Reviewed, UniProtKB/Swiss-Prot P59308 (ARGC2_PSEPK)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase 2
      Short name=AGPR 2
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase 2
      Short name=NAGSA dehydrogenase 2

Gene names

Name:	argC2
Ordered Locus Names:	PP_3633

Organism

Pseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]

Taxonomic identifier

160488 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	N-acetyl-gamma-glutamyl-phosphate reductase 2 HAMAP MF_01110		PRO_0000112508
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59308-1 [UniParc]. Last modified February 12, 2003. Version 1. Checksum: CC4602FB3DF1E335	FASTA	313	33,396
	10 20 30 40 50 60 MHTPVVFIDG DQGTTGLQIH ARLQGRSDLR LLTLPEAERK DPQRRCEAIN SADIALLCLP 70 80 90 100 110 120 DDAAREAVAA IHNPQVRVID ASSAHRTTPG WVYGLPELDE QQAERIAQST RVSNPGCYPT 130 140 150 160 170 180 GAIALLHPLV KAGLLPADYP LNIHAVSGYS GGGRAAVERH EQPGAAKAPA LQLYGLELAH 190 200 210 220 230 240 KHVPEIQQHA GLSARPMFMP GYGAYRQGIA LSIPLQLRLL PGQVSAEHLQ ACLEQHYQGA 250 260 270 280 290 300 RHVQVMPLHQ CGAAANLDPE ALNGSNDLRL ALYANPEHGQ VLLTAVFDNL GKGASGAAVQ 310 NLDLMLGALQ AHG

References

[1]

"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440." Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O. , Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M. Environ. Microbiol. 4:799-808(2002) [PubMed: 12534463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015451 Genomic DNA. Translation: AAN69233.1.
RefSeq	NP_745769.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P59308.
Genome annotation databases
GeneID	1046203.
GenomeReviews	Gene locus PP_3633 in contig AE015451_GR.
KEGG	ppu:PP_3633.
NMPDR	fig|160488.1.peg.3599.
TIGR	PP_3633.
Phylogenomic databases
HOGENOM	P59308.
OMA	EIQQHAG.
Enzyme and pathway databases
BioCyc	PPUT160488:PP_3633-MON.
Family and domain databases
HAMAP	MF_01110. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR010136. AGPR_subtype. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01851. argC_other. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC2_PSEPK

Accession

Primary (citable) accession number: P59308

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	February 12, 2003
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)