Skip Header

Contribute Send feedback
Read comments (?) or add your own

P59397 (HISX_BRAJA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase
Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:blr1256
OrganismBradyrhizobium japonicum
Taxonomic identifier375 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Histidinol dehydrogenase HAMAP MF_01024
PRO_0000135739

Sites

Active site3271Proton acceptor By similarity
Active site3281Proton acceptor By similarity
Metal binding2591Zinc By similarity
Metal binding2621Zinc By similarity
Metal binding3611Zinc By similarity
Metal binding4201Zinc By similarity
Binding site1301NAD By similarity
Binding site1911NAD By similarity
Binding site2141NAD By similarity
Binding site2371Substrate By similarity
Binding site2591Substrate By similarity
Binding site2621Substrate By similarity
Binding site3281Substrate By similarity
Binding site3611Substrate By similarity
Binding site4151Substrate By similarity
Binding site4201Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P59397 [UniParc].

Last modified March 25, 2003. Version 1.
Checksum: 6FBB4505AD936B6D

FASTA43144,907
        10         20         30         40         50         60 
MPVRLDRSSA DFDQRFAAFL AAKREVSADV EAAARAIVDD VARRGDAALL EATAKFDRLT 

        70         80         90        100        110        120 
LDASGLRVSA AEIEAAVKAC DAATLDALSL ARDRIETYHR RQLPKDERFT DPLGVELGWR 

       130        140        150        160        170        180 
YTAIESAGLY VPGGTAAYPS SVLMNAVPAK VAGVSRLVMV VPSPDGKLNP LVLAAARLGG 

       190        200        210        220        230        240 
VTEIYRVGGA QAVAALAHGT ATIAPVAKIV GPGNAYVAAA KRLVFGKVGI DMIAGPSEVL 

       250        260        270        280        290        300 
VIADDTGNAD WIAADLLAQA EHDTSAQSIL ITDSARLAAD VEKAVEAQLK TLPRTAIASA 

       310        320        330        340        350        360 
SWADFGAIIM VKNLNDAIPL ADAIAAEHLE IMTTDPDALA ARIRNAGAVF LGAHTPEAIG 

       370        380        390        400        410        420 
DYVGGSNHVL PTARSARFSS GLSVHDFMKR TSILKCGPDQ LRALGPAAMT LGKAEGLDAH 

       430 
SRSIGLRLNL S

« Hide

References

[1]"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110."
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.
DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USDA 110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000040 Genomic DNA. Translation: BAC46521.1.
RefSeqNP_767896.1. NC_004463.1.

3D structure databases

ProteinModelPortalP59397.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1049433.
GenomeReviewsGene locus blr1256 in contig BA000040_GR.
KEGGbja:blr1256.
NMPDRfig|224911.1.peg.1256.
PATRIC21186068. VBIBraJap65052_1303.

Phylogenomic databases

HOGENOMHBG329596.
OMAARDRIEF.
PhylomeDBP59397.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycBJAP224911:BLR1256-MONOMER.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
KOK00013.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00069. HisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_BRAJA
AccessionPrimary (citable) accession number: P59397
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents