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P59450 (MURB_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase

EC=1.1.1.158
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene names
Name:murB
Ordered Locus Names:bbp_046
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00037

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity. HAMAP MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm By similarity HAMAP MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_0000179189

Regions

Domain16 – 186171FAD-binding PCMH-type

Sites

Active site1621 By similarity
Active site2321Proton donor By similarity
Active site3291 By similarity

Sequences

Sequence LengthMass (Da)Tools
P59450 [UniParc].

Last modified March 28, 2003. Version 1.
Checksum: C0703B4E5BA64B05

FASTA33438,428
        10         20         30         40         50         60 
MKTYYTSLKK FHTFKINVFA KKIIIVKTIK TLIKTWKKCN QENLPFLLLG KGSNVLFTKN 

        70         80         90        100        110        120 
YNGFVVVNRI SGITIHEQKD YWLLHVKGGT KWNNLVKYTI QKKIYGLENL ALIPGTVGAA 

       130        140        150        160        170        180 
PIQNIGAYGV EFKDVCQYVD VLYLNNSKIV RINSNNCLFG YRDSIFKKKH NPNSIILSVG 

       190        200        210        220        230        240 
IKLPKTWKPK ISHLELQKLS FKNITSHQIF HYICKLRKKK LPNPKKIGNA GSFFKNPIIK 

       250        260        270        280        290        300 
KNKAHKIICE YKDLPFYPEP HGMIKLSAGW LIEKCKLKNF SVGNAKIYHK QALILINKNN 

       310        320        330 
LATSKNIIKL AKIIISKVKK KFDITLELEV QIIN 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016826 Genomic DNA. Translation: AAO26785.1.
RefSeqNP_777680.1. NC_004545.1.

3D structure databases

ProteinModelPortalP59450.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002560; EBBUCP00000002384; EBBUCG00000002560.
GeneID1058361.
GenomeReviewsGene locus bbp_046 in contig AE016826_GR.
KEGGbab:bbp046.
PATRIC21244865. VBIBucAph80364_0043.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007998.
HOGENOMHBG686573.
OMALAYEITS.
PhylomeDBP59450.
ProtClustDBPRK00046.

Enzyme and pathway databases

BioCycBAPH224915:BBP_046-MONOMER.

Family and domain databases

HAMAPMF_00037. MurB.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
KOK00075.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. FAD-binding_2. 1 hit.
SSF56194. MurB_C. 1 hit.
TIGRFAMsTIGR00179. MurB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB_BUCBP
AccessionPrimary (citable) accession number: P59450
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families