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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136NADUniRule annotation1
Binding sitei197NADUniRule annotation1
Binding sitei220NADUniRule annotation1
Binding sitei243SubstrateUniRule annotation1
Metal bindingi265ZincUniRule annotation1
Binding sitei265SubstrateUniRule annotation1
Metal bindingi268ZincUniRule annotation1
Binding sitei268SubstrateUniRule annotation1
Active sitei333Proton acceptorUniRule annotation1
Active sitei334Proton acceptorUniRule annotation1
Binding sitei334SubstrateUniRule annotation1
Metal bindingi367ZincUniRule annotation1
Binding sitei367SubstrateUniRule annotation1
Binding sitei421SubstrateUniRule annotation1
Metal bindingi426ZincUniRule annotation1
Binding sitei426SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPPUT160488:G1G01-1040-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PP_0966
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358211 – 441Histidinol dehydrogenaseAdd BLAST441

Proteomic databases

PRIDEiP59400

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_0966

Structurei

3D structure databases

ProteinModelPortaliP59400
SMRiP59400
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P59400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSTAIARL NAADPDFARH LDHLLSWESV SDDAVNQRVL DIIKAVRERG
60 70 80 90 100
DAALVEFTQR FDGVDAKSID DLILDRARLE LALTRITPVQ REALEKAANR
110 120 130 140 150
VRIYHERQKQ DSWQYTEADG TVLGQKVTPL DRAGLYVPGG KASYPSSVLM
160 170 180 190 200
NAIPAKVAGV TEVVMVVPTP RGEVNELVLA AACIAGVDRV FTVGGAQAVA
210 220 230 240 250
ALAYGTESVP QVDKIVGPGN IYVATAKRHV FGQVGIDMIA GPSEILVVCD
260 270 280 290 300
GQTDPDWIAM DLFSQAEHDE DAQAILVSPD AAFLDRVAAS IDKLMPTMER
310 320 330 340 350
ADIIEKSING RGALIQVRDM QQAMDVANRI APEHLELSVA DPQAWLPHIR
360 370 380 390 400
HAGAIFMGRH TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII
410 420 430 440
FCSEQGASEL GHTASVLARG ESLTAHARSA EYRILTQEKG N
Length:441
Mass (Da):47,605
Last modified:March 25, 2003 - v1
Checksum:iB028899679A1F9BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA Translation: AAN66591.1
RefSeqiNP_743127.1, NC_002947.4
WP_010952156.1, NC_002947.4

Genome annotation databases

EnsemblBacteriaiAAN66591; AAN66591; PP_0966
GeneIDi1044886
KEGGippu:PP_0966
PATRICifig|160488.4.peg.1028

Entry informationi

Entry nameiHISX_PSEPK
AccessioniPrimary (citable) accession number: P59400
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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