Reviewed, UniProtKB/Swiss-Prot P59391 (ARGC1_LACPL)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase 1
      Short name=AGPR 1
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase 1
      Short name=NAGSA dehydrogenase 1

Gene names

Name:	argC1
Ordered Locus Names:	lp_0487

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	N-acetyl-gamma-glutamyl-phosphate reductase 1 HAMAP MF_00150		PRO_0000112412
Sites
	Active site	153	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59391-1 [UniParc]. Last modified March 25, 2003. Version 1. Checksum: E4EF40E7125488E0	FASTA	343	37,699
	10 20 30 40 50 60 MKNNMKVGIL GGSGYAGAEL YRLLLNHPNF NVTFISSEKY AGKPVEKMLK GFAHNGHSHN 70 80 90 100 110 120 LRFNHLDDLP FDLDFVFSAL PTGVLPKYVE KILEKTSLIF NVSGDFRFKD ATTLQQYYPE 130 140 150 160 170 180 TLAIESDQIL SSYYIPEFSD FDKNANIINL PGCMALASIY AAYPLVKNKL INPNIFVDVK 190 200 210 220 230 240 TGSSGAGKST KETAADRFGN FRLYRAFNHR HLPEIAMALG SSVGKVGFAA YSLDISRGIY 250 260 270 280 290 300 ASVYSQIKKG VTEVDVKKAY FKTYKSCKFV ANLTGKQSVP MLKSTNGTNF AEVKATVHEG 310 320 330 340 QCIAVVSLDN LLKGAAGQAV QAANKYYQLV EDTGLDTLAG MWP

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL935253 Genomic DNA. Translation: CAD63112.1.
RefSeq	NP_784273.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1061450.
GenomeReviews	Gene locus lp_0487 in contig AL935263_GR.
KEGG	lpl:lp_0487.
NMPDR	fig|220668.1.peg.407.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P59391.
OMA	GCNATAT.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_0487-MON.
BRENDA	1.2.1.38. 593.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC1_LACPL

Accession

Primary (citable) accession number: P59391

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	March 25, 2003
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)