P59416 (AROA_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	bbp_288

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]

Taxonomic identifier

224915 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000088237

Sequences

	Sequence		Length	Mass (Da)
	P59416 [UniParc]. Last modified March 28, 2003. Version 1. Checksum: E05DFBACB2BB0AB0	FASTA	427	47,083
	10 20 30 40 50 60 MHECLTLNPI SLVNGTINLP GSKSITNRAL LLSAMSNSTT HLKNILYSQD TQYMLNTLKI 70 80 90 100 110 120 CGIKFNCSYT NLSCTIEGCN KPLNISHKTS LFLGNAGTAF RSLAAIFSLN NNNILLTGNK 130 140 150 160 170 180 RMKQRPIKHL VQALQQGGAQ ITYSEQDQYP PIKIKGGFIG GNIFVSGKIS SQFLSALLIA 190 200 210 220 230 240 TPLAQLDSTI TVTEKLVSKP YIDITLNLIS KFGIKIIHKD YTKFNVQGRQ KYISPKEYSI 250 260 270 280 290 300 EGDASSASYF LAAAAIKGGS VKVTGIGLNS IQGDVKFANV LKKMGAYITF GKDFIVCKKK 310 320 330 340 350 360 DLIGIDLDMN DIPDAAMTIA IVALFSKGKT VIRNIYNWRV KETDRLSAMT NELKKIGAQV 370 380 390 400 410 420 IEGNDYIEIL PPINFVYAKI NTYDDHRIAM CFALIALSGI KVTLLNYKCV NKTFPDYFQK LKSICSY

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016826 Genomic DNA. Translation: AAO27013.1.
RefSeq	NP_777908.1. NC_004545.1.
3D structure databases
ProteinModelPortal	P59416.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000002227; EBBUCP00000002051; EBBUCG00000002227.
GeneID	1058414.
GenomeReviews	Gene locus bbp_288 in contig AE016826_GR.
KEGG	bab:bbp288.
PATRIC	21245363. VBIBucAph80364_0284.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000008084.
HOGENOM	HBG646626.
OMA	GADIEWG.
PhylomeDB	P59416.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_288-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BUCBP

Accession

Primary (citable) accession number: P59416

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 28, 2003
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program