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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei240ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH224915:G1G09-66-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:bbp_065
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001195281 – 472Glutamate--tRNA ligaseAdd BLAST472

Proteomic databases

PRIDEiP59423

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi224915.bbp065

Structurei

3D structure databases

ProteinModelPortaliP59423
SMRiP59423
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi237 – 241"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

P59423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIKTRFAPS PTGPLHIGSV RTALYAWLFA KSMNGKFVLR IEDTDKRRST
60 70 80 90 100
NAFTSEIINN LEWLGLNWDE GPYFQSDRLE YYRNIIKKMV EAGLAYKCYC
110 120 130 140 150
TNDRLLKLRK FQISLGKKPK YDRKCRYLVK KDILSTDYVI RFCNPDFGCV
160 170 180 190 200
TFCDKIRGKI SIENKELDDL VIQRADGIPT YNFCVVIDDR DMNITHVIRG
210 220 230 240 250
EDHISNTPRQ INILRALNAN IPIYAHVSMV LSEDKQKLSK RNNTITSISE
260 270 280 290 300
YRLCGYLPES LLNYIVRLGW SHGNQEIFSI SEMIKYFTLE SLNKSSSCLN
310 320 330 340 350
KKKLLWLNRF YINNLPETVI KKHLQYQFNK NNIDYKNDSD LLKLVKLLGS
360 370 380 390 400
RYYTLQEIVD YSRCFYNKSI CFNSNIMSKH LDNSSKLILK KIYDKFLDLE
410 420 430 440 450
VWNVEVIRSL LNSSVCELQI SFKKVSMTIR IAVTGHVFSP NLCSVICFLG
460 470
KNKFLLRIKE ALLYIKNMCF EV
Length:472
Mass (Da):55,162
Last modified:March 28, 2003 - v1
Checksum:i39E1D9775632E2DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA Translation: AAO26802.1
RefSeqiWP_011091203.1, NC_004545.1

Genome annotation databases

EnsemblBacteriaiAAO26802; AAO26802; bbp_065
KEGGibab:bbp_065

Similar proteinsi

Entry informationi

Entry nameiSYE_BUCBP
AccessioniPrimary (citable) accession number: P59423
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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