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P59433

- SYL_BUCBP

UniProt

P59433 - SYL_BUCBP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (28 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-395-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:bbp_395
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 861861Leucine--tRNA ligasePRO_0000151989Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224915.bbp395.

    Structurei

    3D structure databases

    ProteinModelPortaliP59433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi618 – 6225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59433-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQNYCPKTI EPYVQSIWKK KNTFKVTENS NKEKFYCLAM IPYPSGKLHM    50
    GHVRNYTISD VIARYQRMLG KNVLHPMGWD AFGLPAENAA IKNNTHPAQW 100
    TYENIKYMKQ QLISLGLSYD WDREITTCKP EYYQWEQWFF IELYKKNLVY 150
    KKKSWVNWCE YDKTVLANEQ VINELCWRCN NKVIKKKIFQ WFIKITKYAE 200
    ELLNDLDNLP EWPEKVKTMQ HNWIGRNHGI KIKLKLANQH TILNDVFISK 250
    PSTLMGATFI TLSPSHELSF KIARKKHKIQ EFIENCSSNT NTYNDINNTN 300
    IGINTNEFAL HPITKKKLPI WITNYVLSDY DTNSILCVPA HNQHDLNFAI 350
    KYNLKIKAVI LNLDGTEPKI KNTAMTSMGK LFNSNQYNNL NYQEGSYRII 400
    QDLENNHIGK KITYYRLRDW SISRQRYWGA PIPMAVLENK KNVPIPKQYL 450
    PIILPETIPF KNIKPLSNNI LLKKIYIDEK IAICESDTFD TFLESSWYYA 500
    RFTCNNFHKG MISQKLANYW LPVDQYIGGI EHAVMHLIYF RFVHKLLRDL 550
    GLVYSNEPVK KLLCQGMVLS DAFYYFDHNK QKQWISAKSI TIKYDSNHKI 600
    QSHFYSNNKK IFHAGMIKMS KSKFNGIEPE DIIKKYGTDT IRLFIMFAAP 650
    VESALEWKES GVKGIHKFLK KLWVLSYNHI KLYNHKIKLR INLFTEQQQH 700
    IYSELHKTIK IVSQYITDTQ SFNVAISKIM KFSNTLMSIS LKNEQNQALM 750
    QESLLAVIQM LYPFIPHFSF AIWEFLSPKK ENIDFISWPK YNFKAILSKL 800
    KYTIIIQING KKRHKILALK NSSQEKILEI ILNENKIKKY LNNKPIQKII 850
    YIPNKILNLV I 861
    Length:861
    Mass (Da):101,600
    Last modified:March 28, 2003 - v1
    Checksum:i35F7B75BE5A45012
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27107.1.
    RefSeqiNP_778002.1. NC_004545.1.
    WP_011091508.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO27107; AAO27107; bbp_395.
    GeneIDi1058295.
    KEGGibab:bbp395.
    PATRICi21245593. VBIBucAph80364_0390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27107.1 .
    RefSeqi NP_778002.1. NC_004545.1.
    WP_011091508.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali P59433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp395.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO27107 ; AAO27107 ; bbp_395 .
    GeneIDi 1058295.
    KEGGi bab:bbp395.
    PATRICi 21245593. VBIBucAph80364_0390.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BAPH224915:GJ9D-395-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiSYL_BUCBP
    AccessioniPrimary (citable) accession number: P59433
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: March 28, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3