P59414 (AROE_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	bbp_437

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]

Taxonomic identifier

224915 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000135997
Regions
	Nucleotide binding	132 – 136	5	NADP By similarity
Sites
	Active site	70	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	P59414 [UniParc]. Last modified March 28, 2003. Version 1. Checksum: 344F5BDC826A9327	FASTA	282	31,975
	10 20 30 40 50 60 MVKHCIDQFC VFGNPINHTQ SPYIHSLFSK QTGIVYEYSA RLVPFKEFNS YVLNFFLNKG 70 80 90 100 110 120 KGANITVPFK ENAYVISNNL TIRAKMSRAV NTFKKLHNNK ILGDNTDGIG VLHDLKRIKF 130 140 150 160 170 180 IKSKFNRVLL IGAGGAARGI IFSLLSYGCS IVVLNRTITR ALQLVEDFKN VGSISIFKEK 190 200 210 220 230 240 FASNYSFNLI INATTINICQ NSNLSTIKSL IHKDVYCYDI NYSIKHKYTE FLLWCIKNGA 250 260 270 280 ICVSNGIGML VSQAAHSFYL WYGILPETNS IICKLNRQFY ML

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016826 Genomic DNA. Translation: AAO27143.1.
RefSeq	NP_778038.1. NC_004545.1.
3D structure databases
ProteinModelPortal	P59414.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000002443; EBBUCP00000002267; EBBUCG00000002443.
GeneID	1058638.
GenomeReviews	Gene locus bbp_437 in contig AE016826_GR.
KEGG	bab:bbp437.
PATRIC	21245691. VBIBucAph80364_0434.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000008051.
HOGENOM	HBG553408.
OMA	VVFGNPI.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_437-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BUCBP

Accession

Primary (citable) accession number: P59414

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 28, 2003
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program