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P59382

- PXMP4_RAT

UniProt

P59382 - PXMP4_RAT

Protein

Peroxisomal membrane protein 4

Gene

Pxmp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein 4
    Alternative name(s):
    24 kDa peroxisomal intrinsic membrane protein
    Gene namesi
    Name:Pxmp4
    Synonyms:Pmp24
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi628782. Pxmp4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. peroxisomal membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 212211Peroxisomal membrane protein 4PRO_0000218934Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP59382.

    PTM databases

    PhosphoSiteiP59382.

    Expressioni

    Tissue specificityi

    Liver.

    Gene expression databases

    GenevestigatoriP59382.

    Interactioni

    Subunit structurei

    Interacts with PEX19.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000022914.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79127.
    GeneTreeiENSGT00390000001562.
    HOGENOMiHOG000157771.
    HOVERGENiHBG053773.
    InParanoidiP59382.
    KOiK13350.
    OMAiQATYTHS.
    OrthoDBiEOG7NSB3Q.
    PhylomeDBiP59382.
    TreeFamiTF105313.

    Family and domain databases

    InterProiIPR019531. Pmp4.
    IPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]
    PIRSFiPIRSF013674. PXMP4. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59382-1 [UniParc]FASTAAdd to Basket

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    MAAPPQLRAL LQAVNKLLRQ RRYHAALAVI KGFRNGAVYG VKIRAPHALV    50
    MTFLFRSGSL QEKLQAILKA TYTHSRNLAC FVFTYKSLQA LQSHVQGGTH 100
    QMHSFLAAFI GGLLLFGENN NINSQINMYL TSRVLFALCR LGVEKGYIPA 150
    LKWDPFPLHT AVIWGLVLWL FEYHRPTLQP SLQSSMTYLY EDSNVWHDLS 200
    DFLIFNKSRP SK 212
    Length:212
    Mass (Da):24,136
    Last modified:January 23, 2007 - v2
    Checksum:i07D3A5F0A7841A36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY151834 mRNA. Translation: AAN72218.1.
    BC081699 mRNA. Translation: AAH81699.1.
    RefSeqiNP_757377.1. NM_172223.2.
    UniGeneiRn.7752.

    Genome annotation databases

    EnsembliENSRNOT00000022914; ENSRNOP00000022914; ENSRNOG00000016975.
    GeneIDi282634.
    KEGGirno:282634.
    UCSCiRGD:628782. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY151834 mRNA. Translation: AAN72218.1 .
    BC081699 mRNA. Translation: AAH81699.1 .
    RefSeqi NP_757377.1. NM_172223.2.
    UniGenei Rn.7752.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000022914.

    PTM databases

    PhosphoSitei P59382.

    Proteomic databases

    PRIDEi P59382.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022914 ; ENSRNOP00000022914 ; ENSRNOG00000016975 .
    GeneIDi 282634.
    KEGGi rno:282634.
    UCSCi RGD:628782. rat.

    Organism-specific databases

    CTDi 11264.
    RGDi 628782. Pxmp4.

    Phylogenomic databases

    eggNOGi NOG79127.
    GeneTreei ENSGT00390000001562.
    HOGENOMi HOG000157771.
    HOVERGENi HBG053773.
    InParanoidi P59382.
    KOi K13350.
    OMAi QATYTHS.
    OrthoDBi EOG7NSB3Q.
    PhylomeDBi P59382.
    TreeFami TF105313.

    Miscellaneous databases

    NextBioi 624827.
    PROi P59382.

    Gene expression databases

    Genevestigatori P59382.

    Family and domain databases

    InterProi IPR019531. Pmp4.
    IPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF013674. PXMP4. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A new Rattus norvegicus gene is highly homologous to Mus musculus PMP24 protein."
      Yao R., Wang Y., You M.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Fischer 344.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes."
      Reguenga C., Oliveira M.E.M., Gouveia A.M.M., Eckerskorn C., Sa-Miranda C., Azevedo J.E.
      Biochim. Biophys. Acta 1445:337-341(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-14, CHARACTERIZATION.
      Tissue: Liver.

    Entry informationi

    Entry nameiPXMP4_RAT
    AccessioniPrimary (citable) accession number: P59382
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3