Reviewed, UniProtKB/Swiss-Prot P59398 (HISX_BUCBP)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23

Gene names

Name:	hisD
Ordered Locus Names:	bbp_094

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Histidinol dehydrogenase		PRO_0000135743
Sites
	Active site	327	1	Proton acceptor By similarity
	Active site	328	1	Proton acceptor By similarity
	Metal binding	260	1	Zinc By similarity
	Metal binding	263	1	Zinc By similarity
	Metal binding	361	1	Zinc By similarity
	Metal binding	420	1	Zinc By similarity
	Binding site	131	1	NAD By similarity
	Binding site	189	1	NAD By similarity
	Binding site	212	1	NAD By similarity
	Binding site	238	1	Substrate By similarity
	Binding site	260	1	Substrate By similarity
	Binding site	263	1	Substrate By similarity
	Binding site	328	1	Substrate By similarity
	Binding site	361	1	Substrate By similarity
	Binding site	415	1	Substrate By similarity
	Binding site	420	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59398-1 [UniParc]. Last modified March 25, 2003. Version 1. Checksum: 8A2F3ED2073D73F2	FASTA	435	48,185
	10 20 30 40 50 60 MEVYIPIIYW KSCSEKEKRE ILFRPVVNDN SQIKEVVKEI ITNVKNSGDK ALYDYTKTFD 70 80 90 100 110 120 KIRLESIQVS YGEIVDSDSF VNEEIQKSIS VAKNNIKIFH EKQTHNVVNI EIQPGVFCRQ 130 140 150 160 170 180 IIRPIQSVGL YIPGGCAPLV STVLMLAIPA KIVGCKNIIL CSPPPITKEI LYASKICGIH 190 200 210 220 230 240 NIFQVGGAQA IAAMAFGTKT IPKVNKIFGP GNVYVTEAKL QINALLNDLS IDMLAGPSEI 250 260 270 280 290 300 LIIADFKANA CIIASDFLSQ MEHGIYSQAI LVTPSYDLAC NVIFEINIQL KNLSRKKVIN 310 320 330 340 350 360 KSLKYSRIIV TKTLLECFEI SNLYAPEHLI IQCENSNRLL VYVINAGSIF LGRWSAVASG 370 380 390 400 410 420 DYVTGTNHVL PTYGSAIVNS GLTVMDFQKI ISVQKLDQQG LIDVSSSIIS LSEVERMDAH 430 TNSIKQRLIA LQDVK

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016826 Genomic DNA. Translation: AAO26829.1.
RefSeq	NP_777724.1.
3D structure databases
HSSP	HSSP built from PDB template 1KAE based on UniProtKB P06988.
ModBase	Search...
Genome annotation databases
GeneID	1058171.
GenomeReviews	Gene locus bbp_094 in contig AE016826_GR.
KEGG	bab:bbp094.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P59398.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_094-MON.
Family and domain databases
HAMAP	MF_01024. [Tree]
InterPro	IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX_BUCBP

Accession

Primary (citable) accession number: P59398

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	March 25, 2003
Last modified:	November 25, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)