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Protein

Leucine-rich repeat neuronal protein 4

Gene

Lrrn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in hippocampus-dependent long-lasting memory.1 Publication

GO - Biological processi

  • long-term memory Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 4
Alternative name(s):
Neuronal leucine-rich repeat protein 4
Short name:
NLRR-4
Gene namesi
Name:Lrrn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2445154. Lrrn4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 676ExtracellularSequence analysisAdd BLAST657
Transmembranei677 – 697HelicalSequence analysisAdd BLAST21
Topological domaini698 – 733CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile, but show impaired memory retention. Lrrn4-deficient mice are able to maintain memories for one day in hippocampus-dependent learning tasks, but are unable of retaining memories for four days after learning. In contrast, in hippocampus-independent tasks Lrrn4-deficient mice normally retain memories for at least seven days.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002103020 – 733Leucine-rich repeat neuronal protein 4Add BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi327N-linked (GlcNAc...)Sequence analysis1
Glycosylationi408N-linked (GlcNAc...)Sequence analysis1
Glycosylationi469N-linked (GlcNAc...)Sequence analysis1
Glycosylationi619N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP59383.
PaxDbiP59383.
PRIDEiP59383.

PTM databases

PhosphoSitePlusiP59383.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043110.
GenevisibleiP59383. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057005.

Structurei

3D structure databases

ProteinModelPortaliP59383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 82LRR 1Add BLAST21
Repeati83 – 106LRR 2Add BLAST24
Repeati107 – 128LRR 3Add BLAST22
Repeati130 – 151LRR 4Add BLAST22
Repeati154 – 175LRR 5Add BLAST22
Repeati178 – 199LRR 6Add BLAST22
Repeati207 – 230LRR 7Add BLAST24
Repeati231 – 253LRR 8Add BLAST23
Repeati256 – 278LRR 9Add BLAST23
Repeati281 – 302LRR 10Add BLAST22
Domaini311 – 364LRRCTAdd BLAST54
Domaini576 – 675Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064159.
HOVERGENiHBG051176.
InParanoidiP59383.
OMAiEGDIFKM.
OrthoDBiEOG091G02GQ.
TreeFamiTF351118.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWTLMLQLL QLLLQLLMAQ SQSLERISQD RIPLFRLTQQ GDWDSLDRHP
60 70 80 90 100
TDSLCVGLPA AGVTTLNLAN RSLESLPSCL PRTLRSLDGS HNLLRALSEP
110 120 130 140 150
VLGRLPELRV LTLHHNRISV LHWGRDTLAE LRELDLSHNL LTELPPCAGP
160 170 180 190 200
SGSSLRSLAL AGNPLRALLP RTFACFPALR LLNLSCSELG HIAQEAFAGV
210 220 230 240 250
DGGPLAALEL LDLSGTSLER VESGWIRNLP KLKSLFLRKM PRLKTLEGDI
260 270 280 290 300
FKMTPNLRQL DCGDSPALTS VHTEIFQDTP NLQVLQFQNC NLSSFGPWNS
310 320 330 340 350
SQVLSVSLFG NPLICSCELA WLLVDVNKTV LHRAADTMCE PALGSTGPFS
360 370 380 390 400
GPLSLSHLSN VCRSDQSTTL LPSNPGRFDH SVFAPRIQGP SIEQSTALSA
410 420 430 440 450
QPGGSQQNIT KVPSLTMTSP TQGSWMYKDA SEETAQSTNS ELVYSPSRAL
460 470 480 490 500
PGAASSGAEQ TATHILEPNI SSASTPLVSK YLEPLPTSPN PRSLPQTKQR
510 520 530 540 550
TQATPRALHT DPPQDEIPVL LLDDDSEEEE TRDQVAAPPQ DVSCEYHPCK
560 570 580 590 600
HLQTPCAELQ RRFRCRCPGL SGEDTTPDPP TLQGVSEVTD TSVLVHWCAP
610 620 630 640 650
NSVVLWYQIH YVAEGRSGNQ SVVDIYATAR QHPLYKLTPG TTYHVCVLAA
660 670 680 690 700
NRAGLSQSQT SGWRRSCATF TTKPSSVVIF WGLCTASGLL LVSTLVLSVC
710 720 730
LWRQRWKPHR QFYDTHLVAF KNPARAEEVT QWE
Length:733
Mass (Da):80,489
Last modified:July 27, 2011 - v2
Checksum:iF2DF7F9D5791DF63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti316S → G in BAC39399 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085246 mRNA. Translation: BAC39399.1.
AK080889 mRNA. Translation: BAC38065.1.
AL831763, AL929562 Genomic DNA. Translation: CAM20381.1.
AL929562, AL831763 Genomic DNA. Translation: CAM26895.1.
CCDSiCCDS16780.1.
RefSeqiNP_796277.2. NM_177303.4.
XP_011237904.1. XM_011239602.2.
UniGeneiMm.357342.
Mm.386903.

Genome annotation databases

EnsembliENSMUST00000049787; ENSMUSP00000057005; ENSMUSG00000043110.
GeneIDi320974.
KEGGimmu:320974.
UCSCiuc008mnn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085246 mRNA. Translation: BAC39399.1.
AK080889 mRNA. Translation: BAC38065.1.
AL831763, AL929562 Genomic DNA. Translation: CAM20381.1.
AL929562, AL831763 Genomic DNA. Translation: CAM26895.1.
CCDSiCCDS16780.1.
RefSeqiNP_796277.2. NM_177303.4.
XP_011237904.1. XM_011239602.2.
UniGeneiMm.357342.
Mm.386903.

3D structure databases

ProteinModelPortaliP59383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057005.

PTM databases

PhosphoSitePlusiP59383.

Proteomic databases

MaxQBiP59383.
PaxDbiP59383.
PRIDEiP59383.

Protocols and materials databases

DNASUi320974.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049787; ENSMUSP00000057005; ENSMUSG00000043110.
GeneIDi320974.
KEGGimmu:320974.
UCSCiuc008mnn.1. mouse.

Organism-specific databases

CTDi164312.
MGIiMGI:2445154. Lrrn4.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064159.
HOVERGENiHBG051176.
InParanoidiP59383.
OMAiEGDIFKM.
OrthoDBiEOG091G02GQ.
TreeFamiTF351118.

Miscellaneous databases

PROiP59383.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043110.
GenevisibleiP59383. MM.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRN4_MOUSE
AccessioniPrimary (citable) accession number: P59383
Secondary accession number(s): A2ANX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.