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P59399

- HISX_LACPL

UniProt

P59399 - HISX_LACPL

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (25 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei125 – 1251NADUniRule annotation
    Binding sitei186 – 1861NADUniRule annotation
    Binding sitei209 – 2091NADUniRule annotation
    Binding sitei232 – 2321SubstrateUniRule annotation
    Metal bindingi254 – 2541ZincUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Metal bindingi257 – 2571ZincUniRule annotation
    Binding sitei257 – 2571SubstrateUniRule annotation
    Active sitei322 – 3221Proton acceptorUniRule annotation
    Active sitei323 – 3231Proton acceptorUniRule annotation
    Binding sitei323 – 3231SubstrateUniRule annotation
    Metal bindingi356 – 3561ZincUniRule annotation
    Binding sitei356 – 3561SubstrateUniRule annotation
    Binding sitei410 – 4101SubstrateUniRule annotation
    Metal bindingi415 – 4151ZincUniRule annotation
    Binding sitei415 – 4151SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-2206-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:lp_2559
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Histidinol dehydrogenasePRO_0000135782Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi220668.lp_2559.

    Structurei

    3D structure databases

    ProteinModelPortaliP59399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiDEMAMPI.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59399-1 [UniParc]FASTAAdd to Basket

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    MKIINEDLAS LKRLVQTKTQ QLTDLKVESA VREIIANVIK NGDAAVKDYE    50
    TQFDKVTLTD FKLSQTVIDD AYNNLDPQVK DALLLAKRNI TSFHEKEKAT 100
    GFIDAEQPGV LRGQKLMPLN RVGLYVPGGT AAYPSTLLMS ALPAKIAGVN 150
    EVIMVTPPQV DGINPAVLAA AKIAGVDAIY QVGGAQAIAA LAYGTESIPA 200
    VDKIIGPGNI FVATAKKQVF GQVAIDMVAG PSEIGILADD SADPRQLAAD 250
    LLSQAEHDRR ARPILITDSA DLAQAVSDNV TSQLKVLPRE AIATDAVNEK 300
    GFIAVVAKIE EMFDLMNTVA PEHLEVQLKN PTQYLNLIKN AGSVFLGRYA 350
    SEPLGDYVAG PNHILPTSGT ARFSSPLGVY DFVKRTSFIQ YTKDALAKEA 400
    PAITTLARVE GLEGHARAIE SRFDTYYD 428
    Length:428
    Mass (Da):45,986
    Last modified:March 25, 2003 - v1
    Checksum:i9DE9DDE6D8487D2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC79714.1.
    RefSeqiWP_011101827.1. NC_004567.2.
    YP_004890228.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC79714; CCC79714; lp_2559.
    GeneIDi1062752.
    KEGGilpl:lp_2559.
    PATRICi22251085. VBILacPla27411_2150.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC79714.1 .
    RefSeqi WP_011101827.1. NC_004567.2.
    YP_004890228.1. NC_004567.2.

    3D structure databases

    ProteinModelPortali P59399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_2559.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC79714 ; CCC79714 ; lp_2559 .
    GeneIDi 1062752.
    KEGGi lpl:lp_2559.
    PATRICi 22251085. VBILacPla27411_2150.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi DEMAMPI.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci LPLA220668-WGS:GSPK-2206-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiHISX_LACPL
    AccessioniPrimary (citable) accession number: P59399
    Secondary accession number(s): F9UR75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 25, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3