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Protein

Peroxisomal membrane protein 4

Gene

Pxmp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 4
Alternative name(s):
24 kDa peroxisomal intrinsic membrane protein
Gene namesi
Name:Pxmp4
Synonyms:Pmp24
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi628782. Pxmp4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • peroxisomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 212211Peroxisomal membrane protein 4PRO_0000218934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP59382.

PTM databases

PhosphoSiteiP59382.

Expressioni

Tissue specificityi

Liver.

Gene expression databases

GenevestigatoriP59382.

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022914.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79127.
GeneTreeiENSGT00390000001562.
HOGENOMiHOG000157771.
HOVERGENiHBG053773.
InParanoidiP59382.
KOiK13350.
OMAiYTHSRNL.
OrthoDBiEOG7NSB3Q.
PhylomeDBiP59382.
TreeFamiTF105313.

Family and domain databases

InterProiIPR019531. Pmp4.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
PIRSFiPIRSF013674. PXMP4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPQLRAL LQAVNKLLRQ RRYHAALAVI KGFRNGAVYG VKIRAPHALV
60 70 80 90 100
MTFLFRSGSL QEKLQAILKA TYTHSRNLAC FVFTYKSLQA LQSHVQGGTH
110 120 130 140 150
QMHSFLAAFI GGLLLFGENN NINSQINMYL TSRVLFALCR LGVEKGYIPA
160 170 180 190 200
LKWDPFPLHT AVIWGLVLWL FEYHRPTLQP SLQSSMTYLY EDSNVWHDLS
210
DFLIFNKSRP SK
Length:212
Mass (Da):24,136
Last modified:January 23, 2007 - v2
Checksum:i07D3A5F0A7841A36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151834 mRNA. Translation: AAN72218.1.
BC081699 mRNA. Translation: AAH81699.1.
RefSeqiNP_757377.1. NM_172223.2.
UniGeneiRn.7752.

Genome annotation databases

EnsembliENSRNOT00000022914; ENSRNOP00000022914; ENSRNOG00000016975.
GeneIDi282634.
KEGGirno:282634.
UCSCiRGD:628782. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151834 mRNA. Translation: AAN72218.1.
BC081699 mRNA. Translation: AAH81699.1.
RefSeqiNP_757377.1. NM_172223.2.
UniGeneiRn.7752.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022914.

PTM databases

PhosphoSiteiP59382.

Proteomic databases

PRIDEiP59382.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022914; ENSRNOP00000022914; ENSRNOG00000016975.
GeneIDi282634.
KEGGirno:282634.
UCSCiRGD:628782. rat.

Organism-specific databases

CTDi11264.
RGDi628782. Pxmp4.

Phylogenomic databases

eggNOGiNOG79127.
GeneTreeiENSGT00390000001562.
HOGENOMiHOG000157771.
HOVERGENiHBG053773.
InParanoidiP59382.
KOiK13350.
OMAiYTHSRNL.
OrthoDBiEOG7NSB3Q.
PhylomeDBiP59382.
TreeFamiTF105313.

Miscellaneous databases

NextBioi624827.
PROiP59382.

Gene expression databases

GenevestigatoriP59382.

Family and domain databases

InterProiIPR019531. Pmp4.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
PIRSFiPIRSF013674. PXMP4. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new Rattus norvegicus gene is highly homologous to Mus musculus PMP24 protein."
    Yao R., Wang Y., You M.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes."
    Reguenga C., Oliveira M.E.M., Gouveia A.M.M., Eckerskorn C., Sa-Miranda C., Azevedo J.E.
    Biochim. Biophys. Acta 1445:337-341(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-14, CHARACTERIZATION.
    Tissue: Liver.

Entry informationi

Entry nameiPXMP4_RAT
AccessioniPrimary (citable) accession number: P59382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.