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P59433

- SYL_BUCBP

UniProt

P59433 - SYL_BUCBP

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Protein
Leucine--tRNA ligase
Gene
leuS, bbp_395
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-395-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:bbp_395
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Leucine--tRNA ligaseUniRule annotation
PRO_0000151989Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224915.bbp395.

Structurei

3D structure databases

ProteinModelPortaliP59433.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi618 – 6225"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59433-1 [UniParc]FASTAAdd to Basket

« Hide

MKQNYCPKTI EPYVQSIWKK KNTFKVTENS NKEKFYCLAM IPYPSGKLHM    50
GHVRNYTISD VIARYQRMLG KNVLHPMGWD AFGLPAENAA IKNNTHPAQW 100
TYENIKYMKQ QLISLGLSYD WDREITTCKP EYYQWEQWFF IELYKKNLVY 150
KKKSWVNWCE YDKTVLANEQ VINELCWRCN NKVIKKKIFQ WFIKITKYAE 200
ELLNDLDNLP EWPEKVKTMQ HNWIGRNHGI KIKLKLANQH TILNDVFISK 250
PSTLMGATFI TLSPSHELSF KIARKKHKIQ EFIENCSSNT NTYNDINNTN 300
IGINTNEFAL HPITKKKLPI WITNYVLSDY DTNSILCVPA HNQHDLNFAI 350
KYNLKIKAVI LNLDGTEPKI KNTAMTSMGK LFNSNQYNNL NYQEGSYRII 400
QDLENNHIGK KITYYRLRDW SISRQRYWGA PIPMAVLENK KNVPIPKQYL 450
PIILPETIPF KNIKPLSNNI LLKKIYIDEK IAICESDTFD TFLESSWYYA 500
RFTCNNFHKG MISQKLANYW LPVDQYIGGI EHAVMHLIYF RFVHKLLRDL 550
GLVYSNEPVK KLLCQGMVLS DAFYYFDHNK QKQWISAKSI TIKYDSNHKI 600
QSHFYSNNKK IFHAGMIKMS KSKFNGIEPE DIIKKYGTDT IRLFIMFAAP 650
VESALEWKES GVKGIHKFLK KLWVLSYNHI KLYNHKIKLR INLFTEQQQH 700
IYSELHKTIK IVSQYITDTQ SFNVAISKIM KFSNTLMSIS LKNEQNQALM 750
QESLLAVIQM LYPFIPHFSF AIWEFLSPKK ENIDFISWPK YNFKAILSKL 800
KYTIIIQING KKRHKILALK NSSQEKILEI ILNENKIKKY LNNKPIQKII 850
YIPNKILNLV I 861
Length:861
Mass (Da):101,600
Last modified:March 28, 2003 - v1
Checksum:i35F7B75BE5A45012
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO27107.1.
RefSeqiNP_778002.1. NC_004545.1.
WP_011091508.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO27107; AAO27107; bbp_395.
GeneIDi1058295.
KEGGibab:bbp395.
PATRICi21245593. VBIBucAph80364_0390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO27107.1 .
RefSeqi NP_778002.1. NC_004545.1.
WP_011091508.1. NC_004545.1.

3D structure databases

ProteinModelPortali P59433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp395.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO27107 ; AAO27107 ; bbp_395 .
GeneIDi 1058295.
KEGGi bab:bbp395.
PATRICi 21245593. VBIBucAph80364_0390.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BAPH224915:GJ9D-395-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiSYL_BUCBP
AccessioniPrimary (citable) accession number: P59433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi