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P59400

- HISX_PSEPK

UniProt

P59400 - HISX_PSEPK

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Protein

Histidinol dehydrogenase

Gene
hisD, PP_0966
Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NAD By similarity
Binding sitei197 – 1971NAD By similarity
Binding sitei220 – 2201NAD By similarity
Binding sitei243 – 2431Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Metal bindingi268 – 2681Zinc By similarity
Binding sitei268 – 2681Substrate By similarity
Active sitei333 – 3331Proton acceptor By similarity
Active sitei334 – 3341Proton acceptor By similarity
Binding sitei334 – 3341Substrate By similarity
Metal bindingi367 – 3671Zinc By similarity
Binding sitei367 – 3671Substrate By similarity
Binding sitei421 – 4211Substrate By similarity
Metal bindingi426 – 4261Zinc By similarity
Binding sitei426 – 4261Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-998-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:PP_0966
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Histidinol dehydrogenaseUniRule annotationPRO_0000135821Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_0966.

Structurei

3D structure databases

ProteinModelPortaliP59400.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59400-1 [UniParc]FASTAAdd to Basket

« Hide

MTVSTAIARL NAADPDFARH LDHLLSWESV SDDAVNQRVL DIIKAVRERG    50
DAALVEFTQR FDGVDAKSID DLILDRARLE LALTRITPVQ REALEKAANR 100
VRIYHERQKQ DSWQYTEADG TVLGQKVTPL DRAGLYVPGG KASYPSSVLM 150
NAIPAKVAGV TEVVMVVPTP RGEVNELVLA AACIAGVDRV FTVGGAQAVA 200
ALAYGTESVP QVDKIVGPGN IYVATAKRHV FGQVGIDMIA GPSEILVVCD 250
GQTDPDWIAM DLFSQAEHDE DAQAILVSPD AAFLDRVAAS IDKLMPTMER 300
ADIIEKSING RGALIQVRDM QQAMDVANRI APEHLELSVA DPQAWLPHIR 350
HAGAIFMGRH TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII 400
FCSEQGASEL GHTASVLARG ESLTAHARSA EYRILTQEKG N 441
Length:441
Mass (Da):47,605
Last modified:March 25, 2003 - v1
Checksum:iB028899679A1F9BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66591.1.
RefSeqiNP_743127.1. NC_002947.3.
WP_010952156.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN66591; AAN66591; PP_0966.
GeneIDi1044886.
KEGGippu:PP_0966.
PATRICi19940084. VBIPsePut30601_1028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66591.1 .
RefSeqi NP_743127.1. NC_002947.3.
WP_010952156.1. NC_002947.3.

3D structure databases

ProteinModelPortali P59400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160488.PP_0966.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN66591 ; AAN66591 ; PP_0966 .
GeneIDi 1044886.
KEGGi ppu:PP_0966.
PATRICi 19940084. VBIPsePut30601_1028.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PPUT160488:GIXO-998-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiHISX_PSEPK
AccessioniPrimary (citable) accession number: P59400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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