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Protein

Leucine-rich repeat neuronal protein 4

Gene

Lrrn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in hippocampus-dependent long-lasting memory.1 Publication

GO - Biological processi

  • long-term memory Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 4
Alternative name(s):
Neuronal leucine-rich repeat protein 4
Short name:
NLRR-4
Gene namesi
Name:Lrrn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2445154. Lrrn4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 676657ExtracellularSequence analysisAdd
BLAST
Transmembranei677 – 69721HelicalSequence analysisAdd
BLAST
Topological domaini698 – 73336CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile, but show impaired memory retention. Lrrn4-deficient mice are able to maintain memories for one day in hippocampus-dependent learning tasks, but are unable of retaining memories for four days after learning. In contrast, in hippocampus-independent tasks Lrrn4-deficient mice normally retain memories for at least seven days.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 733714Leucine-rich repeat neuronal protein 4PRO_0000021030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence analysis
Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence analysis
Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence analysis
Glycosylationi619 – 6191N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP59383.
PaxDbiP59383.
PRIDEiP59383.

Expressioni

Gene expression databases

BgeeiP59383.
GenevisibleiP59383. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057005.

Structurei

3D structure databases

ProteinModelPortaliP59383.
SMRiP59383. Positions 17-359, 578-681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 8221LRR 1Add
BLAST
Repeati83 – 10624LRR 2Add
BLAST
Repeati107 – 12822LRR 3Add
BLAST
Repeati130 – 15122LRR 4Add
BLAST
Repeati154 – 17522LRR 5Add
BLAST
Repeati178 – 19922LRR 6Add
BLAST
Repeati207 – 23024LRR 7Add
BLAST
Repeati231 – 25323LRR 8Add
BLAST
Repeati256 – 27823LRR 9Add
BLAST
Repeati281 – 30222LRR 10Add
BLAST
Domaini311 – 36454LRRCTAdd
BLAST
Domaini576 – 675100Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064159.
HOVERGENiHBG051176.
InParanoidiP59383.
OMAiEGDIFKM.
OrthoDBiEOG7FJH01.
TreeFamiTF351118.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWTLMLQLL QLLLQLLMAQ SQSLERISQD RIPLFRLTQQ GDWDSLDRHP
60 70 80 90 100
TDSLCVGLPA AGVTTLNLAN RSLESLPSCL PRTLRSLDGS HNLLRALSEP
110 120 130 140 150
VLGRLPELRV LTLHHNRISV LHWGRDTLAE LRELDLSHNL LTELPPCAGP
160 170 180 190 200
SGSSLRSLAL AGNPLRALLP RTFACFPALR LLNLSCSELG HIAQEAFAGV
210 220 230 240 250
DGGPLAALEL LDLSGTSLER VESGWIRNLP KLKSLFLRKM PRLKTLEGDI
260 270 280 290 300
FKMTPNLRQL DCGDSPALTS VHTEIFQDTP NLQVLQFQNC NLSSFGPWNS
310 320 330 340 350
SQVLSVSLFG NPLICSCELA WLLVDVNKTV LHRAADTMCE PALGSTGPFS
360 370 380 390 400
GPLSLSHLSN VCRSDQSTTL LPSNPGRFDH SVFAPRIQGP SIEQSTALSA
410 420 430 440 450
QPGGSQQNIT KVPSLTMTSP TQGSWMYKDA SEETAQSTNS ELVYSPSRAL
460 470 480 490 500
PGAASSGAEQ TATHILEPNI SSASTPLVSK YLEPLPTSPN PRSLPQTKQR
510 520 530 540 550
TQATPRALHT DPPQDEIPVL LLDDDSEEEE TRDQVAAPPQ DVSCEYHPCK
560 570 580 590 600
HLQTPCAELQ RRFRCRCPGL SGEDTTPDPP TLQGVSEVTD TSVLVHWCAP
610 620 630 640 650
NSVVLWYQIH YVAEGRSGNQ SVVDIYATAR QHPLYKLTPG TTYHVCVLAA
660 670 680 690 700
NRAGLSQSQT SGWRRSCATF TTKPSSVVIF WGLCTASGLL LVSTLVLSVC
710 720 730
LWRQRWKPHR QFYDTHLVAF KNPARAEEVT QWE
Length:733
Mass (Da):80,489
Last modified:July 27, 2011 - v2
Checksum:iF2DF7F9D5791DF63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti316 – 3161S → G in BAC39399 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085246 mRNA. Translation: BAC39399.1.
AK080889 mRNA. Translation: BAC38065.1.
AL831763, AL929562 Genomic DNA. Translation: CAM20381.1.
AL929562, AL831763 Genomic DNA. Translation: CAM26895.1.
CCDSiCCDS16780.1.
RefSeqiNP_796277.2. NM_177303.4.
XP_011237904.1. XM_011239602.1.
UniGeneiMm.357342.
Mm.386903.

Genome annotation databases

EnsembliENSMUST00000049787; ENSMUSP00000057005; ENSMUSG00000043110.
GeneIDi320974.
KEGGimmu:320974.
UCSCiuc008mnn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085246 mRNA. Translation: BAC39399.1.
AK080889 mRNA. Translation: BAC38065.1.
AL831763, AL929562 Genomic DNA. Translation: CAM20381.1.
AL929562, AL831763 Genomic DNA. Translation: CAM26895.1.
CCDSiCCDS16780.1.
RefSeqiNP_796277.2. NM_177303.4.
XP_011237904.1. XM_011239602.1.
UniGeneiMm.357342.
Mm.386903.

3D structure databases

ProteinModelPortaliP59383.
SMRiP59383. Positions 17-359, 578-681.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057005.

Proteomic databases

MaxQBiP59383.
PaxDbiP59383.
PRIDEiP59383.

Protocols and materials databases

DNASUi320974.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049787; ENSMUSP00000057005; ENSMUSG00000043110.
GeneIDi320974.
KEGGimmu:320974.
UCSCiuc008mnn.1. mouse.

Organism-specific databases

CTDi164312.
MGIiMGI:2445154. Lrrn4.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000064159.
HOVERGENiHBG051176.
InParanoidiP59383.
OMAiEGDIFKM.
OrthoDBiEOG7FJH01.
TreeFamiTF351118.

Miscellaneous databases

PROiP59383.
SOURCEiSearch...

Gene expression databases

BgeeiP59383.
GenevisibleiP59383. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00369. LRR_TYP. 6 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Adipose tissue and Stomach.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory."
    Bando T., Sekine K., Kobayashi S., Watabe A.M., Rump A., Tanaka M., Suda Y., Kato S., Morikawa Y., Manabe T., Miyajima A.
    Mol. Cell. Biol. 25:4166-4175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-619.

Entry informationi

Entry nameiLRRN4_MOUSE
AccessioniPrimary (citable) accession number: P59383
Secondary accession number(s): A2ANX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.