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P59399 (HISX_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:lp_2559
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135782

Sites

Active site3221Proton acceptor By similarity
Active site3231Proton acceptor By similarity
Metal binding2541Zinc By similarity
Metal binding2571Zinc By similarity
Metal binding3561Zinc By similarity
Metal binding4151Zinc By similarity
Binding site1251NAD By similarity
Binding site1861NAD By similarity
Binding site2091NAD By similarity
Binding site2321Substrate By similarity
Binding site2541Substrate By similarity
Binding site2571Substrate By similarity
Binding site3231Substrate By similarity
Binding site3561Substrate By similarity
Binding site4101Substrate By similarity
Binding site4151Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P59399 [UniParc].

Last modified March 25, 2003. Version 1.
Checksum: 9DE9DDE6D8487D2C

FASTA42845,986
        10         20         30         40         50         60 
MKIINEDLAS LKRLVQTKTQ QLTDLKVESA VREIIANVIK NGDAAVKDYE TQFDKVTLTD 

        70         80         90        100        110        120 
FKLSQTVIDD AYNNLDPQVK DALLLAKRNI TSFHEKEKAT GFIDAEQPGV LRGQKLMPLN 

       130        140        150        160        170        180 
RVGLYVPGGT AAYPSTLLMS ALPAKIAGVN EVIMVTPPQV DGINPAVLAA AKIAGVDAIY 

       190        200        210        220        230        240 
QVGGAQAIAA LAYGTESIPA VDKIIGPGNI FVATAKKQVF GQVAIDMVAG PSEIGILADD 

       250        260        270        280        290        300 
SADPRQLAAD LLSQAEHDRR ARPILITDSA DLAQAVSDNV TSQLKVLPRE AIATDAVNEK 

       310        320        330        340        350        360 
GFIAVVAKIE EMFDLMNTVA PEHLEVQLKN PTQYLNLIKN AGSVFLGRYA SEPLGDYVAG 

       370        380        390        400        410        420 
PNHILPTSGT ARFSSPLGVY DFVKRTSFIQ YTKDALAKEA PAITTLARVE GLEGHARAIE 


SRFDTYYD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC79714.1.
RefSeqYP_004890228.1. NC_004567.2.

3D structure databases

ProteinModelPortalP59399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_2559.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC79714; CCC79714; lp_2559.
GeneID1062752.
KEGGlpl:lp_2559.
PATRIC22251085. VBILacPla27411_2150.

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMADEMAMPI.

Enzyme and pathway databases

BioCycLPLA220668-WGS:GSPK-2206-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_LACPL
AccessionPrimary (citable) accession number: P59399
Secondary accession number(s): F9UR75
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways