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P59398

- HISX_BUCBP

UniProt

P59398 - HISX_BUCBP

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Protein

Histidinol dehydrogenase

Gene
hisD, bbp_094
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311NAD By similarity
Binding sitei189 – 1891NAD By similarity
Binding sitei212 – 2121NAD By similarity
Binding sitei238 – 2381Substrate By similarity
Metal bindingi260 – 2601Zinc By similarity
Binding sitei260 – 2601Substrate By similarity
Metal bindingi263 – 2631Zinc By similarity
Binding sitei263 – 2631Substrate By similarity
Active sitei327 – 3271Proton acceptor By similarity
Active sitei328 – 3281Proton acceptor By similarity
Binding sitei328 – 3281Substrate By similarity
Metal bindingi361 – 3611Zinc By similarity
Binding sitei361 – 3611Substrate By similarity
Binding sitei415 – 4151Substrate By similarity
Metal bindingi420 – 4201Zinc By similarity
Binding sitei420 – 4201Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-94-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:bbp_094
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Histidinol dehydrogenaseUniRule annotationPRO_0000135743Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224915.bbp094.

Structurei

3D structure databases

ProteinModelPortaliP59398.
SMRiP59398. Positions 6-433.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiGFLFHAN.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59398-1 [UniParc]FASTAAdd to Basket

« Hide

MEVYIPIIYW KSCSEKEKRE ILFRPVVNDN SQIKEVVKEI ITNVKNSGDK    50
ALYDYTKTFD KIRLESIQVS YGEIVDSDSF VNEEIQKSIS VAKNNIKIFH 100
EKQTHNVVNI EIQPGVFCRQ IIRPIQSVGL YIPGGCAPLV STVLMLAIPA 150
KIVGCKNIIL CSPPPITKEI LYASKICGIH NIFQVGGAQA IAAMAFGTKT 200
IPKVNKIFGP GNVYVTEAKL QINALLNDLS IDMLAGPSEI LIIADFKANA 250
CIIASDFLSQ MEHGIYSQAI LVTPSYDLAC NVIFEINIQL KNLSRKKVIN 300
KSLKYSRIIV TKTLLECFEI SNLYAPEHLI IQCENSNRLL VYVINAGSIF 350
LGRWSAVASG DYVTGTNHVL PTYGSAIVNS GLTVMDFQKI ISVQKLDQQG 400
LIDVSSSIIS LSEVERMDAH TNSIKQRLIA LQDVK 435
Length:435
Mass (Da):48,185
Last modified:March 25, 2003 - v1
Checksum:i8A2F3ED2073D73F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26829.1.
RefSeqiNP_777724.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26829; AAO26829; bbp_094.
GeneIDi1058171.
KEGGibab:bbp094.
PATRICi21244967. VBIBucAph80364_0091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26829.1 .
RefSeqi NP_777724.1. NC_004545.1.

3D structure databases

ProteinModelPortali P59398.
SMRi P59398. Positions 6-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp094.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO26829 ; AAO26829 ; bbp_094 .
GeneIDi 1058171.
KEGGi bab:bbp094.
PATRICi 21244967. VBIBucAph80364_0091.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi GFLFHAN.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BAPH224915:GJ9D-94-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiHISX_BUCBP
AccessioniPrimary (citable) accession number: P59398
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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