Reviewed, UniProtKB/Swiss-Prot P59318 (ARGD_MYXXA)

Names and origin

Protein names

Recommended name:
    Acetylornithine aminotransferase
      Short name=ACOAT
    EC=2.6.1.11

Gene names

Name:

argD

Organism

Myxococcus xanthus

Taxonomic identifier

34 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. HAMAP MF_01107
Cofactor	Binds 1 pyridoxal phosphate per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. HAMAP MF_01107
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Miscellaneous	May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. HAMAP MF_01107
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Acetylornithine aminotransferase HAMAP MF_01107		PRO_0000112758
Regions
	Region	239 – 242	4	Pyridoxal phosphate binding By similarity
Sites
	Binding site	154	1	Pyridoxal phosphate; via carbonyl oxygen By similarity
	Binding site	157	1	N(2)-acetyl-L-ornithine By similarity
	Binding site	296	1	N(2)-acetyl-L-ornithine By similarity
	Binding site	297	1	Pyridoxal phosphate By similarity
Amino acid modifications
	Modified residue	268	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59318-1 [UniParc]. Last modified February 12, 2003. Version 1. Checksum: 423403389D7947E5	FASTA	401	42,652
	10 20 30 40 50 60 MTALSQSEPS LSASSDSSTD ALVQKAKRHL LQNYKQPPFV LARGQGARVW DMDGREYLDL 70 80 90 100 110 120 IGGIATCALG HCHPEVVAAA KAQLDSLWHV SNVFYSQPQI DLAAQLTEWS GLSRAFFCNS 130 140 150 160 170 180 GAEANEALLK LTRKVMKDRG TPERFEVISF DSSFHGRTLA TVTATGQAKY QKGFEPLPAG 190 200 210 220 230 240 FTHVPYGDLE AVRKAVGPAT AAILVEPIQG EGGVRMAPLG FLVGLRALCD EHGLLLLVDE 250 260 270 280 290 300 VQTGMGRTGK PFGFMHEGIV PDGISVAKAL GNGLPIGAML CKEELGASLT PGTHGSTFGG 310 320 330 340 350 360 NPVAAAAANA VVRILRRPGF LDEVQEKGAY LLARARELQG RLPAGRIQAV RGQGLLVGVQ 370 380 390 400 LDHKVAPVIA QVHEEGLLVN PAGDRTMLFA PPFIVTVREL D

References

[1]	"Identification of genes required for adventurous gliding motility in Myxococcus xanthus with the transposable element mariner." Youderian P.A., Burke N., White D.J., Hartzell P.L. Mol. Microbiol. 49:555-570(2003) [PubMed: 12828649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY204472 Genomic DNA. Translation: AAO22926.1.
3D structure databases
HSSP	HSSP built from PDB template 1QJ3 based on UniProtKB P12995.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.6.1.11. 926.
Family and domain databases
HAMAP	MF_01107. [Tree]
InterPro	IPR005814. Aminotrans_3. IPR004636. ArgD_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF19. ArgD_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00707. argD. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGD_MYXXA

Accession

Primary (citable) accession number: P59318

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	February 12, 2003
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)