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P59399

- HISX_LACPL

UniProt

P59399 - HISX_LACPL

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Protein

Histidinol dehydrogenase

Gene
hisD, lp_2559
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251NAD By similarity
Binding sitei186 – 1861NAD By similarity
Binding sitei209 – 2091NAD By similarity
Binding sitei232 – 2321Substrate By similarity
Metal bindingi254 – 2541Zinc By similarity
Binding sitei254 – 2541Substrate By similarity
Metal bindingi257 – 2571Zinc By similarity
Binding sitei257 – 2571Substrate By similarity
Active sitei322 – 3221Proton acceptor By similarity
Active sitei323 – 3231Proton acceptor By similarity
Binding sitei323 – 3231Substrate By similarity
Metal bindingi356 – 3561Zinc By similarity
Binding sitei356 – 3561Substrate By similarity
Binding sitei410 – 4101Substrate By similarity
Metal bindingi415 – 4151Zinc By similarity
Binding sitei415 – 4151Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-2206-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:lp_2559
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenaseUniRule annotationPRO_0000135782Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_2559.

Structurei

3D structure databases

ProteinModelPortaliP59399.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiDEMAMPI.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59399-1 [UniParc]FASTAAdd to Basket

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MKIINEDLAS LKRLVQTKTQ QLTDLKVESA VREIIANVIK NGDAAVKDYE    50
TQFDKVTLTD FKLSQTVIDD AYNNLDPQVK DALLLAKRNI TSFHEKEKAT 100
GFIDAEQPGV LRGQKLMPLN RVGLYVPGGT AAYPSTLLMS ALPAKIAGVN 150
EVIMVTPPQV DGINPAVLAA AKIAGVDAIY QVGGAQAIAA LAYGTESIPA 200
VDKIIGPGNI FVATAKKQVF GQVAIDMVAG PSEIGILADD SADPRQLAAD 250
LLSQAEHDRR ARPILITDSA DLAQAVSDNV TSQLKVLPRE AIATDAVNEK 300
GFIAVVAKIE EMFDLMNTVA PEHLEVQLKN PTQYLNLIKN AGSVFLGRYA 350
SEPLGDYVAG PNHILPTSGT ARFSSPLGVY DFVKRTSFIQ YTKDALAKEA 400
PAITTLARVE GLEGHARAIE SRFDTYYD 428
Length:428
Mass (Da):45,986
Last modified:March 25, 2003 - v1
Checksum:i9DE9DDE6D8487D2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79714.1.
RefSeqiWP_011101827.1. NC_004567.2.
YP_004890228.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC79714; CCC79714; lp_2559.
GeneIDi1062752.
KEGGilpl:lp_2559.
PATRICi22251085. VBILacPla27411_2150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79714.1 .
RefSeqi WP_011101827.1. NC_004567.2.
YP_004890228.1. NC_004567.2.

3D structure databases

ProteinModelPortali P59399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_2559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC79714 ; CCC79714 ; lp_2559 .
GeneIDi 1062752.
KEGGi lpl:lp_2559.
PATRICi 22251085. VBILacPla27411_2150.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi DEMAMPI.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci LPLA220668-WGS:GSPK-2206-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiHISX_LACPL
AccessioniPrimary (citable) accession number: P59399
Secondary accession number(s): F9UR75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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