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P59362

- GLMS_BRADU

UniProt

P59362 - GLMS_BRADU

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.By similarity

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityBy similarity
    Active sitei603 – 6031For Fru-6P isomerization activityBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-4639-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferase
    GFAT
    Glucosamine-6-phosphate synthase
    Hexosephosphate aminotransferase
    L-glutamine--D-fructose-6-phosphate amidotransferase
    Gene namesi
    Name:glmS
    Ordered Locus Names:bll4607
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 608607Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135307Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi224911.bll4607.

    Structurei

    3D structure databases

    ProteinModelPortaliP59362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 217216Glutamine amidotransferase type-2Add
    BLAST
    Domaini284 – 423140SIS 1Add
    BLAST
    Domaini456 – 598143SIS 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 SIS domains.Curated

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OrthoDBiEOG6KT2Q1.
    PhylomeDBiP59362.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59362-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGILGR EPVAEQLVDS LKRLEYRGYD SAGVATLEGR HLERRRAEGK    50
    LKNLEKRLEA EPLKGTTGIG HTRWATHGKP TVNNAHPHAT ERVAVVHNGI 100
    IENFRELREE LEKNGTVFHT ETDTEIVLHL VDDLLTRGNK PVEAVKLALA 150
    RLRGAFALGF IFAGDNDLMI GARNGPPLAI GYGDGEMYLG SDAIALGPFT 200
    DTISYLEDGD WVVLTRNSAT IFDKDGHAVQ REKIKHAAST SLVDKANYRH 250
    FMAKEIHEQP EVVGHTLARY VDMATERVSL PVKLPFDFKN IQRINITACG 300
    TASYAGFVAK YWFERFARLP VEVDVASEFR YREAPLRKGD LAIFISQSGE 350
    TADTLAALRY AKAEGVHTVA VVNVPTSTIA RESETVLPTL AGPEIGVAST 400
    KAFTCQLMVL ANLAIAAGKA RGELSDEDET KLVHGLVEIP RLMSDALTTE 450
    LQIEKLAREI AKSRDVLYLG RGTSFPLALE GALKLKEISY IHAEGYAAGE 500
    LKHGPIALID ETMPVVVIAP YDRVFEKTVS NMQEVAARGG KIILMTDAKG 550
    AEEATVESLV TIVMPDMAAA FTPMVYAVPV QLLAYHTAVI MGTDVDQPRN 600
    LAKSVTVE 608
    Length:608
    Mass (Da):66,370
    Last modified:January 23, 2007 - v2
    Checksum:iA2627F79781AF783
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC49872.1.
    RefSeqiNP_771247.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC49872; BAC49872; BAC49872.
    GeneIDi1052463.
    KEGGibja:bll4607.
    PATRICi21192848. VBIBraJap65052_4674.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC49872.1 .
    RefSeqi NP_771247.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali P59362.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.bll4607.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC49872 ; BAC49872 ; BAC49872 .
    GeneIDi 1052463.
    KEGGi bja:bll4607.
    PATRICi 21192848. VBIBraJap65052_4674.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OrthoDBi EOG6KT2Q1.
    PhylomeDBi P59362.

    Enzyme and pathway databases

    BioCyci BJAP224911:GJEJ-4639-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiGLMS_BRADU
    AccessioniPrimary (citable) accession number: P59362
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3