110
PRO_0000140719

Sequences

Sequence LengthMass (Da)Tools
P59487 [UniParc].

Last modified April 4, 2003. Version 1.
Checksum: 076C797926BD0DCA

FASTA35539,822
        10         20         30         40         50         60 
MVNLGKDTYP VYIGSNLLEI SNIFFPIESN TQVAIITNDV VFKIWNKKIT YYLHKLGAQV 

        70         80         90        100        110        120 
KNVIISDGEI YKNIDTVEII LSTLLKYSYC RDAVLIALGG GVIGDITGFV ASIYQRGIKF 

       130        140        150        160        170        180 
VQIPTTLLAQ VDASIGGKTS VNHVLGKNMI GSFWQPSSVI INFDFLNTLP RRQLISGIAE 

       190        200        210        220        230        240 
IVKYAVSFDV NFFNWLEENL ERVLKLDYSA LSYCINRCCE IKISIVEKDE KEIHDRMLLN 

       250        260        270        280        290        300 
LGHTYGHAIE TFLGYGTWLH GEAVSVGIVM ASKTSELLGF MKDNDITRII SLLQRVGLPI 

       310        320        330        340        350 
SGPKNMSFES YISNFKRDKK VISGKLRMVL PVFIGNVKIF SNVHENILMS VIKNC

« Hide

References

[1]"Reductive genome evolution in Buchnera aphidicola."
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016826 Genomic DNA. Translation: AAO27186.1.
RefSeqNP_778081.1. NC_004545.1.

3D structure databases

ProteinModelPortalP59487.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002350; EBBUCP00000002174; EBBUCG00000002350.
GeneID1058319.
GenomeReviewsGene locus bbp_480 in contig AE016826_GR.
KEGGbab:bbp480.
PATRIC21245777. VBIBucAph80364_0477.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000008095.
HOGENOMHBG632303.
OMAGTFTQPD.
PhylomeDBP59487.

Enzyme and pathway databases

BioCycBAPH224915:BBP_480-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BUCBP
AccessionPrimary (citable) accession number: P59487
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: April 4, 2003
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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